Insulin signaling in adipocytes (normal condition) (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none INSRINSRINSRIRS1pIRS1IRS1p307mTORC1aIRS1307XmTORC1PKB308pPKB308p473pmTORC2amTORC2PKBPKB473pAS160pAS160GLUT4mGLUT4S6KpS6KS6pS6INSRinsulinINSRPXPinsulinName: Insulin signalling in human adipocytes (diabetic condition)Organism: Homo sapiens


Description

No description

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

 

Bibliography

  1. Brännmark C, Nyman E, Fagerholm S, Bergenholm L, Ekstrand EM, Cedersund G, Strålfors P; ''Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.''; J Biol Chem, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137773
Approved
view01:01, 8 March 2025KhanspersModified description
116602view09:30, 9 May 2021EweitzModified title
116438view09:43, 7 May 2021EweitzModified title
115355view19:59, 15 February 2021EveloModified description
106618view20:46, 12 September 2019KhanspersModified description
105627view05:02, 10 August 2019KhanspersModified description
104380view02:49, 23 May 2019RyanmillerUpdated interaction that had used the wrong Database Name. Changed name to KeGG Compound.
102467view05:59, 24 December 2018EgonwFixed data sources.
102466view05:57, 24 December 2018EgonwFixed a data source.
97676view13:08, 1 June 2018AMTanOntology Term : 'fat cell' added !
86060view23:22, 28 June 2016KhanspersOntology Term : 'insulin signaling pathway' added !
85136view01:56, 19 April 2016AnweshaModified description
85134view01:53, 19 April 2016AnweshaModified description
85131view01:45, 19 April 2016AnweshaModified title
85130view01:36, 19 April 2016AnweshaNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AS160ProteinO60343 (Uniprot-TrEMBL)
AS160pGeneProductPATO:0002220 (pato)
GLUT4ProteinP14672 (Uniprot-TrEMBL)
GLUT4mProteinP14672 (Uniprot-TrEMBL)
INSRProteinP06213 (Uniprot-TrEMBL) Inactive, internalized
IRS1307ProteinP35568 (Uniprot-TrEMBL)
IRS1ProteinP35568 (Uniprot-TrEMBL)
IRS1p307ProteinP35568 (Uniprot-TrEMBL)
IRS1pProteinP35568 (Uniprot-TrEMBL)
PMetaboliteCHEBI:28659 (ChEBI)
PKB308p473pProteinP31751 (Uniprot-TrEMBL)
PKB308pProteinP31751 (Uniprot-TrEMBL)
PKB473pProteinP31751 (Uniprot-TrEMBL)
PKBProteinP31751 (Uniprot-TrEMBL)
S6KProteinP23443 (Uniprot-TrEMBL)
S6KpProteinP23443 (Uniprot-TrEMBL)
S6ProteinP62753 (Uniprot-TrEMBL)
S6pProteinP62753 (Uniprot-TrEMBL)
XMetaboliteC00562 (KEGG Compound) active feedback protein
XMetaboliteCHEBI:36080 (ChEBI) inactive feedback protein
insulinMetaboliteCHEBI:5931 (ChEBI)
mTORC1ProteinP42345 (Uniprot-TrEMBL)
mTORC1aProteinP42345 (Uniprot-TrEMBL)
mTORC2ProteinP42345 (Uniprot-TrEMBL)
mTORC2aProteinP42345 (Uniprot-TrEMBL)

Annotated Interactions

View all...
Source  ↓Target  ↓Type  ↓Database reference  ↓Comment  ↓
AS160O60343 (Uniprot-TrEMBL)
AS160SBGN-CatalysisO60343 (Uniprot-TrEMBL)
AS160SBGN-ProductionO60343 (Uniprot-TrEMBL)
AS160pPATO:0002220 (pato)
AS160pSBGN-CatalysisPATO:0002220 (pato)
AS160pSBGN-InhibitionPATO:0002220 (pato)
AS160pSBGN-ProductionPATO:0002220 (pato)
C00562 (kegg.compound)
GLUT4P14672 (Uniprot-TrEMBL)
GLUT4SBGN-CatalysisP14672 (Uniprot-TrEMBL)
GLUT4SBGN-ProductionP14672 (Uniprot-TrEMBL)
GLUT4mP14672 (Uniprot-TrEMBL)
GLUT4mSBGN-CatalysisP14672 (Uniprot-TrEMBL)
GLUT4mSBGN-ProductionP14672 (Uniprot-TrEMBL)
INSRP06213 (Uniprot-TrEMBL)
INSRSBGN-CatalysisP06213 (Uniprot-TrEMBL)
INSRSBGN-ProductionP06213 (Uniprot-TrEMBL)
IRS1307P35568 (Uniprot-TrEMBL)
IRS1307SBGN-CatalysisP35568 (Uniprot-TrEMBL)
IRS1307SBGN-ProductionP35568 (Uniprot-TrEMBL)
IRS1P35568 (Uniprot-TrEMBL)
IRS1SBGN-CatalysisP35568 (Uniprot-TrEMBL)
IRS1SBGN-ProductionP35568 (Uniprot-TrEMBL)
IRS1p307P35568 (Uniprot-TrEMBL)
IRS1p307SBGN-CatalysisP35568 (Uniprot-TrEMBL)
IRS1p307SBGN-ProductionP35568 (Uniprot-TrEMBL)
IRS1pP35568 (Uniprot-TrEMBL)
IRS1pSBGN-CatalysisP35568 (Uniprot-TrEMBL)
IRS1pSBGN-ProductionP35568 (Uniprot-TrEMBL)
P06213 (Uniprot-TrEMBL)
PKB308p473pP31751 (Uniprot-TrEMBL)
PKB308p473pSBGN-CatalysisP31751 (Uniprot-TrEMBL)
PKB308p473pSBGN-ProductionP31751 (Uniprot-TrEMBL)
PKB308pP31751 (Uniprot-TrEMBL)
PKB308pSBGN-CatalysisP31751 (Uniprot-TrEMBL)
PKB308pSBGN-ProductionP31751 (Uniprot-TrEMBL)
PKB473pP31751 (Uniprot-TrEMBL)
PKB473pSBGN-CatalysisP31751 (Uniprot-TrEMBL)
PKB473pSBGN-ProductionP31751 (Uniprot-TrEMBL)
PKBP31751 (Uniprot-TrEMBL)
PKBSBGN-CatalysisP31751 (Uniprot-TrEMBL)
PKBSBGN-ProductionP31751 (Uniprot-TrEMBL)
R02584 (KEGG Reaction)
S6KP23443 (Uniprot-TrEMBL)
S6KSBGN-CatalysisP23443 (Uniprot-TrEMBL)
S6KSBGN-ProductionP23443 (Uniprot-TrEMBL)
S6KpP23443 (Uniprot-TrEMBL)
S6KpSBGN-CatalysisP23443 (Uniprot-TrEMBL)
S6KpSBGN-ProductionP23443 (Uniprot-TrEMBL)
S6P62753 (Uniprot-TrEMBL)
S6SBGN-CatalysisP62753 (Uniprot-TrEMBL)
S6SBGN-ProductionP62753 (Uniprot-TrEMBL)
S6pP62753 (Uniprot-TrEMBL)
S6pSBGN-CatalysisP62753 (Uniprot-TrEMBL)
S6pSBGN-ProductionP62753 (Uniprot-TrEMBL)
SBGN-CatalysisC00562 (kegg.compound)
SBGN-CatalysisP06213 (Uniprot-TrEMBL)
SBGN-ProductionC00562 (kegg.compound)
SBGN-ProductionP06213 (Uniprot-TrEMBL)
XCHEBI:36080 (ChEBI)
XSBGN-CatalysisCHEBI:36080 (ChEBI)
XSBGN-ProductionCHEBI:36080 (ChEBI)
mTORC1P42345 (Uniprot-TrEMBL)
mTORC1SBGN-CatalysisP42345 (Uniprot-TrEMBL)
mTORC1SBGN-ProductionP42345 (Uniprot-TrEMBL)
mTORC1aP42345 (Uniprot-TrEMBL)
mTORC1aSBGN-CatalysisP42345 (Uniprot-TrEMBL)
mTORC1aSBGN-ProductionP42345 (Uniprot-TrEMBL)
mTORC2P42345 (Uniprot-TrEMBL)
mTORC2SBGN-CatalysisP42345 (Uniprot-TrEMBL)
mTORC2SBGN-ProductionP42345 (Uniprot-TrEMBL)
mTORC2aP42345 (Uniprot-TrEMBL)
mTORC2aSBGN-CatalysisP42345 (Uniprot-TrEMBL)
mTORC2aSBGN-ProductionP42345 (Uniprot-TrEMBL)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3634"
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