mir219 in oligodendrocyte differentiation and myelination (Rattus norvegicus)

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1Neural stem cellNeuronOligodendrocyte precursor cell (O4)Pre-Oligodendrocyte (O1)Myelinating Oligodendrocyte (MBP)Zfp238Neurod1PdgfraFoxj3Elovl7Mir219-1Sox6Hes5Mir219-1Mir219-1Mir219-2Mir219-2Mir219-2


Description

Young and environmentally enriched exosomes deliver functional miR-219 that impacts oligodendrocyte differentiation and myelination. Schematic illustration of the involvement of miR-219 in oligodendrocyte differentiation. Upon exposure to nutritive exosomes, neural stem cells preferentially enter the oligodendrocyte lineage due to the inhibition of the proneurogenic factor NeuroD1. miR-219 also suppresses expression of a number of other factors that inhibit OPC differentiation, such as PDGFRα, a receptor for a mitogenic factor that promotes proliferation and prohibits differentiation. Finally, miR-219 decreases levels of ELOVL7, a regulator of lipid metabolism whose over-activity could lead to demyelination.

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Bibliography

  1. Dugas JC, Cuellar TL, Scholze A, Ason B, Ibrahim A, Emery B, Zamanian JL, Foo LC, McManus MT, Barres BA; ''''; , PubMed Europe PMC Scholia
  2. Zhao X, He X, Han X, Yu Y, Ye F, Chen Y, Hoang T, Xu X, Mi QS, Xin M, Wang F, Appel B, Lu QR; ''MicroRNA-mediated control of oligodendrocyte differentiation.''; Neuron, 2010 PubMed Europe PMC Scholia
  3. Shin D, Shin JY, McManus MT, Ptácek LJ, Fu YH; ''Dicer ablation in oligodendrocytes provokes neuronal impairment in mice.''; Ann Neurol, 2009 PubMed Europe PMC Scholia
  4. Pusic AD, Kraig RP; ''Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination.''; Glia, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117000view10:59, 16 May 2021EweitzModified title
96487view17:51, 15 March 2018Khanspersfixed cutoff labels
94255view20:49, 29 August 2017Khanspersadded lit refs
87839view11:47, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
83025view01:55, 18 November 2015Mkutmonfix outdated identifier
81928view23:50, 5 September 2015AlexanderPicoQuick edit to datanode annotation or property
81927view23:49, 5 September 2015AlexanderPicoQuick edit to datanode annotation or property
80168view22:30, 14 May 2015KhanspersAdded mir219-2
80166view21:50, 14 May 2015Khanspersremoved extra mir219's
75391view23:26, 21 May 2014KhanspersModified title
75390view23:23, 21 May 2014KhanspersOntology Term : 'neuroglioblast' added !
75389view23:22, 21 May 2014KhanspersOntology Term : 'neuron' added !
75388view22:07, 21 May 2014KhanspersModified description
75387view22:06, 21 May 2014KhanspersNew pathway
75386view22:03, 21 May 2014KhanspersModified description
75385view22:01, 21 May 2014KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Elovl7GeneProductENSRNOG00000010450 (Ensembl)
Foxj3GeneProductENSRNOG00000008787 (Ensembl)
Hes5GeneProductENSRNOG00000013850 (Ensembl)
Mir219-1Rna100314058 (Entrez Gene)
Mir219-2Rna100314293 (Entrez Gene)
Neurod1GeneProductENSRNOG00000005609 (Ensembl)
PdgfraGeneProductENSRNOG00000002244 (Ensembl)
Sox6GeneProductENSRNOG00000020514 (Ensembl)
Zfp238GeneProductENSRNOG00000004423 (Ensembl)

Annotated Interactions

No annotated interactions

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