ApoE and miR-146 in inflammation and atherosclerosis (Mus musculus)

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1LipopolysaccharideIrak1Tlr2Mir146Nfkb2PU.1p65Tlr4ApoETraf4Pox-LDLp65PNfkb2Monocyte and macrophage activationpri-miR-146apre-miR-146apre-miR-146acytokine genes


Description

Apolipoprotein E (ApoE) enhances purine-rich PU-box–binding protein 1 (PU.1)-dependent miR-146a transcription to suppress nuclear factor-κB (NF-κB)−driven monocyte and macrophage activation and thereby inflammation and atherosclerosis.

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Ontology Terms

 

Bibliography

  1. Li K, Ching D, Luk FS, Raffai RL; ''Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis.''; Circ Res, 2015 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134240view12:31, 17 July 2024EweitzOntology Term : 'macrophage' added !
134239view12:31, 17 July 2024EweitzOntology Term : 'monocyte' added !
134238view12:30, 17 July 2024EweitzOntology Term : 'atherosclerosis' added !
94329view20:54, 1 September 2017Khanspersupdated xref
89801view11:31, 6 October 2016Mkutmonfixed special characters in description
89132view21:48, 22 August 2016AriuttaOntology Term : 'disease pathway' added !
87398view11:05, 22 July 2016MaintBotadded missing graphids
84852view21:41, 28 March 2016Khanspersupdated interactions
84084view10:36, 13 January 2016EgonwAdded IDs for two metabolites.
84081view00:04, 13 January 2016Khansperschanged interaction types
83897view00:39, 23 December 2015Khansperschanged interaction types
83896view00:36, 23 December 2015KhanspersModified description
83895view00:35, 23 December 2015Khanspersremoved miR locus
83866view00:19, 18 December 2015KhanspersAdjusted state position
83865view00:18, 18 December 2015KhanspersAdded literature reference
83864view00:15, 18 December 2015KhanspersModified description
83862view21:13, 17 December 2015KhanspersNew pathway
83863view21:13, 17 December 2015KhanspersModified title

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ApoEGeneProductENSMUSG00000002985 (Ensembl)
Irak1GeneProductENSMUSG00000031392 (Ensembl)
Mir146GeneProductMI0000170 (miRBase Sequence)
Nfkb2GeneProductENSMUSG00000025225 (Ensembl)
PU.1GeneProduct20375 (Entrez Gene)
Tlr2GeneProductENSMUSG00000027995 (Ensembl)
Tlr4GeneProductENSMUSG00000039005 (Ensembl)
Traf4GeneProductENSMUSG00000017386 (Ensembl)
p65GeneProductENSMUSG00000024927 (Ensembl)

Annotated Interactions

No annotated interactions

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