BDNF-TrkB signaling (Homo sapiens)

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ERGolgiTranslationRegulates multiple molecular eventsGene transcriptionFormation of synaptic PSD-95 TrkB complexMAPK, PI3K, and PLCG pathwaystranscriptionProtein Translation and TransportERSynaptic activityL-LTPPrtoein Translation and TransportGene transcriptionRskTRPC3cAMPMTORNMDARPSD95Ca2+DAGPI3KTSC2Mnk14E-BP1adenyl cyclaseRasGRB2TrkBMEKIP3SOSPKCBRAFSHCTSC1GAB2other synaptic proteinsAKTBDNFGAB1MAPK/ErkRHEBCREBPLCGTRPC6p70S6BDNFTrkBPLCGCa2+CREBMAPK/ErkBDNFTrkBPLCGCa2+adenyl cyclasecAMPPI3KTrkBTrkBPSD95NMDARPSD95PSD95BDNFTrkBAKTPI3KMTORMAPK/ErkPSD95PSD95NMDARNMDARPSD95BDNFTrkBPLCGPI3KMAPK/ErkPSD95TrkBCa2+Synaptic activityL-LTP


Description

Brain-derived neurotrophic factor (BDNF) is an important neurotrophin for the regulation of synaptic activity. BDNF-TrkB signaling, TrkB being the receptor of BDNF, is involved in transcription, translation, and trafficking of proteins in the various stages of synaptic development and evidence indicates that it also plays a significant role in synaptic plasticity, the ability of synapses to strengthen or weaken over time. Synaptic plasticity has been associated with learning and memory development. These functions are carried out through three pathways: mitogen-activated protein kinase (MAPK), phospholipase CG (PLC/PLCG), and phosphatidylinositol 3-kinase (PI3K). Pi3K and MAPK have crucial roles in the protein translation and transport caused by synaptic activity. PLCG regulates intracellular levels of Ca2+, which drives gene transcription through cyclic AMP. Evidence strongly indicates that abnormal levels of BDNF leads to significant developmental and neurodegenerative diseases by disrupting neural development and function. An understanding of how the BDNF-TrkB pathway regulates synaptic activity and plasticity is essential to an understanding of how we can effectively treat genetic disruptions of this pathway that lead to terrible neurodevelopmental diseases.

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Ontology Terms

 

Bibliography

  1. Yoshii A, Constantine-Paton M; ''Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease.''; Dev Neurobiol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128137view19:19, 27 January 2024EweitzStandardize case
116809view10:11, 14 May 2021EweitzModified title
106307view17:46, 20 August 2019KhanspersModified description
105538view06:05, 9 August 2019KhanspersModified description
94186view14:04, 25 August 2017Mkutmonadded missing metabolite identifier
89741view23:42, 29 September 2016KhanspersModified title
88594view19:41, 11 August 2016Mkutmonfix unconnected lines
87117view18:26, 18 July 2016AAR&CoReverted to version '01:18, 18 July 2016' by AAR&Co
87116view18:25, 18 July 2016AAR&CoReverted to version '13:09, 1 July 2016' by AAR&Co
87067view01:18, 18 July 2016AlexanderPicoOntology Term : 'neuron' added !
87066view01:18, 18 July 2016AlexanderPicoOntology Term : 'brain-derived neurotrophic factor signaling pathway' added !
87065view01:18, 18 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87064view01:17, 18 July 2016AlexanderPicoAdded cellular labels
87063view01:14, 18 July 2016AlexanderPicoSimplified into single diagram
86132view13:09, 1 July 2016AAR&CoModified description
86131view13:08, 1 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4E-BP1GeneProductENSG00000187840 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
BDNFGeneProductENSG00000176697 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
Ca2+
DAGMetabolitediacylglycerol
GAB1GeneProductENSG00000109458 (Ensembl)
GAB2GeneProductENSG00000033327 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
IP3Metabolite388562 (Chemspider) Inositol 1, 4, 5- triphosphate
MAPK/ErkGeneProductENSG00000100030 (Ensembl)
MEKGeneProductENSG00000169032 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
Mnk1GeneProductENSG00000079277 (Ensembl)
NMDARGeneProductENSG00000176884 (Ensembl)
PI3K GeneProductENSG00000105851 (Ensembl)
PKCGeneProductprotein kinase C
PLCGGeneProductENSG00000124181 (Ensembl)
PSD95GeneProductENSG00000132535 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RasGeneProduct
RskGeneProductENSG00000117676 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
TRPC3GeneProductENSG00000138741 (Ensembl)
TRPC6GeneProductENSG00000137672 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TrkBGeneProductENSG00000148053 (Ensembl)
adenyl cyclase GeneProductENSG00000164742 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)
other synaptic proteinsProtein
p70S6GeneProductENSG00000108443 (Ensembl)

Annotated Interactions

No annotated interactions

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