Biosynthesis and regulation of nematode bile acids (Caenorhabditis elegans)

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Description

Quality Tags

Ontology Terms

Bibliography

1. Rottiers V, Motola DL, Gerisch B, Cummins CL, Nishiwaki K, Mangelsdorf DJ, Antebi A; ''Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.''; Dev Cell, 2006 PubMed Europe PMC Scholia
2. Wollam J, Magomedova L, Magner DB, Shen Y, Rottiers V, Motola DL, Mangelsdorf DJ, Cummins CL, Antebi A; ''The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.''; Aging Cell, 2011 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	142455	view	14:24, 17 February 2026	Egonw	Modified description
	142454	view	14:23, 17 February 2026	Egonw	Added three missing identifiers
	142151	view	11:14, 6 December 2025	Egonw	Modified description
	106026	view	11:55, 16 August 2019	MaintBot	HMDB identifier normalization
	84472	view	19:28, 25 February 2016	AlexanderPico	Quick edit to datanode annotation or property
	84471	view	19:27, 25 February 2016	AlexanderPico	Quick edit to datanode annotation or property
	84470	view	19:26, 25 February 2016	AlexanderPico	Quick edit to datanode annotation or property
	84469	view	19:26, 25 February 2016	AlexanderPico	Quick edit to datanode annotation or property
	73760	view	00:10, 22 February 2014	MaintBot	updating schema
	71816	view	19:02, 18 October 2013	Egonw	Added a metabolite ID.
	67089	view	10:04, 26 June 2013	Christine Chichester	Ontology Term : 'bile acid biosynthetic pathway' added !
	58830	view	23:23, 20 February 2013	MaintBot
	53114	view	01:31, 30 October 2012	MaintBot	Modified categories
	51240	view	12:01, 3 September 2012	Anwesha	Added literature refernces to DHS-16
	51239	view	11:52, 3 September 2012	Anwesha	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
7-Dehydrocholesterol	Metabolite	HMDB00032 (HMDB)
Cholestenone	Metabolite	HMDB00921 (HMDB)
Cholesterol	Metabolite	HMDB00067 (HMDB)
DAF-36	GeneProduct	C12D8.5 (Ensembl)
DAF-9	GeneProduct	T13C5.1 (Ensembl)
Dafachronic acid	Metabolite
EMB-8	GeneProduct	K10D2.6 (Ensembl)
HSD-1	Protein	Y6B3B.11 (WormBase)
Lathosterol	Metabolite	HMDB01170 (HMDB)
Lathosterone	Metabolite	CHEBI:71550 (ChEBI)
dhs-16	GeneProduct	WBGene00000979 (Ensembl)
Δ4-Dafachronic Acid	Metabolite
Δ7-Dafachronic Acid	Metabolite

Annotated Interactions

No annotated interactions