Physico-chemical features and toxicity-associated pathways (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Antczak P, Ortega F, Chipman JK, Falciani F; ''Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome.''; PLoS One, 2010 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	123395	view	06:24, 23 July 2022	Egonw	Made a pathway clickable
	117651	view	11:45, 22 May 2021	Eweitz	Modified title
	106306	view	17:45, 20 August 2019	Khanspers	Modified description
	106167	view	12:06, 16 August 2019	MaintBot	HMDB identifier normalization
	105537	view	06:05, 9 August 2019	Khanspers	Modified description
	96435	view	07:49, 15 March 2018	Egonw	Replaced secondary ChEBI identifiers with primary identifiers.
	90113	view	21:26, 13 October 2016	Khanspers	overhaul
	90112	view	20:38, 13 October 2016	Khanspers	Modified title
	88751	view	18:36, 14 August 2016	AAR&Co	Fixed Unonnected Line
	88750	view	18:34, 14 August 2016	AAR&Co	Ontology Term : 'pancreatic cancer' added !
	88749	view	18:33, 14 August 2016	AAR&Co	Ontology Term : 'amyotrophic lateral sclerosis disease pathway' added !
	88748	view	18:32, 14 August 2016	AAR&Co	Modified title
	88535	view	00:46, 11 August 2016	AAR&Co	Ontology Term : 'signaling pathway' added !
	88530	view	00:26, 11 August 2016	AAR&Co	Periodical save, work in progress
	88528	view	00:19, 11 August 2016	AAR&Co	Modify Datanode
	88526	view	00:16, 11 August 2016	AAR&Co	Periodical save, work in progress
	88522	view	00:06, 11 August 2016	AAR&Co	Periodical save, work in progress
	88521	view	23:58, 10 August 2016	AAR&Co	Modify Datanodes
	88519	view	23:56, 10 August 2016	AAR&Co	Periodical save, work in progress
	88516	view	23:53, 10 August 2016	AAR&Co	Modify Datanodes
	88515	view	23:51, 10 August 2016	AAR&Co	Modify Datanodes
	88513	view	23:48, 10 August 2016	AAR&Co	Modify Datanode
	88511	view	23:25, 10 August 2016	AAR&Co	Modify Datanoed
	88510	view	23:22, 10 August 2016	AAR&Co	Modify Datanode
	88507	view	23:18, 10 August 2016	AAR&Co	Periodical save, work in progress
	88504	view	23:04, 10 August 2016	AAR&Co	Modify Datanode
	88500	view	22:58, 10 August 2016	AAR&Co	Modify Datanode
	88495	view	22:48, 10 August 2016	AAR&Co	Modify Datanode
	88494	view	22:44, 10 August 2016	AAR&Co	Periodical save, work in progress
	88492	view	22:43, 10 August 2016	AAR&Co	Modify Datanode
	88488	view	22:32, 10 August 2016	AAR&Co	Modified description
	88487	view	22:28, 10 August 2016	AAR&Co	Modified description
	88482	view	22:22, 10 August 2016	AAR&Co	Modify Datanodes
	87131	view	18:49, 18 July 2016	AAR&Co	Fixed Unconnected Lines
	86140	view	13:23, 1 July 2016	AAR&Co	Modified description
	86139	view	13:23, 1 July 2016	AAR&Co	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
APC	Metabolite	HMDB60661 (HMDB)
ARP2	GeneProduct	ENSG00000138071 (Ensembl)
ARP3	GeneProduct	ENSG00000115091 (Ensembl)
AXIN1	GeneProduct	ENSG00000103126 (Ensembl)
Actin	Protein	IPR004000 (InterPro)
Arginine	Metabolite	29016 (ChEBI)
B-catenin	GeneProduct	ENSG00000168036 (Ensembl)
CAMK	GeneProduct	ENSG00000134072 (Ensembl)
CBL	GeneProduct	ENSG00000110395 (Ensembl)
DAAM1	GeneProduct	ENSG00000100592 (Ensembl)	assists in formation of Dvl-Rho complex
DVL1	GeneProduct	ENSG00000107404 (Ensembl)
ELK	GeneProduct	ENSG00000126767 (Ensembl)
ErbB-1	GeneProduct	ENSG00000146648 (Ensembl)
ErbB-2	GeneProduct	ENSG00000141736 (Ensembl)
ErbB-4	GeneProduct	ENSG00000178568 (Ensembl)
FAK	GeneProduct	ENSG00000169398 (Ensembl)	PRK2 Focal adhesion kinase
FN1	GeneProduct	ENSG00000115414 (Ensembl)
GPX1	GeneProduct	ENSG00000233276 (Ensembl)
GRB2	GeneProduct	ENSG00000177885 (Ensembl)
GSK3B	GeneProduct	ENSG00000082701 (Ensembl)
GluR	GeneProduct		General glutamate receptor
JNK	GeneProduct	ENSG00000107643 (Ensembl)
JNKK	GeneProduct	ENSG00000065559 (Ensembl)
JUN	GeneProduct	ENSG00000177606 (Ensembl)
MAPK/ERK	GeneProduct	ENSG00000100030 (Ensembl)
MEK	GeneProduct	ENSG00000169032 (Ensembl)
MLC	GeneProduct	ENSG00000168530 (Ensembl)
MLCK	GeneProduct	ENSG00000065534 (Ensembl)	myosin light chain kinase
MLCP	GeneProduct	ENSG00000228868 (Ensembl)	myosin-light chain phosphatase
MYC	GeneProduct	ENSG00000136997 (Ensembl)
NCK	GeneProduct	ENSG00000158092 (Ensembl)
NEFH	GeneProduct	ENSG00000100285 (Ensembl)
NEFL	GeneProduct	ENSG00000277586 (Ensembl)
NEFM	GeneProduct	ENSG00000104722 (Ensembl)
NOS1	GeneProduct	ENSG00000089250 (Ensembl)
PAK	GeneProduct	ENSG00000149269 (Ensembl)
PI3K	GeneProduct	ENSG00000105851 (Ensembl)
PKB/AKT	GeneProduct	ENSG00000142208 (Ensembl)
PLCG	GeneProduct	ENSG00000124181 (Ensembl)
PP2A	GeneProduct	ENSG00000113575 (Ensembl)
Profilin	Protein	IPR002097 (InterPro)
RHOA	GeneProduct	ENSG00000067560 (Ensembl)
ROCK2	GeneProduct	ENSG00000134318 (Ensembl)
Ras	GeneProduct	ENSG00000132155 (Ensembl)
Ras	Protein	IPR020849 (InterPro)
SOD1	GeneProduct	ENSG00000142168 (Ensembl)
SOS1	GeneProduct	ENSG00000115904 (Ensembl)
STAT5	GeneProduct	ENSG00000126561 (Ensembl)
Shc1	GeneProduct	ENSG00000160691 (Ensembl)
Src	GeneProduct	ENSG00000197122 (Ensembl)
TGFA	GeneProduct	ENSG00000163235 (Ensembl)
TMSB4	GeneProduct	K05764 (KEGG Genes)
WNT11	GeneProduct	ENSG00000085741 (Ensembl)
WNT16	GeneProduct	ENSG00000002745 (Ensembl)
frizzled	GeneProduct	ENSG00000111432 (Ensembl)
glutamate	Metabolite	29988 (ChEBI)
p21	GeneProduct	ENSG00000124762 (Ensembl)
p27	GeneProduct	ENSG00000111276 (Ensembl)

Annotated Interactions

No annotated interactions