Melatonin metabolism and effects (Homo sapiens)

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Melatonin synthesis and disposalmelatonin inhibits colon cancer growth by inhibiting endothelin expressionMelatonin effectsLiverCYP2A6EDN1Nf-kbN-acetylserotoninCYP1B1ECE-1FOXO1CYP3ASerotoninCYP2C196-HydroxymelatoninASMTMelatonincAMPCYP1A1EthinhyloestradiolCYP1A25-methoxypsoralenAANAT6-sulphatoxymelatoninedu-1-mRNA331333233


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Bibliography

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  1. Veatch OJ, Pendergast JS, Allen MJ, Leu RM, Johnson CH, Elsea SH, Malow BA; ''Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.''; J Autism Dev Disord, 2015 PubMed Europe PMC Scholia
  2. Papagiannidou E, Skene DJ, Ioannides C; ''Potential drug interactions with melatonin.''; Physiol Behav, 2014 PubMed Europe PMC Scholia
  3. Domínguez-Alonso A, Valdés-Tovar M, Solís-Chagoyán H, Benítez-King G; ''Melatonin stimulates dendrite formation and complexity in the hilar zone of the rat hippocampus: participation of the Ca++/Calmodulin complex.''; Int J Mol Sci, 2015 PubMed Europe PMC Scholia
  4. Tian X, Huo X, Dong P, Wu B, Wang X, Wang C, Liu K, Ma X; ''Sulfation of melatonin: enzymatic characterization, differences of organs, species and genders, and bioactivity variation.''; Biochem Pharmacol, 2015 PubMed Europe PMC Scholia
  5. Yu AM, Idle JR, Byrd LG, Krausz KW, Küpfer A, Gonzalez FJ.; ''Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6''; Pharmacogenetics. 2003 Mar;13(3):173-81., 2003 PubMed Europe PMC Scholia
  6. Schomerus C, Korf HW; ''Mechanisms regulating melatonin synthesis in the mammalian pineal organ.''; Ann N Y Acad Sci, 2005 PubMed Europe PMC Scholia
  7. Ma X, Idle JR, Krausz KW, Gonzalez FJ; ''Metabolism of melatonin by human cytochromes p450.''; Drug Metab Dispos, 2005 PubMed Europe PMC Scholia
  8. León J, Casado J, Jiménez Ruiz SM, Zurita MS, González-Puga C, Rejón JD, Gila A, Muñoz de Rueda P, Pavón EJ, Reiter RJ, Ruiz-Extremera A, Salmerón J.; ''Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-κβ''; J Pineal Res. 2014 May;56(4):415-26., 2014 PubMed Europe PMC Scholia
  9. Liu YJ, Meng FT, Wang LL, Zhang LF, Cheng XP, Zhou JN; ''Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells.''; J Pineal Res, 2012 PubMed Europe PMC Scholia
  10. Carloni S, Favrais G, Saliba E, Albertini MC, Chalon S, Longini M, Gressens P, Buonocore G, Balduini W; ''Melatonin modulates neonatal brain inflammation through ER stress, autophagy and miR-34a/SIRT1 pathway.''; J Pineal Res, 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123268view09:08, 9 July 2022EgonwMade three pathways clickable
120642view12:58, 22 December 2021EweitzFix "Light" text position
120641view12:55, 22 December 2021EweitzStandardize node size, etc.
120639view00:30, 22 December 2021EweitzUse gene symbols
120638view00:28, 22 December 2021EweitzRefine case
107142view14:22, 17 September 2019MaintBotChEBI identifier normalization
106641view21:03, 12 September 2019KhanspersModified description
106153view12:05, 16 August 2019MaintBotHMDB identifier normalization
105644view05:09, 10 August 2019KhanspersModified description
91618view12:20, 23 March 2017Mkutmonfix references
91561view20:01, 13 March 2017Khanspersfixed literature refs
91550view13:10, 10 March 2017FehrhartID update
91549view13:03, 10 March 2017FehrhartID correction of MTNR1B and A
91533view08:14, 9 March 2017Marvin M2Reverted to version '21:59, 15 December 2016' by Marvin M2
91516view08:15, 8 March 2017JustgerrardzModified description
90887view21:59, 15 December 2016Khanspersfixed bad format lit refs
90688view15:22, 8 December 2016FehrhartUpdated IDs for cyclic hydroxymelatonins and sulfatoxymelatonin
88827view09:01, 15 August 2016Fehrhartfixed a line
88826view08:58, 15 August 2016FehrhartAdded melatonin effects on LPS induced inflammation pathways
84382view10:30, 18 February 2016FehrhartAdded AANAT breakdown
84381view10:10, 18 February 2016FehrhartUpgrade of melatonin-serotonin cycle
84145view16:04, 19 January 2016Fehrhartadded literature and details for noradrenaline pathway influencing melatonin synthesis
84143view13:41, 19 January 2016EgonwOntology Term : 'hormone signaling pathway' added !
84142view13:35, 19 January 2016EgonwOntology Term : 'cancer' added !
84141view13:35, 19 January 2016EgonwOntology Term : 'developmental disorder of mental health' added !
84140view13:33, 19 January 2016EgonwOntology Term : 'sleep disorder' added !
84139view13:27, 19 January 2016EgonwFixed the data source name.
84138view13:25, 19 January 2016EgonwAdded a extra identifiers.
83822view22:43, 11 December 2015AlexanderPicoClearing incomplete xref for PKA
82917view22:03, 12 November 2015Khanspersconnected interactions
82856view13:20, 10 November 2015FehrhartAdded dendrite formation pathway
82757view15:41, 30 October 2015Fehrhartfixed some ensembl identifiers
82738view15:35, 26 October 2015FehrhartAdded 3rd melatonin breakdown pathway via O-methylserotonin
81803view14:50, 30 August 2015EgonwFixed weird characters in a paper title.
81802view14:49, 30 August 2015EgonwFixed weird characters in autors names.
81801view13:52, 30 August 2015EgonwAdded a ChEBI ID for 'free radical'.
81796view11:19, 28 August 2015FehrhartSome more literature
81795view10:29, 28 August 2015FehrhartModified description
81794view10:26, 28 August 2015FehrhartMelatonin breakdown pathways
81784view14:24, 27 August 2015FehrhartLiver location of CYP and light dependant noradrenaline stimulation of melatonin production
81783view13:28, 27 August 2015FehrhartAdded backpage annotations
81782view10:47, 27 August 2015FehrhartAdded circadian regulation of clock genes by melatonin
81661view16:06, 22 August 2015MaintBotModified title
81212view15:47, 4 August 2015FehrhartSome more MIM stuff and addition of MAOA
81209view15:18, 4 August 2015Mkutmonfixed literature reference
81208view15:10, 4 August 2015EveloSome MIM stuff
81206view13:01, 4 August 2015FehrhartConnecting lines and added tryptophan pathway
81205view12:37, 4 August 2015FehrhartModified description
81204view12:28, 4 August 2015FehrhartConnection to biogenic amine synthesis pathway
81203view12:25, 4 August 2015FehrhartNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
5-methoxypsoralenMetabolite2355 (PubChem-compound)
6-HydroxymelatoninMetaboliteCHEBI:2198 (ChEBI)
6-sulphatoxymelatoninMetabolite65096 (PubChem-compound)
AANATGeneProductENSP00000250615 (Ensembl)
ASMTGeneProductENSP00000370639 (Ensembl)
CYP1A1GeneProductENSG00000140465 (Ensembl)
CYP1A2GeneProductENST00000343932 (Ensembl) Synonym CP12, P3-450
CYP1B1GeneProductENSP00000479876 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl) proven only for rat
CYP2C19GeneProductENSP00000360372 (Ensembl)
CYP3A GeneProductENSRNOG00000001379 (Ensembl) proven for rat only
ECE-1GeneProductENSG00000117298 (Ensembl)
EDN1GeneProductENSP00000368683 (Ensembl)
EthinhyloestradiolMetabolite5991 (PubChem-compound)
FOXO1GeneProductENSG00000150907 (Ensembl)
MelatoninMetaboliteCHEBI:16796 (ChEBI)
N-acetylserotoninMetaboliteCHEBI:17697 (ChEBI)
Nf-kbGeneProductENSG00000109320 (Ensembl)
SerotoninMetaboliteCHEBI:28790 (ChEBI)
cAMPMetaboliteCHEBI:17489 (ChEBI)
edu-1-mRNAGeneProduct

Annotated Interactions

No annotated interactions

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