MHC class II antigen presentation (Homo sapiens)

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9, 26, 38, 48, 6914, 3320, 22, 35, 393, 6, 41, 51, 60174, 14, 23, 33, 36...4, 14, 17, 23, 33...8, 551, 2, 16, 21, 47...12, 24, 5815, 20, 3912, 17, 40, 6413, 18, 42, 5015, 20, 25, 37, 39...12, 24, 28, 3310, 27, 34, 41, 46...7, 31, 337, 1938, 44, 57, 635, 29, 43, 44, 59...11, 30, 32, 67, 68127, 3312, 4056, 61Golgi membranetrans-Golgi network membraneclathrin-coated endocytic vesicleintegral component of lumenal side of endoplasmic reticulum membranecytosolER to Golgi transport vesiclelysosomal lumenendocytic vesicleendoplasmic reticulum membranetransport vesicleHLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DRB1-10beta chain Nonameric complexHLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor AP2A2(1-939) HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DRB1-13beta chain CD74 HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DRB1-12beta chain Nonameric complexSEC23A CD74(1-117) HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DP SEC31A PiHLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DRB1-11beta chain AP1S2 HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA II alpha chainCLTA HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DQ AP1M1 HLA class IIhistocompatibilityantigen, DRB1-7beta chain Clathrin light chainHLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DRB1-11beta chain SAR1B HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DRB1-10beta chain SEC13 HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DR alphachain precursor SEC24C HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DQ beta 2chain Clathrin-coatedvesicleHLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DR-1 betachain precursor SH3GL2HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DR beta 5chain AntigenHLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor MHC II alpha betaheterodimerHLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DRB1-10beta chain MHC II alpha betaheterodimerHLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor AP1M1 AP1S2 HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DR beta 5chain OSBPL1A KIF2C HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DR-1 betachain precursor Invariant chaintrimerHLA class IIhistocompatibilityantigen, DQ beta 2chain AP2B1 HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DR alphachain precursor AP2M1 SEC24D HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB1-11beta chain AP1G1 AP2B1 HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DRB1-12beta chain SEC23A HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DR beta 5chain CD74(81-104) HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DQ AP1G1 HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB1-12beta chain CathepsinHLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DO betachain precursor MHC class IIalpha/beta/IinonamerAP2S1 SEC13 HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DRB1-13beta chain AP2S1 HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB1-1beta chain H2OHLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-4beta chain CD74 HLA class IIhistocompatibilityantigen, DRB1-13beta chain DCTN3 CD74 DCTN6 HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DR beta 4chain AP1B1 HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DQ KIF3B HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DR-1 betachain precursor Sar1b:GTP:Sec23p:Sec24p:Sec13p:Sec31p ComplexCD74 CD74 HLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DRB1-14beta chain RACGAP1 HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DRB1-12beta chain AP2M1 HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor KIF22 AP2M1 HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DRB1-1beta chain KIF3C HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DP alphachain precursor ADPHLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DQ DCTN1 HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor Dynein:Dynactin:microtubuleCLTC-1 HLA class IIhistocompatibilityantigen, DRB1-10beta chain Clathrin light chainAP2A1 HLA class IIhistocompatibilityantigen, DRB1-16beta chain AP-1 ComplexHLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DRB1-8beta chain Clathrin TriskelionHLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DRB1-16beta chain Clathrin light chainHLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor AP2S1 AP2M1 HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DQ Clathrin light chainDYNLL1 HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DRB1-8beta chain CD74 HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor AP1B1 SEC31A HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DQ DynaminGTP HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DP alphachain precursor DYNC1LI2 HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-10beta chain SEC24B HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain GTP HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DQ SEC24D HLA class IIhistocompatibilityantigen, DP AP1S1 HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DRB1-8beta chain CathepsinHLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor CLTA HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DR alphachain precursor AP2A1 HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DRB1-7beta chain DYNC2H1 HLA class IIhistocompatibilityantigen, DR beta 4chain CLTC1-1 RAB7:RILP:ORP1LcomplexSPTBN2HLA class IIhistocompatibilityantigen, DP alphachain precursor DCTN2 CLTC1-1 KIF2B HLA class IIhistocompatibilityantigen, DRB1-8beta chain GTPHLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DR beta 5chain AP-1 Clathrin coatednonameric complexCD74(81-104)HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DQ AP2A2(1-939) PiNonameric complexHLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DRB1-14beta chain DYNLL2 AP2S1 ATPHLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DR beta 4chain AP1S3 DCTN1 HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor SEC24B HLA class IIhistocompatibilityantigen, DRB1-14beta chain LGMNHLA class IIhistocompatibilityantigen, DRB1-16beta chain TGN-lysosome vesiclewith nonamericcomplexHLA class IIhistocompatibilityantigen, DM alphachain precursor HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DM betachain precursor HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor SEC24A HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DQ KIF4A HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-8beta chain DCTN4 KIFAP3 HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA-DM/HLA-DOHLA class IIhistocompatibilityantigen, DRB1-12beta chain RAB7A AP2A1 HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DR beta 5chain SEC24C HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DRB1-14beta chain AP1G1 HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DR beta 5chain CathepsinHLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-14beta chain AP1S1 HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DQ CLTC-1 GTP HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DR beta 4chain DYNC1I2 HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DP alphachain precursor KIF18A HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-12beta chain DYNC1H1 CLTC-1 HLA class IIhistocompatibilityantigen, DQ GTP HLA class IIhistocompatibilityantigen, DRB1-16beta chain SEC24A HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DQ beta 2chain Clathrin light chainHLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DO alphachain precursor HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor KIF3A AP1S3 HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DRB1-10beta chain GDPHLA class IIhistocompatibilityantigen, DR-1 betachain precursor AP2A2(1-939) HLA class IIhistocompatibilityantigen, DRB1-14beta chain Arf1-GDPHLA class IIhistocompatibilityantigen, DQ DCTN4 CD74 AP1M1 HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DRB1-12beta chain CD74 GTPHLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DP alphachain precursor MHC II:lip22 nonamerHLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DP alphachain precursor Clathrin coated MHCclass IIalpha/beta/IinonamerHLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DP alphachain precursor AP1S1 HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DRB1-1beta chain KIF26A HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DR beta 5chain SAR1B peptide loaded MHCclass IIHLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DRB1-7beta chain Arf1-GTPHLA class IIhistocompatibilityantigen, DRB1-8beta chain HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DQ Clathrin coated MHCclass IIalpha/beta/IinonamerDCTN3 HLA class IIhistocompatibilityantigen, DQ KIF4B HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor CD74 CD74 HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DR-1 betachain precursor RILP HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-7beta chain AP1B1 HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor KIF11 CD74 CD74 KIF15 CD74(1-176) HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor Nonameric complex inCOPII vesicleHLA class IIhistocompatibilityantigen, DRB1-12beta chain MHC class IIepitopesHLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA II beta chainDCTN5 MHC class IIalpha/beta/IinonamerHLA class IIhistocompatibilityantigen, DRB1-8beta chain Clathrin-coatedvesicleHLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DQ alpha beta dimer:Iitrimer:calnexinHLA class IIhistocompatibilityantigen, DQ beta 2chain CD74 HLA class IIhistocompatibilityantigen, DRB1-10beta chain IFI30HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DP alphachain precursor CENPE HLA class IIhistocompatibilityantigen, DRB1-16beta chain DYNC2LI1 ARF1 Nonameric complexHLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-15beta chain PiHLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain MHC II:lip10 nonamerHLA class IIhistocompatibilityantigen, DR alphachain precursor AntigenHLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DQ AP2A1 DCTN5 AP1M2 HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DQ beta 2chain HLA class IIhistocompatibilityantigen, DRB1-8beta chain AP1S2 HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-4beta chain AP1M2 Nonameric complexHLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-13beta chain MHC II:CLIPHLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DR alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-8beta chain DYNC1I1 HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DR-1 betachain precursor HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DRB1-1beta chain AP1S3 HLA class IIhistocompatibilityantigen, DP alphachain precursor HLA class IIhistocompatibilityantigen, DRB1-10beta chain CANXHLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain AP2A2(1-939) HLA class IIhistocompatibilityantigen, DRB1-12beta chain unfolded antigenHLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DQ CANX peptide free MHCII:HLA-DMHLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-12beta chain AP2B1 HLA class IIhistocompatibilityantigen, DRB1-15beta chain KIF2A GDP DCTN2 HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor ARP-1HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-15beta chain HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DRB3-1beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DP HLA class IIhistocompatibilityantigen, DRB1-16beta chain ARF1 HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain Kinesins:Dynactin:microtubuleHLA class IIhistocompatibilityantigen, DRB1-12beta chain HLA class IIhistocompatibilityantigen, DRB1-1beta chain SH3GL2 CD74 HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-10beta chain HLA class IIhistocompatibilityantigen, DQ AP2B1 SH3GL2HLA class IIhistocompatibilityantigen, DRB1-9beta chainprecursor HLA class IIhistocompatibilityantigen, DRB1-11beta chain HLA class IIhistocompatibilityantigen, DRB1-14beta chain HLA class IIhistocompatibilityantigen, DRB1-7beta chain HLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DRB1-13beta chain GDPHLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DQB1*0602beta chainprecursor HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-16beta chain HLA class IIhistocompatibilityantigen, DR beta 4chain HLA class IIhistocompatibilityantigen, DR beta 5chain HLA class IIhistocompatibilityantigen, DQ peptide loaded MHCclass IIHLA class IIhistocompatibilityantigen, DRB1-4beta chain HLA class IIhistocompatibilityantigen, DRB1-10beta chain Dynamin-1/2/3HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DR beta 5chain AP1M2 HLA class IIhistocompatibilityantigen, DRB1-13beta chain HLA class IIhistocompatibilityantigen, DQ HLA class IIhistocompatibilityantigen, DRB1-1beta chain HLA class IIhistocompatibilityantigen, DRB1-1beta chain DCTN6


Description

Antigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exogenous antigenic peptides to CD4+ T helper cells. CD4+ T cells play a central role in immune protection. On their activation they stimulate differentiation of B cells into antibody-producing B-cell blasts and initiate adaptive immune responses. MHC class II molecules are transmembrane glycoprotein heterodimers of alpha and beta subunits. Newly synthesized MHC II molecules present in the endoplasmic reticulum bind to a chaperone protein called invariant (Ii) chain. The binding of Ii prevents the premature binding of self antigens to the nascent MHC molecules in the ER and also guides MHC molecules to endocytic compartments. In the acidic endosomal environment, Ii is degraded in a stepwise manner, ultimately to free the class II peptide-binding groove for loading of antigenic peptides. Exogenous antigens are internalized by the APC by receptor mediated endocytosis, phagocytosis or pinocytosis into endocytic compartments of MHC class II positive cells, where engulfed antigens are degraded in a low pH environment by multiple acidic proteases, generating MHC class II epitopes. Antigenic peptides are then loaded into the class II ligand-binding groove. The resulting class II peptide complexes then move to the cell surface, where they are scanned by CD4+ T cells for specific recognition (Berger & Roche 2009, Zhou & Blum 2004, Watts 2004, Landsverk et al. 2009). Source:Reactome.

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
114894view16:40, 25 January 2021ReactomeTeamReactome version 75
113340view11:41, 2 November 2020ReactomeTeamReactome version 74
112550view15:51, 9 October 2020ReactomeTeamReactome version 73
101464view11:33, 1 November 2018ReactomeTeamreactome version 66
101002view21:12, 31 October 2018ReactomeTeamreactome version 65
100538view19:46, 31 October 2018ReactomeTeamreactome version 64
100085view16:31, 31 October 2018ReactomeTeamreactome version 63
99636view15:02, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93803view13:37, 16 August 2017ReactomeTeamreactome version 61
93341view11:20, 9 August 2017ReactomeTeamreactome version 61
87930view13:02, 25 July 2016RyanmillerOntology Term : 'signaling pathway pertinent to immunity' added !
87927view13:01, 25 July 2016RyanmillerOntology Term : 'signaling pathway' added !
87926view13:01, 25 July 2016RyanmillerOntology Term : 'PW:0000002' removed !
87925view13:01, 25 July 2016RyanmillerOntology Term : 'classic metabolic pathway' added !
86428view09:17, 11 July 2016ReactomeTeamreactome version 56
83080view09:53, 18 November 2015ReactomeTeamVersion54
81402view12:55, 21 August 2015ReactomeTeamVersion53
76872view08:14, 17 July 2014ReactomeTeamFixed remaining interactions
76577view11:55, 16 July 2014ReactomeTeamFixed remaining interactions
75910view09:56, 11 June 2014ReactomeTeamRe-fixing comment source
75610view10:46, 10 June 2014ReactomeTeamReactome 48 Update
74965view13:48, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74609view08:39, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
AP-1 Clathrin coated nonameric complexComplexR-HSA-2130552 (Reactome)
AP-1 ComplexComplexR-HSA-167717 (Reactome)
AP1B1 ProteinQ10567 (Uniprot-TrEMBL)
AP1G1 ProteinO43747 (Uniprot-TrEMBL)
AP1M1 ProteinQ9BXS5 (Uniprot-TrEMBL)
AP1M2 ProteinQ9Y6Q5 (Uniprot-TrEMBL)
AP1S1 ProteinP61966 (Uniprot-TrEMBL)
AP1S2 ProteinP56377 (Uniprot-TrEMBL)
AP1S3 ProteinQ96PC3 (Uniprot-TrEMBL)
AP2A1 ProteinO95782 (Uniprot-TrEMBL)
AP2A2(1-939) ProteinO94973 (Uniprot-TrEMBL)
AP2B1 ProteinP63010 (Uniprot-TrEMBL)
AP2M1 ProteinQ96CW1 (Uniprot-TrEMBL)
AP2S1 ProteinP53680 (Uniprot-TrEMBL)
ARF1 ProteinP84077 (Uniprot-TrEMBL)
ARP-1ProteinR-HSA-2228747 (Reactome)
ATPMetaboliteCHEBI:15422 (ChEBI)
AntigenR-NUL-2213221 (Reactome)
AntigenR-NUL-983667 (Reactome)
Arf1-GDPComplexR-HSA-201340 (Reactome)
Arf1-GTPComplexR-HSA-199981 (Reactome)
CANX ProteinP27824 (Uniprot-TrEMBL)
CANXProteinP27824 (Uniprot-TrEMBL)
CD74 ProteinP04233 (Uniprot-TrEMBL)
CD74(1-117) ProteinP04233 (Uniprot-TrEMBL)
CD74(1-176) ProteinP04233 (Uniprot-TrEMBL)
CD74(81-104) ProteinP04233 (Uniprot-TrEMBL)
CD74(81-104)ProteinP04233 (Uniprot-TrEMBL)
CENPE ProteinQ02224 (Uniprot-TrEMBL)
CLTA ProteinP09496 (Uniprot-TrEMBL)
CLTC-1 ProteinQ00610-1 (Uniprot-TrEMBL)
CLTC1-1 ProteinQ00610-1 (Uniprot-TrEMBL)
CathepsinProteinR-HSA-2130544 (Reactome)
CathepsinProteinR-HSA-2130682 (Reactome)
Clathrin TriskelionComplexR-HSA-350827 (Reactome)
Clathrin coated MHC

class II alpha/beta/Ii

nonamer		ComplexR-HSA-2130309 (Reactome)
Clathrin coated MHC

class II alpha/beta/Ii

nonamer		ComplexR-HSA-2130331 (Reactome)
Clathrin light chain ProteinP09496-1 (Uniprot-TrEMBL)
Clathrin-coated vesicleComplexR-HSA-177505 (Reactome)
Clathrin-coated vesicleComplexR-HSA-2130671 (Reactome)
DCTN1 ProteinQ14203 (Uniprot-TrEMBL)
DCTN2 ProteinQ13561 (Uniprot-TrEMBL)
DCTN3 ProteinO75935 (Uniprot-TrEMBL)
DCTN4 ProteinQ9UJW0 (Uniprot-TrEMBL)
DCTN5 ProteinQ9BTE1 (Uniprot-TrEMBL)
DCTN6 ProteinO00399 (Uniprot-TrEMBL)
DYNC1H1 ProteinQ14204 (Uniprot-TrEMBL)
DYNC1I1 ProteinO14576 (Uniprot-TrEMBL)
DYNC1I2 ProteinQ13409 (Uniprot-TrEMBL)
DYNC1LI2 ProteinO43237 (Uniprot-TrEMBL)
DYNC2H1 ProteinQ8NCM8 (Uniprot-TrEMBL)
DYNC2LI1 ProteinQ8TCX1 (Uniprot-TrEMBL)
DYNLL1 ProteinP63167 (Uniprot-TrEMBL)
DYNLL2 ProteinQ96FJ2 (Uniprot-TrEMBL)
Dynamin-1/2/3ProteinR-HSA-446847 (Reactome)
DynaminProteinR-HSA-2213185 (Reactome)
Dynein:Dynactin:microtubuleComplexR-HSA-2029135 (Reactome)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HLA II alpha chainProteinR-HSA-2130718 (Reactome)
HLA II beta chainProteinR-HSA-2130672 (Reactome)
HLA class II

histocompatibility antigen, DM alpha

chain precursor 		ProteinP28067 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DM beta

chain precursor 		ProteinP28068 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DO alpha

chain precursor 		ProteinP06340 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DO beta

chain precursor 		ProteinP13765 (Uniprot-TrEMBL)
HLA class II

histocompatibility

antigen, DP 		ProteinP04440 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DP alpha

chain precursor 		ProteinP20036 (Uniprot-TrEMBL)
HLA class II

histocompatibility

antigen, DQ 		ProteinP01906 (Uniprot-TrEMBL)
HLA class II

histocompatibility

antigen, DQ 		ProteinP01909 (Uniprot-TrEMBL)
HLA class II

histocompatibility

antigen, DQ 		ProteinP01920 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DQ beta 2

chain 		ProteinP05538 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DQB1*0602 beta chain

precursor 		ProteinP01920 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DR alpha

chain precursor 		ProteinP01903 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DR beta 4

chain 		ProteinP13762 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DR beta 5

chain 		ProteinQ30154 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DR-1 beta

chain precursor 		ProteinP01912 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-1

beta chain 		ProteinP04229 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-10

beta chain 		ProteinQ30167 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-11

beta chain 		ProteinP20039 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-12

beta chain 		ProteinQ95IE3 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-13

beta chain 		ProteinQ5Y7A7 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-14

beta chain 		ProteinQ9GIY3 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-15

beta chain 		ProteinP01911 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-16

beta chain 		ProteinQ29974 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-4

beta chain 		ProteinP13760 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-7

beta chain 		ProteinP13761 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-8

beta chain 		ProteinQ30134 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB1-9 beta chain

precursor 		ProteinQ9TQE0 (Uniprot-TrEMBL)
HLA class II

histocompatibility antigen, DRB3-1 beta chain

precursor 		ProteinP79483 (Uniprot-TrEMBL)
HLA-DM/HLA-DOProteinR-HSA-2213230 (Reactome)
IFI30ProteinP13284 (Uniprot-TrEMBL)
Invariant chain trimerComplexR-HSA-2130599 (Reactome)
KIF11 ProteinP52732 (Uniprot-TrEMBL)
KIF15 ProteinQ9NS87 (Uniprot-TrEMBL)
KIF18A ProteinQ8NI77 (Uniprot-TrEMBL)
KIF22 ProteinQ14807 (Uniprot-TrEMBL)
KIF26A ProteinQ9ULI4 (Uniprot-TrEMBL) KIF26A is atypical as it lacks ATPase activity.
KIF2A ProteinO00139 (Uniprot-TrEMBL)
KIF2B ProteinQ8N4N8 (Uniprot-TrEMBL)
KIF2C ProteinQ99661 (Uniprot-TrEMBL)
KIF3A ProteinQ9Y496 (Uniprot-TrEMBL)
KIF3B ProteinO15066 (Uniprot-TrEMBL)
KIF3C ProteinO14782 (Uniprot-TrEMBL)
KIF4A ProteinO95239 (Uniprot-TrEMBL)
KIF4B ProteinQ2VIQ3 (Uniprot-TrEMBL)
KIFAP3 ProteinQ92845 (Uniprot-TrEMBL)
Kinesins:Dynactin:microtubuleComplexR-HSA-2213219 (Reactome)
LGMNProteinQ99538 (Uniprot-TrEMBL)
MHC II alpha beta heterodimerComplexR-HSA-2213186 (Reactome)
MHC II:CLIPComplexR-HSA-2130574 (Reactome)
MHC II:lip10 nonamerComplexR-HSA-2130723 (Reactome)
MHC II:lip22 nonamerComplexR-HSA-2130680 (Reactome)
MHC class II

alpha/beta/Ii

nonamer		ComplexR-HSA-2130431 (Reactome)
MHC class II

alpha/beta/Ii

nonamer		ComplexR-HSA-2130467 (Reactome)
MHC class II epitopesR-NUL-2213226 (Reactome)
Nonameric complex in COPII vesicleComplexR-HSA-2213211 (Reactome)
Nonameric complexComplexR-HSA-2130477 (Reactome)
Nonameric complexComplexR-HSA-2130491 (Reactome)
Nonameric complexComplexR-HSA-2130531 (Reactome)
Nonameric complexComplexR-HSA-2130532 (Reactome)
Nonameric complexComplexR-HSA-2214394 (Reactome)
OSBPL1A ProteinQ9BXW6 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RAB7:RILP:ORP1L complexComplexR-HSA-2213215 (Reactome)
RAB7A ProteinP51149 (Uniprot-TrEMBL)
RACGAP1 ProteinQ9H0H5 (Uniprot-TrEMBL)
RILP ProteinQ96NA2 (Uniprot-TrEMBL)
SAR1B ProteinQ9Y6B6 (Uniprot-TrEMBL)
SEC13 ProteinP55735 (Uniprot-TrEMBL)
SEC23A ProteinQ15436 (Uniprot-TrEMBL)
SEC24A ProteinO95486 (Uniprot-TrEMBL)
SEC24B ProteinO95487 (Uniprot-TrEMBL)
SEC24C ProteinP53992 (Uniprot-TrEMBL)
SEC24D ProteinO94855 (Uniprot-TrEMBL)
SEC31A ProteinO94979 (Uniprot-TrEMBL)
SH3GL2 ProteinQ99962 (Uniprot-TrEMBL)
SH3GL2ProteinQ99962 (Uniprot-TrEMBL)
SPTBN2ProteinO15020 (Uniprot-TrEMBL)
Sar1b:GTP:Sec23p:Sec24p:Sec13p:Sec31p ComplexComplexR-HSA-203999 (Reactome)
TGN-lysosome vesicle

with nonameric

complex		ComplexR-HSA-2213234 (Reactome)
alpha beta dimer:Ii trimer:calnexinComplexR-HSA-2213212 (Reactome)
peptide free MHC II:HLA-DMComplexR-HSA-2213227 (Reactome)
peptide loaded MHC class IIComplexR-HSA-2213223 (Reactome)
peptide loaded MHC class IIComplexR-HSA-2213232 (Reactome)
unfolded antigenR-NUL-2213225 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADPArrowR-HSA-2213248 (Reactome)
AP-1 Clathrin coated nonameric complexArrowR-HSA-2130619 (Reactome)
AP-1 Clathrin coated nonameric complexR-HSA-2130641 (Reactome)
AP-1 ComplexArrowR-HSA-2213236 (Reactome)
AP-1 ComplexR-HSA-2130619 (Reactome)
ARP-1ArrowR-HSA-2213248 (Reactome)
ARP-1R-HSA-2213248 (Reactome)
ATPR-HSA-2213248 (Reactome)
AntigenArrowR-HSA-2130627 (Reactome)
AntigenR-HSA-2130627 (Reactome)
AntigenR-HSA-2213240 (Reactome)
Arf1-GDPArrowR-HSA-2130619 (Reactome)
Arf1-GTPR-HSA-2130619 (Reactome)
CANXArrowR-HSA-2213241 (Reactome)
CANXR-HSA-2130478 (Reactome)
CD74(81-104)ArrowR-HSA-2213246 (Reactome)
Cathepsinmim-catalysisR-HSA-2130349 (Reactome)
Cathepsinmim-catalysisR-HSA-2130504 (Reactome)
Cathepsinmim-catalysisR-HSA-2130706 (Reactome)
Clathrin TriskelionArrowR-HSA-2213236 (Reactome)
Clathrin TriskelionR-HSA-2130619 (Reactome)
Clathrin coated MHC

class II alpha/beta/Ii

nonamer		ArrowR-HSA-2130640 (Reactome)
Clathrin coated MHC

class II alpha/beta/Ii

nonamer		ArrowR-HSA-2130725 (Reactome)
Clathrin coated MHC

class II alpha/beta/Ii

nonamer		R-HSA-2130486 (Reactome)
Clathrin coated MHC

class II alpha/beta/Ii

nonamer		R-HSA-2130725 (Reactome)
Clathrin-coated vesicleArrowR-HSA-2130486 (Reactome)
Clathrin-coated vesicleR-HSA-2130640 (Reactome)
Dynamin-1/2/3mim-catalysisR-HSA-2130725 (Reactome)
DynaminArrowR-HSA-2130641 (Reactome)
DynaminR-HSA-2130619 (Reactome)
Dynaminmim-catalysisR-HSA-2130641 (Reactome)
Dynein:Dynactin:microtubuleArrowR-HSA-2213248 (Reactome)
Dynein:Dynactin:microtubuleR-HSA-2213248 (Reactome)
GDPArrowR-HSA-2130641 (Reactome)
GDPArrowR-HSA-2130725 (Reactome)
GTPR-HSA-2130641 (Reactome)
GTPR-HSA-2130725 (Reactome)
H2OR-HSA-2130725 (Reactome)
HLA II alpha chainR-HSA-2213239 (Reactome)
HLA II beta chainR-HSA-2213239 (Reactome)
HLA-DM/HLA-DOArrowR-HSA-2213244 (Reactome)
HLA-DM/HLA-DOR-HSA-2213246 (Reactome)
IFI30mim-catalysisR-HSA-2213240 (Reactome)
Invariant chain trimerR-HSA-2130478 (Reactome)
Kinesins:Dynactin:microtubuleArrowR-HSA-2213248 (Reactome)
Kinesins:Dynactin:microtubuleR-HSA-2213248 (Reactome)
LGMNmim-catalysisR-HSA-2130336 (Reactome)
MHC II alpha beta heterodimerArrowR-HSA-2213239 (Reactome)
MHC II alpha beta heterodimerR-HSA-2130478 (Reactome)
MHC II alpha beta heterodimerR-HSA-2213241 (Reactome)
MHC II:CLIPArrowR-HSA-2130349 (Reactome)
MHC II:CLIPR-HSA-2213246 (Reactome)
MHC II:lip10 nonamerArrowR-HSA-2130504 (Reactome)
MHC II:lip10 nonamerR-HSA-2130349 (Reactome)
MHC II:lip22 nonamerArrowR-HSA-2130336 (Reactome)
MHC II:lip22 nonamerR-HSA-2130504 (Reactome)
MHC class II

alpha/beta/Ii

nonamer		ArrowR-HSA-2130378 (Reactome)
MHC class II

alpha/beta/Ii

nonamer		ArrowR-HSA-2130500 (Reactome)
MHC class II

alpha/beta/Ii

nonamer		R-HSA-2130500 (Reactome)
MHC class II

alpha/beta/Ii

nonamer		R-HSA-2130640 (Reactome)
MHC class II epitopesArrowR-HSA-2130706 (Reactome)
MHC class II epitopesR-HSA-2213244 (Reactome)
Nonameric complex in COPII vesicleArrowR-HSA-2130731 (Reactome)
Nonameric complex in COPII vesicleR-HSA-2213243 (Reactome)
Nonameric complexArrowR-HSA-2130393 (Reactome)
Nonameric complexArrowR-HSA-2130486 (Reactome)
Nonameric complexArrowR-HSA-2213235 (Reactome)
Nonameric complexArrowR-HSA-2213236 (Reactome)
Nonameric complexArrowR-HSA-2213241 (Reactome)
Nonameric complexArrowR-HSA-2213243 (Reactome)
Nonameric complexR-HSA-2130336 (Reactome)
Nonameric complexR-HSA-2130378 (Reactome)
Nonameric complexR-HSA-2130393 (Reactome)
Nonameric complexR-HSA-2130619 (Reactome)
Nonameric complexR-HSA-2130731 (Reactome)
Nonameric complexR-HSA-2213235 (Reactome)
PiArrowR-HSA-2130619 (Reactome)
PiArrowR-HSA-2130641 (Reactome)
PiArrowR-HSA-2130725 (Reactome)
R-HSA-2130336 (Reactome) Within acidic endocytic compartments Ii is proteolytically cleaved, ultimately freeing the class II peptide-binding groove for loading of antigenic peptides. Ii is degraded in a stepwise manner by a combination of aspartyl and cysteine proteases, following a well defined path with intermediates lip22, lip10 and finally CLIP. The initial Ii cleavage has been ascribed to leupeptin-insensitive cysteine or aspartic proteases, which include aspartyl protease and asparagine endopeptidase (AEP) (Maric et al. 1994, Manoury et al. 2003, Costantino et al. 2008). These proteases generate 22 kDa fragments of Ii (lip22). The trimerization domain of human Ii (residues 134-208) has three possible AEP cleavage sites, Asn148, 165 and 171. Asn171, located at the C-terminal end of helix B, is the demonstrated cleavage site for AEP (Manoury et al. 2003, Jasanoff et al. 1998). This cleavage eliminates the C-terminal trimerization domain of Ii, which causes disassociation of the (MHC II:Ii)3 nonamer and exposes new cleavage sites in the MHC II:lip22 trimers (Villadangos et al. 1999, Guillaume et al. 2008). The residue numbering of Ii given above is based on Uniprot isoform 1.
R-HSA-2130349 (Reactome) The lip10 fragments bound in the nonameric complex are processed leaving only the CLIP fragment (81-105) bound to the MHC II peptide binding groove. Three cysteine proteases have been shown to be capable of digesting lip10, each with a different expression pattern among different APC. Cathepsin (Cat) S digests Ii in B cells and dendritic cells, thymic epithelial cells use Cat L and Cat L, while Cat S and F are active in macrophages (Villadangos, 2001; Bryant et al, 2002). Cat S appears to be the major enzyme involved as demonstrated by the use of specific inhibitors and of knockout experiments (Stumptner-Cuvelette et al. 2002). Following lip10 digestion, the MHC-like molecule HLA-DM induces the exchange of CLIP fragment for a highly diverse array of antigens (Denzin & Cresswell. 1995).
R-HSA-2130378 (Reactome) The newly formed MHC II-Ii complex exits the TGN and ultimately is delivered to late-endosome/lysosome compartments. A proportion of the nonameric complex traffics directly from the TGN to these compartments, while a substantial population follow the indirect pathway involving transport from the TGN to the plasma membrane, followed by endocytic delivery to early endosomes, late endosomes, and finally lysosomes (McCormick et al. 2005). Transport carrier vesicles may traffic the cargo MHC II-Ii complex from the TGN to the plasma membrane.
R-HSA-2130393 (Reactome) Nonameric MHC II:Ii complex move through the various cisternae to reach the trans-golgi network (TGN), a tubulo-vesicular organelle located at the trans-face of Golgi stacks. From the TGN, MHC II:Ii complexes are targeted to the endocytic pathway for peptide loading.
R-HSA-2130478 (Reactome) MHC II alpha beta dimers associate with a third polypeptide, the invariant chain (Ii), required for class II molecules to reach the endocytic pathway (Roche et al. 1991). The interaction of Ii with the MHC II alpha beta dimer serves multiple functions. It plays a role in assembly, folding, egress from the ER and transport through the Golgi. Ii exists as a trimer; residues 163-183 of the Ii lumenal domain are involved in covalent cross-linking. Residues 96-104 are critical for association with class II alpha beta dimers (Bijlmakers et al. 1994, Freisewinkel et al. 1993). Residues 89-104 known as CLIP (Class II-associated invariant chain peptide) are the part of the Ii chain that binds antigen binding MHC class II groove, remaining bound until the MHC receptor is completely assembled. This CLIP domain prevents the premature binding of self-peptide fragments present in ER prior to MHC II localization within the endosomal compartment. The ER-resident chaperone protein calnexin rapidly associates with newly synthesized alpha, beta and invariant chains, and remains associated until the final nonamer assembly. The stoichiometry of calnexin in this interaction and the dynamics of association-dissociation are not known. Calnexin may stabilize the free class II chains and regulate their intracellular transport by facilitating the production of transport competent molecules out of the ER (Anderson & Cresswell 1994, Schreiber et al. 1995).
R-HSA-2130486 (Reactome) MHC II:Ii complexes bound to clathrin-coated vesicles rapidly fuse with endosomes.
R-HSA-2130500 (Reactome) On reaching the cell surface, transport carrier vesicles insert the cargo MHC II:Ii complex into the plasma membrane.
R-HSA-2130504 (Reactome) The cleavage of lip22 occurs in residues 115-125, closer to the C-terminus than CLIP (residues 81-105). The resulting lip10 fragment is approximately 100 residues long and extends just through the C-terminus of the Ii CLIP. The proteases responsible for generating lip10 in vivo are not determined. Cysteine proteases like cathepsin S (CatS) are capable of degrading lip22 to lip10 (Bania et al. 2003) but in the presence of LHVS, an inhibitor of CatS, lip22 degradation is still observed, suggesting that other proteases are involved (Villadangos et al. 1997), possibly aspartic proteinases such as cathepsins D and E (Kageyama et al. 1996). The degradation of lip22 may depend on cell type (Bania et al. 2003). The lip22 and lip10 intermediate forms are still maintained as a nonameric complex due to the existence of the last trimerisation domain in the transmembrane region.
R-HSA-2130619 (Reactome) The trans-Golgi network (TGN) is the sorting and package centre for trafficking cargo to the endoplasmic reticulum, plasma membrane and endosomes. Signal peptides determine the sorting and trafficking of proteins to the endosomal-lysosomal pathway or to the cell surface. The main signals that mediate targeting of MHC-II molecules to the endocytic pathway are two dileucine-based motifs, Leu23-Ile24 and Pro31-Leu33 present in the short cytoplasmic tail of Ii (Odorizzi et al. 1994). These motifs bind both the adaptor proteins AP-1 and AP-2, which are components of clathrin coats associated with the TGN/endosomes and the plasma membrane, respectively (McCormick et al. 2005). The precise pathway of class II:Ii complex trafficking from TGN to endocytic pathway is not well understood. In one view MHC II:Ii complexes directly traffic from the TGN to lysosomes, possibly using AP-1 dependent endocytic vesicles (Peters et al. 1991, Amigorena et al. 1994). Alternatively trafficking occurs via transient expression on the cell surface followed by rapid internalization and delivery to endocytic compartments. Early immunoelectron microscopy data has shown the presence of MHC class II:Ii complex molecules primarily in TGN and lysosomes (Peters et al. 1991, Hiltbold & Roche 2002). This theory was further supported by a study examining the trafficking of sulphate-tagged class II molecules, which concluded that the rapid appearance of these molecules in lysosomes was consistent with their direct transport from the TGN to lysosomes (Hiltbold & Roche 2002, Davidson 1999). The transport of cargo MHC II:Ii complexes from the TGN to lysosomes may be mediated by small TGN vesicles coated with AP-1 and clathrin. The di-leucine-based sorting signal in the Ii cytoplasmic chain recruits AP-1 and clathrin from cytosol to TGN to form AP-1 clathrin-coated TGN-derived vesicles. This process is regulated by the small GTPase ARF-1 (Salamero et al. 1996).
R-HSA-2130627 (Reactome) MHC II typically presents antigens derived from exogenous proteins internalized by APCs such as macrophages, B cells or dendritic cells. Different types of antigen use different routes of internalization. Endocytosis may be specific, mediated by a range of receptors expressed on APC, or may occur by nonspecific mechanisms such as phagocytosis, macropinocytosis or autophagy. Antigens are first loaded into endocytic vesicles and progress along the early endosomes (EE)-late endosomes (LE) lysosomal axis. Antigens are exposed to increasingly acidic, more denaturing and proteolytic conditions (Doherty & McMahon 2009, Underhill & Ozinsky 2002).
R-HSA-2130640 (Reactome) Plasma membrane-associated nonameric complexes (MHC II alpha/beta/Ii complex) are rapidly internalized and delivered to late endosomes (LEs) and lysosomes. The dileucine-based signal present in the cytoplasmic tail of Ii is required for sorting of the nonameric MHC II-Ii complex from the plasma membrane to peptide loading compartments. These signals promote rapid internalization by recognising and binding to clathrin adaptor AP-2, a scaffolding-protein complex that brings together components of the vesicle-formation machinery. AP-2 is an essential component of an endocytic clathrin coat and participates in initiation of coat assembly. The critical role of AP2 in delivering MHC II:Ii complex to antigen processing compartments came from RNA interference studies targeting clathrin and AP2. The knockout of AP2 profoundly inhibited MHC II:Ii complex internalization and resulted in the accumulation of Ii at the surface (Dugast et al. 2005, McCormick et al. 2005).
R-HSA-2130641 (Reactome) Budding vesicles loaded with the nonameric complex bud off from the TGN to reach the late-endosome/lysosome membrane.
R-HSA-2130706 (Reactome) Antigen processing and loading on to MHC class II molecules occurs in late endocytic/lysosomal vesicles, where epitopes which require extensive proteolytic processing are generated (Bryant & Ploegh 2003). These late endosome/lysosomal-like compartments are enriched in MHC II and are referred to as MIICs (MHC class II compartments) (Peters et al. 1991). A variety of lysosomal proteases like cathepsins S, D, B etc. and Asparaginyl endopeptidase (AEP) are suggested to be involved in the processing of antigens to generate CD4+ T cell epitopes (Deusing et al. 1998, Shi et al. 1999, Pluger et al. 2002, Watts et al. 2005). An initial cleavage by endopeptidases (AEP) would be necessary to unlock the antigen and allow further trimming of the ends by exopeptidases (Cathepsins). In the acidic environment of the lysosome, cathepsins are generally activated by autocatalytic cleavage of a propeptide which otherwise blocks the active site.
R-HSA-2130725 (Reactome) MHC II:Ii complexes are internalized in to the endocytic clathrin coated-pit. Dynamin, the GTPase involved in the scission of clathrin-coated vesicles from plasma membrane is observed to be involved in the effective endocytosis of MHC II:Ii complexes. Wang et al, demonstrated that overexpression of a dominant-negative mutant of the GTPase dynamin resulted in the cell surface accumulation of MHC II:Ii complex, supporting that endocytosis is required for delivery to antigen processing compartments (Wang et al, 1997). However, another study using the same dynamin mutant generated opposite conclusions (Davidson, 1999). This discrepancy may be caused by differences in experimental set-up and in the levels of expression of the dynamin mutant and MHC II chains (Dugast et al, 2005).
R-HSA-2130731 (Reactome) Immediately after assembly in the ER nonameric (alpha beta:Ii)3 complexes egress from ER, facilitated by the presence of Ii, and enter the Golgi complex (Wolf & Ploegh 1995, Geuze 1998). Incorrectly folded or oligomerized alpha, beta and Ii chains are retained in the ER and degraded. The Sec23/24-Sar1 pre-budding complex binds to the nonameric complex and then recruits Sec13/31 outer shell, which buds off from the membrane as a coat protein complex II (COPII) vesicle to be transported to the Golgi complex (Bickford et al. 2004).
R-HSA-2213235 (Reactome) The internalized nonameric complex passes through the endocytic pathway and finally reach the acidic late endosomal/lysosomal compartments, where the Ii component is progressively degraded by proteases. Proteolysis of Ii occurs through sequential cleavages from the lumenal (C-terminal) side, generating cleavage products of approximately 22 kDa (lip22) and 10 kDa (lip10), finally leaving only CLIP bound within the peptide binding groove of MHC II (Landsverk et al. 2009).
R-HSA-2213236 (Reactome) On reaching the late endosomes/lysosomes the TGN-lysosome vesicle uncoats and fuses with the lysosome to releases the MHC II nonameric complex.
R-HSA-2213239 (Reactome) MHC II alpha and beta chains translocate to the ER and associate noncovalently to form an alpha beta heterodimer (Roche et al. 1991). This heterodimer then associates with a preformed invariant (Ii) chain trimer.
R-HSA-2213240 (Reactome) MHC class II epitopes require protein denaturation and removal of intra- and inter-chain disulphide bonds prior to proteolysis. The lysosomal thiol reductase gamma-IFN-inducible lysosomal thiol reductase (GILT) has been shown to facilitate MHC class II-restricted antigen (Ag) processing by breaking disulphide bonds. GILT is constitutively expressed in APCs. The reduction of disulphide bonds by mature GILT is optimal at acidic pH (Hastings et al. 2006, Arunachalam et al. 2000).
R-HSA-2213241 (Reactome) Progressive addition of two more preformed alpha beta dimers to the invariant chain trimer and alpha beta complex ((alpha beta)1:(Ii)3) forms the complete nonameric structure ((alpha beta:Ii)3). Calnexin then disassociates on egress of the nonameric complex from the ER.
R-HSA-2213243 (Reactome) The COPII vesicle uncoats and fuses with the cis-Golgi, releasing the MHC II:Ii complex into the Golgi.
R-HSA-2213244 (Reactome) In the acidic compartments of MIICs the empty MHC II molecules are protected from unfolding and degradation by HLA-DM (DM). DM acts as a peptide editor, favouring the formation and presentation of long-lived MHC II peptide complexes on the surface of APCs. The intrinsic stability of a ligand determines whether a peptide is resistant or sensitive to DM-mediated release (Kropshofer et al. 1996, Weber et al. 1996). From X-ray structure analysis it is known that two types of forces contribute to the intrinsic stability of class II-peptide complexes: i) interactions of the anchor side chains of the peptides with specificity pockets of polymorphic residues of the peptide binding groove of MHC II and ii) hydrogen bonds between the peptide backbone and conserved residues of the peptide binding grooves (Stern et al. 1994, Kropshofer et al. 1999). Naturally-processed antigenic peptides 14-16 residues in length with many anchor residues and few destabilizing residues (glycine and proline) at non-anchor positions are the most resistant to DM-mediated release (Radrizzani et al. 1999, Kropshofer et al. 1999).
R-HSA-2213246 (Reactome) To gain the capacity to activate antigen-specific T cells, MHC class II-associated CLIP must be exchanged for an antigenic peptide (Kropshofer et al. 1999). There are two CLIP variants in humans: CLIP(long) with 21-26 residues, and CLIP(short) with 14-19 residues. CLIP(long) disassociates rapidly from HLA-DR molecules at endosomal/lysosomal pH, whereas CLIP(short) displays a lower off-rate. The N-terminal 9 residues of CLIP (81-89) facilitate its rapid release (Urban et al. 1994, Kropshofer et al. 1995a, Kropshofer et al. 1995b). The non-classical MHC class II molecule HLA-DM (DM) functions as a mediator of peptide exchange by accelerating the removal of CLIP. DM mediated peptide release involves a direct interaction between DM and the class II molecule. In addition to peptide release, DM also acts as a chaperone for MHC class II molecules in endosomal/lysosomal compartments. It stabilizes the peptide-receptive empty MHC II molecules and prevents them from unfolding and also favors the generation of high-stability peptide-MHC class II complexes by promoting release of low-stability peptide ligands (Kropshofer et al. 1999, Kropshofer et al. 1997). Another non-classical MHC II molecule HLA-DO (DO), only expressed in B-cells and thymic epithelial cells, binds tightly to DM modulating DM activity both negatively and positively, depending on the amount of DO present in an APC. Heterotypic DR-DM-DO complexes are receptive for peptide loading, in these complexes DO does not appear to be inhibitory (Denzin et al. 1997, Kropshofer et al. 1998, Kropshofer et al. 1999).
R-HSA-2213248 (Reactome) Once MHC class II-peptide complexes are formed, they must be transported back to the cell surface. It is unclear how this occurs. LEs/lysosomes with peptide loaded MHC II molecules may move in a bidirectional manner in a stop-and-go fashion along microtubules to the plasma membrane, driven by the activities of the oppositely-directed motor proteins dynein and kinesin (Wubbolts et al. 1996, 1999, Chow et al. 2002, Rocha & Neefjes 2007). Ultimately, LEs/lysosomes fuse to the plasma membrane delivering the MHC II-peptide complexes to the surface (Raposo et al. 1996, Rocha & Neefjes 2007). RAB7-GTP present on LEs/lysosome membrane interacts with Rab7-interacting lysosomal protein (RILP) and oxysterol-binding protein-related protein 1L (ORP1L) to form a tripartite RILP-Rab7-ORP1L complex. RILP binds to the p150 dynactin subunit to recruit the dynein or kinesin motor proteins. ORP1L recruits this complex to betaIII spectrin domains, which appears to be critical for dynein motor activation and transport of LEs/lysosome vesicles to the cell periphery (Johansson et al. 2007, Rocha & Neefjes 2008).
RAB7:RILP:ORP1L complexArrowR-HSA-2213248 (Reactome)
RAB7:RILP:ORP1L complexR-HSA-2213248 (Reactome)
SH3GL2ArrowR-HSA-2130486 (Reactome)
SH3GL2R-HSA-2130725 (Reactome)
SPTBN2ArrowR-HSA-2213248 (Reactome)
SPTBN2R-HSA-2213248 (Reactome)
Sar1b:GTP:Sec23p:Sec24p:Sec13p:Sec31p ComplexArrowR-HSA-2213243 (Reactome)
Sar1b:GTP:Sec23p:Sec24p:Sec13p:Sec31p ComplexR-HSA-2130731 (Reactome)
TGN-lysosome vesicle

with nonameric

complex		ArrowR-HSA-2130641 (Reactome)
TGN-lysosome vesicle

with nonameric

complex		R-HSA-2213236 (Reactome)
alpha beta dimer:Ii trimer:calnexinArrowR-HSA-2130478 (Reactome)
alpha beta dimer:Ii trimer:calnexinR-HSA-2213241 (Reactome)
peptide free MHC II:HLA-DMArrowR-HSA-2213246 (Reactome)
peptide free MHC II:HLA-DMR-HSA-2213244 (Reactome)
peptide loaded MHC class IIArrowR-HSA-2213244 (Reactome)
peptide loaded MHC class IIArrowR-HSA-2213248 (Reactome)
peptide loaded MHC class IIR-HSA-2213248 (Reactome)
unfolded antigenArrowR-HSA-2213240 (Reactome)
unfolded antigenR-HSA-2130706 (Reactome)
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