Glycosaminoglycan metabolism (Homo sapiens)
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Description
Glycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)) and a uronic acid (glucuronate or iduronate). They can be heavily sulfated. GAGs are located primarily in the extracellular matrix (ECM) and on cell membranes, acting as a lubricating fluid for joints and as part of signalling processes. They have structural roles in connective tissue, cartilage, bone and blood vessels (Esko et al. 2009). GAGs are degraded in the lysosome as part of their natural turnover. Defects in the lysosomal enzymes responsible for the metabolism of membrane-associated GAGs lead to lysosomal storage diseases called mucopolysaccharidoses (MPS). MPSs are characterised by the accumulation of GAGs in lysosomes resulting in chronic, progressively debilitating disorders that in many instances lead to severe psychomotor retardation and premature death (Cantz & Gehler 1976, Clarke 2008). The biosynthesis and breakdown of the main GAGs (hyaluronate, keratan sulfate, chondroitin sulfate, dermatan sulfate and heparan sulfate) is described here.
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- Habuchi H, Tanaka M, Habuchi O, Yoshida K, Suzuki H, Ban K, Kimata K.; ''The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.''; PubMed Europe PMC Scholia
- Ozeran JD, Westley J, Schwartz NB.; ''Identification and partial purification of PAPS translocase.''; PubMed Europe PMC Scholia
- Lee-Chen GJ, Lin SP, Tang YF, Chin YW.; ''Mucopolysaccharidosis type I: characterization of novel mutations affecting alpha-L-iduronidase activity.''; PubMed Europe PMC Scholia
- Pacheco B, Malmström A, Maccarana M.; ''Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate.''; PubMed Europe PMC Scholia
- Wilson PJ, Morris CP, Anson DS, Occhiodoro T, Bielicki J, Clements PR, Hopwood JJ.; ''Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA.''; PubMed Europe PMC Scholia
- Li Y, Laue K, Temtamy S, Aglan M, Kotan LD, Yigit G, Canan H, Pawlik B, Nürnberg G, Wakeling EL, Quarrell OW, Baessmann I, Lanktree MB, Yilmaz M, Hegele RA, Amr K, May KW, Nürnberg P, Topaloglu AK, Hammerschmidt M, Wollnik B.; ''Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling.''; PubMed Europe PMC Scholia
- Zheng H, Li Y, Ji C, Li J, Zhang J, Yin G, Xu J, Ye X, Wu M, Zou X, Gu S, Xie Y, Mao Y.; ''Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase.''; PubMed Europe PMC Scholia
- Fukuda S, Tomatsu S, Masue M, Sukegawa K, Iwata H, Ogawa T, Nakashima Y, Hori T, Yamagishi A, Hanyu Y.; ''Mucopolysaccharidosis type IVA. N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases.''; PubMed Europe PMC Scholia
- Silbert JE, Sugumaran G.; ''Biosynthesis of chondroitin/dermatan sulfate.''; PubMed Europe PMC Scholia
- Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ.; ''Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1.''; PubMed Europe PMC Scholia
- Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD.; ''Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).''; PubMed Europe PMC Scholia
- Toyoshima M, Nakajima M.; ''Human heparanase. Purification, characterization, cloning, and expression.''; PubMed Europe PMC Scholia
- Mishima M, Wakabayashi S, Kojima C.; ''Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1.''; PubMed Europe PMC Scholia
- Okajima T, Fukumoto S, Miyazaki H, Ishida H, Kiso M, Furukawa K, Urano T, Furukawa K.; ''Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids.''; PubMed Europe PMC Scholia
- Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A.; ''Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2.''; PubMed Europe PMC Scholia
- Schaub BE, Berger B, Berger EG, Rohrer J.; ''Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated.''; PubMed Europe PMC Scholia
- Jedrzejas MJ, Stern R.; ''Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis.''; PubMed Europe PMC Scholia
- Yada T, Sato T, Kaseyama H, Gotoh M, Iwasaki H, Kikuchi N, Kwon YD, Togayachi A, Kudo T, Watanabe H, Narimatsu H, Kimata K.; ''Chondroitin sulfate synthase-3. Molecular cloning and characterization.''; PubMed Europe PMC Scholia
- Evers MR, Xia G, Kang HG, Schachner M, Baenziger JU.; ''Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.''; PubMed Europe PMC Scholia
- Harris EN, Weigel JA, Weigel PH.; ''The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin.''; PubMed Europe PMC Scholia
- Durand S, Feldhammer M, Bonneil E, Thibault P, Pshezhetsky AV.; ''Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC.''; PubMed Europe PMC Scholia
- Gorham SD, Cantz M.; ''Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide.''; PubMed Europe PMC Scholia
- Winchester B.; ''Lysosomal metabolism of glycoproteins.''; PubMed Europe PMC Scholia
- Xia G, Chen J, Tiwari V, Ju W, Li JP, Malmstrom A, Shukla D, Liu J.; ''Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1.''; PubMed Europe PMC Scholia
- Weber B, Blanch L, Clements PR, Scott HS, Hopwood JJ.; ''Cloning and expression of the gene involved in Sanfilippo B syndrome (mucopolysaccharidosis III B).''; PubMed Europe PMC Scholia
- Gotoh M, Yada T, Sato T, Akashima T, Iwasaki H, Mochizuki H, Inaba N, Togayachi A, Kudo T, Watanabe H, Kimata K, Narimatsu H.; ''Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine.''; PubMed Europe PMC Scholia
- Lee JK, Bhakta S, Rosen SD, Hemmerich S.; ''Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue.''; PubMed Europe PMC Scholia
- Masue M, Sukegawa K, Orii T, Hashimoto T.; ''N-acetylgalactosamine-6-sulfate sulfatase in human placenta: purification and characteristics.''; PubMed Europe PMC Scholia
- Robertson DA, Freeman C, Morris CP, Hopwood JJ.; ''A cDNA clone for human glucosamine-6-sulphatase reveals differences between arylsulphatases and non-arylsulphatases.''; PubMed Europe PMC Scholia
- Lederkremer GZ.; ''Glycoprotein folding, quality control and ER-associated degradation.''; PubMed Europe PMC Scholia
- Hrebícek M, Mrázová L, Seyrantepe V, Durand S, Roslin NM, Nosková L, Hartmannová H, Ivánek R, Cízkova A, Poupetová H, Sikora J, Urinovská J, Stranecký V, Zeman J, Lepage P, Roquis D, Verner A, Ausseil J, Beesley CE, Maire I, Poorthuis BJ, van de Kamp J, van Diggelen OP, Wevers RA, Hudson TJ, Fujiwara TM, Majewski J, Morgan K, Kmoch S, Pshezhetsky AV.; ''Mutations in TMEM76* cause mucopolysaccharidosis IIIC (Sanfilippo C syndrome).''; PubMed Europe PMC Scholia
- Lim CT, Horwitz AL.; ''Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase.''; PubMed Europe PMC Scholia
- Götting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K.; ''Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II.''; PubMed Europe PMC Scholia
- Lepperdinger G, Strobl B, Kreil G.; ''HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity.''; PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
(HA)2 | R-ALL-2160866 (Reactome) | ||
(HA)50 | R-ALL-2160864 (Reactome) | ||
(HA)50 | R-ALL-2160894 (Reactome) | ||
ABCC5 | Protein | O15440 (Uniprot-TrEMBL) | |
ACAN | Protein | P16112 (Uniprot-TrEMBL) | |
ADP | Metabolite | CHEBI:16761 (ChEBI) | |
AGRN(30-2045) | Protein | O00468 (Uniprot-TrEMBL) | |
APS | Metabolite | CHEBI:17709 (ChEBI) | |
ARSB:Ca2+ | Complex | R-HSA-1606792 (Reactome) | |
ATP | Metabolite | CHEBI:15422 (ChEBI) | |
Ac-CoA | Metabolite | CHEBI:15351 (ChEBI) | |
Asparagine N-linked glycosylation | Pathway | R-HSA-446203 (Reactome) | N-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 revealed that about 50% of the proteins in the Swiss-Prot database at the time were N-glycosylated (Apweiler et al. 1999). It is now established that the majority of the proteins in the secretory pathway require glycosylation in order to achieve proper folding. The addition of an N-glycan to a protein can have several roles (Shental-Bechor & Levy 2009). First, glycans enhance the solubility and stability of the proteins in the ER, the golgi and on the outside of the cell membrane, where the composition of the medium is strongly hydrophilic and where proteins, that are mostly hydrophobic, have difficulty folding properly. Second, N-glycans are used as signal molecules during the folding and transport process of the protein: they have the role of labels to determine when a protein must interact with a chaperon, be transported to the golgi, or targeted for degradation in case of major folding defects. Third, and most importantly, N-glycans on completely folded proteins are involved in a wide range of processes: they help determine the specificity of membrane receptors in innate immunity or in cell-to-cell interactions, they can change the properties of hormones and secreted proteins, or of the proteins in the vesicular system inside the cell. All N-linked glycans are derived from a common 14-sugar oligosaccharide synthesized in the ER, which is attached co-translationally to a protein while this is being translated inside the reticulum. The process of the synthesis of this glycan, known as Synthesis of the N-glycan precursor or LLO, constitutes one of the most conserved pathways in eukaryotes, and has been also observed in some eubacteria. The attachment usually happens on an asparagine residue within the consensus sequence asparagine-X-threonine by an complex called oligosaccharyl transferase (OST). After being attached to an unfolded protein, the glycan is used as a label molecule in the folding process (also known as Calnexin/Calreticulin cycle) (Lederkremer 2009). The majority of the glycoproteins in the ER require at least one glycosylated residue in order to achieve proper folding, even if it has been shown that a smaller portion of the proteins in the ER can be folded without this modification. Once the glycoprotein has achieved proper folding, it is transported via the cis-Golgi through all the Golgi compartments, where the glycan is further modified according to the properties of the glycoprotein. This process involves relatively few enzymes but due to its combinatorial nature, can lead to several millions of different possible modifications. The exact topography of this network of reactions has not been established yet, representing one of the major challenges after the sequencing of the human genome (Hossler et al. 2006). Since N-glycosylation is involved in an great number of different processes, from cell-cell interaction to folding control, mutations in one of the genes involved in glycan assembly and/or modification can lead to severe development problems (often affecting the central nervous system). All the diseases in genes involved in glycosylation are collectively known as Congenital Disorders of Glycosylation (CDG) (Sparks et al. 2003), and classified as CDG type I for the genes in the LLO synthesis pathway, and CDG type II for the others. |
B3GALT6 | Protein | Q96L58 (Uniprot-TrEMBL) | |
B3GAT dimers | Complex | R-HSA-1889954 (Reactome) | |
B3GAT1 | Protein | Q9P2W7 (Uniprot-TrEMBL) | |
B3GAT2 | Protein | Q9NPZ5 (Uniprot-TrEMBL) | |
B3GAT3 | Protein | O94766 (Uniprot-TrEMBL) | |
B3GNT1 | Protein | O43505 (Uniprot-TrEMBL) | |
B3GNT1,2,3,4,7 | Complex | R-HSA-2046221 (Reactome) | |
B3GNT2 | Protein | Q9NY97 (Uniprot-TrEMBL) | |
B3GNT3 | Protein | Q9Y2A9 (Uniprot-TrEMBL) | |
B3GNT4 | Protein | Q9C0J1 (Uniprot-TrEMBL) | |
B3GNT7 | Protein | Q8NFL0 (Uniprot-TrEMBL) | |
B4GALT1 | Protein | P15291 (Uniprot-TrEMBL) | |
B4GALT1-6 homodimers | Complex | R-HSA-975898 (Reactome) | |
B4GALT2 | Protein | O60909 (Uniprot-TrEMBL) | |
B4GALT3 | Protein | O60512 (Uniprot-TrEMBL) | |
B4GALT4 | Protein | O60513 (Uniprot-TrEMBL) | |
B4GALT5 | Protein | O43286 (Uniprot-TrEMBL) | |
B4GALT6 | Protein | Q9UBX8 (Uniprot-TrEMBL) | |
B4GALT7 | Protein | Q9UBV7 (Uniprot-TrEMBL) | |
BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
BGAL | Complex | R-HSA-3229251 (Reactome) | This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis. |
BGN | Protein | P21810 (Uniprot-TrEMBL) | |
C4S chain | Metabolite | CHEBI:63513 (ChEBI) | |
C4S-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
C4S-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
C4S-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
C4S-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
C4S-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
C4S-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
C4S-PG | R-HSA-2064226 (Reactome) | ||
C4S-PG | R-HSA-2065134 (Reactome) | ||
C4S-PG | Complex | R-HSA-2064226 (Reactome) | |
C4S-PGs | R-HSA-2063982 (Reactome) | ||
C4S-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
C4S/C6S chains | Complex | R-HSA-R-ALL-2065251 (Reactome) | |
C6S chain | Metabolite | CHEBI:63512 (ChEBI) | |
C6S-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
C6S-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
C6S-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
C6S-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
C6S-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
C6S-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
C6S-PG | R-HSA-2064219 (Reactome) | ||
C6S-PG | R-HSA-2065083 (Reactome) | ||
C6S-PG | Complex | R-HSA-2064219 (Reactome) | |
C6S-PGs | R-HSA-2064078 (Reactome) | ||
C6S-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
CD44 | Protein | P16070 (Uniprot-TrEMBL) | |
CEMIP | Protein | Q8WUJ3 (Uniprot-TrEMBL) | |
CH3COO- | Metabolite | CHEBI:15366 (ChEBI) | |
CHEBI:63868 chain | Metabolite | CHEBI:63868 (ChEBI) | |
CHPF | Protein | Q8IZ52 (Uniprot-TrEMBL) | |
CHPF,CHPF2,CHSY1,CHSY3 | Complex | R-HSA-1971467 (Reactome) | |
CHPF,CHSY1,CHSY3 | Complex | R-HSA-1971425 (Reactome) | |
CHPF2 | Protein | Q9P2E5 (Uniprot-TrEMBL) | |
CHST11 | Protein | Q9NPF2 (Uniprot-TrEMBL) | |
CHST12 | Protein | Q9NRB3 (Uniprot-TrEMBL) | |
CHST13 | Protein | Q8NET6 (Uniprot-TrEMBL) | |
CHST14 products | Complex | R-HSA-5607524 (Reactome) | |
CHST14 substrates | Complex | R-HSA-5607518 (Reactome) | |
CHST14 | Protein | Q8NCH0 (Uniprot-TrEMBL) | |
CHST15 | Protein | Q7LFX5 (Uniprot-TrEMBL) | |
CHST1 | Protein | O43916 (Uniprot-TrEMBL) | |
CHST2 | Protein | Q9Y4C5 (Uniprot-TrEMBL) | |
CHST2,5,6 | Complex | R-HSA-2046158 (Reactome) | |
CHST3 | Protein | Q7LGC8 (Uniprot-TrEMBL) | |
CHST3,7 | Complex | R-HSA-2018661 (Reactome) | |
CHST5 | Protein | Q9GZS9 (Uniprot-TrEMBL) | |
CHST6 | Protein | Q9GZX3 (Uniprot-TrEMBL) | |
CHST7 | Protein | Q9NS84 (Uniprot-TrEMBL) | |
CHST9,11,12,13 | Complex | R-HSA-1971481 (Reactome) | |
CHST9-2 | Protein | Q7L1S5-2 (Uniprot-TrEMBL) | |
CHSY1 | Protein | Q86X52 (Uniprot-TrEMBL) | |
CHSY3 | Protein | Q70JA7 (Uniprot-TrEMBL) | |
CMP-Neu5Ac | Metabolite | CHEBI:16556 (ChEBI) | |
CMP | Metabolite | CHEBI:17361 (ChEBI) | |
CS/DS core proteins | Complex | R-HSA-2065248 (Reactome) | |
CS/HS precursor | Metabolite | CHEBI:63505 (ChEBI) | |
CSE-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
CSE-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
CSE-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
CSE-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
CSE-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
CSE-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
CSE-PG | R-HSA-2064101 (Reactome) | ||
CSE-PG | R-HSA-2065112 (Reactome) | ||
CSE-PG | Complex | R-HSA-2064101 (Reactome) | |
CSE-PGs | R-HSA-2064081 (Reactome) | ||
CSE-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
CSGALNACT1 | Protein | Q8TDX6 (Uniprot-TrEMBL) | |
CSGALNACT2 | Protein | Q8N6G5 (Uniprot-TrEMBL) | |
CSGALNACT | Complex | R-HSA-1971496 (Reactome) | |
CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
CSPGs | Complex | R-HSA-2024088 (Reactome) | |
CSPGs | Complex | R-HSA-2064124 (Reactome) | |
CSPGs | Complex | R-HSA-2065110 (Reactome) | |
Ca2+ | Metabolite | CHEBI:29108 (ChEBI) | |
ChEBI:63515 chain | Metabolite | CHEBI:63515 (ChEBI) | |
ChEBI:63515 chain | Metabolite | CHEBI:63515 (ChEBI) | |
ChEBI:63516 chain | Metabolite | CHEBI:63516 (ChEBI) | |
ChEBI:63517 chain | Metabolite | CHEBI:63517 (ChEBI) | |
ChEBI:63519 chain | Metabolite | CHEBI:63519 (ChEBI) | |
Chondroitin chain | Metabolite | CHEBI:63511 (ChEBI) | |
Chondroitin chain | Metabolite | CHEBI:63511 (ChEBI) | |
Chondroitin chains | Complex | R-HSA-R-ALL-2065257 (Reactome) | |
CoA-SH | Metabolite | CHEBI:15346 (ChEBI) | |
D-xylose | Metabolite | CHEBI:15936 (ChEBI) | |
D2,4(S)2-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
D2,4(S)2-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
D2,4(S)2-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
D2,4(S)2-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
D2,4(S)2-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
D2,4(S)2-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
D2,4(S)2-PG | R-HSA-2065145 (Reactome) | ||
D2,4(S)2-PG | Complex | R-HSA-2065145 (Reactome) | |
D2,4(S)2-PGs | R-HSA-2065202 (Reactome) | ||
D2,4(S)2-PGs | R-HSA-2065226 (Reactome) | ||
D2,4(S)2-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
D2,4,4(S)3-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
D2,4,4(S)3-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
D2,4,4(S)3-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
D2,4,4(S)3-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
D2,4,4(S)3-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
D2,4,4(S)3-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
D2,4,4(S)3-PGs | R-HSA-2065087 (Reactome) | ||
D2,4,4(S)3-PGs | R-HSA-2065132 (Reactome) | ||
D2,4,4(S)3-PGs | R-HSA-2065138 (Reactome) | ||
D2,4,4(S)3-PGs | Complex | R-HSA-2065138 (Reactome) | |
D2,4,4(S)3-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
D4S-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
D4S-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
D4S-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
D4S-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
D4S-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
D4S-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
D4S-PGs | R-HSA-2065135 (Reactome) | ||
D4S-PGs | R-HSA-2065207 (Reactome) | ||
D4S-PGs | R-HSA-2065235 (Reactome) | ||
D4S-PGs | Complex | R-HSA-2065135 (Reactome) | |
D4S-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
DCN | Protein | P07585 (Uniprot-TrEMBL) | |
DSE | Protein | Q9UL01 (Uniprot-TrEMBL) | |
DSE,DSEL products | Complex | R-HSA-5607545 (Reactome) | |
DSE,DSEL substrates | Complex | R-HSA-5607547 (Reactome) | |
DSE,DSEL | Complex | R-HSA-3734047 (Reactome) | |
DSEL | Protein | Q8IZU8 (Uniprot-TrEMBL) | |
DSPGs | Complex | R-HSA-2065214 (Reactome) | |
DSPGs | Complex | R-HSA-2065240 (Reactome) | |
DSPGs | Complex | R-HSA-2065267 (Reactome) | |
EXT1 | Protein | Q16394 (Uniprot-TrEMBL) | |
EXT1:EXT2 | Complex | R-HSA-2022878 (Reactome) | |
EXT2 | Protein | Q93063 (Uniprot-TrEMBL) | |
FMOD | Protein | Q06828 (Uniprot-TrEMBL) | |
GAG core proteins | Complex | R-HSA-2054107 (Reactome) | |
GALNS oligomer | R-HSA-1630327 (Reactome) | ||
GLB1 | Protein | P16278 (Uniprot-TrEMBL) | |
GLB1L | Protein | Q6UWU2 (Uniprot-TrEMBL) | |
GLCE | Protein | O94923 (Uniprot-TrEMBL) | |
GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
GPC3(25-?) | Protein | P51654 (Uniprot-TrEMBL) | |
GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
GPC5(25-?) | Protein | P78333 (Uniprot-TrEMBL) | |
GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
GUSB | Protein | P08236 (Uniprot-TrEMBL) | |
GUSB tetramer | Complex | R-HSA-1678867 (Reactome) | |
GXYLT1 | Protein | Q4G148 (Uniprot-TrEMBL) | |
GXYLT2 | Protein | A0PJZ3 (Uniprot-TrEMBL) | |
GXYLTs | Complex | R-HSA-1877994 (Reactome) | |
Gal(S)-GlcNAc(S)-Gal-GlcNAc(S)-Gal | Metabolite | CHEBI:63846 (ChEBI) | |
Gal-Gal-Xyl-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
Gal-Gal-Xyl-proteins | Complex | R-HSA-2064214 (Reactome) | |
Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal | Metabolite | CHEBI:63850 (ChEBI) | |
Gal-GlcNAc(S)-Gal | Metabolite | CHEBI:63853 (ChEBI) | |
Gal-Xyl-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
Gal-Xyl-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
Gal-Xyl-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
Gal-Xyl-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
Gal-Xyl-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
Gal-Xyl-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
Gal-Xyl-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
Gal-Xyl-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
Gal-Xyl-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
Gal-Xyl-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
Gal-Xyl-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
Gal-Xyl-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
Gal-Xyl-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
Gal-Xyl-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
Gal-Xyl-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
Gal-Xyl-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
Gal-Xyl-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
Gal-Xyl-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
Gal-Xyl-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
Gal-Xyl-proteins | Complex | R-HSA-2064058 (Reactome) | |
Gal-glycan ACAN | Protein | P16112 (Uniprot-TrEMBL) | |
Gal-glycan FMOD | Protein | Q06828 (Uniprot-TrEMBL) | |
Gal-glycan KERA | Protein | O60938 (Uniprot-TrEMBL) | |
Gal-glycan LUM | Protein | P51884 (Uniprot-TrEMBL) | |
Gal-glycan OGN | Protein | P20774 (Uniprot-TrEMBL) | |
Gal-glycan OMD | Protein | Q99983 (Uniprot-TrEMBL) | |
Gal-glycan PRELP | Protein | P51888 (Uniprot-TrEMBL) | |
Gal-glycan-protein | Complex | R-HSA-2046271 (Reactome) | |
Gal | Metabolite | CHEBI:28061 (ChEBI) | |
GalNAc | Metabolite | CHEBI:28037 (ChEBI) | |
GlcA-Gal-Gal-Xyl-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-CS proteins | Complex | R-HSA-2064233 (Reactome) | |
GlcA-Gal-Gal-Xyl-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-HS proteins | Complex | R-HSA-2076551 (Reactome) | |
GlcA-Gal-Gal-Xyl-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
GlcA-Gal-Gal-Xyl-proteins | Complex | R-HSA-2064225 (Reactome) | |
GlcA-b1,3-GlcNAc | Metabolite | CHEBI:64024 (ChEBI) | |
GlcA | Metabolite | CHEBI:15748 (ChEBI) | |
GlcA | Metabolite | CHEBI:4178 (ChEBI) | |
GlcNAc(S)-Gal-GlcNAc(S)-Gal | Metabolite | CHEBI:63851 (ChEBI) | |
GlcNAc-Gal-GlcNAc(S)-Gal | Metabolite | CHEBI:63852 (ChEBI) | |
GlcNAc-GlcA-GlcNAc | R-NUL-2162223 (Reactome) | ||
GlcNAc | Metabolite | CHEBI:17411 (ChEBI) | |
H+ | Metabolite | CHEBI:15378 (ChEBI) | |
H2O | Metabolite | CHEBI:15377 (ChEBI) | |
HA | R-ALL-2160848 (Reactome) | ||
HA polymer | R-ALL-2142896 (Reactome) | ||
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ | Complex | R-HSA-2160891 (Reactome) | |
HA:HAR:HYAL2 | Complex | R-HSA-2160889 (Reactome) | |
HA | R-ALL-2160848 (Reactome) | ||
HARs | Complex | R-HSA-2160926 (Reactome) | |
HAS1 | Protein | Q92839 (Uniprot-TrEMBL) | |
HAS1,2,3 | Complex | R-HSA-2142875 (Reactome) | |
HAS2 | Protein | Q92819 (Uniprot-TrEMBL) | |
HAS3 | Protein | O00219 (Uniprot-TrEMBL) | |
HEXA | Protein | P06865 (Uniprot-TrEMBL) | |
HEXA,B | Complex | R-HSA-3662340 (Reactome) | |
HEXB(122-311) | Protein | P07686 (Uniprot-TrEMBL) | |
HEXB(315-556) | Protein | P07686 (Uniprot-TrEMBL) | |
HGSNAT oligomer | R-HSA-1678773 (Reactome) | ||
HMMR | Protein | O75330 (Uniprot-TrEMBL) | |
HPSE dimer | Complex | R-HSA-1666976 (Reactome) | |
HPSE(158-543) | Protein | Q9Y251 (Uniprot-TrEMBL) | |
HPSE(36-109) | Protein | Q9Y251 (Uniprot-TrEMBL) | |
HPSE2(1-592) | Protein | Q8WWQ2 (Uniprot-TrEMBL) | |
HS core proteins | Complex | R-HSA-2090039 (Reactome) | |
HS core proteins | Complex | R-HSA-2090076 (Reactome) | |
HS(1)-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
HS(1)-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
HS(1)-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
HS(1)-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
HS(1)-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
HS(1)-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
HS(1)-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
HS(1)-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
HS(1)-PGs | R-HSA-2076452 (Reactome) | ||
HS(1)-PGs | R-HSA-2076647 (Reactome) | ||
HS(1)-PGs | Complex | R-HSA-2076452 (Reactome) | |
HS(1)-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
HS(1)-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
HS(1)-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
HS(1)-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
HS(2)-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
HS(2)-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
HS(2)-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
HS(2)-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
HS(2)-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
HS(2)-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
HS(2)-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
HS(2)-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
HS(2)-PGs | R-HSA-2076425 (Reactome) | ||
HS(2)-PGs | R-HSA-2076620 (Reactome) | ||
HS(2)-PGs | Complex | R-HSA-2076425 (Reactome) | |
HS(2)-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
HS(2)-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
HS(2)-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
HS(2)-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
HS(3)-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
HS(3)-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
HS(3)-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
HS(3)-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
HS(3)-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
HS(3)-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
HS(3)-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
HS(3)-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
HS(3)-PGs | R-HSA-2076297 (Reactome) | ||
HS(3)-PGs | R-HSA-2076690 (Reactome) | ||
HS(3)-PGs | Complex | R-HSA-2076297 (Reactome) | |
HS(3)-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
HS(3)-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
HS(3)-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
HS(3)-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
HS(4)-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
HS(4)-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
HS(4)-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
HS(4)-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
HS(4)-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
HS(4)-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
HS(4)-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
HS(4)-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
HS(4)-PGs | R-HSA-2076491 (Reactome) | ||
HS(4)-PGs | R-HSA-2076655 (Reactome) | ||
HS(4)-PGs | Complex | R-HSA-2076491 (Reactome) | |
HS(4)-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
HS(4)-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
HS(4)-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
HS(4)-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
HS(5)-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
HS(5)-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
HS(5)-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
HS(5)-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
HS(5)-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
HS(5)-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
HS(5)-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
HS(5)-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
HS(5)-PGs | R-HSA-2076461 (Reactome) | ||
HS(5)-PGs | R-HSA-2076688 (Reactome) | ||
HS(5)-PGs | Complex | R-HSA-2076461 (Reactome) | |
HS(5)-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
HS(5)-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
HS(5)-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
HS(5)-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
HS(6)-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
HS(6)-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
HS(6)-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
HS(6)-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
HS(6)-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
HS(6)-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
HS(6)-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
HS(6)-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
HS(6)-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
HS(6)-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
HS(6)-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
HS(6)-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
HS/HPIN-PGs | R-HSA-2076357 (Reactome) | ||
HS/HPIN-PGs | R-HSA-2076639 (Reactome) | ||
HS/HPIN-PGs | Complex | R-HSA-2076357 (Reactome) | |
HS/HPIN-PGs | Complex | R-HSA-2076639 (Reactome) | |
HS/HPIN-PGs | Complex | R-HSA-2090050 (Reactome) | |
HS2ST1 | Protein | Q7LGA3 (Uniprot-TrEMBL) | |
HS3ST sulfotransferases | Complex | R-HSA-2869445 (Reactome) | This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis. |
HS3ST1 | Protein | O14792 (Uniprot-TrEMBL) | |
HS3ST1 | Protein | O14792 (Uniprot-TrEMBL) | |
HS3ST2 | Protein | Q9Y278 (Uniprot-TrEMBL) | |
HS3ST3A1 | Protein | Q9Y663 (Uniprot-TrEMBL) | |
HS3ST3B1 | Protein | Q9Y662 (Uniprot-TrEMBL) | |
HS3ST4 | Protein | Q9Y661 (Uniprot-TrEMBL) | |
HS3ST5 | Protein | Q8IZT8 (Uniprot-TrEMBL) | |
HS3ST6 | Protein | Q96QI5 (Uniprot-TrEMBL) | |
HS3STs | Complex | R-HSA-2076438 (Reactome) | |
HS6ST1 | Protein | O60243 (Uniprot-TrEMBL) | |
HS6ST2 | Protein | Q96MM7 (Uniprot-TrEMBL) | |
HS6ST3 | Protein | Q8IZP7 (Uniprot-TrEMBL) | |
HS6STs | Complex | R-HSA-2076470 (Reactome) | |
HSPG2(22-4391) | Protein | P98160 (Uniprot-TrEMBL) | |
HSPGs | Complex | R-HSA-2076618 (Reactome) | |
HSPGs | Complex | R-HSA-2076619 (Reactome) | |
HYAL1 | Protein | Q12794 (Uniprot-TrEMBL) | |
HYAL1-like proteins | Complex | R-HSA-3907265 (Reactome) | This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis. |
HYAL2 | Protein | Q12891 (Uniprot-TrEMBL) | |
HYAL2 | Protein | Q12891 (Uniprot-TrEMBL) | |
HYAL3 | Protein | O43820 (Uniprot-TrEMBL) | |
Heparan chain(1) | Metabolite | CHEBI:63811 (ChEBI) | |
Heparan chain(2) | Metabolite | CHEBI:63645 (ChEBI) | |
Heparan sulfate chain(1) | Metabolite | CHEBI:63666 (ChEBI) | |
Heparan sulfate chain(2) | Metabolite | CHEBI:63805 (ChEBI) | |
Heparan sulfate chain(3) | Metabolite | CHEBI:63806 (ChEBI) | |
Heparan sulfate chain(4) | Metabolite | CHEBI:63807 (ChEBI) | |
Heparan sulfate chain(5) | Metabolite | CHEBI:63808 (ChEBI) | |
Heparan sulfate chain(6) | Metabolite | CHEBI:63809 (ChEBI) | |
Heparan sulfate chain(7) | Metabolite | CHEBI:63810 (ChEBI) | |
Heparan sulfate chain | Metabolite | CHEBI:63666 (ChEBI) | |
Heparan(1)-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
Heparan(1)-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
Heparan(1)-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
Heparan(1)-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
Heparan(1)-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
Heparan(1)-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
Heparan(1)-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
Heparan(1)-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
Heparan(1)-PGs | Complex | R-HSA-2076416 (Reactome) | |
Heparan(1)-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
Heparan(1)-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
Heparan(1)-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
Heparan(1)-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
Heparan(2)-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
Heparan(2)-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
Heparan(2)-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
Heparan(2)-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
Heparan(2)-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
Heparan(2)-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
Heparan(2)-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
Heparan(2)-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
Heparan(2)-PGs | Complex | R-HSA-2076412 (Reactome) | |
Heparan(2)-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
Heparan(2)-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
Heparan(2)-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
Heparan(2)-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
Heparan(3)-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
Heparan(3)-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
Heparan(3)-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
Heparan(3)-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
Heparan(3)-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
Heparan(3)-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
Heparan(3)-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
Heparan(3)-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
Heparan(3)-PGs | Complex | R-HSA-2076535 (Reactome) | |
Heparan(3)-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
Heparan(3)-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
Heparan(3)-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
Heparan(3)-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
Heparan(4)-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
Heparan(4)-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
Heparan(4)-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
Heparan(4)-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
Heparan(4)-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
Heparan(4)-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
Heparan(4)-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
Heparan(4)-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
Heparan(4)-PGs | Complex | R-HSA-2076346 (Reactome) | |
Heparan(4)-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
Heparan(4)-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
Heparan(4)-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
Heparan(4)-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
Heparan-AGRN | Protein | O00468 (Uniprot-TrEMBL) | |
Heparan-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
Heparan-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
Heparan-GPC3 | Protein | P51654 (Uniprot-TrEMBL) | |
Heparan-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
Heparan-GPC5 | Protein | P78333 (Uniprot-TrEMBL) | |
Heparan-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
Heparan-HSPG2 | Protein | P98160 (Uniprot-TrEMBL) | |
Heparan-PGs | Complex | R-HSA-2076465 (Reactome) | |
Heparan-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
Heparan-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
Heparan-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
Heparan-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
IDS dimer | Complex | R-HSA-1678638 (Reactome) | |
IDS(34-455) | Protein | P22304 (Uniprot-TrEMBL) | |
IDS(456-550) | Protein | P22304 (Uniprot-TrEMBL) | |
IDUA | Protein | P35475 (Uniprot-TrEMBL) | |
IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl | Metabolite | CHEBI:63873 (ChEBI) | |
KERA | Protein | O60938 (Uniprot-TrEMBL) | |
KS core proteins | Complex | R-HSA-2105011 (Reactome) | |
KS(1)-ACAN | Protein | P16112 (Uniprot-TrEMBL) | |
KS(1)-FMOD | Protein | Q06828 (Uniprot-TrEMBL) | |
KS(1)-KERA | Protein | O60938 (Uniprot-TrEMBL) | |
KS(1)-LUM | Protein | P51884 (Uniprot-TrEMBL) | |
KS(1)-OGN | Protein | P20774 (Uniprot-TrEMBL) | |
KS(1)-OMD | Protein | Q99983 (Uniprot-TrEMBL) | |
KS(1)-PRELP | Protein | P51888 (Uniprot-TrEMBL) | |
KS(2)-ACAN | Protein | P16112 (Uniprot-TrEMBL) | |
KS(2)-FMOD | Protein | Q06828 (Uniprot-TrEMBL) | |
KS(2)-KERA | Protein | O60938 (Uniprot-TrEMBL) | |
KS(2)-LUM | Protein | P51884 (Uniprot-TrEMBL) | |
KS(2)-OGN | Protein | P20774 (Uniprot-TrEMBL) | |
KS(2)-OMD | Protein | Q99983 (Uniprot-TrEMBL) | |
KS(2)-PRELP | Protein | P51888 (Uniprot-TrEMBL) | |
KSPG(1) | Complex | R-HSA-2046166 (Reactome) | |
KSPG(2) | Complex | R-HSA-2046191 (Reactome) | |
KSPG(2) | Complex | R-HSA-2046244 (Reactome) | |
KSPG(2) | Complex | R-HSA-2046288 (Reactome) | |
Keratan(1)-ACAN | Protein | P16112 (Uniprot-TrEMBL) | |
Keratan(1)-FMOD | Protein | Q06828 (Uniprot-TrEMBL) | |
Keratan(1)-KERA | Protein | O60938 (Uniprot-TrEMBL) | |
Keratan(1)-LUM | Protein | P51884 (Uniprot-TrEMBL) | |
Keratan(1)-OGN | Protein | P20774 (Uniprot-TrEMBL) | |
Keratan(1)-OMD | Protein | Q99983 (Uniprot-TrEMBL) | |
Keratan(1)-PG | Complex | R-HSA-2046187 (Reactome) | |
Keratan(1)-PRELP | Protein | P51888 (Uniprot-TrEMBL) | |
Keratan(2)-ACAN | Protein | P16112 (Uniprot-TrEMBL) | |
Keratan(2)-FMOD | Protein | Q06828 (Uniprot-TrEMBL) | |
Keratan(2)-KERA | Protein | O60938 (Uniprot-TrEMBL) | |
Keratan(2)-LUM | Protein | P51884 (Uniprot-TrEMBL) | |
Keratan(2)-OGN | Protein | P20774 (Uniprot-TrEMBL) | |
Keratan(2)-OMD | Protein | Q99983 (Uniprot-TrEMBL) | |
Keratan(2)-PG | Complex | R-HSA-2046206 (Reactome) | |
Keratan(2)-PRELP | Protein | P51888 (Uniprot-TrEMBL) | |
Keratan(3)-ACAN | Protein | P16112 (Uniprot-TrEMBL) | |
Keratan(3)-FMOD | Protein | Q06828 (Uniprot-TrEMBL) | |
Keratan(3)-KERA | Protein | O60938 (Uniprot-TrEMBL) | |
Keratan(3)-LUM | Protein | P51884 (Uniprot-TrEMBL) | |
Keratan(3)-OGN | Protein | P20774 (Uniprot-TrEMBL) | |
Keratan(3)-OMD | Protein | Q99983 (Uniprot-TrEMBL) | |
Keratan(3)-PG | Complex | R-HSA-2046314 (Reactome) | |
Keratan(3)-PRELP | Protein | P51888 (Uniprot-TrEMBL) | |
Keratan(4)-ACAN | Protein | P16112 (Uniprot-TrEMBL) | |
Keratan(4)-FMOD | Protein | Q06828 (Uniprot-TrEMBL) | |
Keratan(4)-KERA | Protein | O60938 (Uniprot-TrEMBL) | |
Keratan(4)-LUM | Protein | P51884 (Uniprot-TrEMBL) | |
Keratan(4)-OGN | Protein | P20774 (Uniprot-TrEMBL) | |
Keratan(4)-OMD | Protein | Q99983 (Uniprot-TrEMBL) | |
Keratan(4)-PG | Complex | R-HSA-2046203 (Reactome) | |
Keratan(4)-PRELP | Protein | P51888 (Uniprot-TrEMBL) | |
L-Asp | Metabolite | CHEBI:17053 (ChEBI) | |
LUM | Protein | P51884 (Uniprot-TrEMBL) | |
LYVE1 | Protein | Q9Y5Y7 (Uniprot-TrEMBL) | |
Mn2+ | Metabolite | CHEBI:29035 (ChEBI) | |
N-glycan ACAN | Protein | P16112 (Uniprot-TrEMBL) | |
N-glycan FMOD | Protein | Q06828 (Uniprot-TrEMBL) | |
N-glycan KERA | Protein | O60938 (Uniprot-TrEMBL) | |
N-glycan LUM | Protein | P51884 (Uniprot-TrEMBL) | |
N-glycan OGN | Protein | P20774 (Uniprot-TrEMBL) | |
N-glycan OMD | Protein | Q99983 (Uniprot-TrEMBL) | |
N-glycan PRELP | Protein | P51888 (Uniprot-TrEMBL) | |
N-glycan-protein | Complex | R-HSA-2046280 (Reactome) | |
NAGLU(59-743) | Protein | P54802 (Uniprot-TrEMBL) | |
NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
NDST1 | Protein | P52848 (Uniprot-TrEMBL) | |
NDST2 | Protein | P52849 (Uniprot-TrEMBL) | |
NDST3 | Protein | O95803 (Uniprot-TrEMBL) | |
NDST4 | Protein | Q9H3R1 (Uniprot-TrEMBL) | |
NDSTs | Complex | R-HSA-2022936 (Reactome) | |
OGN | Protein | P20774 (Uniprot-TrEMBL) | |
OMD | Protein | Q99983 (Uniprot-TrEMBL) | |
OxA-ARSB | Protein | P15848 (Uniprot-TrEMBL) | |
OxA-GNS | Protein | P15586 (Uniprot-TrEMBL) | |
PAP | Metabolite | CHEBI:17985 (ChEBI) | |
PAPS | Metabolite | CHEBI:17980 (ChEBI) | |
PAPSS1 | Protein | O43252 (Uniprot-TrEMBL) | |
PAPSS1,2 | Complex | R-HSA-174400 (Reactome) | |
PAPSS2 | Protein | O95340 (Uniprot-TrEMBL) | |
PPi | Metabolite | CHEBI:29888 (ChEBI) | |
PRELP | Protein | P51888 (Uniprot-TrEMBL) | |
SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
SGSH | Protein | P51688 (Uniprot-TrEMBL) | |
SLC26A1 | Protein | Q9H2B4 (Uniprot-TrEMBL) | |
SLC26A1,2 | Complex | R-HSA-427632 (Reactome) | |
SLC26A2 | Protein | P50443 (Uniprot-TrEMBL) | |
SLC35B2 | Protein | Q8TB61 (Uniprot-TrEMBL) | |
SLC35B2,3 | Complex | R-HSA-3465611 (Reactome) | |
SLC35B3 | Protein | Q9H1N7 (Uniprot-TrEMBL) | |
SLC35D2 | Protein | Q76EJ3 (Uniprot-TrEMBL) | |
SLC9A1 | Protein | P19634 (Uniprot-TrEMBL) | |
SLC9A1:p-CHP:Ca2+ | Complex | R-HSA-5333682 (Reactome) | |
SO4(2-) | Metabolite | CHEBI:16189 (ChEBI) | |
ST3GAL1 | Protein | Q11201 (Uniprot-TrEMBL) | |
ST3GAL1-4,6 | Complex | R-HSA-2046170 (Reactome) | |
ST3GAL2 | Protein | Q16842 (Uniprot-TrEMBL) | |
ST3GAL3 | Protein | Q11203 (Uniprot-TrEMBL) | |
ST3GAL4 | Protein | Q11206 (Uniprot-TrEMBL) | |
ST3GAL6 | Protein | Q9Y274 (Uniprot-TrEMBL) | |
STAB2(1136-2551) | Protein | Q8WWQ8 (Uniprot-TrEMBL) | |
UDP-Gal | Metabolite | CHEBI:18307 (ChEBI) | |
UDP-GalNAc | Metabolite | CHEBI:16650 (ChEBI) | |
UDP-Glc | Metabolite | CHEBI:18066 (ChEBI) | |
UDP-GlcA | Metabolite | CHEBI:17200 (ChEBI) | |
UDP-GlcNAc | Metabolite | CHEBI:16264 (ChEBI) | |
UDP-GlcNAc | Metabolite | CHEBI:16264 (ChEBI) | |
UDP-sugars | Complex | R-HSA-R-ALL-744229 (Reactome) | |
UDP-sugars | Complex | R-HSA-R-ALL-744234 (Reactome) | |
UDP-xyl | Metabolite | CHEBI:16082 (ChEBI) | |
UDP | Metabolite | CHEBI:17659 (ChEBI) | |
UMP | Metabolite | CHEBI:16695 (ChEBI) | |
UST | Protein | Q9Y2C2 (Uniprot-TrEMBL) | |
VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
XylS-AGRN(30-2045) | Protein | O00468 (Uniprot-TrEMBL) | |
XylS-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
XylS-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
XylS-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
XylS-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
XylS-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
XylS-GPC1 | Protein | P35052 (Uniprot-TrEMBL) | |
XylS-GPC2 | Protein | Q8N158 (Uniprot-TrEMBL) | |
XylS-GPC3(25-?) | Protein | P51654 (Uniprot-TrEMBL) | |
XylS-GPC4 | Protein | O75487 (Uniprot-TrEMBL) | |
XylS-GPC5(25-?) | Protein | P78333 (Uniprot-TrEMBL) | |
XylS-GPC6 | Protein | Q9Y625 (Uniprot-TrEMBL) | |
XylS-HSPG2(22-4391) | Protein | P98160 (Uniprot-TrEMBL) | |
XylS-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
XylS-SDC1 | Protein | P18827 (Uniprot-TrEMBL) | |
XylS-SDC2 | Protein | P34741 (Uniprot-TrEMBL) | |
XylS-SDC3 | Protein | O75056 (Uniprot-TrEMBL) | |
XylS-SDC4 | Protein | P31431 (Uniprot-TrEMBL) | |
XylS-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
aldehydo-L-iduronic acid | Metabolite | CHEBI:28481 (ChEBI) | |
beta-xylosidase | R-HSA-2247521 (Reactome) | ||
chondroitin(1)-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
chondroitin(1)-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
chondroitin(1)-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
chondroitin(1)-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
chondroitin(1)-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
chondroitin(1)-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
chondroitin(1)-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
chondroitin(1)-core proteins | Complex | R-HSA-2064172 (Reactome) | |
chondroitin(2)-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
chondroitin(2)-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
chondroitin(2)-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
chondroitin(2)-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
chondroitin(2)-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
chondroitin(2)-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
chondroitin(2)-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
chondroitin(2)-core proteins | Complex | R-HSA-2064050 (Reactome) | |
chondroitin(3)-BCAN | Protein | Q96GW7 (Uniprot-TrEMBL) | |
chondroitin(3)-BGN | Protein | P21810 (Uniprot-TrEMBL) | |
chondroitin(3)-CSPG4 | Protein | Q6UVK1 (Uniprot-TrEMBL) | |
chondroitin(3)-CSPG5 | Protein | O95196 (Uniprot-TrEMBL) | |
chondroitin(3)-DCN | Protein | P07585 (Uniprot-TrEMBL) | |
chondroitin(3)-NCAN | Protein | O14594 (Uniprot-TrEMBL) | |
chondroitin(3)-VCAN | Protein | P13611 (Uniprot-TrEMBL) | |
chondroitin(3)-core proteins | Complex | R-HSA-2064075 (Reactome) | |
chondroitin(3)-core proteins | R-HSA-2064075 (Reactome) | ||
dermatan-core proteins | R-HSA-5607515 (Reactome) | ||
keratan
sulfate 1,4-beta-D-galactosidase | R-HSA-1793214 (Reactome) | ||
linker chain(2) | Metabolite | CHEBI:63503 (ChEBI) | |
p-CHP1 | Protein | Q99653 (Uniprot-TrEMBL) | |
xylosyl-core proteins | Complex | R-HSA-2064201 (Reactome) |
Annotated Interactions
View all... |
Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
(HA)2 | 2162227 (Reactome) | |||
(HA)2 | Arrow | 2160874 (Reactome) | ||
(HA)50 | 2160874 (Reactome) | |||
(HA)50 | 2160906 (Reactome) | |||
(HA)50 | Arrow | 2160892 (Reactome) | ||
(HA)50 | Arrow | 2160906 (Reactome) | ||
1606789 (Reactome) | ||||
1678660 (Reactome) | ||||
1678742 (Reactome) | ||||
1678854 (Reactome) | ||||
174389 (Reactome) | ||||
174392 (Reactome) | ||||
1793176 (Reactome) | ||||
1793182 (Reactome) | ||||
1793186 (Reactome) | ||||
1793207 (Reactome) | ||||
1793209 (Reactome) | ||||
1878002 (Reactome) | ||||
1889955 (Reactome) | ||||
1889978 (Reactome) | ||||
1889981 (Reactome) | ||||
1971482 (Reactome) | ||||
1971483 (Reactome) | ||||
1971487 (Reactome) | ||||
1971491 (Reactome) | ||||
2018659 (Reactome) | ||||
2018682 (Reactome) | ||||
2022052 (Reactome) | ||||
2022056 (Reactome) | ||||
2022061 (Reactome) | ||||
2022063 (Reactome) | ||||
2022065 (Reactome) | ||||
2022851 (Reactome) | ||||
2022856 (Reactome) | ||||
2022860 (Reactome) | ||||
2022887 (Reactome) | ||||
2022911 (Reactome) | ||||
2022919 (Reactome) | ||||
2024084 (Reactome) | ||||
2024100 (Reactome) | ||||
2024108 (Reactome) | ||||
2025723 (Reactome) | ||||
2025724 (Reactome) | ||||
2046175 (Reactome) | ||||
2046180 (Reactome) | ||||
2046222 (Reactome) | ||||
2046239 (Reactome) | ||||
2046265 (Reactome) | ||||
2046285 (Reactome) | ||||
2046298 (Reactome) | ||||
2065233 (Reactome) | ||||
2076371 (Reactome) | ||||
2076383 (Reactome) | ||||
2076392 (Reactome) | ||||
2076419 (Reactome) | ||||
2076508 (Reactome) | ||||
2076611 (Reactome) | ||||
2090037 (Reactome) | ||||
2090038 (Reactome) | ||||
2090043 (Reactome) | ||||
2090079 (Reactome) | ||||
2090085 (Reactome) | ||||
2105001 (Reactome) | ||||
2142859 (Reactome) | ||||
2160851 (Reactome) | ||||
2160874 (Reactome) | ||||
2160884 (Reactome) | ||||
2160892 (Reactome) | ||||
2160906 (Reactome) | ||||
2160915 (Reactome) | ||||
2162225 (Reactome) | ||||
2162226 (Reactome) | ||||
2162227 (Reactome) | ||||
2162229 (Reactome) | ||||
427555 (Reactome) | ||||
5693356 (Reactome) | ||||
741449 (Reactome) | ||||
744231 (Reactome) | ||||
ABCC5 | mim-catalysis | 2142859 (Reactome) | ||
ADP | Arrow | 174389 (Reactome) | ||
APS | 174389 (Reactome) | |||
APS | Arrow | 174392 (Reactome) | ||
ARSB:Ca2+ | mim-catalysis | 1606789 (Reactome) | ||
ARSB:Ca2+ | mim-catalysis | 1793207 (Reactome) | ||
ATP | 174389 (Reactome) | |||
ATP | 174392 (Reactome) | |||
Ac-CoA | 1678660 (Reactome) | |||
Ac-CoA | 2090085 (Reactome) | |||
B3GALT6 | mim-catalysis | 1889978 (Reactome) | ||
B3GAT dimers | mim-catalysis | 1889955 (Reactome) | ||
B3GNT1,2,3,4,7 | mim-catalysis | 2025724 (Reactome) | ||
B4GALT1-6 homodimers | mim-catalysis | 2025723 (Reactome) | ||
B4GALT1-6 homodimers | mim-catalysis | 2046265 (Reactome) | ||
B4GALT1-6 homodimers | mim-catalysis | 2046298 (Reactome) | ||
B4GALT7 | mim-catalysis | 1889981 (Reactome) | ||
BGAL | mim-catalysis | 2090079 (Reactome) | ||
BGAL | mim-catalysis | R-HSA-1630306 (Reactome) | ||
C4S-PG | 2018659 (Reactome) | |||
C4S-PG | Arrow | 1971483 (Reactome) | ||
C4S/C6S chains | 1793207 (Reactome) | |||
C4S/C6S chains | Arrow | 2065233 (Reactome) | ||
C6S-PG | Arrow | 2018682 (Reactome) | ||
CEMIP | mim-catalysis | 5693356 (Reactome) | ||
CH3COO- | Arrow | 2022887 (Reactome) | ||
CHEBI:63868 chain | Arrow | 1793186 (Reactome) | ||
CHPF,CHPF2,CHSY1,CHSY3 | mim-catalysis | 1971491 (Reactome) | ||
CHPF,CHSY1,CHSY3 | mim-catalysis | 1971487 (Reactome) | ||
CHST14 products | Arrow | 2022063 (Reactome) | ||
CHST14 substrates | 2022063 (Reactome) | |||
CHST14 | mim-catalysis | 2022063 (Reactome) | ||
CHST15 | mim-catalysis | 2018659 (Reactome) | ||
CHST1 | mim-catalysis | 2046175 (Reactome) | ||
CHST2,5,6 | mim-catalysis | 2046222 (Reactome) | ||
CHST3,7 | mim-catalysis | 2018682 (Reactome) | ||
CHST9,11,12,13 | mim-catalysis | 1971483 (Reactome) | ||
CMP-Neu5Ac | 2046285 (Reactome) | |||
CMP | Arrow | 2046285 (Reactome) | ||
CS/DS core proteins | Arrow | 1793176 (Reactome) | ||
CS/DS core proteins | Arrow | 2065233 (Reactome) | ||
CS/HS precursor | 1678854 (Reactome) | |||
CS/HS precursor | Arrow | 1793209 (Reactome) | ||
CS/HS precursor | Arrow | 2090038 (Reactome) | ||
CSE-PG | Arrow | 2018659 (Reactome) | ||
CSGALNACT | mim-catalysis | 1971482 (Reactome) | ||
CSPGs | 2022056 (Reactome) | |||
CSPGs | 2022911 (Reactome) | |||
CSPGs | 2065233 (Reactome) | |||
CSPGs | Arrow | 2022056 (Reactome) | ||
CSPGs | Arrow | 2022911 (Reactome) | ||
ChEBI:63516 chain | 2105001 (Reactome) | |||
ChEBI:63516 chain | Arrow | 1793182 (Reactome) | ||
ChEBI:63517 chain | 1793182 (Reactome) | |||
ChEBI:63517 chain | Arrow | 1606789 (Reactome) | ||
ChEBI:63519 chain | 1606789 (Reactome) | |||
ChEBI:63519 chain | Arrow | 1793176 (Reactome) | ||
Chondroitin chain | Arrow | 1793207 (Reactome) | ||
Chondroitin chains | 1793209 (Reactome) | |||
CoA-SH | Arrow | 1678660 (Reactome) | ||
CoA-SH | Arrow | 2090085 (Reactome) | ||
D-xylose | Arrow | 2090079 (Reactome) | ||
D2,4(S)2-PG | Arrow | 2022061 (Reactome) | ||
D2,4,4(S)3-PGs | 1793176 (Reactome) | |||
D4S-PGs | 2022061 (Reactome) | |||
DSE,DSEL products | Arrow | 2022052 (Reactome) | ||
DSE,DSEL substrates | 2022052 (Reactome) | |||
DSE,DSEL | mim-catalysis | 2022052 (Reactome) | ||
DSPGs | 2022056 (Reactome) | |||
DSPGs | 2022065 (Reactome) | |||
DSPGs | Arrow | 2022056 (Reactome) | ||
DSPGs | Arrow | 2022065 (Reactome) | ||
EXT1:EXT2 | mim-catalysis | 2022851 (Reactome) | ||
EXT1:EXT2 | mim-catalysis | 2022856 (Reactome) | ||
EXT1:EXT2 | mim-catalysis | 2022919 (Reactome) | ||
EXT1:EXT2 | mim-catalysis | 2076392 (Reactome) | ||
GAG core proteins | 1878002 (Reactome) | |||
GALNS oligomer | mim-catalysis | R-HSA-1630304 (Reactome) | ||
GLCE | mim-catalysis | 2024100 (Reactome) | ||
GLCE | mim-catalysis | 2076371 (Reactome) | ||
GUSB tetramer | mim-catalysis | 1678854 (Reactome) | ||
GUSB tetramer | mim-catalysis | 2162226 (Reactome) | ||
GUSB tetramer | mim-catalysis | 2162227 (Reactome) | ||
GXYLTs | mim-catalysis | 1878002 (Reactome) | ||
Gal(S)-GlcNAc(S)-Gal-GlcNAc(S)-Gal | Arrow | R-HSA-1793217 (Reactome) | ||
Gal(S)-GlcNAc(S)-Gal-GlcNAc(S)-Gal | R-HSA-1630304 (Reactome) | |||
Gal-Gal-Xyl-proteins | 1889955 (Reactome) | |||
Gal-Gal-Xyl-proteins | Arrow | 1889978 (Reactome) | ||
Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal | Arrow | R-HSA-1630304 (Reactome) | ||
Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal | R-HSA-1630306 (Reactome) | |||
Gal-GlcNAc(S)-Gal | Arrow | R-HSA-1638053 (Reactome) | ||
Gal-Xyl-proteins | 1889978 (Reactome) | |||
Gal-Xyl-proteins | Arrow | 1889981 (Reactome) | ||
Gal-glycan-protein | 2025724 (Reactome) | |||
Gal-glycan-protein | Arrow | 2025723 (Reactome) | ||
Gal | Arrow | 2090079 (Reactome) | ||
Gal | Arrow | R-HSA-1630306 (Reactome) | ||
GalNAc | Arrow | 2105001 (Reactome) | ||
GalNAc | Arrow | R-HSA-1638053 (Reactome) | ||
GlcA-Gal-Gal-Xyl-CS proteins | 1971482 (Reactome) | |||
GlcA-Gal-Gal-Xyl-HS proteins | 2022919 (Reactome) | |||
GlcA-Gal-Gal-Xyl-proteins | Arrow | 1889955 (Reactome) | ||
GlcA-b1,3-GlcNAc | 2160851 (Reactome) | |||
GlcA-b1,3-GlcNAc | 2162226 (Reactome) | |||
GlcA-b1,3-GlcNAc | Arrow | 2162225 (Reactome) | ||
GlcA-b1,3-GlcNAc | Arrow | 5693356 (Reactome) | ||
GlcA | 2162229 (Reactome) | |||
GlcA | Arrow | 1678854 (Reactome) | ||
GlcA | Arrow | 2162226 (Reactome) | ||
GlcA | Arrow | 2162227 (Reactome) | ||
GlcA | Arrow | 2162229 (Reactome) | ||
GlcNAc(S)-Gal-GlcNAc(S)-Gal | Arrow | R-HSA-1630306 (Reactome) | ||
GlcNAc(S)-Gal-GlcNAc(S)-Gal | R-HSA-1638032 (Reactome) | |||
GlcNAc-Gal-GlcNAc(S)-Gal | Arrow | R-HSA-1638032 (Reactome) | ||
GlcNAc-Gal-GlcNAc(S)-Gal | R-HSA-1638053 (Reactome) | |||
GlcNAc-GlcA-GlcNAc | 2162225 (Reactome) | |||
GlcNAc-GlcA-GlcNAc | Arrow | 2162227 (Reactome) | ||
GlcNAc | 2162229 (Reactome) | |||
GlcNAc | Arrow | 1678742 (Reactome) | ||
GlcNAc | Arrow | 2090038 (Reactome) | ||
GlcNAc | Arrow | 2162225 (Reactome) | ||
GlcNAc | Arrow | 2162226 (Reactome) | ||
GlcNAc | Arrow | 2162229 (Reactome) | ||
H+ | 427555 (Reactome) | |||
H+ | Arrow | 427555 (Reactome) | ||
H2O | 1606789 (Reactome) | |||
H2O | 1678742 (Reactome) | |||
H2O | 1678854 (Reactome) | |||
H2O | 1793176 (Reactome) | |||
H2O | 1793182 (Reactome) | |||
H2O | 1793186 (Reactome) | |||
H2O | 1793207 (Reactome) | |||
H2O | 1793209 (Reactome) | |||
H2O | 2022887 (Reactome) | |||
H2O | 2065233 (Reactome) | |||
H2O | 2090037 (Reactome) | |||
H2O | 2090038 (Reactome) | |||
H2O | 2090043 (Reactome) | |||
H2O | 2090079 (Reactome) | |||
H2O | 2105001 (Reactome) | |||
H2O | 2162225 (Reactome) | |||
H2O | 2162226 (Reactome) | |||
H2O | 2162227 (Reactome) | |||
H2O | R-HSA-1630304 (Reactome) | |||
H2O | R-HSA-1630306 (Reactome) | |||
H2O | R-HSA-1638032 (Reactome) | |||
H2O | R-HSA-1638053 (Reactome) | |||
H2O | R-HSA-1667005 (Reactome) | |||
H2O | R-HSA-1678650 (Reactome) | |||
H2O | R-HSA-1678694 (Reactome) | |||
H2O | R-HSA-1678708 (Reactome) | |||
H2O | R-HSA-1678716 (Reactome) | |||
H2O | R-HSA-1793217 (Reactome) | |||
HA polymer | 2142859 (Reactome) | |||
HA polymer | Arrow | 2160851 (Reactome) | ||
HA | 2160915 (Reactome) | |||
HA | 5693356 (Reactome) | |||
HA:HAR:HYAL2 | 2160884 (Reactome) | |||
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ | 2160892 (Reactome) | |||
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ | Arrow | 2160884 (Reactome) | ||
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ | Arrow | 2160892 (Reactome) | ||
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ | mim-catalysis | 2160892 (Reactome) | ||
HA:HAR:HYAL2 | Arrow | 2160915 (Reactome) | ||
HA | Arrow | 2142859 (Reactome) | ||
HA | Arrow | 5693356 (Reactome) | ||
HARs | 2160915 (Reactome) | |||
HAS1,2,3 | mim-catalysis | 2160851 (Reactome) | ||
HEXA,B | mim-catalysis | 2105001 (Reactome) | ||
HEXA,B | mim-catalysis | 2162225 (Reactome) | ||
HEXA,B | mim-catalysis | R-HSA-1638053 (Reactome) | ||
HGSNAT oligomer | mim-catalysis | 1678660 (Reactome) | ||
HGSNAT oligomer | mim-catalysis | 2090085 (Reactome) | ||
HPSE dimer | mim-catalysis | R-HSA-1667005 (Reactome) | ||
HPSE2(1-592) | mim-catalysis | R-HSA-1678694 (Reactome) | ||
HS core proteins | Arrow | R-HSA-1667005 (Reactome) | ||
HS core proteins | Arrow | R-HSA-1678694 (Reactome) | ||
HS(1)-PGs | 2024100 (Reactome) | |||
HS(1)-PGs | Arrow | 2022860 (Reactome) | ||
HS(2)-PGs | 2076508 (Reactome) | |||
HS(2)-PGs | Arrow | 2024100 (Reactome) | ||
HS(3)-PGs | 2076383 (Reactome) | |||
HS(3)-PGs | 2076611 (Reactome) | |||
HS(3)-PGs | Arrow | 2076508 (Reactome) | ||
HS(4)-PGs | 2076371 (Reactome) | |||
HS(4)-PGs | Arrow | 2076383 (Reactome) | ||
HS(4)-PGs | Arrow | 2076611 (Reactome) | ||
HS(5)-PGs | 2076419 (Reactome) | |||
HS(5)-PGs | Arrow | 2076371 (Reactome) | ||
HS/HPIN-PGs | 2024084 (Reactome) | |||
HS/HPIN-PGs | Arrow | 2024084 (Reactome) | ||
HS/HPIN-PGs | Arrow | 2076419 (Reactome) | ||
HS/HPIN-PGs | R-HSA-1667005 (Reactome) | |||
HS/HPIN-PGs | R-HSA-1678694 (Reactome) | |||
HS2ST1 | mim-catalysis | 2076508 (Reactome) | ||
HS3ST sulfotransferases | mim-catalysis | 2076383 (Reactome) | ||
HS3STs | mim-catalysis | 2076611 (Reactome) | ||
HS6STs | mim-catalysis | 2076419 (Reactome) | ||
HSPGs | 2024108 (Reactome) | |||
HSPGs | Arrow | 2024108 (Reactome) | ||
HYAL1-like proteins | mim-catalysis | 1793209 (Reactome) | ||
HYAL1-like proteins | mim-catalysis | 2160874 (Reactome) | ||
HYAL2 | 2160915 (Reactome) | |||
Heparan chain(1) | 2090085 (Reactome) | |||
Heparan chain(1) | Arrow | 2090043 (Reactome) | ||
Heparan chain(2) | 2090038 (Reactome) | |||
Heparan chain(2) | Arrow | 2090085 (Reactome) | ||
Heparan sulfate chain(1) | Arrow | R-HSA-1667005 (Reactome) | ||
Heparan sulfate chain(1) | R-HSA-1678716 (Reactome) | |||
Heparan sulfate chain(2) | Arrow | R-HSA-1678716 (Reactome) | ||
Heparan sulfate chain(2) | R-HSA-1678708 (Reactome) | |||
Heparan sulfate chain(3) | 1678660 (Reactome) | |||
Heparan sulfate chain(3) | Arrow | R-HSA-1678708 (Reactome) | ||
Heparan sulfate chain(4) | 1678742 (Reactome) | |||
Heparan sulfate chain(4) | Arrow | 1678660 (Reactome) | ||
Heparan sulfate chain(5) | Arrow | 1678742 (Reactome) | ||
Heparan sulfate chain(5) | R-HSA-1678650 (Reactome) | |||
Heparan sulfate chain(6) | 2090037 (Reactome) | |||
Heparan sulfate chain(6) | Arrow | R-HSA-1678650 (Reactome) | ||
Heparan sulfate chain(7) | 2090043 (Reactome) | |||
Heparan sulfate chain(7) | Arrow | 2090037 (Reactome) | ||
Heparan sulfate chain | Arrow | R-HSA-1678694 (Reactome) | ||
Heparan(1)-PGs | 2022851 (Reactome) | |||
Heparan(1)-PGs | Arrow | 2022856 (Reactome) | ||
Heparan(2)-PGs | 2076392 (Reactome) | |||
Heparan(2)-PGs | Arrow | 2022851 (Reactome) | ||
Heparan(3)-PGs | 2022887 (Reactome) | |||
Heparan(3)-PGs | Arrow | 2076392 (Reactome) | ||
Heparan(4)-PGs | 2022860 (Reactome) | |||
Heparan(4)-PGs | Arrow | 2022887 (Reactome) | ||
Heparan-PGs | 2022856 (Reactome) | |||
Heparan-PGs | Arrow | 2022919 (Reactome) | ||
IDS dimer | mim-catalysis | 1793182 (Reactome) | ||
IDS dimer | mim-catalysis | R-HSA-1678650 (Reactome) | ||
IDUA | mim-catalysis | 1793186 (Reactome) | ||
IDUA | mim-catalysis | 2090037 (Reactome) | ||
IDUA | mim-catalysis | R-HSA-1678716 (Reactome) | ||
IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl | 1793186 (Reactome) | |||
IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl | Arrow | 2105001 (Reactome) | ||
KS core proteins | Arrow | R-HSA-1793217 (Reactome) | ||
KSPG(1) | 2046175 (Reactome) | |||
KSPG(1) | Arrow | 2046222 (Reactome) | ||
KSPG(2) | 2046180 (Reactome) | |||
KSPG(2) | 2046239 (Reactome) | |||
KSPG(2) | Arrow | 2046175 (Reactome) | ||
KSPG(2) | Arrow | 2046180 (Reactome) | ||
KSPG(2) | Arrow | 2046239 (Reactome) | ||
KSPG(2) | R-HSA-1793217 (Reactome) | |||
Keratan(1)-PG | 2046265 (Reactome) | |||
Keratan(1)-PG | Arrow | 2025724 (Reactome) | ||
Keratan(2)-PG | 2046298 (Reactome) | |||
Keratan(2)-PG | Arrow | 2046265 (Reactome) | ||
Keratan(3)-PG | 2046285 (Reactome) | |||
Keratan(3)-PG | Arrow | 2046298 (Reactome) | ||
Keratan(4)-PG | 2046222 (Reactome) | |||
Keratan(4)-PG | Arrow | 2046285 (Reactome) | ||
L-Asp | TBar | 1678854 (Reactome) | ||
N-glycan-protein | 2025723 (Reactome) | |||
NAGLU(59-743) | mim-catalysis | 1678742 (Reactome) | ||
NAGLU(59-743) | mim-catalysis | 2090038 (Reactome) | ||
NDSTs | mim-catalysis | 2022860 (Reactome) | ||
NDSTs | mim-catalysis | 2022887 (Reactome) | ||
OxA-GNS | mim-catalysis | R-HSA-1638032 (Reactome) | ||
PAP | Arrow | 1971483 (Reactome) | ||
PAP | Arrow | 2018659 (Reactome) | ||
PAP | Arrow | 2018682 (Reactome) | ||
PAP | Arrow | 2022061 (Reactome) | ||
PAP | Arrow | 2022063 (Reactome) | ||
PAP | Arrow | 2022860 (Reactome) | ||
PAP | Arrow | 2046175 (Reactome) | ||
PAP | Arrow | 2046222 (Reactome) | ||
PAP | Arrow | 2076383 (Reactome) | ||
PAP | Arrow | 2076419 (Reactome) | ||
PAP | Arrow | 2076508 (Reactome) | ||
PAP | Arrow | 2076611 (Reactome) | ||
PAPS | 1971483 (Reactome) | |||
PAPS | 2018659 (Reactome) | |||
PAPS | 2018682 (Reactome) | |||
PAPS | 2022061 (Reactome) | |||
PAPS | 2022063 (Reactome) | |||
PAPS | 2022860 (Reactome) | |||
PAPS | 2046175 (Reactome) | |||
PAPS | 2046222 (Reactome) | |||
PAPS | 2076383 (Reactome) | |||
PAPS | 2076419 (Reactome) | |||
PAPS | 2076508 (Reactome) | |||
PAPS | 2076611 (Reactome) | |||
PAPS | 741449 (Reactome) | |||
PAPS | Arrow | 174389 (Reactome) | ||
PAPS | Arrow | 741449 (Reactome) | ||
PAPSS1,2 | mim-catalysis | 174389 (Reactome) | ||
PAPSS1,2 | mim-catalysis | 174392 (Reactome) | ||
PPi | Arrow | 174392 (Reactome) | ||
R-HSA-1630304 (Reactome) | N-acetylgalactosamine 6-sulfate sulfatase (GALNS) hydrolyses sulfate from galactose 6-sulfate units of keratan sulfate (KS, shown here) and sulfate from N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate (CS, not shown) (Lim & Horwitz 1981, Masue et al. 1991). The conversion to 3-oxoalanine (C-formylglycine, FGly) of a cysteine residue in eukaryotes, is critical for catalytic activity, based on similarity to the prototypical arylsulfatase ARSA (Chruszcz et al. 2003, Lukatela et al. 1998). Defects in GALNS cause mucopolysaccharidosis type IVA (MPSIVA, MIM:253000), also called Morquio A syndrome, a lysosomal storage disease characterized by intracellular accumulation of KS and CS (Fukuda et al. 1992). | |||
R-HSA-1630306 (Reactome) | Beta-galactosidase (GLB1) can cleave terminal galactose residues from glycosaminoglycans such as keratan sulfate (KS) (Asp et al. 1969). Defects in GLB1 cause the lysosomal storage diseases GM1gangliosidosis (Yoshida et al. 1991) and Morquio syndrome type B (Oshima et al. 1991). | |||
R-HSA-1638032 (Reactome) | N-acetylglucosamine 6-sulfatase (GNS) is a lysosomal enzyme which degrades glycosaminoglycans such as heparan sulfate and keratan sulfate. GNS shows strong sequence similarity to other sulphatases such as the family of arylsulfatases and the conversion to 3-oxo-alanine (formylglycine, FGly) of a cysteine residue is critical for catalytic activity, based on this similarity (Robertson et al. 1992, Robertson et al. 1988). Defects in GNS are the cause of mucopolysaccharidosis type IIID (MPSIIID, MIM:252940), also called Sanfilippo D syndrome (Valstar et al. 2010). | |||
R-HSA-1638053 (Reactome) | Beta-hexosaminidase (HEX) cleaves the terminal N-acetyl galactosamine (GalNAc) from glucosaminoglycans (GAGs) and any other molecules containing a terminal GalNAc. There are two forms of HEX: HEXA and B. The A form is a trimer of the subunits alpha, beta A and beta B. The B form is a tetramer of 2 beta A and 2 beta B subunits (O'Dowd et al. 1988). Defects in the two subunits cause lysosomal storage diseases marked by the accumulation of GM2 gangliosides in neuronal cells. | |||
R-HSA-1667005 (Reactome) | Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate (HS) from its HS proteoglycan (HSPG) (Toyoshima & Nakajima 1999). The formation of a heterodimer of 8kDa and 50kDa subunits cleaved from the 65kDa form is required for enzyme activity (Levy-Adam et al. 2003) and this proteolytic cleavage occurs in the lysosome (Goldshmidt et al. 2002). Acidic conditions within the lysosome optimises HPSE activity. | |||
R-HSA-1678650 (Reactome) | Iduronate 2sulfatase (IDS) hydrolyses 2-sulfate groups from Liduronate 2-sulfate units of heparan sulfate. Defects in IDS are the cause of mucopolysaccharidosis type II (MPSII, MIM:309900), also called Hunter syndrome (Wilson et al. 1990). | |||
R-HSA-1678694 (Reactome) | Heparanase 2 (HPSE2) (McKenzie et al. 2000) is a membrane-bound endoglycosidase that cleaves heparan sulfate (HS) from its HS proteoglycan (HSPG), either in the extracellular matrix or the basement membranes of cells. Defects in HPSE2 are the cause of urofacial syndrome (UFS) (MIM:236730) (Daly et al. 2010, Pang et al. 2010). | |||
R-HSA-1678708 (Reactome) | N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses the sulfate group from the terminal N-sulphoglucosamine residue of heparan sulfate (Scott et al. 1995). Defects in SGSH cause mucopolysaccharidosis type IIIA (MPSIIIA, MIM:252900), also called Sanfilippo syndrome A (Weber et al. 1997). | |||
R-HSA-1678716 (Reactome) | An L-iduronic acid residue can be cleaved from either heparan sulfate or dermatan sulfate by the lysosomal enzyme alpha-L-iduronidase (IDUA) (Scott et al. 1991). Defects in IDUA are the cause of mucopolysaccharidosis type IH (MPS IH, Hurler syndrome, MIM:607014), mucopolysaccharidosis IH/S (MPSIH/S, HurlerScheie syndrome, MIM:607015) and mucopolysaccharidosis type IS (MPSIS, Scheie syndrome, MIM:607016) (LeeChen et al. 1999). | |||
R-HSA-1793217 (Reactome) | Keratan sulfate (KS) is cleaved from its KS proteoglycan (KSPG) by an as yet unknown beta-galactosidase. It performs a similar function to beta-galactosidase GLB1 (Asp et al. 1969). A simplified version of KS is used to demonstrate cleavage reactions. | |||
SGSH | mim-catalysis | 2090043 (Reactome) | ||
SGSH | mim-catalysis | R-HSA-1678708 (Reactome) | ||
SLC26A1,2 | mim-catalysis | 427555 (Reactome) | ||
SLC35B2,3 | mim-catalysis | 741449 (Reactome) | ||
SLC35D2 | mim-catalysis | 744231 (Reactome) | ||
SLC9A1:p-CHP:Ca2+ | 2160884 (Reactome) | |||
SO4(2-) | 174392 (Reactome) | |||
SO4(2-) | 427555 (Reactome) | |||
SO4(2-) | Arrow | 1606789 (Reactome) | ||
SO4(2-) | Arrow | 1793182 (Reactome) | ||
SO4(2-) | Arrow | 1793207 (Reactome) | ||
SO4(2-) | Arrow | 2090043 (Reactome) | ||
SO4(2-) | Arrow | 427555 (Reactome) | ||
SO4(2-) | Arrow | R-HSA-1630304 (Reactome) | ||
SO4(2-) | Arrow | R-HSA-1638032 (Reactome) | ||
SO4(2-) | Arrow | R-HSA-1678650 (Reactome) | ||
SO4(2-) | Arrow | R-HSA-1678708 (Reactome) | ||
ST3GAL1-4,6 | mim-catalysis | 2046285 (Reactome) | ||
UDP-Gal | 1889978 (Reactome) | |||
UDP-Gal | 1889981 (Reactome) | |||
UDP-Gal | 2025723 (Reactome) | |||
UDP-Gal | 2046265 (Reactome) | |||
UDP-Gal | 2046298 (Reactome) | |||
UDP-GalNAc | 1971482 (Reactome) | |||
UDP-GalNAc | 1971487 (Reactome) | |||
UDP-GlcA | 1889955 (Reactome) | |||
UDP-GlcA | 1971491 (Reactome) | |||
UDP-GlcA | 2022856 (Reactome) | |||
UDP-GlcA | 2076392 (Reactome) | |||
UDP-GlcNAc | 2022851 (Reactome) | |||
UDP-GlcNAc | 2022919 (Reactome) | |||
UDP-GlcNAc | 2025724 (Reactome) | |||
UDP-sugars | 744231 (Reactome) | |||
UDP-sugars | Arrow | 744231 (Reactome) | ||
UDP-xyl | 1878002 (Reactome) | |||
UDP | Arrow | 1878002 (Reactome) | ||
UDP | Arrow | 1889955 (Reactome) | ||
UDP | Arrow | 1889978 (Reactome) | ||
UDP | Arrow | 1889981 (Reactome) | ||
UDP | Arrow | 1971482 (Reactome) | ||
UDP | Arrow | 1971487 (Reactome) | ||
UDP | Arrow | 1971491 (Reactome) | ||
UDP | Arrow | 2022851 (Reactome) | ||
UDP | Arrow | 2022856 (Reactome) | ||
UDP | Arrow | 2022919 (Reactome) | ||
UDP | Arrow | 2025723 (Reactome) | ||
UDP | Arrow | 2025724 (Reactome) | ||
UDP | Arrow | 2046265 (Reactome) | ||
UDP | Arrow | 2046298 (Reactome) | ||
UDP | Arrow | 2076392 (Reactome) | ||
UMP | 744231 (Reactome) | |||
UMP | Arrow | 744231 (Reactome) | ||
UST | mim-catalysis | 2022061 (Reactome) | ||
aldehydo-L-iduronic acid | Arrow | 1793186 (Reactome) | ||
aldehydo-L-iduronic acid | Arrow | 2090037 (Reactome) | ||
aldehydo-L-iduronic acid | Arrow | R-HSA-1678716 (Reactome) | ||
beta-xylosidase | mim-catalysis | 1793176 (Reactome) | ||
beta-xylosidase | mim-catalysis | 2065233 (Reactome) | ||
chondroitin(1)-core proteins | 1971491 (Reactome) | |||
chondroitin(1)-core proteins | Arrow | 1971482 (Reactome) | ||
chondroitin(2)-core proteins | 1971487 (Reactome) | |||
chondroitin(2)-core proteins | Arrow | 1971491 (Reactome) | ||
chondroitin(3)-core proteins | 1971483 (Reactome) | |||
chondroitin(3)-core proteins | 2018682 (Reactome) | |||
chondroitin(3)-core proteins | Arrow | 1971487 (Reactome) | ||
keratan
sulfate 1,4-beta-D-galactosidase | mim-catalysis | R-HSA-1793217 (Reactome) | ||
linker chain(2) | 2090079 (Reactome) | |||
linker chain(2) | Arrow | 1678854 (Reactome) | ||
xylosyl-core proteins | 1889981 (Reactome) | |||
xylosyl-core proteins | Arrow | 1878002 (Reactome) |