Pathways affected in adenoid cystic carcinoma (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Epigenetic ModificationChromatin RemodelingDNA Damage/Checkpoint SignalingDNA DamageGrowth Control/HomeostasisDNA RepairApoptosisDNA RepairG2/M ProgressionS-Phase ProgressionMYB/MYC SignalingMYB DepressionGrowth ProliferationGrowth/ProliferationFGF/IGF/PI3K SignalingApoptosisCell Growth/MigrationNotch SignalPathway ActivationPRKDCATMCREBBPSMC1ABRCA1TP53Serine/threonine-protein kinase Chk1UHRF1Serine/threonine-protein kinase Chk2TLK1CDC2NFIBCREBBPMYCBPNCOR1CEBPAMGAMAXSMARCA2IL17RDFGF16ERBB2IPPIK3CAERBB2HRASPTENRAF1AKT1FOXO3MAP2K2CNTN6NOTCH1CTBP1FOXP2NICDMYCNMAML3SMARCA2SMARCE1ATRXARID1ASRCAPCREBBPMORF4L1KAT6ABRD1EP300KANSL1SETD2NSD1KMT2CCMTR2ARID4BBCORBCORL1KDM6BKDM6AARID5BJMJD1CHIST1H1EHIST1H2ALMYBL1MYBMYCMYCNFGFR4INSRRMAGI1MAGI2DTX4FBXW7Name: Pathways Affected in Adenoid Cystic CarcinomaOrganism: Homo sapiens


Description

Protein pathways altered by mutations in adenoid cystic carcinoma. Pathways include epigentic modification, DNA damage checkpoint signals, MYB/MYC signalling pathway, FGF/IGF/PI3K signalling, and notch signalling. These pathways are from figure 4 from Ho et al.

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Disease : heart disease
 

Bibliography

  1. Ho AS, Kannan K, Roy DM, Morris LG, Ganly I, Katabi N, Ramaswami D, Walsh LA, Eng S, Huse JT, Zhang J, Dolgalev I, Huberman K, Heguy A, Viale A, Drobnjak M, Leversha MA, Rice CE, Singh B, Iyer NG, Leemans CR, Bloemena E, Ferris RL, Seethala RR, Gross BE, Liang Y, Sinha R, Peng L, Raphael BJ, Turcan S, Gong Y, Schultz N, Kim S, Chiosea S, Shah JP, Sander C, Lee W, Chan TA; ''The mutational landscape of adenoid cystic carcinoma.''; Nat Genet, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137777
Approved
view01:04, 8 March 2025KhanspersModified description
134972view12:55, 30 July 2024EweitzEconomize layout
134971view12:49, 30 July 2024EweitzEconomize layout
134970view12:43, 30 July 2024EweitzEconomize layout
134969view12:37, 30 July 2024EweitzEconomize layout
134968view12:31, 30 July 2024EweitzIncrease font size
134967view12:27, 30 July 2024EweitzEconomize layout
134966view12:25, 30 July 2024EweitzOntology Term : 'adenoid cystic carcinoma' added !
134965view12:25, 30 July 2024EweitzUse gene symbols, refine positioning
134964view12:19, 30 July 2024EweitzEconomize layout, standardize case
134963view12:11, 30 July 2024EweitzEconomize layout
134271view06:47, 19 July 2024EgonwRemoved a template comment
122573view10:57, 16 April 2022EgonwMade multiple pathways clickable
116547view12:46, 7 May 2021EweitzModified title
106546view00:09, 6 September 2019KhanspersModified description
105781view19:43, 15 August 2019KhanspersModified description
89271view23:23, 28 August 2016Khanspersadded xref for NICD (using id for NOTCH)
88845view19:04, 15 August 2016AAR&CoSpecify description
88844view18:06, 15 August 2016AAR&CoEdited Complexes and Interactions
88454view15:43, 8 August 2016AAR&CoOntology Term : 'S phase pathway' added !
88210view14:22, 31 July 2016AAR&CoAdded Labels
88209view14:19, 31 July 2016AAR&CoAdded Pathway Data Nodes
88208view14:13, 31 July 2016AAR&CoWork in Progress
88207view14:05, 31 July 2016AAR&CoWork in Progress
87300view19:22, 20 July 2016AAR&CoFixed Interactions and Labels
87299view19:19, 20 July 2016AAR&CoWork in Progress
87298view19:16, 20 July 2016AAR&CoPeriodical save, work in progress
87297view19:14, 20 July 2016AAR&CoWork in Process
87296view19:12, 20 July 2016AAR&CoWork in Progress
87295view19:10, 20 July 2016AAR&CoWork in Progress
87294view18:54, 20 July 2016AAR&CoOntology Term : 'chromatin remodeling pathway' added !
87291view18:53, 20 July 2016AAR&CoOntology Term : 'DNA damage response pathway' added !
87290view18:53, 20 July 2016AAR&CoOntology Term : 'breast adenoid cystic carcinoma' added !
87289view18:51, 20 July 2016AAR&CoModified description
85926view18:23, 21 June 2016AAR&CoUnconnected Lines Fixed
85915view18:04, 21 June 2016AAR&CoModified description
85765view18:10, 12 June 2016AAR&CoModified description
85764view17:54, 12 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProductENSG00000142208 (Ensembl) AKT Not Specified
ARID1AGeneProductENSG00000117713 (Ensembl)
ARID4BGeneProductENSG00000054267 (Ensembl)
ARID5BGeneProductENSG00000150347 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ATRXGeneProductENSG00000085224 (Ensembl)
BCORGeneProductENSG00000183337 (Ensembl)
BCORL1GeneProductENSG00000085185 (Ensembl)
BRCA1GeneProductENSG00000012048 (Ensembl)
BRD1GeneProductENSG00000100425 (Ensembl)
CDC2GeneProduct78070384 (NCBI Protein)
CEBPAGeneProductENSG00000245848 (Ensembl) CEBP Not Specified
CMTR2GeneProductENSG00000180917 (Ensembl)
CNTN6GeneProductENSG00000134115 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CTBP1GeneProductENSG00000159692 (Ensembl) CTBP Not Specified
DTX4GeneProductENSG00000110042 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
ERBB2GeneProductENSG00000141736 (Ensembl) ERBB Not Specified
ERBB2IPGeneProductENSG00000112851 (Ensembl)
FBXW7GeneProductENSG00000109670 (Ensembl)
FGF16GeneProductENSG00000196468 (Ensembl)
FGFR4GeneProductENSG00000160867 (Ensembl)
FOXO3GeneProductENSG00000118689 (Ensembl)
FOXP2GeneProductENSG00000128573 (Ensembl)
HIST1H1EGeneProductENSG00000168298 (Ensembl)
HIST1H2ALGeneProductENSG00000276903 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IL17RDGeneProductENSG00000144730 (Ensembl)
INSRRGeneProductENSG00000027644 (Ensembl)
JMJD1CGeneProductENSG00000171988 (Ensembl)
KANSL1GeneProductENSG00000120071 (Ensembl)
KAT6AGeneProductENSG00000083168 (Ensembl)
KDM6AGeneProductENSG00000147050 (Ensembl)
KDM6BGeneProductENSG00000132510 (Ensembl)
KMT2CGeneProductENSG00000055609 (Ensembl)
MAGI1GeneProductENSG00000151276 (Ensembl)
MAGI2GeneProductENSG00000187391 (Ensembl)
MAML3GeneProductENSG00000196782 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAXGeneProductENSG00000125952 (Ensembl)
MGAGeneProductENSG00000174197 (Ensembl)
MORF4L1GeneProductENSG00000185787 (Ensembl)
MYBGeneProductENSG00000118513 (Ensembl)
MYBL1GeneProductENSG00000185697 (Ensembl)
MYCBPGeneProductENSG00000214114 (Ensembl)
MYCGeneProductMYC (HGNC)
MYCNGeneProductENSG00000134323 (Ensembl)
NCOR1GeneProductENSG00000141027 (Ensembl) Which NCOR not specified
NFIBGeneProductENSG00000147862 (Ensembl)
NICDIntracellular Domains of NOTCH Receptor
NOTCH1GeneProductENSG00000148400 (Ensembl)
NSD1GeneProductENSG00000165671 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PRKDCGeneProductENSG00000253729 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl) RAF Not Specified
SETD2GeneProductENSG00000181555 (Ensembl)
SMARCA2GeneProductENSG00000080503 (Ensembl)
SMARCE1GeneProductENSG00000073584 (Ensembl)
SMC1AGeneProductENSG00000072501 (Ensembl)
SRCAPGeneProductENSG00000080603 (Ensembl)
Serine/threonine-protein kinase Chk1ProteinE7EPP6 (Uniprot-TrEMBL)
Serine/threonine-protein kinase Chk2ProteinC9JFD7 (Uniprot-TrEMBL)
TLK1GeneProductENSG00000198586 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
UHRF1GeneProductENSG00000276043 (Ensembl)

Annotated Interactions

No annotated interactions

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