Cholesterol metabolism (Rattus norvegicus)
From WikiPathways
Description
Cholesterol is essential for life - it's a required for the regulation of membrane fluidity. Cholesterol also serves as a precursor for many other biochemical pathways.
Cholesterol is synthesized throughout the body but mainly in liver, intestines, adrenal glands and reproductive organs. Synthesis starts with the combination of Acetyl-CoA and Acetoacetyl-CoA. An important intemediary in the synthesis of cholesterol is mevalonate.
Synthesis of cholesterol is regulated by a homeostatic mechanism.Quality Tags
Ontology Terms
Bibliography
- Gadbut AP, Wu L, Tang D, Papageorge A, Watson JA, Galper JB; ''Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins.''; EMBO J, 1997 PubMed Europe PMC Scholia
- Wassmann S, Nickenig G; ''Improvement of Endothelial Function by HMG-CoA Reductase Inhibitors.''; Drug News Perspect, 2002 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
(S)-2,3-Epoxysqualene | Metabolite | HMDB01188 (HMDB) ![]() | |
Acetoacetyl-CoA | Metabolite | HMDB01484 (HMDB) ![]() | |
Acetyl-CoA | Metabolite | HMDB01206 (HMDB) ![]() | |
Apoc1 | GeneProduct | ENSRNOG00000018426 (Ensembl) ![]() | |
Apoc2 | GeneProduct | ENSRNOG00000018402 (Ensembl) ![]() | |
Apoe | GeneProduct | ENSRNOG00000018454 (Ensembl) ![]() | |
Cholesterol ester | Metabolite | CHEBI:17002 (ChEBI) ![]() | |
Cholesterol | Metabolite | HMDB00067 (HMDB) ![]() | |
Dehydrocholesterol | Metabolite | HMDB00032 (HMDB) ![]() | |
Dhcr7 | GeneProduct | ENSRNOG00000020776 (Ensembl) ![]() | |
Dimethylallylpyrophosphate | Metabolite | HMDB01120 (HMDB) ![]() | |
Farnesyl pyrophosphate | Metabolite | HMDB00961 (HMDB) ![]() | |
Fatty Acid CoA | Metabolite | ||
Fdft1 | GeneProduct | ENSRNOG00000021314 (Ensembl) ![]() | |
Fdps | GeneProduct | 83791 (Entrez Gene) ![]() | |
Geranyl pyrophosphate | Metabolite | HMDB01285 (HMDB) ![]() | |
HDL | Metabolite | ||
HMG-CoA | Metabolite | HMDB01375 (HMDB) ![]() | |
Hmgcr | GeneProduct | 25675 (Entrez Gene) ![]() | |
Hmgcs1 | GeneProduct | 29637 (Entrez Gene) ![]() | |
IDL | Metabolite | ||
Idi1 | GeneProduct | ENSRNOG00000016690 (Ensembl) ![]() | |
Isopentenyl pyrophosphate | Metabolite | HMDB01347 (HMDB) ![]() | |
LDL | Metabolite | ||
Lanosterin | Metabolite | HMDB01251 (HMDB) ![]() | |
Lathosterol | Metabolite | HMDB01170 (HMDB) ![]() | |
Ldlr | GeneProduct | ENSRNOG00000009946 (Ensembl) ![]() | |
Lipc | GeneProduct | ENSRNOG00000060338 (Ensembl) ![]() | |
Lpl | GeneProduct | ENSRNOG00000012181 (Ensembl) ![]() | |
Lrp1 | GeneProduct | 299858 (Entrez Gene) ![]() | |
Lss | GeneProduct | ENSRNOG00000054549 (Ensembl) ![]() | |
MVK | GeneProduct | 81727 (Entrez Gene) ![]() | |
Mevalonate Pyrophosphat | Metabolite | HMDB01981 (HMDB) ![]() | |
Mevalonate | Metabolite | HMDB00227 (HMDB) ![]() | |
Mvd | GeneProduct | ENSRNOG00000013376 (Ensembl) ![]() | |
Nsdhl | GeneProduct | ENSRNOG00000057814 (Ensembl) ![]() | |
Sc4mol | GeneProduct | ENSRNOG00000032297 (Ensembl) ![]() | |
Sc5d | GeneProduct | ENSRNOG00000008305 (Ensembl) ![]() | |
Scarb1 | GeneProduct | ENSRNOG00000000981 (Ensembl) ![]() | |
Soat1 | GeneProduct | ENSRNOG00000004111 (Ensembl) ![]() | |
Sqle | GeneProduct | ENSRNOG00000009550 (Ensembl) ![]() | |
Squalene | Metabolite | HMDB00256 (HMDB) ![]() | |
Srebf1 | GeneProduct | ENSRNOG00000003463 (Ensembl) ![]() | |
VLDL | Metabolite |
Annotated Interactions
No annotated interactions