Gut-liver indole metabolism (Homo sapiens)

Revision as of 08:10, 1 April 2016 by Egonw (Talk | contribs)

Description

No description

View approved pathways at the new wikipathways.org.

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Pathway Ontology : signaling pathway pertinent to development signaling pathway

Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, Siuzdak G; ''Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
137436 Approved	view	12:01, 2 March 2025	Egonw	L-tryptophan
119388	view	16:34, 25 June 2021	Egonw	IPA translocation from the gut to the blood circulation
119387	view	16:31, 25 June 2021	Egonw	Indole is translocated twice
117744	view	12:45, 22 May 2021	Eweitz	Modified title
90137	view	07:47, 16 October 2016	Egonw	Fixed the direction of the interaction.
88578	view	19:09, 11 August 2016	Mkutmon	fix unconnected lines
85226	view	17:03, 2 May 2016	Khanspers	replaced unconnected lines with graphical lines
85162	view	05:13, 22 April 2016	Egonw	Ontology Term : 'classic metabolic pathway' added !
84913	view	10:03, 1 April 2016	Egonw	Modified title
84912	view	08:17, 1 April 2016	Egonw	Modified description
84911	view	08:13, 1 April 2016	Egonw	Clean up of the layout.
84910	view	08:10, 1 April 2016	Egonw	Added indoxyl sulfate.
84909	view	08:07, 1 April 2016	Egonw	Added the IPA route (no, not beer).
84908	view	07:47, 1 April 2016	Egonw	Indole to liver path added.
84907	view	07:37, 1 April 2016	Egonw	New pathway

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Name	Type	Database reference
CYP2E1	GeneProduct	ENSG00000130649 (Ensembl)
IPA	Metabolite	CHEBI:43580 (ChEBI)
dietary tryptophan	Metabolite	CHEBI:27897 (ChEBI)
indole	Metabolite	CHEBI:16881 (ChEBI)
indoxyl sulfate	Metabolite	CHEBI:43355 (ChEBI)
indoxyl	Metabolite	CHEBI:17840 (ChEBI)
sulfotransferase	GeneProduct
tryptophanase	GeneProduct	4.1.99.1 (Enzyme Nomenclature)

No annotated interactions