NAD metabolism, sirtuins and aging (Homo sapiens)

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High-fat dietInflammationDNA DamageAgingSIRT5PARP1GeneProductNADNicotinamide ribosideReservatrolNAMPTSIRT3SIRT1


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Verdin E; ''NAD⁺ in aging, metabolism, and neurodegeneration.''; Science, 2015 PubMed Europe PMC Scholia
  2. Kolthur-Seetharam U, Dantzer F, McBurney MW, de Murcia G, Sassone-Corsi P; ''Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage.''; Cell Cycle, 2006 PubMed Europe PMC Scholia
  3. Rajamohan SB, Pillai VB, Gupta M, Sundaresan NR, Birukov KG, Samant S, Hottiger MO, Gupta MP; ''SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1.''; Mol Cell Biol, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128523view14:27, 11 February 2024EweitzNudge text into alignment
128522view02:42, 11 February 2024EweitzUpgrade disease nodes
128521view01:28, 11 February 2024EweitzEconomize layout, refine legend, standardize case
121716view14:03, 26 February 2022EweitzUse gene symbol
118942view22:32, 4 June 2021EweitzOntology Term : 'aging pathway' added !
118941view22:32, 4 June 2021EweitzOntology Term : 'Sirtuin mediated pathway' added !
106745view13:22, 17 September 2019MaintBotHMDB identifier normalization
106655view21:16, 12 September 2019KhanspersModified description
105656view05:15, 10 August 2019KhanspersModified description
94184view13:55, 25 August 2017Mkutmonadded missing metabolite identifier
92696view19:24, 28 June 2017Mkutmonremoved undefined xref
88178view16:25, 29 July 2016JmeliusOntology Term : 'classic metabolic pathway' added !
85545view23:30, 27 May 2016AlexanderPicoUpdated layout and groupings
85544view23:17, 27 May 2016AlexanderPicoQuick edit to datanode annotation or property
85530view18:53, 26 May 2016Khanspersfixed unconnected interactions
85439view20:40, 15 May 2016SusanQuick edit to datanode annotation or property
85406view05:09, 13 May 2016Khanspersinteractions
85394view05:35, 12 May 2016Khansperslayout
85393view05:32, 12 May 2016Khanspersadded literature references
85392view18:32, 11 May 2016Khanspersupdate to interactions
85236view23:18, 3 May 2016Khanspersadded identifier to reservatrol
85235view23:10, 3 May 2016KhanspersModified description
85234view23:07, 3 May 2016Khanspersoverhaul
85231view04:59, 3 May 2016KhanspersModified description
85230view04:57, 3 May 2016KhanspersModified description
85227view20:08, 2 May 2016Khanspersrearrange
84991view20:35, 4 April 2016KhanspersPeriodical save, work in progress
84988view20:25, 4 April 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
GeneProductGeneProduct
NADMetaboliteHMDB00902 (HMDB)
NAMPTGeneProductENSG00000105835 (Ensembl)
Nicotinamide ribosideMetaboliteHMDB00855 (HMDB)
PARP1GeneProductENSG00000143799 (Ensembl)
ReservatrolMetabolite
SIRT1GeneProductENSG00000096717 (Ensembl)
SIRT3GeneProductENSG00000142082 (Ensembl)
SIRT5GeneProductENSG00000124523 (Ensembl)

Annotated Interactions

No annotated interactions

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