Demo_complete (Homo sapiens)

From WikiPathways

Revision as of 19:51, 30 November 2015 by Khanspers (Talk | contribs)
Jump to: navigation, search
1Liver cellPlasmaMevalonateSQLEHMGCRCholesterol esterCholesterolFDFT1SOAT1SqualeneHMG-CoAPDIA2StatinMTTPCholesterol ester


Description

Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Wetterau JR, Lin MC, Jamil H; ''Microsomal triglyceride transfer protein.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106736view13:21, 17 September 2019MaintBotHMDB identifier normalization
85855view23:00, 17 June 2016KhanspersModified description
83620view19:55, 30 November 2015KhanspersModified description
83619view19:54, 30 November 2015KhanspersModified description
83618view19:53, 30 November 2015KhanspersModified description
83617view19:52, 30 November 2015KhanspersModified description
83616view19:51, 30 November 2015KhanspersModified description
83615view19:49, 30 November 2015KhanspersModified description
83614view19:48, 30 November 2015KhanspersModified description
82931view17:04, 13 November 2015KhanspersModified title
82346view23:21, 25 September 2015KhanspersAdded transport of cholesterol esters
82345view23:05, 25 September 2015Khanspersredo part 2
82289view22:18, 24 September 2015KhanspersAdded transport of cholesterol ester
82288view21:43, 24 September 2015Khanspersadded cholesterol ester
82287view21:13, 24 September 2015KhanspersAdded additional steps
82286view21:00, 24 September 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Cholesterol esterMetaboliteC02530 (KEGG Compound)
CholesterolMetaboliteHMDB00067 (HMDB)
FDFT1GeneProductENSG00000079459 (Ensembl)
HMG-CoAMetaboliteHMDB01375 (HMDB)
HMGCRGeneProductENSG00000113161 (Ensembl)
MTTPGeneProductENSG00000138823 (Ensembl)
MevalonateMetaboliteHMDB59629 (HMDB)
PDIA2GeneProductENSG00000185615 (Ensembl)
SOAT1GeneProductENSG00000057252 (Ensembl)
SQLEGeneProductENSG00000104549 (Ensembl)
SqualeneMetaboliteHMDB00256 (HMDB)
StatinMetaboliteHMDB05022 (HMDB)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3418"
Personal tools