O-linked glycosylation (Homo sapiens)

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2, 2126, 27145, 17, 277, 9, 123, 16815, 19, 23, 3041, 16, 2086, 13, 18, 22, 24...1011Golgi lumenendoplasmic reticulum lumenCore 5 mucinsCore 3 mucinsB4GALT5CMP-Neu5AcO-fuc-proteinsUDPUDP-Galextended Core 6mucinsUDP-GalNAcCMP-Neu5AcCMPPOFUT2 substratesGALNT:COSMCUDP-GlcNAcCMP-Neu5AcUDPCore 6 mucinsCore 7 mucinsCMPC1GALT1 UDPC1GALT1:COSMCST6GALNAC3/4UDP-GalSialyl-2,3 TantigensUDP-GalCore 2 mucinsglc-fuc-proteinsCMP-Neu5AcCore 8 mucinsTn antigensCMPUDP-GlcNAcST6GAL1MucinsCMPCMP-Neu5AcC1GALT1C1 B3GNTsDisialyl T antigensUDP-GalNAcCore 1 mucinsST6GALNAC2POFUT2GCNT3B3GALTLSialyl-2,6 TantigensSialyl Tn antigensCore 4 mucinsUDPUDPST3GAL1-4C1GALT1C1 UDPGCNTs


Description

O-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of proteins containing thrombospondin type 1 repeat (TSR) domains and O-glycosylation of mucins are currently described here. Source:Reactome.

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Bibliography

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  1. Crew VK, Singleton BK, Green C, Parsons SF, Daniels G, Anstee DJ.; ''New mutations in C1GALT1C1 in individuals with Tn positive phenotype.''; PubMed Europe PMC Scholia
  2. Manya H, Chiba A, Yoshida A, Wang X, Chiba Y, Jigami Y, Margolis RU, Endo T.; ''Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity.''; PubMed Europe PMC Scholia
  3. Basu SS, Basu M, Li Z, Basu S.; ''Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line.''; PubMed Europe PMC Scholia
  4. Ishida H, Togayachi A, Sakai T, Iwai T, Hiruma T, Sato T, Okubo R, Inaba N, Kudo T, Gotoh M, Shoda J, Tanaka N, Narimatsu H.; ''A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer.''; PubMed Europe PMC Scholia
  5. Vasudevan D, Takeuchi H, Johar SS, Majerus E, Haltiwanger RS.; ''Peters plus syndrome mutations disrupt a noncanonical ER quality-control mechanism.''; PubMed Europe PMC Scholia
  6. Kitagawa H, Paulson JC.; ''Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase.''; PubMed Europe PMC Scholia
  7. de Graffenried CL, Bertozzi CR.; ''Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis.''; PubMed Europe PMC Scholia
  8. Togayachi A, Sato T, Narimatsu H.; ''Comprehensive enzymatic characterization of glycosyltransferases with a beta3GT or beta4GT motif.''; PubMed Europe PMC Scholia
  9. Yeh JC, Ong E, Fukuda M.; ''Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches.''; PubMed Europe PMC Scholia
  10. Schwientek T, Yeh JC, Levery SB, Keck B, Merkx G, van Kessel AG, Fukuda M, Clausen H.; ''Control of O-glycan branch formation. Molecular cloning and characterization of a novel thymus-associated core 2 beta1, 6-n-acetylglucosaminyltransferase.''; PubMed Europe PMC Scholia
  11. Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K.; ''Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.''; PubMed Europe PMC Scholia
  12. Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP.; ''SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.''; PubMed Europe PMC Scholia
  13. Zhang MX, Nakayama J, Hidaka E, Kubota S, Yan J, Ota H, Fukuda M.; ''Immunohistochemical demonstration of alpha1,4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1,4Galbeta residues in human gastrointestinal mucosa.''; PubMed Europe PMC Scholia
  14. Wandall HH, Hassan H, Mirgorodskaya E, Kristensen AK, Roepstorff P, Bennett EP, Nielsen PA, Hollingsworth MA, Burchell J, Taylor-Papadimitriou J, Clausen H.; ''Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.''; PubMed Europe PMC Scholia
  15. Chen CI, Keusch JJ, Klein D, Hess D, Hofsteenge J, Gut H.; ''Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation.''; PubMed Europe PMC Scholia
  16. Dassie-Ajdid J, Causse A, Poidvin A, Granier M, Kaplan J, Burglen L, Doummar D, Teisseire P, Vigouroux A, Malecaze F, Calvas P, Chassaing N.; ''Novel B3GALTL mutation in Peters-plus Syndrome.''; PubMed Europe PMC Scholia
  17. Bertini E, D'Amico A, Gualandi F, Petrini S.; ''Congenital muscular dystrophies: a brief review.''; PubMed Europe PMC Scholia
  18. Shang J, Qiu R, Wang J, Liu J, Zhou R, Ding H, Yang S, Zhang S, Jin C.; ''Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver.''; PubMed Europe PMC Scholia
  19. Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I.; ''Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase.''; PubMed Europe PMC Scholia
  20. Hiruma T, Togayachi A, Okamura K, Sato T, Kikuchi N, Kwon YD, Nakamura A, Fujimura K, Gotoh M, Tachibana K, Ishizuka Y, Noce T, Nakanishi H, Narimatsu H.; ''A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc.''; PubMed Europe PMC Scholia
  21. Yoshida A, Kobayashi K, Manya H, Taniguchi K, Kano H, Mizuno M, Inazu T, Mitsuhashi H, Takahashi S, Takeuchi M, Herrmann R, Straub V, Talim B, Voit T, Topaloglu H, Toda T, Endo T.; ''Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1.''; PubMed Europe PMC Scholia
  22. Kolbinger F, Streiff MB, Katopodis AG.; ''Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains.''; PubMed Europe PMC Scholia
  23. Ju T, Aryal RP, Kudelka MR, Wang Y, Cummings RD.; ''The Cosmc connection to the Tn antigen in cancer.''; PubMed Europe PMC Scholia
  24. Moremen KW, Tiemeyer M, Nairn AV.; ''Vertebrate protein glycosylation: diversity, synthesis and function.''; PubMed Europe PMC Scholia
  25. Samyn-Petit B, Krzewinski-Recchi MA, Steelant WF, Delannoy P, Harduin-Lepers A.; ''Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells.''; PubMed Europe PMC Scholia
  26. Bennett EP, Mandel U, Clausen H, Gerken TA, Fritz TA, Tabak LA.; ''Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.''; PubMed Europe PMC Scholia
  27. Kim YJ, Kim KS, Kim SH, Kim CH, Ko JH, Choe IS, Tsuji S, Lee YC.; ''Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II).''; PubMed Europe PMC Scholia
  28. Inamori K, Hara Y, Willer T, Anderson ME, Zhu Z, Yoshida-Moriguchi T, Campbell KP.; ''Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2.''; PubMed Europe PMC Scholia
  29. Zheng H, Li Y, Ji C, Li J, Zhang J, Yin G, Xu J, Ye X, Wu M, Zou X, Gu S, Xie Y, Mao Y.; ''Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase.''; PubMed Europe PMC Scholia
  30. Manzini MC, Tambunan DE, Hill RS, Yu TW, Maynard TM, Heinzen EL, Shianna KV, Stevens CR, Partlow JN, Barry BJ, Rodriguez J, Gupta VA, Al-Qudah AK, Eyaid WM, Friedman JM, Salih MA, Clark R, Moroni I, Mora M, Beggs AH, Gabriel SB, Walsh CA.; ''Exome sequencing and functional validation in zebrafish identify GTDC2 mutations as a cause of Walker-Warburg syndrome.''; PubMed Europe PMC Scholia
  31. Stevens E, Carss KJ, Cirak S, Foley AR, Torelli S, Willer T, Tambunan DE, Yau S, Brodd L, Sewry CA, Feng L, Haliloglu G, Orhan D, Dobyns WB, Enns GM, Manning M, Krause A, Salih MA, Walsh CA, Hurles M, Campbell KP, Manzini MC, UK10K Consortium, Stemple D, Lin YY, Muntoni F.; ''Mutations in B3GALNT2 cause congenital muscular dystrophy and hypoglycosylation of α-dystroglycan.''; PubMed Europe PMC Scholia
  32. Stamenkovic I, Asheim HC, Deggerdal A, Blomhoff HK, Smeland EB, Funderud S.; ''The B cell antigen CD75 is a cell surface sialytransferase.''; PubMed Europe PMC Scholia
  33. Harduin-Lepers A, Stokes DC, Steelant WF, Samyn-Petit B, Krzewinski-Recchi MA, Vallejo-Ruiz V, Zanetta JP, Augé C, Delannoy P.; ''Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV.''; PubMed Europe PMC Scholia
  34. Wells L.; ''The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy.''; PubMed Europe PMC Scholia
  35. Inamori K, Yoshida-Moriguchi T, Hara Y, Anderson ME, Yu L, Campbell KP.; ''Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE.''; PubMed Europe PMC Scholia
  36. Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S.; ''Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.''; PubMed Europe PMC Scholia
  37. Iwai T, Inaba N, Naundorf A, Zhang Y, Gotoh M, Iwasaki H, Kudo T, Togayachi A, Ishizuka Y, Nakanishi H, Narimatsu H.; ''Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans.''; PubMed Europe PMC Scholia
  38. Weh E, Reis LM, Tyler RC, Bick D, Rhead WJ, Wallace S, McGregor TL, Dills SK, Chao MC, Murray JC, Semina EV.; ''Novel B3GALTL mutations in classic Peters plus syndrome and lack of mutations in a large cohort of patients with similar phenotypes.''; PubMed Europe PMC Scholia
  39. Van den Steen P, Rudd PM, Dwek RA, Opdenakker G.; ''Concepts and principles of O-linked glycosylation.''; PubMed Europe PMC Scholia
  40. Nakayama J, Yeh JC, Misra AK, Ito S, Katsuyama T, Fukuda M.; ''Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin.''; PubMed Europe PMC Scholia
  41. Röttger S, White J, Wandall HH, Olivo JC, Stark A, Bennett EP, Whitehouse C, Berger EG, Clausen H, Nilsson T.; ''Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus.''; PubMed Europe PMC Scholia
  42. Hofsteenge J, Huwiler KG, Macek B, Hess D, Lawler J, Mosher DF, Peter-Katalinic J.; ''C-mannosylation and O-fucosylation of the thrombospondin type 1 module.''; PubMed Europe PMC Scholia
  43. Luo Y, Nita-Lazar A, Haltiwanger RS.; ''Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats.''; PubMed Europe PMC Scholia
  44. Bierhuizen MF, Fukuda M.; ''Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.''; PubMed Europe PMC Scholia
  45. Inamori K, Willer T, Hara Y, Venzke D, Anderson ME, Clarke NF, Guicheney P, Bönnemann CG, Moore SA, Campbell KP.; ''Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of α-dystroglycan in cells and tissues.''; PubMed Europe PMC Scholia
  46. Huang C, Zhou J, Wu S, Shan Y, Teng S, Yu L.; ''Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family.''; PubMed Europe PMC Scholia
  47. Schwientek T, Nomoto M, Levery SB, Merkx G, van Kessel AG, Bennett EP, Hollingsworth MA, Clausen H.; ''Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4.''; PubMed Europe PMC Scholia
  48. Togayachi A, Akashima T, Ookubo R, Kudo T, Nishihara S, Iwasaki H, Natsume A, Mio H, Inokuchi J, Irimura T, Sasaki K, Narimatsu H.; ''Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids.''; PubMed Europe PMC Scholia
  49. Di Costanzo S, Balasubramanian A, Pond HL, Rozkalne A, Pantaleoni C, Saredi S, Gupta VA, Sunu CM, Yu TW, Kang PB, Salih MA, Mora M, Gussoni E, Walsh CA, Manzini MC.; ''POMK mutations disrupt muscle development leading to a spectrum of neuromuscular presentations.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114867view16:37, 25 January 2021ReactomeTeamReactome version 75
113313view11:38, 2 November 2020ReactomeTeamReactome version 74
112524view15:48, 9 October 2020ReactomeTeamReactome version 73
101436view11:31, 1 November 2018ReactomeTeamreactome version 66
100975view21:08, 31 October 2018ReactomeTeamreactome version 65
100512view19:42, 31 October 2018ReactomeTeamreactome version 64
100058view16:26, 31 October 2018ReactomeTeamreactome version 63
99610view14:59, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93999view13:50, 16 August 2017ReactomeTeamreactome version 61
93608view11:28, 9 August 2017ReactomeTeamreactome version 61
88081view09:08, 26 July 2016RyanmillerOntology Term : 'peptide and protein metabolic process' added !
88080view09:07, 26 July 2016RyanmillerOntology Term : 'classic metabolic pathway' added !
86717view09:24, 11 July 2016ReactomeTeamreactome version 56
83262view10:34, 18 November 2015ReactomeTeamVersion54
81374view12:54, 21 August 2015ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
B3GALTLProteinQ6Y288 (Uniprot-TrEMBL)
B3GNTsR-HSA-916814 (Reactome)
B4GALT5R-HSA-2901790 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
C1GALT1 ProteinQ9NS00 (Uniprot-TrEMBL)
C1GALT1:COSMCComplexR-HSA-1964504 (Reactome)
C1GALT1C1 ProteinQ96EU7 (Uniprot-TrEMBL)
CMP-Neu5AcMetaboliteCHEBI:16556 (ChEBI)
CMPMetaboliteCHEBI:17361 (ChEBI)
Core 1 mucinsR-HSA-1462240 (Reactome)
Core 2 mucinsR-HSA-1462066 (Reactome)
Core 3 mucinsR-HSA-1462159 (Reactome)
Core 4 mucinsR-HSA-1462144 (Reactome)
Core 5 mucinsR-HSA-1462179 (Reactome)
Core 6 mucinsR-HSA-1462353 (Reactome)
Core 7 mucinsR-HSA-1462341 (Reactome)
Core 8 mucinsR-HSA-1462115 (Reactome)
Disialyl T antigensR-HSA-1463507 (Reactome)
GALNT:COSMCComplexR-HSA-914019 (Reactome)
GCNT3ProteinO95395 (Uniprot-TrEMBL)
GCNTsR-HSA-914009 (Reactome)
MucinsR-HSA-913666 (Reactome)
O-fuc-proteinsR-HSA-5173164 (Reactome)
POFUT2 substratesR-HSA-5173014 (Reactome)
POFUT2ProteinQ9Y2G5 (Uniprot-TrEMBL)
ST3GAL1-4R-HSA-981491 (Reactome)
ST6GAL1ProteinP15907 (Uniprot-TrEMBL)
ST6GALNAC2ProteinQ9UJ37 (Uniprot-TrEMBL)
ST6GALNAC3/4R-HSA-981824 (Reactome)
Sialyl Tn antigensR-HSA-1463504 (Reactome)
Sialyl-2,3 T antigensR-HSA-1463569 (Reactome)
Sialyl-2,6 T antigensR-HSA-1463568 (Reactome)
Tn antigensR-HSA-913659 (Reactome)
UDP-GalMetaboliteCHEBI:18307 (ChEBI)
UDP-GalNAcMetaboliteCHEBI:16650 (ChEBI)
UDP-GlcNAcMetaboliteCHEBI:16264 (ChEBI)
UDPMetaboliteCHEBI:17659 (ChEBI)
extended Core 6 mucinsR-HSA-1967037 (Reactome)
glc-fuc-proteinsR-HSA-5173276 (Reactome)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
B3GALTLmim-catalysisR-HSA-5173005 (Reactome)
B3GNTsmim-catalysisR-HSA-914010 (Reactome)
B4GALT5mim-catalysisR-HSA-1964501 (Reactome)
C1GALT1:COSMCmim-catalysisR-HSA-1964505 (Reactome)
CMP-Neu5AcR-HSA-977071 (Reactome)
CMP-Neu5AcR-HSA-977228 (Reactome)
CMP-Neu5AcR-HSA-981497 (Reactome)
CMP-Neu5AcR-HSA-981809 (Reactome)
CMP-Neu5AcR-HSA-981814 (Reactome)
CMPArrowR-HSA-977071 (Reactome)
CMPArrowR-HSA-977228 (Reactome)
CMPArrowR-HSA-981497 (Reactome)
CMPArrowR-HSA-981809 (Reactome)
CMPArrowR-HSA-981814 (Reactome)
Core 1 mucinsArrowR-HSA-1964505 (Reactome)
Core 1 mucinsR-HSA-914012 (Reactome)
Core 1 mucinsR-HSA-977228 (Reactome)
Core 1 mucinsR-HSA-981497 (Reactome)
Core 1 mucinsR-HSA-981814 (Reactome)
Core 2 mucinsArrowR-HSA-914012 (Reactome)
Core 3 mucinsArrowR-HSA-914010 (Reactome)
Core 3 mucinsR-HSA-914018 (Reactome)
Core 4 mucinsArrowR-HSA-914018 (Reactome)
Core 5 mucinsArrowR-HSA-914005 (Reactome)
Core 6 mucinsArrowR-HSA-914008 (Reactome)
Core 6 mucinsR-HSA-1964501 (Reactome)
Core 7 mucinsArrowR-HSA-914017 (Reactome)
Core 8 mucinsArrowR-HSA-914006 (Reactome)
Disialyl T antigensArrowR-HSA-981809 (Reactome)
GALNT:COSMCmim-catalysisR-HSA-913675 (Reactome)
GCNT3mim-catalysisR-HSA-914018 (Reactome)
GCNTsmim-catalysisR-HSA-914012 (Reactome)
MucinsR-HSA-913675 (Reactome)
O-fuc-proteinsArrowR-HSA-5173192 (Reactome)
O-fuc-proteinsR-HSA-5173005 (Reactome)
POFUT2 substratesR-HSA-5173192 (Reactome)
POFUT2mim-catalysisR-HSA-5173192 (Reactome)
R-HSA-1964501 (Reactome) Beta-1,4-galactosyltransferase 5 (B4GALT5) mediates the transfer of galactose from UDP-galactose to Core 6 glycoproteins (Sato et al. 1998).
R-HSA-1964505 (Reactome) Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1) (Ju et al. 2002) mediates the transfer of galactose from UDP-galactose to Tn antigens to form Core 1 mucins. C1GALT1 is acitve when in complex with the molecular chaperone COSMC (C1GALT1C1) (Ju & Cummings 2002).
R-HSA-5173005 (Reactome) Sato et al. identified the human beta-1,3-glucosyltransferase-like protein (B3GALTL), localised on the ER membrane, which glucosylates O-fucosylated proteins (Sato et al. 2006). The resultant glc-beta-1,3-fuc disaccharide modification on TSR1 domain-containing proteins is thought assist in the secretion of many of these proteins from the ER lumen.
R-HSA-5173192 (Reactome) The O-fucosylation of proteins containing thrombospondin type 1 repeat (TSR1) domains is carried out by protein fucosyltransferase 2 (POFUT2). Only POFUT2 recognises the consensus sequence CSXS/TCG found in TSR1 domains and the fucosyl residue is attached to the hydroxyl group of conserved serine (S) or threonine (T) residues within the consensus sequence (Chen et al. 2012). The modification was first demonstrated on thrombospondin 1 (THBS1, TSP1), found in platelets and the ECM (Hofsteenge et al. 2001, Luo et al. 2006). In humans, there are more than 60 of these TSR1 domain-containing proteins. Only the proteins with similarity to experimentally confirmed ones are listed as candidates.
R-HSA-913675 (Reactome) The family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (GalNAc-transferases, GALNTs) carry out the addition of N-acetylgalactosamine on serine or threonine residues of proteins, especially mucins (Wandall et al. 1997). This reaction takes place in the Golgi apparatus (Röttger et al. 1998). There are 20 known members of the GALNT family, 15 of which have been characterised and 5 candidate members which are thought to belong to this family based on sequence similarity. The molecular chaperone C1GALT1C1-specific chaperone (COSMC) is thought to be required for N-acetylgalactosaminyltransferase activity (Yu & Cummings 2002).
R-HSA-914005 (Reactome) An unknown N-acetylglucosaminyltransferase mediates the transfer of GlcNAc to Tn antigens via an alpha-1,3 linkage to create Core 5 mucins (Brockhausen et al. 2009).
R-HSA-914006 (Reactome) An unknown galactosyltransferase mediates the transfer of galactose is transferred to Tn antigens via an alpha-1,3 linkage to create Core 8 mucins (Brockhausen et al. 2009).
R-HSA-914008 (Reactome) An unknown N-acetylglucosaminyltransferase mediates the transfer of GlcNAc to Tn antigens via an beta-1,6 linkage to create Core 6 mucins (Brockhausen et al. 2009).
R-HSA-914010 (Reactome) The UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase family (B3GNTs) consists of 9 members in humans (Kolbinger et al, 1998; Shiraishi et al, 2001; Togayachi et al, 2001; Iwai et al, 2002; Huang et al, 2004; Ishida et al, 2005; Zheng et al, 2004). They catalyse the addition of N-acetylglucosamine to the T antigen to form the Core 3 glycoprotein (Togayachi et al, 2006). Thie reaction occurs in the Golgi.
R-HSA-914012 (Reactome) The human gene GCNT encodes beta-1,6-N-acetylglucosaminyltransferase which mediates core 2 O-glycan branching by the addition of N-acetylgalactosamine, an important step in mucin-type biosynthesis. There are 3 defined members in humans, 1, 3 and 4 (Bierhuizen and Fukuda, 1992; Yeh et al, 1999; Schwientek et al, 2000). Two members (6 and 7) may be part of the family based on sequence similarity.
R-HSA-914017 (Reactome) An unknown N-acetylgalactosaminyltransferase mediates the transfer of GalNAc is transferred to Tn antigens via an alpha-1,6 linkage to create Core 7 mucins (Brockhausen et al. 2009).
R-HSA-914018 (Reactome) The glycosyltransferase GCNT3 mediates core 2 and core 4 O-glycan branching (Yeh et al, 1999; Schwientek et al, 1999).
R-HSA-977071 (Reactome) Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to galactose-containing acceptor substrates such as the Tn antigen (Stamenkovic et al. 1990).
R-HSA-977228 (Reactome) Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to the T antigen (Stamenkovic et al. 1990).
R-HSA-981497 (Reactome) The human genes ST3GAL1-4 encode for sialyltransferases1-4 respectively (Shang et al. 1999, Kim et al. 1996, Kitagawa & Paulson 1993, Basu et al. 1993). They add silaic acid (Neu5Ac) onto the T antigen forming an alpha-3-sialyl O-glycan.
R-HSA-981809 (Reactome) The human genes ST6GALNAC3 and 4 encode GalNAc alpha-2,6-sialyltransferase III and IV respectively which can add sialic acid (Neu5Ac) to sialyl T antigen to produce a disialyl T antigen. ST6GALNAC4 is characterised (Harduin-Lepers et al. 2000) while ST6GALNAC3 is thought to perform a similar function based on sequence similarity.
R-HSA-981814 (Reactome) The huma gene ST6GALNAC2 encodes GalNAc alpha-2,6-sialyltransferase II which mediates the transfer of sialic acid (Neu5Ac) onto the T antigen (Samyn-Petit et al. 2000).
ST3GAL1-4mim-catalysisR-HSA-981497 (Reactome)
ST6GAL1mim-catalysisR-HSA-977071 (Reactome)
ST6GAL1mim-catalysisR-HSA-977228 (Reactome)
ST6GALNAC2mim-catalysisR-HSA-981814 (Reactome)
ST6GALNAC3/4mim-catalysisR-HSA-981809 (Reactome)
Sialyl Tn antigensArrowR-HSA-977071 (Reactome)
Sialyl-2,3 T antigensArrowR-HSA-981497 (Reactome)
Sialyl-2,3 T antigensR-HSA-981809 (Reactome)
Sialyl-2,6 T antigensArrowR-HSA-977228 (Reactome)
Sialyl-2,6 T antigensArrowR-HSA-981814 (Reactome)
Tn antigensArrowR-HSA-913675 (Reactome)
Tn antigensR-HSA-1964505 (Reactome)
Tn antigensR-HSA-914005 (Reactome)
Tn antigensR-HSA-914006 (Reactome)
Tn antigensR-HSA-914008 (Reactome)
Tn antigensR-HSA-914010 (Reactome)
Tn antigensR-HSA-914017 (Reactome)
Tn antigensR-HSA-977071 (Reactome)
UDP-GalNAcR-HSA-913675 (Reactome)
UDP-GalNAcR-HSA-914017 (Reactome)
UDP-GalR-HSA-1964501 (Reactome)
UDP-GalR-HSA-1964505 (Reactome)
UDP-GalR-HSA-914006 (Reactome)
UDP-GlcNAcR-HSA-914005 (Reactome)
UDP-GlcNAcR-HSA-914008 (Reactome)
UDP-GlcNAcR-HSA-914010 (Reactome)
UDP-GlcNAcR-HSA-914012 (Reactome)
UDP-GlcNAcR-HSA-914018 (Reactome)
UDPArrowR-HSA-1964501 (Reactome)
UDPArrowR-HSA-1964505 (Reactome)
UDPArrowR-HSA-913675 (Reactome)
UDPArrowR-HSA-914005 (Reactome)
UDPArrowR-HSA-914006 (Reactome)
UDPArrowR-HSA-914008 (Reactome)
UDPArrowR-HSA-914010 (Reactome)
UDPArrowR-HSA-914012 (Reactome)
UDPArrowR-HSA-914017 (Reactome)
UDPArrowR-HSA-914018 (Reactome)
extended Core 6 mucinsArrowR-HSA-1964501 (Reactome)
glc-fuc-proteinsArrowR-HSA-5173005 (Reactome)
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