Mitotic Telophase/Cytokinesis (Homo sapiens)
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Description
In this final phase of mitosis, new membranes are formed around two sets of chromatids and two daughter cells are formed. The chromosomes and the spindle fibers disperse, and the fiber ring around the center of the cell, composed of actin, contracts, pinching the cell into two daughter cells.
View original pathway at:Reactome.
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Saving...Bibliography
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- Gandhi R, Gillespie PJ, Hirano T.; ''Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.''; PubMed Europe PMC Scholia
- Liu X, Zhou T, Kuriyama R, Erikson RL.; ''Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1.''; PubMed Europe PMC Scholia
- Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA.; ''Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.''; PubMed Europe PMC Scholia
- Kueng S, Hegemann B, Peters BH, Lipp JJ, Schleiffer A, Mechtler K, Peters JM.; ''Wapl controls the dynamic association of cohesin with chromatin.''; PubMed Europe PMC Scholia
- Watrin E, Schleiffer A, Tanaka K, Eisenhaber F, Nasmyth K, Peters JM.; ''Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.''; PubMed Europe PMC Scholia
- Shintomi K, Hirano T.; ''Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1.''; PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| Chromatin | R-ALL-2537690 (Reactome)  | ||
| Cohesin Complex | Complex | R-HSA-1641505 (Reactome) | |
| Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromatin | Complex | R-HSA-2537688 (Reactome) | |
| Cohesin:PDS5:WAPAL | Complex | R-HSA-2468042 (Reactome) | |
| KIF20A | Protein | O95235 (Uniprot-TrEMBL) | |
| KIF23 | Protein | Q02241 (Uniprot-TrEMBL) | |
| MAU2 | Protein | Q9Y6X3 (Uniprot-TrEMBL) | |
| NIPBL | Protein | Q6KC79 (Uniprot-TrEMBL) | |
| NIPBL:MAU2 | Complex | R-HSA-2470930 (Reactome) | |
| NUDC | Protein | Q9Y266 (Uniprot-TrEMBL) | |
| PDS5 | Protein | R-HSA-2468044 (Reactome) | |
| PLK1 | Protein | P53350 (Uniprot-TrEMBL) | |
| RAD21 | Protein | O60216 (Uniprot-TrEMBL) | |
| S Phase | Pathway | R-HSA-69242 (Reactome) | DNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues, the E type cyclins shared by the G1 and S phases, are destroyed and the levels of the mitotic cyclins rise. |
| SMC1A | Protein | Q14683 (Uniprot-TrEMBL) | |
| SMC3 | Protein | Q9UQE7 (Uniprot-TrEMBL) | |
| STAG1 | Protein | Q8WVM7 (Uniprot-TrEMBL) | |
| STAG2 | Protein | Q8N3U4 (Uniprot-TrEMBL) | |
| WAPAL | Protein | Q7Z5K2 (Uniprot-TrEMBL) | |
| WAPAL | Protein | Q7Z5K2 (Uniprot-TrEMBL) | |
| p-S274,S326-NUDC | Protein | Q9Y266 (Uniprot-TrEMBL) | |
| p-S528-KIF20A | Protein | O95235 (Uniprot-TrEMBL) | |
| p-S904,S905-KIF23 | Protein | Q02241 (Uniprot-TrEMBL) |
Annotated Interactions
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| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| Chromatin | R-HSA-2470935 (Reactome) | |||
| Cohesin Complex | R-HSA-2468040 (Reactome) | |||
| Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromatin | Arrow | R-HSA-2470935 (Reactome) | ||
| Cohesin:PDS5:WAPAL | Arrow | R-HSA-2468040 (Reactome) | ||
| Cohesin:PDS5:WAPAL | R-HSA-2470935 (Reactome) | |||
| KIF20A | R-HSA-156723 (Reactome) | |||
| KIF23 | R-HSA-156673 (Reactome) | |||
| NIPBL:MAU2 | R-HSA-2470935 (Reactome) | |||
| NUDC | R-HSA-156682 (Reactome) | |||
| PDS5 | R-HSA-2468040 (Reactome) | |||
| PLK1 | mim-catalysis | R-HSA-156673 (Reactome) | ||
| PLK1 | mim-catalysis | R-HSA-156682 (Reactome) | ||
| PLK1 | mim-catalysis | R-HSA-156723 (Reactome) | ||
| R-HSA-156673 (Reactome) | The polo-like kinase PLK1 phosphorylates KIF23 (also known as MKLP1 i.e. mitotic kinesin-like protein 1) on serine residues S904 and S905. | |||
| R-HSA-156682 (Reactome) | The polo-like kinase PLK1 phosphorylates NUDC on serine residues S274 and S326. | |||
| R-HSA-156723 (Reactome) | The polo-like kinase PLK1 phosphorylates KIF20A (also known as MKLP2 i.e. mitotic kinesin-like protein 2) on serine residue S528. | |||
| R-HSA-2468040 (Reactome) | WAPAL (WAPL) and PDS5 proteins (PDS5A and/or PDS5B) are associated with cohesin throughout most of the cell cycle (Kueng et al. 2006, Gandhi et al. 2006). FGF motifs present in the N-terminal region of WAPAL participate in WAPAL binding to PDS5 and cohesin subunits RAD21, STAG1 (SA1) and STAG2 (SA2) (Shintomi and Hirano 2009). | |||
| R-HSA-2470935 (Reactome) | Cohesin, in complex with WAPAL and PDS5 (PDS5A or PDS5B) binds decondensed chromatin in telophase (Kueng et al. 2006). This binding is facilitated by the NIPBL:MAU2 complex, also known as the 'cohesin loading complex'. NIPBL:MAU2 complex is associated with chromatin from telophase until prophase (Watrin et al. 2006) but seems to form a transient rather than stable complex with cohesin. | |||
| WAPAL | R-HSA-2468040 (Reactome) | |||
| p-S274,S326-NUDC | Arrow | R-HSA-156682 (Reactome) | ||
| p-S528-KIF20A | Arrow | R-HSA-156723 (Reactome) | ||
| p-S904,S905-KIF23 | Arrow | R-HSA-156673 (Reactome) |
