BDNF-TrkB signaling (Homo sapiens)

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ERGolgiTranslationRegulates multiple molecular eventsGene transcriptionFormation of synaptic PSD-95 TrkB complexMAPK, PI3K, and PLCG pathwaystranscriptionProtein Translation and TransportERSynaptic activityL-LTPPrtoein Translation and TransportGene transcriptionRskTRPC3cAMPMTORNMDARPSD95Ca2+DAGPI3KTSC2Mnk14E-BP1adenyl cyclaseRasGRB2TrkBMEKIP3SOSPKCBRAFSHCTSC1GAB2other synaptic proteinsAKTBDNFGAB1MAPK/ErkRHEBCREBPLCGTRPC6p70S6BDNFTrkBPLCGCa2+CREBMAPK/ErkBDNFTrkBPLCGCa2+adenyl cyclasecAMPPI3KTrkBTrkBPSD95NMDARPSD95PSD95BDNFTrkBAKTPI3KMTORMAPK/ErkPSD95PSD95NMDARNMDARPSD95BDNFTrkBPLCGPI3KMAPK/ErkPSD95TrkBCa2+Synaptic activityL-LTP


Description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Yoshii A, Constantine-Paton M; ''Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease.''; Dev Neurobiol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128137view19:19, 27 January 2024EweitzStandardize case
116809view10:11, 14 May 2021EweitzModified title
106307view17:46, 20 August 2019KhanspersModified description
105538view06:05, 9 August 2019KhanspersModified description
94186view14:04, 25 August 2017Mkutmonadded missing metabolite identifier
89741view23:42, 29 September 2016KhanspersModified title
88594view19:41, 11 August 2016Mkutmonfix unconnected lines
87117view18:26, 18 July 2016AAR&CoReverted to version '01:18, 18 July 2016' by AAR&Co
87116view18:25, 18 July 2016AAR&CoReverted to version '13:09, 1 July 2016' by AAR&Co
87067view01:18, 18 July 2016AlexanderPicoOntology Term : 'neuron' added !
87066view01:18, 18 July 2016AlexanderPicoOntology Term : 'brain-derived neurotrophic factor signaling pathway' added !
87065view01:18, 18 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87064view01:17, 18 July 2016AlexanderPicoAdded cellular labels
87063view01:14, 18 July 2016AlexanderPicoSimplified into single diagram
86132view13:09, 1 July 2016AAR&CoModified description
86131view13:08, 1 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4E-BP1GeneProductENSG00000187840 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
BDNFGeneProductENSG00000176697 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
Ca2+
DAGMetabolitediacylglycerol
GAB1GeneProductENSG00000109458 (Ensembl)
GAB2GeneProductENSG00000033327 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
IP3Metabolite388562 (Chemspider) Inositol 1, 4, 5- triphosphate
MAPK/ErkGeneProductENSG00000100030 (Ensembl)
MEKGeneProductENSG00000169032 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
Mnk1GeneProductENSG00000079277 (Ensembl)
NMDARGeneProductENSG00000176884 (Ensembl)
PI3K GeneProductENSG00000105851 (Ensembl)
PKCGeneProductprotein kinase C
PLCGGeneProductENSG00000124181 (Ensembl)
PSD95GeneProductENSG00000132535 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RasGeneProduct
RskGeneProductENSG00000117676 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
TRPC3GeneProductENSG00000138741 (Ensembl)
TRPC6GeneProductENSG00000137672 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TrkBGeneProductENSG00000148053 (Ensembl)
adenyl cyclase GeneProductENSG00000164742 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)
other synaptic proteinsProtein
p70S6GeneProductENSG00000108443 (Ensembl)

Annotated Interactions

No annotated interactions

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