Gut-liver indole metabolism (Homo sapiens)

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1LiverBloodGut lumenGut bacteriaFoodCYP2E1indoxyldietarytryptophanIPAindolesulfotransferasetryptophanaseindoleindoleIPAindoxyl sulfateindoxyl sulfate


Description

Dietary tryptophane is metabolised by the gut microbiome to indole and IPA which reaches the human blood system. Indole is further metabolized into indoxyl sulfate which also reached the blood.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, Siuzdak G; ''Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
119388view16:34, 25 June 2021EgonwIPA translocation from the gut to the blood circulation
119387view16:31, 25 June 2021EgonwIndole is translocated twice
117744view12:45, 22 May 2021EweitzModified title
90137view07:47, 16 October 2016EgonwFixed the direction of the interaction.
88578view19:09, 11 August 2016Mkutmonfix unconnected lines
85226view17:03, 2 May 2016Khanspersreplaced unconnected lines with graphical lines
85162view05:13, 22 April 2016EgonwOntology Term : 'classic metabolic pathway' added !
84913view10:03, 1 April 2016EgonwModified title
84912view08:17, 1 April 2016EgonwModified description
84911view08:13, 1 April 2016EgonwClean up of the layout.
84910view08:10, 1 April 2016EgonwAdded indoxyl sulfate.
84909view08:07, 1 April 2016EgonwAdded the IPA route (no, not beer).
84908view07:47, 1 April 2016EgonwIndole to liver path added.
84907view07:37, 1 April 2016EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CYP2E1GeneProductENSG00000130649 (Ensembl)
IPAMetaboliteCHEBI:43580 (ChEBI)
dietary tryptophanMetaboliteCHEBI:27897 (ChEBI)
indoleMetaboliteCHEBI:16881 (ChEBI)
indoxyl sulfateMetaboliteCHEBI:43355 (ChEBI)
indoxylMetaboliteCHEBI:17840 (ChEBI)
sulfotransferaseGeneProduct
tryptophanaseGeneProduct4.1.99.1 (Enzyme Nomenclature)

Annotated Interactions

No annotated interactions

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