Pathway Talk:WP3664
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Start a new discussionPathway looks great! (1)
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The pathway looks great! After reviewing the original figure, I have a few suggestions: - For the inhibition of Wnt in the extracellular space (DKK3 etc), it would preferred if the inhibition arrow pointed to a copy of Wnt in the extracellular space instead of to the binding arrow. That is a more direct way of representing the information. If you keep the current representation, you could use a dashed arrow instead. - The representation of the destruction complex (with APC/Axin) and how it binds to beta-catenin could be improved. The arrow going from FZD/LRP to beta-catenin should be removed, I think. And while the complex facilitates destruction of beta-catenin like you illustrated, it is doing so while bound to beta-catenin. So I think a representation that is more similar to the one in the figure is more correct, with beta-catenin as part of the complex, with an arrow pointing to a mim-degradation object. - Inside the nucleus, you could use a mim-transcription-translation arrow instead of the regular arrow.
