EV release from cardiac cells and their functional effects (Homo sapiens)

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1Multiple targetsDNARNAHSP70Serum starvationMonocyte(THP-1)Decreased metabolic activityHypoxiaMigrationTNFalphamRNAOx-LDLHomocysteineERBB4MIR126MIR146AMIR150MIR143KLF2EthanolCXCL12ProlactinRGS16C-MybMIR146AEthanolMIR145Serum starvationEndothelial cells(HUVECs, HMEC-1, and rataortic endothelial cells)Sheer stressSmooth muscle cells(HASMCs)Cardiomyocyte(NRVM, adult ratcardiomyocyte, HL-1)Cardiomyocyte(NRVM)DNARNAFibroblast(NIH-3T3)ApoptosisCD63HSP60HSC70HSC90


Description

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Bibliography

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  1. Danielson KM, Das S; ''Extracellular Vesicles in Heart Disease: Excitement for the Future ?''; Exosomes Microvesicles, 2014 PubMed Europe PMC Scholia
  2. Halkein J, Tabruyn SP, Ricke-Hoch M, Haghikia A, Nguyen NQ, Scherr M, Castermans K, Malvaux L, Lambert V, Thiry M, Sliwa K, Noel A, Martial JA, Hilfiker-Kleiner D, Struman I; ''MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy.''; J Clin Invest, 2013 PubMed Europe PMC Scholia
  3. Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S; ''Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.''; Nat Cell Biol, 2012 PubMed Europe PMC Scholia
  4. Yu X, Deng L, Wang D, Li N, Chen X, Cheng X, Yuan J, Gao X, Liao M, Wang M, Liao Y; ''Mechanism of TNF-α autocrine effects in hypoxic cardiomyocytes: initiated by hypoxia inducible factor 1α, presented by exosomes.''; J Mol Cell Cardiol, 2012 PubMed Europe PMC Scholia
  5. Malik ZA, Kott KS, Poe AJ, Kuo T, Chen L, Ferrara KW, Knowlton AA; ''Cardiac myocyte exosomes: stability, HSP60, and proteomics.''; Am J Physiol Heart Circ Physiol, 2013 PubMed Europe PMC Scholia
  6. Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, Hristov M, Köppel T, Jahantigh MN, Lutgens E, Wang S, Olson EN, Schober A, Weber C; ''Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection.''; Sci Signal, 2009 PubMed Europe PMC Scholia
  7. Gupta S, Knowlton AA; ''HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway.''; Am J Physiol Heart Circ Physiol, 2007 PubMed Europe PMC Scholia
  8. Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, Sun F, Lu J, Yin Y, Cai X, Sun Q, Wang K, Ba Y, Wang Q, Wang D, Yang J, Liu P, Xu T, Yan Q, Zhang J, Zen K, Zhang CY; ''Secreted monocytic miR-150 enhances targeted endothelial cell migration.''; Mol Cell, 2010 PubMed Europe PMC Scholia
  9. Zhan R, Leng X, Liu X, Wang X, Gong J, Yan L, Wang L, Wang Y, Qian LJ; ''Heat shock protein 70 is secreted from endothelial cells by a non-classical pathway involving exosomes.''; Biochem Biophys Res Commun, 2009 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
127847view14:42, 23 December 2023EweitzOntology Term : 'endothelial cell' added !
127846view14:42, 23 December 2023EweitzOntology Term : 'fibroblast' added !
127845view14:42, 23 December 2023EweitzOntology Term : 'monocyte' added !
127844view14:41, 23 December 2023EweitzOntology Term : 'cardiac muscle cell' added !
127842view14:34, 23 December 2023EweitzModified description
106734view13:21, 17 September 2019MaintBotHMDB identifier normalization
103019view15:34, 31 January 2019Marvin M2Updated Id for MIR146A
102152view19:03, 4 December 2018Khanspersupdated identifier for MIR143
96966view00:58, 24 April 2018AlexanderPicoModified description
88048view13:43, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
87383view11:05, 22 July 2016MaintBotadded missing graphids
83780view15:22, 4 December 2015SusanChange miRNA names and IDs
81231view19:25, 6 August 2015Khanspersfixed unconnected interactions
81157view00:38, 29 July 2015KhanspersModified description
81156view00:38, 29 July 2015KhanspersModified description
81155view00:30, 29 July 2015KhanspersAdded literature references
81144view21:54, 27 July 2015KhanspersModified description
81143view21:54, 27 July 2015KhanspersModified description
81142view21:53, 27 July 2015KhanspersModified description
81141view21:51, 27 July 2015KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
C-MybGeneProductENSG00000118513 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
ERBB4GeneProductENSG00000178568 (Ensembl)
EthanolMetaboliteHMDB00108 (HMDB)
HomocysteineMetaboliteHMDB00742 (HMDB)
KLF2GeneProductENSG00000127528 (Ensembl)
MIR126RnaENSG00000199161 (Ensembl)
MIR143RnaENSG00000208035 (Ensembl)
MIR145GeneProductENSG00000207700 (Ensembl)
MIR146ARnaENSG00000207936 (Ensembl)
MIR150RnaENSG00000207782 (Ensembl)
Ox-LDLMetaboliteCHEBI:60151 (ChEBI)
ProlactinGeneProductENSG00000172179 (Ensembl)
RGS16GeneProductENSG00000143333 (Ensembl)
TNFalpha mRNARna7124 (Entrez Gene)

Annotated Interactions

No annotated interactions

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