Immunoregulatory interactions between lymphoid and non-lymphoid cells (Homo sapiens)

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1, 3, 38, 48, 50...4915, 7840, 76, 84, 8568, 80, 8263, 757, 8, 37, 46, 59...6514, 32, 719, 6944, 5110, 5468, 80, 8245624, 4513, 1815, 7833, 39-41, 856468, 80, 826, 1252, 53, 672922, 36, 4347, 7268, 80, 8252, 53, 6716, 27268, 80, 8268, 80, 8255, 6657, 6928, 3411, 35, 8321, 23, 5868, 80, 825, 31, 742025, 30, 81cellvirion membranecellcellcellHLA-H HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B58 Ig lambda chain V-II region WIN CD33 IGLV10-54(1-?) SIGLEC:sialic acidPhosphatidylserine CD3G HLA class I histocompatibility antigen, A-43 alpha chain VCAM1C16 sulfatide HLA class I histocompatibility antigen, A-32 alpha chain IGLV2-33(1-?) Ig kappa chain V-I region BAN LILR setCRTAM bound to NECL2HemagglutininCollagen types I,II,III CD247-1 HLA class I histocompatibility antigen, A-34 alpha chain Ig lambda chain V region 4A Ig lambda chain V-I region EPS IGLV11-55(1-?) HLA Bw4 interactingwith KIR3DL1HLA class I histocompatibility antigen, A-23 alpha chain TYROBP HLA class I histocompatibility antigen, Cw-16 alpha chain Ig kappa chain V-I region BAN FCGR1A Ig lambda chain V-II region TRO SIGLEC8 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain SIGLEC7 CLEC2D HLA class I histocompatibility antigen, A-34 alpha chain Ig kappa chain V-III region HAH HLA class I histocompatibility antigen, Cw-3 alpha chain precursor Ig kappa chain V-IV region STH class I MHC B58 Ig lambda chain V-II region BUR HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain B2M(21-119) class I MHC B42 Ig lambda chain V-II region VIL HLA class I histocompatibility antigen, A-24 alpha chain Ig heavy chain V-III region TEI IGLV2-18(1-?) TCRA IGLV2-33(1-?) Ig lambda chain V-II region NIG-58 class I MHC B40 Ig kappa chain V-III region Ti IGKC HLA class I histocompatibility antigen, A-11 alpha chain KLRK1 IGLV4-60(1-?) CD3D HLA class I histocompatibility antigen, A-32 alpha chain MADCAM1-1class I MHC B38 class I MHC B45 TRBV12-3 SIGLEC9 CD200Ig lambda chain V-VI region WLT Ig lambda chain V-VI region WLT Ig kappa chain V-IV region Len Ig lambda chain V-II region NIG-84 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain IGLV3-27(1-?) HLA class I histocompatibility antigen, A-3 alpha chain precursor Ig kappa chain V-I region Rei class I MHC B82 HLA-C IGKV4-1(21-?) B2M(21-119) HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor Ig kappa chain V-III region NG9 Lymphoid-expressedFc-gamma receptorsIg kappa chain V-III region NG9 T-cell receptorcomplexSIGLEC10 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain CD19 KLRG1 CD81 class I MHC B73 PVRL2 KLRG1GalA-GSL HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B82 Ac2SGL Ig kappa chain V-I region AU IGLV1-40(1-?) TCRB T-cell receptor alpha chain V region HPB-MLT precursor SIGLEC11 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor T-cell receptor alpha chain V region PY14 precursor class I MHC B15 HLA class I histocompatibility antigen, A-29 alpha chain ICAM3 LAIR2:Collagen typeI,IIIHLA class I histocompatibility antigen, Cw-17 alpha chain CD96:PVRNCR3LG1:NCR3:FCRG3A:CD3Z dimerKLRK1 NCR1:FCRG1A:CD3ZdimerIg heavy chain V-III region ZAP Ig lambda chain V-IV region MOL Ig lambda chain V-IV region X MICA Ig heavy chain V-III region GAL Ig heavy chain V-III region JON HLA class I histocompatibility antigen, Cw-2 alpha chain CD200 Ig kappa chain V-III region CLL Ig kappa chain V-I region AG KIR2DL4 IGLV4-69(1-?) HLA class I histocompatibility antigen, Cw-17 alpha chain C3d complexed withantigenCD226CD40LG trimerT-cell receptor alpha chain V region HPB-MLT precursor class I MHC B7 LILRB5 IGLV5-37(1-?) HLA class I histocompatibility antigen, Cw-4 alpha chain precursor LILRA2 Ig heavy chain V-II region OU class I MHC B35 SH2D1B HLA class I histocompatibility antigen, Cw-16 alpha chain SIGLEC9 IGLV4-60(1-?) IGLV3-27(1-?) class I MHC B8 Ig lambda chain V-II region VIL KIR2DL1 IGLV1-40(1-?) Ig kappa chain V-I region WEA class I MHC B35 class I MHC B47 HLA class I histocompatibility antigen, A-74 alpha chain SIGLEC6 class I MHC B50 Ig kappa chain V-III region VG CD226:PVRSLAMF6 Ig kappa chain V-I region Mev class I MHC B7 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor TCRB class I MHC B14 Ig lambda chain V-IV region Bau Ig lambda chain V-I region VOR class I MHC B47 class I MHC B45 class I MHC B15 class I MHC B56 CD1A KIR2DS2 Ig heavy chain V-III region TUR HLA class I histocompatibility antigen, B-48 alpha chain IGLV1-36(1-?) LILRA4 HLA class I histocompatibility antigen, A-24 alpha chain OSCARHLA class I histocompatibility antigen, A-33 alpha chain Ig kappa chain V-I region Walker HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B56 Ig kappa chain V-I region OU TREM, CD300Ig heavy chain V-II region DAW Ig lambda chain V-VI region AR class I MHC B54 HLA class I histocompatibility antigen, A-31 alpha chain CD247-1 HLA-C Cw3 (group 1)Ig kappa chain V-III region POM class I MHC B73 class I MHC B50 ITGA4 Ig kappa chain V-I region HK101 HLA class I histocompatibility antigen, B-48 alpha chain class I MHC B49 HLA-Cgroup-I-interactingKIRsHLA class I histocompatibility antigen, A-1 alpha chain precursor TCR interacting withantigen-bearing MHCClass IIg heavy chain V-II region HE SIGLEC6 HLA class I histocompatibility antigen, A-2 alpha chain MHC Class Iinteracting withCD160CD8A Ig kappa chain V-III region GOL Ig kappa chain V-II region TEW class I MHC B78 BbGL-2c class I MHC B78 class I MHC B49 Ig lambda chain V-II region NIG-84 Ig heavy chain V-I region ND KIR2DS1 complexedwith DAP12class I MHC B52 Ig heavy chain V-II region COR Antigen TCRA IGLV(23-?) NCR3 Ig kappa chain V-III region WOL FCGR3A IGLV3-16(1-?) Ig kappa chain V-I region Hau Ig heavy chain V-III region LAY CD200R1 Collagen type XVII fibril class I MHC B14 B2M(21-119) HLA class I histocompatibility antigen, alpha chain G precursor Ig kappa chain V region EV15 CD1A Ig kappa chain V-III region HAH ITGB2 CD247-1 GM1 TCRB Ig lambda chain V-V region DEL HLA class I histocompatibility antigen, A-24 alpha chain Ig kappa chain V-III region SIE HLA class I histocompatibility antigen, alpha chain F precursor Glc-DAG-s2 KIR2DS1 Ig kappa chain V-III region POM Ig kappa chain V-IV region B17 LILRA5 Ig heavy chain V-III region LAY CLEC2B Ig heavy chain V-III region BUR ICAM5 CD3D HLA class I histocompatibility antigen, Cw-16 alpha chain IGLV3-25(1-?) Ig heavy chain V-I region EU IgH heavy chain V-III region VH26 precursor class I MHC B53 Ig heavy chain V-III region JON class I MHC B39 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, A-23 alpha chain CXADRIg kappa chain V-I region Gal IGHV(1-?) CD247-1 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA-C group 1interacting withKIR2DL2/3Ig heavy chain V-I region Mot ICAM 1-5ITGB7 Ig kappa chain V-I region WEA Sialic acid CD1C CD160SIGLECCD1B CD3G B2M(21-119) HLA class I histocompatibility antigen, A-80 alpha chain IGKV1-5(23-?) HLA class I histocompatibility antigen, A-11 alpha chain Ig kappa chain V-I region Gal HLA class I histocompatibility antigen, Cw-4 alpha chain precursor Ig heavy chain V-III region BRO Collagen typesI,II,III/SP-DIg kappa chain V-I region AG SLAMF7CD40-1 Ig kappa chain V-I region WAT CD8A Phosphatidylserine TYROBP CMVPP65:NCR3:FCRG3A:CD3Z dimerclass I MHC B73 CMVPP65Antigen SLAMF7:SLAMF7HLA class I histocompatibility antigen, E alpha chain precursor Ig heavy chain V-II region ARH-77 C3d fragment HLA-H ULBP3 KIR3DL1CD1:B2M:self-lipidHLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B81 Ig kappa chain V-I region Ni T-cell receptor alpha chain V region PY14 precursor TRAC Ig heavy chain V-III region BUR CRTAM KLRC1 TRBV12-3 class I MHC B40 HLA class I histocompatibility antigen, A-33 alpha chain Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region HK101 CERA,PE,PSTCRA HLA class I histocompatibility antigen, A-26 alpha chain PI Ig kappa chain V-III region VH CD34-1 LILRA2 class I MHC B54 Ig kappa chain V-I region OU Ig kappa chain V-I region Ka class I MHC B46 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor CD3G Ig kappa chain V-II region Cum Ig kappa chain V-I region Daudi class I MHC B13 CD1C Ig kappa chain V-II region GM607 IGLV4-3(1-?) HLA class I histocompatibility antigen, Cw-3 alpha chain precursor ITGA4 Ig heavy chain V-III region CAM MICB PI class I MHC B55 Ac2SGL HLA class I histocompatibility antigen, Cw-5 alpha chain precursor Ig kappa chain V-III region WOL Ig heavy chain V-II region WAH Ig heavy chain V-II region MCE CD81 Ig heavy chain V-III region TUR CD247-1 NCR3 Ig lambda chain V-I region NIG-64 BbGL-2c class I MHC B53 class I MHC B54 CD1B ITGB1 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B57 HLA class I histocompatibility antigen, A-68 alpha chain Ig lambda chain V-VI region AR FCGR1A CD1B CD40 trimerCD34-1 ULBP3 B2M(21-119) TRAC Collagen type III fibril CXADR bound to JAMLIg heavy chain V-III region TIL SIGLEC1 AMICA1IGLC3 Ig heavy chain V-II region DAW LAM Ig kappa chain V-I region Roy alpha-mycolic acid HLA class I histocompatibility antigen, Cw-18 alpha chain Ig lambda chain V-III region SH TRBC1 Antigen CD226 IGKV1-5(23-?) Ig heavy chain V-I region HG3 LILRA5 ICAM4 Ig heavy chain V-III region WEA B2M(21-119) CD247-1 Ig heavy chain V-II region MCE Ig heavy chain V-III region BUT HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain IGLV5-37(1-?) IFITM1 Ig lambda chain V-II region BOH class I MHC B81 IGLC7 Ig lambda chain V-V region DEL CERA IGLV8-61(1-?) SELLIg heavy chain V-I region ND class I MHC B52 Ig lambda chain V-I region WAH Ig kappa chain V-I region Hau class I MHC B14 HCST T-cell receptor alpha chain V region HPB-MLT precursor Ig lambda chain V-VII region MOT Ig lambda chain V-VI region SUT IGKV4-1(21-?) LILRA6 Ig heavy chain V-III region HIL HN HLA class I histocompatibility antigen, Cw-6 alpha chain precursor KLRF1 CD3E HLA class I histocompatibility antigen, Cw-17 alpha chain Ig kappa chain V-IV region STH NCR3 Ig kappa chain V-III region VH HLA class I histocompatibility antigen, A-11 alpha chain TYROBP C3d fragment HLA class I histocompatibility antigen, A-3 alpha chain precursor KIR2DL3 class I MHC B46 TRBC1 class I MHC B55 NCR1:FCRG1A:CD3Zdimer:Hemagglutininclass I MHC B15 HLA class I histocompatibility antigen, A-33 alpha chain Antigen LAIR1:Collagen typeXVIIHLA class I histocompatibility antigen, A-68 alpha chain KIR2DL4Antigen-bound Ig GAntibodyHLA class I histocompatibility antigen, A-31 alpha chain Ig kappa chain V-II region FR IGLC6 class I MHC B27 class I MHC B42 class I MHC B15 class I MHC B38 IGLV5-45(1-?) CD200R1IGLV2-23(1-?) HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B53 SIGLEC12 Collagen type I fibril CD300 integrinalpha4beta1:VCAM1class I MHC B54 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain Ig kappa chain V region EV15 IGKVA18(21-?) Ig heavy chain V-II region OU KIR2DS1 HLA class I histocompatibility antigen, alpha chain F precursor IGLV3-16(1-?) MHC Class Imoleculesinteracting withCD160class I MHC B56 AMICA1 LAIR1B2M(21-119) HLA class I histocompatibility antigen, Cw-8 alpha chain Ig kappa chain V-II region GM607 Ig heavy chain V-III region KOL CD1D NCR3LG1 HLA class I histocompatibility antigen, A-26 alpha chain NKG2D ligandLILRB2 SP-D oligomer HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B38 CD33 LILRB4 alpha-mycolic acid Ig heavy chain V-II region WAH CLEC2D dimerIg lambda chain V-I region HA IGLC1 Ig heavy chain V-II region ARH-77 T-cell receptor alpha chain V region PY14 precursor B2M(21-119) Ig lambda chain V-VI region SUT Ig heavy chain V-III region TRO LILRA1 PG class I MHC B82 HLA class I histocompatibility antigen, A-2 alpha chain Ig kappa chain V-I region Lay class I MHC B8 ITGB1 class I MHC B27 Ig kappa chain V-I region EU Ig lambda chain V-VII region MOT HLA class I histocompatibility antigen, A-1 alpha chain precursor IGLV10-54(1-?) LILRB4 class I MHC B52 class I MHC B13 KLRB1 dimerCD40LG(1-261) Sialic acidCD3G SIGLEC7 CD1:B2M:microbiallipidHLA class I histocompatibility antigen, Cw-5 alpha chain precursor B2M(21-119) CD247-1 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-1 alpha chain LAM CD1D KLRD1 class I MHC B40 HLA-C class I MHC B40 MADCAM1-1 class I MHC B27 HLA class I histocompatibility antigen, A-30 alpha chain SLAMF6HLA-GB2M(21-119) ULBP1 CD226 bound toNectin 2HCST Ig kappa chain V-I region WAT Ig heavy chain V-I region HG3 Ig lambda chain V-VI region EB4 CD300 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor KIR2DL2 CD226 IFITM1 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor Ig lambda chain V-III region SH CD40LG(1-261) class I MHC B59 Ig lambda chain V-I region NEW SIGLEC11 HLA class I histocompatibility antigen, E alpha chain precursor Antigen peptidebound class I MHCSIGLEC8 ICAM1 KLRB1 KLRB1 Ligand interactingwith NKG2Dclass I MHC B56 CD247-1 Integrin alpha4beta1HLA-C Cw4 (group 2)Ig lambda chain V-II region TRO Ig kappa chain V-III region Ti class I MHC B13 IgH heavy chain V-III region VH26 precursor HLA class I histocompatibility antigen, A-74 alpha chain IGLC1 B2M(21-119) SIGLEC10 IGLV4-3(1-?) PVRL2HLA class I histocompatibility antigen, A-66 alpha chain Ig heavy chain V-II region HE HLA class I histocompatibility antigen, E alpha chain precursor SH2D1B HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B57 IGHV7-81(1-?) HLA class I histocompatibility antigen, A-2 alpha chain Ig lambda chain V-I region MEM class I MHC B18 MICA HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor Ig kappa chain V-I region Bi HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B37 Ig lambda chain V-II region NEI class I MHC B57 IGLV3-22(1-?) Ig heavy chain V-III region NIE LILRA3 HLA-C Ig heavy chain V-III region POM HA Antigen-boundantibody bound tolymphoid Fc gammareceptorsIGLV2-23(1-?) Ig lambda chain V-II region BO HLA-C group 2interacting withKIR2DS1Ig kappa chain V-III region VG T-cell receptor alpha chain V region PY14 precursor CD3D Ig heavy chain V-III region WEA GMM GalNAc-GD1a SIGLEC5 HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B44 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B8 TRBC1 NKG2D complexed withDAP10B2M(21-119) Ig heavy chain V-III region TRO KLRF1 dimer:CLEC2BdimerFCGR1A HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B7 Ig kappa chain V-I region AU GM1 T-cell receptor alpha chain V region PY14 precursor Ig kappa chain V-IV region B17 TCRB class I MHC B27 HLA-A3Ig heavy chain V-III region TEI class I MHC B38 CD3E ICAM2 Ig heavy chain V-II region SESS Ig heavy chain V-I region EU HLA class I histocompatibility antigen, Cw-14 alpha chain Ig heavy chain V-III region DOB PVR IGLV3-12(1-?) CLEC2B dimerIg heavy chain V-III region ZAP ITGAL HN class I MHC B78 ITGA4 squalene squalene class I MHC B38 Ig kappa chain V-I region Mev Ig kappa chain V-IV region JI Ig lambda chain V-II region NIG-58 class I MHC B58 CD1:B2M:microbiallipid:TCRCD1A Ig lambda chain V-II region BO class I MHC B27 Ig heavy chain V-III region GAL Ig heavy chain V-I region WOL KLRF1 KIR2DS2 Ig lambda chain V-I region EPS GLYCAM1 IGLV2-11(1-?) HLA-Eclass I MHC B58 MHC Class Iinteracting withLILRsHLA class I histocompatibility antigen, alpha chain G precursor CLEC2D dimer:KLRB1dimerKIR2DL1class I MHC B49 CD1D C30 mannosyl MPM HLA class I histocompatibility antigen, A-23 alpha chain MHC Class I CD40:CD40L trimerIg kappa chain V-IV region JI KIR3DL1 IGLV8-61(1-?) Ig heavy chain V-III region POM SLAMF6:SLAMF6:SAP,EAT2Collagen type XVIIfibrilB2M(21-119) IGLC3 HLA class I histocompatibility antigen, A-1 alpha chain precursor Complex of CD19,CD81, CD225 andCD21 with C3d-boundAntigenIGLC2 Ig lambda chain V-II region BUR Ig kappa chain V-I region Wes HLA class I histocompatibility antigen, A-69 alpha chain LILRA3 DDM-838 IGHV7-81(1-?) DDM-838 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain Collagen types I,IIICD22 HLA class I histocompatibility antigen, A-43 alpha chain IGLV7-46(1-?) class I MHC B42 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor Ig kappa chain V-I region Scw Ig kappa chain V-I region Kue HLA class I histocompatibility antigen, Cw-3 alpha chain precursor Ig kappa chain V-I region CAR LILRB1 HLA-C Ig kappa chain V-II region FR Integrinalpha4beta7:MADCAM1Ig lambda chain V-II region TOG TCRB HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain SLAMF6 Ig kappa chain V-I region Walker HLA class I histocompatibility antigen, A-29 alpha chain LAIR2 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B81 CERA GMM Ig kappa chain V-IV region Len GalA-GSL class I MHC B18 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor KIR2DS2 complexedwith DAP12HLA class I histocompatibility antigen, Cw-12 alpha chain Ig lambda chain V-VI region NIG-48 B2M(21-119) HLA class I histocompatibility antigen, A-74 alpha chain LILR-interacting MHCClass I moleculesC30 mannosyl MPM ICAM1 Ig heavy chain V-I region Mot HLA-C group 1interacting withKIR2DS2Ig heavy chain V-III region WAS HLA class I histocompatibility antigen, E alpha chain precursor Ig lambda chain V region 4A class I MHC B44 Ig lambda chain V-VI region NIG-48 CD1A Ig kappa chain V-III region CLL HLA class I histocompatibility antigen, A-31 alpha chain IGLV2-11(1-?) HLA-C CD1:B2M:self-lipid:TCRSLAMF7 class I MHC B8 Ig heavy chain V-III region NIE IGLV11-55(1-?) class I MHC B37 HLA class I histocompatibility antigen, A-66 alpha chain SP-D oligomer CMVPP65 T-cell receptor alpha chain V region HPB-MLT precursor Ig lambda chain V-IV region X Collagen type III fibril TRBV12-3 IGLV2-18(1-?) class I MHC B50 PE HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B45 HLA class I histocompatibility antigen, A-25 alpha chain Ig heavy chain V-I region SIE Ig kappa chain V-III region B6 CDH1(155-882) Ig lambda chain V-I region NEWM class I MHC B67 LFA-1:ICAM 1-5Ig lambda chain V-IV region Hil HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B37 OSCAR CD1B class I MHC B41 class I MHC B47 Ig heavy chain V-III region BUT Ig lambda chain V-III region LOI IGLV7-43(1-?) CD1D class I MHC B8 Glc-DAG-s2 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, A-1 alpha chain precursor CD8B GLYCAM1 class I MHC B35 KIR2DL2 KLRC1class I MHC B49 HLA class I histocompatibility antigen, A-36 alpha chain CD3E T-cell receptor alpha chain V region HPB-MLT precursor LILRB2 TRBC1 Ig kappa chain V-III region IARC/BL41 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B53 SAP,EAT2ITGB7 Ig lambda chain V-I region BL2 Ig kappa chain V-III region IARC/BL41 IGLV4-69(1-?) HA Ig kappa chain V-II region RPMI 6410 class I MHC B44 IGLC2 HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B67 Ig kappa chain V-I region Ka Ig kappa chain V-I region Bi class I MHC B52 Ig lambda chain V-IV region Hil class I MHC B51 class I MHC B14 LILRA6 NCR1 Ig heavy chain V-III region GA B2M(21-119) Ig heavy chain V-III region BRO Ig kappa chain V-III region GOL B2M(21-119) KIR2DL3 HLA class I histocompatibility antigen, alpha chain G precursor IGLC7 class I MHC B15 class I MHC B15 Ig lambda chain V-I region HA SIGLEC5 HLA class I histocompatibility antigen, Cw-16 alpha chain TREMs Ig lambda chain V-IV region Kern MADCAM1-1 OSCAR:CollagenI,II,III/SP-DFCGR3A CLEC2B class I MHC B38 Ig lambda chain V-I region NEWM Ig lambda chain V-IV region Kern HLA class I histocompatibility antigen, A-1 alpha chain precursor Ig heavy chain V-III region DOB HLA class I histocompatibility antigen, alpha chain F precursor GalNAc-GD1a RAET1E class I MHC B44 class I MHC B7 ICAM2 class I MHC B18 CXADR TRBV12-3 SIGLEC12 Ig kappa chain V-III region SIE HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA-E interactingwith KLRC1:KLRD1MHC Class I Ig heavy chain V-I region SIE class I MHC B81 VCAM1 LILRA1 HLA-G interactingwith KIR2DL4HLA class I histocompatibility antigen, Cw-15 alpha chain B2M(21-119) HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B55 IGLC6 Integrin alpha4beta7ITGA4 RAET1E SH2D1A C16 sulfatide IGLV7-46(1-?) HLA-C HLA class I histocompatibility antigen, alpha chain G precursor CD160 TYROBP IGLV3-25(1-?) FCGR1A HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor MICB HLA-C group 2interacting withKIR2DL1Ig lambda chain V-III region LOI HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B47 PVR class I MHC B45 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor LILRB1 Ig lambda chain V-I region NEW L-selectininteracting withknown ligandsIg lambda chain V-I region MEM KLRD1cd21(1-?) Ig heavy chain V-II region NEWM Ig kappa chain V-III region HIC TRAC HLA class I histocompatibility antigen, alpha chain G precursor Collagen type I fibril B2M(21-119) Ig heavy chain V-III region WAS class I MHC B7 Ig lambda chain V-II region MGC IGLV1-44(1-?) NCR1 SIGLEC1 B2M(21-119) ITGB2 Ig kappa chain V-I region CAR NCR3LG1Ig heavy chain V-II region NEWM HLA class I histocompatibility antigen, A-30 alpha chain CD40-1 Ig lambda chain V-I region NIG-64 Ig kappa chain V-I region Scw SLAMF6:SLAMF6ITGAL IGLV3-22(1-?) TRIM, CD300:lipidsclass I MHC B39 KLRF1 dimerHLA class I histocompatibility antigen, A-29 alpha chain class I MHC B50 HLA class I histocompatibility antigen, Cw-14 alpha chain IGLV1-36(1-?) Ig kappa chain V-I region Daudi class I MHC B57 CLEC2D HLA class I histocompatibility antigen, B-48 alpha chain class I MHC B7 CD96Ig kappa chain V-I region DEE LAIR2class I MHC B27 Antigen HLA class I histocompatibility antigen, Cw-12 alpha chain LILRA4 E-cadherin bound toKLRG1class I MHC B39 cd21(1-?) IGLV(23-?) class I MHC B73 class I MHC B51 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B37 B2M(21-119) Ig heavy chain V-II region SESS class I MHC B67 ULBP1 Ig kappa chain V-I region Rei Ig kappa chain V-III region HIC HLA class I histocompatibility antigen, A-69 alpha chain Ig kappa chain V-I region DEE IGLV5-45(1-?) Ig lambda chain V-II region NEI PVRL2 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, B-48 alpha chain CD3G HLA class I histocompatibility antigen, A-34 alpha chain Ig kappa chain V-I region Wes HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B41 HLA class I histocompatibility antigen, A-25 alpha chain KIR3DL2HLA class I histocompatibility antigen, alpha chain G precursor Ig heavy chain V-III region CAM HLA class I histocompatibility antigen, A-32 alpha chain Ig kappa chain V-II region Cum Ig lambda chain V-II region TOG TRAC Complex of CD19,CD81, CD225 andCD21Integrin alphaLbeta2Ig kappa chain V-II region MIL L-selectin ligandsIGLV1-44(1-?) FCGR1A Ig kappa chain V-I region Roy Ig kappa chain V-I region Kue B2M(21-119) CRTAMHLA class I histocompatibility antigen, Cw-4 alpha chain precursor ICAM4 TRBV12-3 TREMs IGLV7-43(1-?) class I MHC B51 HLA class I histocompatibility antigen, A-11 alpha chain ICAM5 class I MHC B35 class I MHC B18 HLA class I histocompatibility antigen, Cw-15 alpha chain Ig heavy chain V-II region COR B2M(21-119) CD96 MADCAM1-1 class I MHC B42 Ig kappa chain V-II region MIL Collagen types I,II,III Ig lambda chain V-II region WIN FCGR2B IGKC HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B51 class I MHC B46 HLA-Bw4CD3E CD3D Ig heavy chain V-III region TIL CD22 FCGR2B CD247-1 HLA-A3 interactingwith KIR3DL2IGKVA18(21-?) HLA class I histocompatibility antigen, Cw-1 alpha chain Antigen PG IGLV3-12(1-?) LILRB3 class I MHC B46 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor Ig lambda chain V-VI region EB4 Ig kappa chain V-I region EU HLA class I histocompatibility antigen, alpha chain G precursor LILRB5 SH2D1A LAIR1 class I MHC B82 Ig heavy chain V-III region HIL class I MHC B41 class I MHC B41 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B59 HLA class I histocompatibility antigen, E alpha chain precursor T-cell receptorcomplex with CD8HLA class I histocompatibility antigen, A-36 alpha chain CD3D PE class I MHC B59 Ig heavy chain V-III region GA IGHV(1-?) class I MHC B59 KIR3DL2 Ig lambda chain V-II region MGC HLA class I histocompatibility antigen, Cw-18 alpha chain B2M(21-119) ICAM3 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B8 Ig kappa chain V-I region Lay HLA-H Ig kappa chain V-III region B6 PVRHLA class I histocompatibility antigen, alpha chain F precursor class I MHC B67 TRAC HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA-H HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B39 Ig lambda chain V-I region WAH CD19 Ig lambda chain V-I region BL2 class I MHC B13 TCRA class I MHC B78 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B55 Ig lambda chain V-II region BOH CD8B TCRA CD247-1 Ig lambda chain V-I region VOR HLA class I histocompatibility antigen, A-30 alpha chain LILRB3 Ig lambda chain V-IV region Bau SELL HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain Ig kappa chain V-I region Ni CD3E HLA class I histocompatibility antigen, A-2 alpha chain NCR3:FCRG1A:CD3ZdimerCD200 bound toCD200RHLA class I histocompatibility antigen, Cw-5 alpha chain precursor TRBC1 HLA class I histocompatibility antigen, Cw-12 alpha chain B2M(21-119) HLA class I histocompatibility antigen, Cw-4 alpha chain precursor Ig kappa chain V-II region TEW Ig heavy chain V-III region KOL Ig lambda chain V-IV region MOL CDH1(155-882)Ig heavy chain V-I region WOL HLA class I histocompatibility antigen, E alpha chain precursor 26, 8226, 824226, 8217, 19, 60, 62, 7026, 82


Description

A number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathogenic organisms.

<p>Molecules such as KIRs and LILRs form part of a crucial surveillance system that looks out for any derangement, usually caused by cancer or viral infection, in MHC Class I presentation. Somatic cells are also able to report internal functional impairment by displaying surface stress markers such as MICA. The presence of these molecules on somatic cells is picked up by C-lectin NK immune receptors.<p><p>Lymphoid cells are able to regulate their location and movement in accordance to their state of activation, and home in on tissues expressing the appropriate complementary ligands. For example, lymphoid cells may fine tune the presence and concentration of adhesion molecules belonging to the IgSF, Selectin and Integrin class that interact with a number of vascular markers of inflammation.<p><p>Furthermore, there are a number of avenues through which lymphoid cells may interact with antigen. This may be presented directly to a specific T-cell receptor in the context of an MHC molecule. Antigen-antibody complexes may anchor to the cell via a small number of lymphoid-specific Fc receptors that may, in turn, influence cell function further. Activated complement factor C3d binds to both antigen and to cell surface receptor CD21. In such cases, the far-reaching influence of CD19 on B-lymphocyte function is tempered by its interaction with CD21. View original pathway at:Reactome.</div>

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Bibliography

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History

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CompareRevisionActionTimeUserComment
117760view12:54, 22 May 2021EweitzModified title
112459view15:41, 9 October 2020ReactomeTeamReactome version 73
101366view11:25, 1 November 2018ReactomeTeamreactome version 66
100904view21:00, 31 October 2018ReactomeTeamreactome version 65
100445view19:35, 31 October 2018ReactomeTeamreactome version 64
99994view16:18, 31 October 2018ReactomeTeamreactome version 63
99548view14:53, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99181view12:42, 31 October 2018ReactomeTeamreactome version 62
96981view18:21, 24 April 2018AlexanderPicoReverted to version '06:43, 16 August 2017' by AlexanderPico
96973view15:45, 24 April 2018WpblockedModified title
93898view13:43, 16 August 2017ReactomeTeamreactome version 61
93471view11:24, 9 August 2017ReactomeTeamreactome version 61
86567view09:21, 11 July 2016ReactomeTeamreactome version 56
83164view10:14, 18 November 2015ReactomeTeamVersion54
81523view13:03, 21 August 2015ReactomeTeamVersion53
76993view08:28, 17 July 2014ReactomeTeamFixed remaining interactions
76698view12:06, 16 July 2014ReactomeTeamFixed remaining interactions
76024view10:08, 11 June 2014ReactomeTeamRe-fixing comment source
75733view11:21, 10 June 2014ReactomeTeamReactome 48 Update
75083view14:03, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74730view08:48, 30 April 2014ReactomeTeamReactome46
68927view17:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
44851view09:50, 6 October 2011MartijnVanIerselOntology Term : 'signaling pathway pertinent to immunity' added !
42000view21:22, 4 March 2011MaintBotAutomatic update
39855view05:53, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AMICA1 ProteinQ86YT9 (Uniprot-TrEMBL)
AMICA1ProteinQ86YT9 (Uniprot-TrEMBL)
Ac2SGL MetaboliteCHEBI:62113 (ChEBI) CD1B-presented diacylated sulfoglycolipid produced by Mycobacterium tuberculosis (Gilleron M et al. 2004).
Antigen R-NUL-173548 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-198904 (Reactome)
Antigen-bound

antibody bound to lymphoid Fc gamma

receptors		ComplexR-HSA-198877 (Reactome)
Antigen-bound Ig G AntibodyComplexR-HSA-199174 (Reactome) In view of the highly variable nature of antibody proteins, this biological object is an approximate and fragmented representation of an IgM/IgD antibody, given the limitations of Ig chain enumeration in UniProt. A single mRNA transcript is alternatively spliced to give either IgM or IgD. Thus unactivated B cells contain both classes of antibody.
B2M(21-119) ProteinP61769 (Uniprot-TrEMBL)
BbGL-2c MetaboliteCHEBI:60453 (ChEBI) a CD1D-presented glycolipids from Borrelia burgdorfer (Wang J et al. 2005)
C16 sulfatide MetaboliteCHEBI:60366 (ChEBI)
C30 mannosyl MPM MetaboliteCHEBI:77480 (ChEBI) Mycobacterium tuberculosis antigen
C3d complexed with antigenComplexR-HSA-199000 (Reactome)
C3d fragment ProteinP01024 (Uniprot-TrEMBL)
CD160 ProteinO95971 (Uniprot-TrEMBL)
CD160ProteinO95971 (Uniprot-TrEMBL)
CD19 ProteinP15391 (Uniprot-TrEMBL)
CD1:B2M:microbial lipid:TCRComplexR-HSA-8848850 (Reactome)
CD1:B2M:microbial lipidComplexR-HSA-8848835 (Reactome)
CD1:B2M:self-lipid:TCRComplexR-HSA-8850222 (Reactome)
CD1:B2M:self-lipidComplexR-HSA-8850280 (Reactome)
CD1A ProteinP06126 (Uniprot-TrEMBL)
CD1B ProteinP29016 (Uniprot-TrEMBL)
CD1C ProteinP29017 (Uniprot-TrEMBL)
CD1D ProteinP15813 (Uniprot-TrEMBL)
CD200 ProteinP41217 (Uniprot-TrEMBL)
CD200 bound to CD200RComplexR-HSA-198191 (Reactome)
CD200ProteinP41217 (Uniprot-TrEMBL)
CD200R1 ProteinQ8TD46 (Uniprot-TrEMBL)
CD200R1ProteinQ8TD46 (Uniprot-TrEMBL)
CD22 ProteinP20273 (Uniprot-TrEMBL)
CD226 ProteinQ15762 (Uniprot-TrEMBL)
CD226 bound to Nectin 2ComplexR-HSA-198190 (Reactome)
CD226:PVRComplexR-HSA-198197 (Reactome)
CD226ProteinQ15762 (Uniprot-TrEMBL)
CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
CD300 R-HSA-5696349 (Reactome)
CD33 ProteinP20138 (Uniprot-TrEMBL)
CD34-1 ProteinP28906-1 (Uniprot-TrEMBL)
CD3D ProteinP04234 (Uniprot-TrEMBL)
CD3E ProteinP07766 (Uniprot-TrEMBL)
CD3G ProteinP09693 (Uniprot-TrEMBL)
CD40 trimerComplexR-HSA-5672850 (Reactome)
CD40-1 ProteinP25942-1 (Uniprot-TrEMBL)
CD40:CD40L trimerComplexR-HSA-199402 (Reactome)
CD40LG trimerComplexR-HSA-5672851 (Reactome)
CD40LG(1-261) ProteinP29965 (Uniprot-TrEMBL)
CD81 ProteinP60033 (Uniprot-TrEMBL)
CD8A ProteinP01732 (Uniprot-TrEMBL)
CD8B ProteinP10966 (Uniprot-TrEMBL)
CD96 ProteinP40200 (Uniprot-TrEMBL)
CD96:PVRComplexR-HSA-198194 (Reactome)
CD96ProteinP40200 (Uniprot-TrEMBL)
CDH1(155-882) ProteinP12830 (Uniprot-TrEMBL)
CDH1(155-882)ProteinP12830 (Uniprot-TrEMBL)
CERA MetaboliteCHEBI:17761 (ChEBI)
CERA,PE,PSComplexR-ALL-5696348 (Reactome)
CLEC2B ProteinQ92478 (Uniprot-TrEMBL)
CLEC2B dimerComplexR-HSA-5685596 (Reactome)
CLEC2D ProteinQ9UHP7 (Uniprot-TrEMBL)
CLEC2D dimer:KLRB1 dimerComplexR-HSA-5685592 (Reactome)
CLEC2D dimerComplexR-HSA-5685598 (Reactome)
CMVPP65 ProteinP06725 (Uniprot-TrEMBL)
CMVPP65:NCR3:FCRG3A:CD3Z dimerComplexR-HSA-6793270 (Reactome)
CMVPP65ProteinP06725 (Uniprot-TrEMBL)
CRTAM ProteinO95727 (Uniprot-TrEMBL)
CRTAM bound to NECL2ComplexR-HSA-198195 (Reactome)
CRTAMProteinO95727 (Uniprot-TrEMBL)
CXADR ProteinP78310 (Uniprot-TrEMBL)
CXADR bound to JAMLComplexR-HSA-198198 (Reactome)
CXADRProteinP78310 (Uniprot-TrEMBL)
Collagen type I fibril R-HSA-1474201 (Reactome)
Collagen type III fibril R-HSA-1474212 (Reactome)
Collagen type XVII fibrilR-HSA-2172656 (Reactome)
Collagen type XVII fibril R-HSA-2172656 (Reactome)
Collagen types I,II,III/SP-DComplexR-HSA-5696350 (Reactome)
Collagen types I,II,III R-HSA-5696346 (Reactome)
Collagen types I,IIIComplexR-HSA-5696343 (Reactome)
Complex of CD19,

CD81, CD225 and CD21 with C3d-bound

Antigen		ComplexR-HSA-198991 (Reactome)
Complex of CD19,

CD81, CD225 and

CD21		ComplexR-HSA-198931 (Reactome)
DDM-838 MetaboliteCHEBI:62384 (ChEBI)
E-cadherin bound to KLRG1ComplexR-HSA-198192 (Reactome)
FCGR1A ProteinP12314 (Uniprot-TrEMBL)
FCGR2B ProteinP31994 (Uniprot-TrEMBL)
FCGR3A ProteinP08637 (Uniprot-TrEMBL)
GLYCAM1 ProteinQ8IVK1 (Uniprot-TrEMBL)
GM1 MetaboliteCHEBI:61048 (ChEBI)
GMM MetaboliteCHEBI:42782 (ChEBI) CD1B-presented glycolipid antigen produced by mycobacteria.
GalA-GSL MetaboliteCHEBI:528825 (ChEBI) CD1D-presented glycolipids from Sphingomonas spp. bacteria (Kinjo Y et al. 2005).
GalNAc-GD1a MetaboliteCHEBI:59228 (ChEBI)
Glc-DAG-s2 MetaboliteCHEBI:68524 (ChEBI) A bacterial metabolite that can be presented to T cell receptors by CD1D. Found in Streptococcus pneumoniae.
HA ProteinP03452 (Uniprot-TrEMBL)
HCST ProteinQ9UBK5 (Uniprot-TrEMBL)
HLA Bw4 interacting with KIR3DL1ComplexR-HSA-199565 (Reactome)
HLA class I histocompatibility antigen, A-1 alpha chain precursor ProteinP30443 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-11 alpha chain ProteinP13746 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-2 alpha chain ProteinP01892 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-23 alpha chain ProteinP30447 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-24 alpha chain ProteinP05534 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-25 alpha chain ProteinP18462 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-26 alpha chain ProteinP30450 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-29 alpha chain ProteinP30512 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-3 alpha chain precursor ProteinP04439 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-30 alpha chain ProteinP16188 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-31 alpha chain ProteinP16189 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-32 alpha chain ProteinP10314 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-33 alpha chain ProteinP16190 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-34 alpha chain ProteinP30453 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-36 alpha chain ProteinP30455 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-43 alpha chain ProteinP30456 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-66 alpha chain ProteinP30457 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-68 alpha chain ProteinP01891 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-69 alpha chain ProteinP10316 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-74 alpha chain ProteinP30459 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-80 alpha chain ProteinQ09160 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, B-48 alpha chain ProteinP30486 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-1 alpha chain ProteinP30499 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-12 alpha chain ProteinP30508 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-14 alpha chain ProteinP30510 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-15 alpha chain ProteinQ07000 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-16 alpha chain ProteinQ29960 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-17 alpha chain ProteinQ95604 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-18 alpha chain ProteinQ29865 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-2 alpha chain ProteinP30501 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-3 alpha chain precursor ProteinP04222 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ProteinP30504 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ProteinQ9TNN7 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ProteinQ29963 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-8 alpha chain ProteinP30505 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, E alpha chain precursor ProteinP13747 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain F precursor ProteinP30511 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain G precursor ProteinP17693 (Uniprot-TrEMBL)
HLA-A3 interacting with KIR3DL2ComplexR-HSA-199573 (Reactome)
HLA-A3ComplexR-HSA-199571 (Reactome)
HLA-Bw4ComplexR-HSA-199567 (Reactome)
HLA-C

group-I-interacting

KIRs		ComplexR-HSA-199540 (Reactome)
HLA-C Cw3 (group 1)ComplexR-HSA-199562 (Reactome)
HLA-C Cw4 (group 2)ComplexR-HSA-198911 (Reactome)
HLA-C ProteinP10321 (Uniprot-TrEMBL)
HLA-C group 1

interacting with

KIR2DL2/3		ComplexR-HSA-198909 (Reactome)
HLA-C group 1

interacting with

KIR2DS2		ComplexR-HSA-199588 (Reactome)
HLA-C group 2

interacting with

KIR2DL1		ComplexR-HSA-199560 (Reactome)
HLA-C group 2

interacting with

KIR2DS1		ComplexR-HSA-199585 (Reactome)
HLA-E interacting with KLRC1:KLRD1ComplexR-HSA-198914 (Reactome)
HLA-EComplexR-HSA-198912 (Reactome)
HLA-G interacting with KIR2DL4ComplexR-HSA-199578 (Reactome)
HLA-GComplexR-HSA-199581 (Reactome)
HLA-H ProteinP01893 (Uniprot-TrEMBL)
HN ProteinP04853 (Uniprot-TrEMBL)
HemagglutininComplexR-FLU-5685588 (Reactome)
ICAM 1-5ComplexR-HSA-198193 (Reactome)
ICAM1 ProteinP05362 (Uniprot-TrEMBL)
ICAM2 ProteinP13598 (Uniprot-TrEMBL)
ICAM3 ProteinP32942 (Uniprot-TrEMBL)
ICAM4 ProteinQ14773 (Uniprot-TrEMBL)
ICAM5 ProteinQ9UMF0 (Uniprot-TrEMBL)
IFITM1 ProteinP13164 (Uniprot-TrEMBL)
IGHV(1-?) ProteinA2KUC3 (Uniprot-TrEMBL)
IGHV7-81(1-?) ProteinQ6PIL0 (Uniprot-TrEMBL)
IGKC ProteinP01834 (Uniprot-TrEMBL)
IGKV1-5(23-?) ProteinP01602 (Uniprot-TrEMBL)
IGKV4-1(21-?) ProteinP06312 (Uniprot-TrEMBL)
IGKVA18(21-?) ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1 ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2 ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3 ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6 ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7 ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV(23-?) ProteinA2NXD2 (Uniprot-TrEMBL)
IGLV1-36(1-?) ProteinQ5NV67 (Uniprot-TrEMBL)
IGLV1-40(1-?) ProteinQ5NV69 (Uniprot-TrEMBL)
IGLV1-44(1-?) ProteinQ5NV81 (Uniprot-TrEMBL)
IGLV10-54(1-?) ProteinQ5NV86 (Uniprot-TrEMBL)
IGLV11-55(1-?) ProteinQ5NV87 (Uniprot-TrEMBL)
IGLV2-11(1-?) ProteinQ5NV84 (Uniprot-TrEMBL)
IGLV2-18(1-?) ProteinQ5NV65 (Uniprot-TrEMBL)
IGLV2-23(1-?) ProteinQ5NV89 (Uniprot-TrEMBL)
IGLV2-33(1-?) ProteinQ5NV66 (Uniprot-TrEMBL)
IGLV3-12(1-?) ProteinQ5NV85 (Uniprot-TrEMBL)
IGLV3-16(1-?) ProteinQ5NV64 (Uniprot-TrEMBL)
IGLV3-22(1-?) ProteinQ5NV75 (Uniprot-TrEMBL)
IGLV3-25(1-?) ProteinQ5NV90 (Uniprot-TrEMBL)
IGLV3-27(1-?) ProteinQ5NV91 (Uniprot-TrEMBL)
IGLV4-3(1-?) ProteinQ5NV61 (Uniprot-TrEMBL)
IGLV4-60(1-?) ProteinQ5NV79 (Uniprot-TrEMBL)
IGLV4-69(1-?) ProteinQ5NV92 (Uniprot-TrEMBL)
IGLV5-37(1-?) ProteinQ5NV68 (Uniprot-TrEMBL)
IGLV5-45(1-?) ProteinQ5NV82 (Uniprot-TrEMBL)
IGLV7-43(1-?) ProteinQ5NV80 (Uniprot-TrEMBL)
IGLV7-46(1-?) ProteinQ5NV83 (Uniprot-TrEMBL)
IGLV8-61(1-?) ProteinQ5NV62 (Uniprot-TrEMBL)
ITGA4 ProteinP13612 (Uniprot-TrEMBL)
ITGAL ProteinP20701 (Uniprot-TrEMBL)
ITGB1 ProteinP05556 (Uniprot-TrEMBL)
ITGB2 ProteinP05107 (Uniprot-TrEMBL)
ITGB7 ProteinP26010 (Uniprot-TrEMBL)
Ig heavy chain V-I region EU ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I region HG3 ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-I region Mot ProteinP06326 (Uniprot-TrEMBL)
Ig heavy chain V-I region ND ProteinP01744 (Uniprot-TrEMBL)
Ig heavy chain V-I region SIE ProteinP01761 (Uniprot-TrEMBL)
Ig heavy chain V-I region WOL ProteinP01760 (Uniprot-TrEMBL)
Ig heavy chain V-II region ARH-77 ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II region COR ProteinP01815 (Uniprot-TrEMBL)
Ig heavy chain V-II region DAW ProteinP01816 (Uniprot-TrEMBL)
Ig heavy chain V-II region HE ProteinP01818 (Uniprot-TrEMBL)
Ig heavy chain V-II region MCE ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II region NEWM ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II region OU ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II region SESS ProteinP04438 (Uniprot-TrEMBL)
Ig heavy chain V-II region WAH ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III region BRO ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUR ProteinP01773 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUT ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III region CAM ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III region DOB ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III region GA ProteinP01769 (Uniprot-TrEMBL)
Ig heavy chain V-III region GAL ProteinP01781 (Uniprot-TrEMBL)
Ig heavy chain V-III region HIL ProteinP01771 (Uniprot-TrEMBL)
Ig heavy chain V-III region JON ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III region KOL ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III region LAY ProteinP01775 (Uniprot-TrEMBL)
Ig heavy chain V-III region NIE ProteinP01770 (Uniprot-TrEMBL)
Ig heavy chain V-III region POM ProteinP01774 (Uniprot-TrEMBL)
Ig heavy chain V-III region TEI ProteinP01777 (Uniprot-TrEMBL)
Ig heavy chain V-III region TIL ProteinP01765 (Uniprot-TrEMBL)
Ig heavy chain V-III region TRO ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III region TUR ProteinP01779 (Uniprot-TrEMBL)
Ig heavy chain V-III region WAS ProteinP01776 (Uniprot-TrEMBL)
Ig heavy chain V-III region WEA ProteinP01763 (Uniprot-TrEMBL)
Ig heavy chain V-III region ZAP ProteinP01778 (Uniprot-TrEMBL)
Ig kappa chain V region EV15 ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I region AG ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I region AU ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I region BAN ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I region Bi ProteinP01595 (Uniprot-TrEMBL)
Ig kappa chain V-I region CAR ProteinP01596 (Uniprot-TrEMBL)
Ig kappa chain V-I region DEE ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I region Daudi ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I region EU ProteinP01598 (Uniprot-TrEMBL)
Ig kappa chain V-I region Gal ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I region HK101 ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I region Hau ProteinP01600 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ka ProteinP01603 (Uniprot-TrEMBL)
Ig kappa chain V-I region Kue ProteinP01604 (Uniprot-TrEMBL)
Ig kappa chain V-I region Lay ProteinP01605 (Uniprot-TrEMBL)
Ig kappa chain V-I region Mev ProteinP01612 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ni ProteinP01613 (Uniprot-TrEMBL)
Ig kappa chain V-I region OU ProteinP01606 (Uniprot-TrEMBL)
Ig kappa chain V-I region Rei ProteinP01607 (Uniprot-TrEMBL)
Ig kappa chain V-I region Roy ProteinP01608 (Uniprot-TrEMBL)
Ig kappa chain V-I region Scw ProteinP01609 (Uniprot-TrEMBL)
Ig kappa chain V-I region WAT ProteinP80362 (Uniprot-TrEMBL)
Ig kappa chain V-I region WEA ProteinP01610 (Uniprot-TrEMBL)
Ig kappa chain V-I region Walker ProteinP04431 (Uniprot-TrEMBL)
Ig kappa chain V-I region Wes ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II region Cum ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II region FR ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II region GM607 ProteinP06309 (Uniprot-TrEMBL)
Ig kappa chain V-II region MIL ProteinP01616 (Uniprot-TrEMBL)
Ig kappa chain V-II region RPMI 6410 ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-II region TEW ProteinP01617 (Uniprot-TrEMBL)
Ig kappa chain V-III region B6 ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III region CLL ProteinP04207 (Uniprot-TrEMBL)
Ig kappa chain V-III region GOL ProteinP04206 (Uniprot-TrEMBL)
Ig kappa chain V-III region HAH ProteinP18135 (Uniprot-TrEMBL)
Ig kappa chain V-III region HIC ProteinP18136 (Uniprot-TrEMBL)
Ig kappa chain V-III region IARC/BL41 ProteinP06311 (Uniprot-TrEMBL)
Ig kappa chain V-III region NG9 ProteinP01621 (Uniprot-TrEMBL)
Ig kappa chain V-III region POM ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III region SIE ProteinP01620 (Uniprot-TrEMBL)
Ig kappa chain V-III region Ti ProteinP01622 (Uniprot-TrEMBL)
Ig kappa chain V-III region VG ProteinP04433 (Uniprot-TrEMBL)
Ig kappa chain V-III region VH ProteinP04434 (Uniprot-TrEMBL)
Ig kappa chain V-III region WOL ProteinP01623 (Uniprot-TrEMBL)
Ig kappa chain V-IV region B17 ProteinP06314 (Uniprot-TrEMBL)
Ig kappa chain V-IV region JI ProteinP06313 (Uniprot-TrEMBL)
Ig kappa chain V-IV region Len ProteinP01625 (Uniprot-TrEMBL)
Ig kappa chain V-IV region STH ProteinP83593 (Uniprot-TrEMBL)
Ig lambda chain V region 4A ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I region BL2 ProteinP06316 (Uniprot-TrEMBL)
Ig lambda chain V-I region EPS ProteinP06888 (Uniprot-TrEMBL)
Ig lambda chain V-I region HA ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I region MEM ProteinP06887 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEW ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEWM ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I region NIG-64 ProteinP01702 (Uniprot-TrEMBL)
Ig lambda chain V-I region VOR ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-I region WAH ProteinP04208 (Uniprot-TrEMBL)
Ig lambda chain V-II region BO ProteinP01710 (Uniprot-TrEMBL)
Ig lambda chain V-II region BOH ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II region BUR ProteinP01708 (Uniprot-TrEMBL)
Ig lambda chain V-II region MGC ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II region NEI ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-58 ProteinP01713 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-84 ProteinP04209 (Uniprot-TrEMBL)
Ig lambda chain V-II region TOG ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-II region TRO ProteinP01707 (Uniprot-TrEMBL)
Ig lambda chain V-II region VIL ProteinP01711 (Uniprot-TrEMBL)
Ig lambda chain V-II region WIN ProteinP01712 (Uniprot-TrEMBL)
Ig lambda chain V-III region LOI ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain V-III region SH ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Bau ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Hil ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Kern ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-IV region MOL ProteinP06889 (Uniprot-TrEMBL)
Ig lambda chain V-IV region X ProteinP01716 (Uniprot-TrEMBL)
Ig lambda chain V-V region DEL ProteinP01719 (Uniprot-TrEMBL)
Ig lambda chain V-VI region AR ProteinP01721 (Uniprot-TrEMBL)
Ig lambda chain V-VI region EB4 ProteinP06319 (Uniprot-TrEMBL)
Ig lambda chain V-VI region NIG-48 ProteinP01722 (Uniprot-TrEMBL)
Ig lambda chain V-VI region SUT ProteinP06317 (Uniprot-TrEMBL)
Ig lambda chain V-VI region WLT ProteinP06318 (Uniprot-TrEMBL)
Ig lambda chain V-VII region MOT ProteinP01720 (Uniprot-TrEMBL)
IgH heavy chain V-III region VH26 precursor ProteinP01764 (Uniprot-TrEMBL)
Integrin alpha4beta7:MADCAM1ComplexR-HSA-198925 (Reactome)
Integrin alpha4beta1ComplexR-HSA-198201 (Reactome)
Integrin alpha4beta7ComplexR-HSA-198927 (Reactome)
Integrin alphaLbeta2ComplexR-HSA-198196 (Reactome)
KIR2DL1 ProteinP43626 (Uniprot-TrEMBL)
KIR2DL1ProteinP43626 (Uniprot-TrEMBL)
KIR2DL2 ProteinP43627 (Uniprot-TrEMBL)
KIR2DL3 ProteinP43628 (Uniprot-TrEMBL)
KIR2DL4 ProteinQ99706 (Uniprot-TrEMBL)
KIR2DL4ProteinQ99706 (Uniprot-TrEMBL)
KIR2DS1 ProteinQ14954 (Uniprot-TrEMBL)
KIR2DS1 complexed with DAP12ComplexR-HSA-199586 (Reactome)
KIR2DS2 ProteinP43631 (Uniprot-TrEMBL)
KIR2DS2 complexed with DAP12ComplexR-HSA-199584 (Reactome)
KIR3DL1 ProteinP43629 (Uniprot-TrEMBL)
KIR3DL1ProteinP43629 (Uniprot-TrEMBL)
KIR3DL2 ProteinP43630 (Uniprot-TrEMBL)
KIR3DL2ProteinP43630 (Uniprot-TrEMBL)
KLRB1 ProteinQ12918 (Uniprot-TrEMBL)
KLRB1 dimerComplexR-HSA-5685225 (Reactome)
KLRC1 ProteinP26715 (Uniprot-TrEMBL)
KLRC1ProteinP26715 (Uniprot-TrEMBL)
KLRD1 ProteinQ13241 (Uniprot-TrEMBL)
KLRD1ProteinQ13241 (Uniprot-TrEMBL)
KLRF1 ProteinQ9NZS2 (Uniprot-TrEMBL)
KLRF1 dimer:CLEC2B dimerComplexR-HSA-5685591 (Reactome)
KLRF1 dimerComplexR-HSA-5685224 (Reactome)
KLRG1 ProteinQ96E93 (Uniprot-TrEMBL)
KLRG1ProteinQ96E93 (Uniprot-TrEMBL)
KLRK1 ProteinP26718 (Uniprot-TrEMBL)
L-selectin

interacting with

known ligands		ComplexR-HSA-198924 (Reactome)
L-selectin ligandsComplexR-HSA-198922 (Reactome)
LAIR1 ProteinQ6GTX8 (Uniprot-TrEMBL)
LAIR1:Collagen type XVIIComplexR-HSA-5686611 (Reactome)
LAIR1ProteinQ6GTX8 (Uniprot-TrEMBL)
LAIR2 ProteinQ6ISS4 (Uniprot-TrEMBL)
LAIR2:Collagen type I,IIIComplexR-HSA-5696354 (Reactome)
LAIR2ProteinQ6ISS4 (Uniprot-TrEMBL)
LAM MetaboliteCHEBI:59524 (ChEBI) CD1B-presented lipoglycan lipoarabinomannan (LAM) is synthesized by the genera Mycobacterium, Corynebacterium,and Rhodococcus.
LFA-1:ICAM 1-5ComplexR-HSA-198200 (Reactome)
LILR setComplexR-HSA-198894 (Reactome)
LILR-interacting MHC Class I moleculesComplexR-HSA-199592 (Reactome)
LILRA1 ProteinO75019 (Uniprot-TrEMBL)
LILRA2 ProteinQ8N149 (Uniprot-TrEMBL)
LILRA3 ProteinQ8N6C8 (Uniprot-TrEMBL)
LILRA4 ProteinP59901 (Uniprot-TrEMBL)
LILRA5 ProteinA6NI73 (Uniprot-TrEMBL)
LILRA6 ProteinQ6PI73 (Uniprot-TrEMBL)
LILRB1 ProteinQ8NHL6 (Uniprot-TrEMBL)
LILRB2 ProteinQ8N423 (Uniprot-TrEMBL)
LILRB3 ProteinO75022 (Uniprot-TrEMBL)
LILRB4 ProteinQ8NHJ6 (Uniprot-TrEMBL)
LILRB5 ProteinO75023 (Uniprot-TrEMBL)
Ligand interacting with NKG2DComplexR-HSA-198915 (Reactome)
Lymphoid-expressed Fc-gamma receptorsComplexR-HSA-200284 (Reactome)
MADCAM1-1 ProteinQ13477-1 (Uniprot-TrEMBL)
MADCAM1-1ProteinQ13477-1 (Uniprot-TrEMBL)
MHC Class I

interacting with

CD160		ComplexR-HSA-198906 (Reactome)
MHC Class I

interacting with

LILRs		ComplexR-HSA-198896 (Reactome)
MHC Class I

molecules interacting with

CD160		ComplexR-HSA-199614 (Reactome)
MHC Class I R-HSA-198889 (Reactome)
MICA ProteinQ29983 (Uniprot-TrEMBL)
MICB ProteinQ29980 (Uniprot-TrEMBL)
NCR1 ProteinO76036 (Uniprot-TrEMBL)
NCR1:FCRG1A:CD3Z dimer:HemagglutininComplexR-HSA-5685594 (Reactome)
NCR1:FCRG1A:CD3Z dimerComplexR-HSA-5685701 (Reactome)
NCR3 ProteinO14931 (Uniprot-TrEMBL)
NCR3:FCRG1A:CD3Z dimerComplexR-HSA-5685593 (Reactome)
NCR3LG1 ProteinQ68D85 (Uniprot-TrEMBL)
NCR3LG1:NCR3:FCRG3A:CD3Z dimerComplexR-HSA-6793269 (Reactome)
NCR3LG1ProteinQ68D85 (Uniprot-TrEMBL)
NKG2D complexed with DAP10ComplexR-HSA-198920 (Reactome)
NKG2D ligandComplexR-HSA-198916 (Reactome)
OSCAR ProteinQ8IYS5 (Uniprot-TrEMBL)
OSCAR:Collagen I,II,III/SP-DComplexR-HSA-5696351 (Reactome)
OSCARProteinQ8IYS5 (Uniprot-TrEMBL)
PE MetaboliteCHEBI:16038 (ChEBI)
PG MetaboliteCHEBI:17517 (ChEBI)
PI MetaboliteCHEBI:28874 (ChEBI)
PVR ProteinP15151 (Uniprot-TrEMBL)
PVRL2 ProteinQ92692 (Uniprot-TrEMBL)
PVRL2ProteinQ92692 (Uniprot-TrEMBL)
PVRProteinP15151 (Uniprot-TrEMBL)
Phosphatidylserine MetaboliteCHEBI:18303 (ChEBI)
RAET1E ProteinQ8TD07 (Uniprot-TrEMBL)
SAP,EAT2ComplexR-HSA-5685221 (Reactome)
SELL ProteinP14151 (Uniprot-TrEMBL)
SELLProteinP14151 (Uniprot-TrEMBL)
SH2D1A ProteinO60880 (Uniprot-TrEMBL)
SH2D1B ProteinO14796 (Uniprot-TrEMBL)
SIGLEC1 ProteinQ9BZZ2 (Uniprot-TrEMBL)
SIGLEC10 ProteinQ96LC7 (Uniprot-TrEMBL)
SIGLEC11 ProteinQ96RL6 (Uniprot-TrEMBL)
SIGLEC12 ProteinQ96PQ1 (Uniprot-TrEMBL)
SIGLEC5 ProteinO15389 (Uniprot-TrEMBL)
SIGLEC6 ProteinO43699 (Uniprot-TrEMBL)
SIGLEC7 ProteinQ9Y286 (Uniprot-TrEMBL)
SIGLEC8 ProteinQ9NYZ4 (Uniprot-TrEMBL)
SIGLEC9 ProteinQ9Y336 (Uniprot-TrEMBL)
SIGLEC:sialic acidComplexR-HSA-5685595 (Reactome)
SIGLECComplexR-HSA-5685222 (Reactome)
SLAMF6 ProteinQ96DU3 (Uniprot-TrEMBL)
SLAMF6:SLAMF6:SAP,EAT2ComplexR-HSA-5685227 (Reactome)
SLAMF6:SLAMF6ComplexR-HSA-5685229 (Reactome)
SLAMF6ProteinQ96DU3 (Uniprot-TrEMBL)
SLAMF7 ProteinQ9NQ25 (Uniprot-TrEMBL)
SLAMF7:SLAMF7ComplexR-HSA-5685228 (Reactome)
SLAMF7ProteinQ9NQ25 (Uniprot-TrEMBL)
SP-D oligomer R-HSA-391097 (Reactome)
Sialic acid MetaboliteCHEBI:28879 (ChEBI)
Sialic acidMetaboliteCHEBI:28879 (ChEBI)
T-cell receptor complex with CD8ComplexR-HSA-198898 (Reactome)
T-cell receptor complexComplexR-HSA-198901 (Reactome)
T-cell receptor alpha chain V region HPB-MLT precursor ProteinP04436 (Uniprot-TrEMBL)
T-cell receptor alpha chain V region PY14 precursor ProteinP01737 (Uniprot-TrEMBL)
TCR interacting with

antigen-bearing MHC

Class I		ComplexR-HSA-198897 (Reactome)
TCRA ProteinP04437 (Uniprot-TrEMBL)
TCRB ProteinP04435 (Uniprot-TrEMBL)
TRAC ProteinP01848 (Uniprot-TrEMBL)
TRBC1 ProteinP01850 (Uniprot-TrEMBL)
TRBV12-3 ProteinP01733 (Uniprot-TrEMBL)
TREM, CD300ComplexR-HSA-5696347 (Reactome)
TREMs R-HSA-5696345 (Reactome) Note: This family members include both membrane bound and soluble forms. TRML4 is soluble
TRIM, CD300:lipidsComplexR-HSA-5696352 (Reactome)
TYROBP ProteinO43914 (Uniprot-TrEMBL)
ULBP1 ProteinQ9BZM6 (Uniprot-TrEMBL)
ULBP3 ProteinQ9BZM4 (Uniprot-TrEMBL)
VCAM1 ProteinP19320 (Uniprot-TrEMBL)
VCAM1ProteinP19320 (Uniprot-TrEMBL)
alpha-mycolic acid MetaboliteCHEBI:59235 (ChEBI) CD1B-presented fatty acid produced by Mycobacterium tuberculosis
cd21(1-?) ProteinO15181 (Uniprot-TrEMBL)
class I MHC B13 ProteinP30461 (Uniprot-TrEMBL)
class I MHC B14 ProteinP30462 (Uniprot-TrEMBL)
class I MHC B15 ProteinP30464 (Uniprot-TrEMBL)
class I MHC B18 ProteinP30466 (Uniprot-TrEMBL)
class I MHC B27 ProteinP03989 (Uniprot-TrEMBL)
class I MHC B35 ProteinP30685 (Uniprot-TrEMBL)
class I MHC B37 ProteinP18463 (Uniprot-TrEMBL)
class I MHC B38 ProteinQ95365 (Uniprot-TrEMBL)
class I MHC B39 ProteinP30475 (Uniprot-TrEMBL)
class I MHC B40 ProteinQ04826 (Uniprot-TrEMBL)
class I MHC B41 ProteinP30479 (Uniprot-TrEMBL)
class I MHC B42 ProteinP30480 (Uniprot-TrEMBL)
class I MHC B44 ProteinP30481 (Uniprot-TrEMBL)
class I MHC B45 ProteinP30483 (Uniprot-TrEMBL)
class I MHC B46 ProteinP30484 (Uniprot-TrEMBL)
class I MHC B47 ProteinP30485 (Uniprot-TrEMBL)
class I MHC B49 ProteinP30487 (Uniprot-TrEMBL)
class I MHC B50 ProteinP30488 (Uniprot-TrEMBL)
class I MHC B51 ProteinP18464 (Uniprot-TrEMBL)
class I MHC B52 ProteinP30490 (Uniprot-TrEMBL)
class I MHC B53 ProteinP30491 (Uniprot-TrEMBL)
class I MHC B54 ProteinP30492 (Uniprot-TrEMBL)
class I MHC B55 ProteinP30493 (Uniprot-TrEMBL)
class I MHC B56 ProteinP30495 (Uniprot-TrEMBL)
class I MHC B57 ProteinP18465 (Uniprot-TrEMBL)
class I MHC B58 ProteinP10319 (Uniprot-TrEMBL)
class I MHC B59 ProteinQ29940 (Uniprot-TrEMBL)
class I MHC B67 ProteinQ29836 (Uniprot-TrEMBL)
class I MHC B7 ProteinP01889 (Uniprot-TrEMBL)
class I MHC B73 ProteinQ31612 (Uniprot-TrEMBL)
class I MHC B78 ProteinP30498 (Uniprot-TrEMBL)
class I MHC B8 ProteinP30460 (Uniprot-TrEMBL)
class I MHC B81 ProteinQ31610 (Uniprot-TrEMBL)
class I MHC B82 ProteinQ29718 (Uniprot-TrEMBL)
integrin alpha4beta1:VCAM1ComplexR-HSA-198199 (Reactome)
squalene MetaboliteCHEBI:15440 (ChEBI)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
AMICA1R-HSA-199093 (Reactome)
Antigen peptide bound class I MHCR-HSA-198955 (Reactome)
Antigen-bound

antibody bound to lymphoid Fc gamma

receptors		ArrowR-HSA-199161 (Reactome)
Antigen-bound Ig G AntibodyR-HSA-199161 (Reactome)
C3d complexed with antigenR-HSA-199518 (Reactome)
CD160R-HSA-199169 (Reactome)
CD1:B2M:microbial lipid:TCRArrowR-HSA-8850356 (Reactome)
CD1:B2M:microbial lipidR-HSA-8850356 (Reactome)
CD1:B2M:self-lipid:TCRArrowR-HSA-8850326 (Reactome)
CD1:B2M:self-lipidR-HSA-8850326 (Reactome)
CD200 bound to CD200RArrowR-HSA-199154 (Reactome)
CD200R-HSA-199154 (Reactome)
CD200R1R-HSA-199154 (Reactome)
CD226 bound to Nectin 2ArrowR-HSA-199144 (Reactome)
CD226:PVRArrowR-HSA-199131 (Reactome)
CD226R-HSA-199131 (Reactome)
CD226R-HSA-199144 (Reactome)
CD40 trimerR-HSA-199404 (Reactome)
CD40:CD40L trimerArrowR-HSA-199404 (Reactome)
CD40LG trimerR-HSA-199404 (Reactome)
CD96:PVRArrowR-HSA-199014 (Reactome)
CD96R-HSA-199014 (Reactome)
CDH1(155-882)R-HSA-199079 (Reactome)
CERA,PE,PSR-HSA-5696358 (Reactome)
CLEC2B dimerR-HSA-5685608 (Reactome)
CLEC2D dimer:KLRB1 dimerArrowR-HSA-5685606 (Reactome)
CLEC2D dimerR-HSA-5685606 (Reactome)
CMVPP65:NCR3:FCRG3A:CD3Z dimerArrowR-HSA-6793275 (Reactome)
CMVPP65R-HSA-6793275 (Reactome)
CRTAM bound to NECL2ArrowR-HSA-199112 (Reactome)
CRTAMR-HSA-199112 (Reactome)
CXADR bound to JAMLArrowR-HSA-199093 (Reactome)
CXADRR-HSA-199093 (Reactome)
Collagen type XVII fibrilR-HSA-5686625 (Reactome)
Collagen types I,II,III/SP-DR-HSA-5696356 (Reactome)
Collagen types I,IIIR-HSA-5696357 (Reactome)
Complex of CD19,

CD81, CD225 and CD21 with C3d-bound

Antigen		ArrowR-HSA-199518 (Reactome)
Complex of CD19,

CD81, CD225 and

CD21		R-HSA-199518 (Reactome)
E-cadherin bound to KLRG1ArrowR-HSA-199079 (Reactome)
HLA Bw4 interacting with KIR3DL1ArrowR-HSA-199566 (Reactome)
HLA-A3 interacting with KIR3DL2ArrowR-HSA-199576 (Reactome)
HLA-A3R-HSA-199576 (Reactome)
HLA-Bw4R-HSA-199566 (Reactome)
HLA-C

group-I-interacting

KIRs		R-HSA-198958 (Reactome)
HLA-C Cw3 (group 1)R-HSA-199558 (Reactome)
HLA-C Cw3 (group 1)R-HSA-199583 (Reactome)
HLA-C Cw4 (group 2)R-HSA-198958 (Reactome)
HLA-C Cw4 (group 2)R-HSA-199587 (Reactome)
HLA-C group 1

interacting with

KIR2DL2/3		ArrowR-HSA-198958 (Reactome)
HLA-C group 1

interacting with

KIR2DS2		ArrowR-HSA-199583 (Reactome)
HLA-C group 2

interacting with

KIR2DL1		ArrowR-HSA-199558 (Reactome)
HLA-C group 2

interacting with

KIR2DS1		ArrowR-HSA-199587 (Reactome)
HLA-E interacting with KLRC1:KLRD1ArrowR-HSA-199062 (Reactome)
HLA-ER-HSA-199062 (Reactome)
HLA-G interacting with KIR2DL4ArrowR-HSA-199579 (Reactome)
HLA-GR-HSA-199579 (Reactome)
HemagglutininR-HSA-5685600 (Reactome)
ICAM 1-5R-HSA-199050 (Reactome)
Integrin alpha4beta7:MADCAM1ArrowR-HSA-199032 (Reactome)
Integrin alpha4beta1R-HSA-198941 (Reactome)
Integrin alpha4beta7R-HSA-199032 (Reactome)
Integrin alphaLbeta2R-HSA-199050 (Reactome)
KIR2DL1R-HSA-199558 (Reactome)
KIR2DL4R-HSA-199579 (Reactome)
KIR2DS1 complexed with DAP12R-HSA-199587 (Reactome)
KIR2DS2 complexed with DAP12R-HSA-199583 (Reactome)
KIR3DL1R-HSA-199566 (Reactome)
KIR3DL2R-HSA-199576 (Reactome)
KLRB1 dimerR-HSA-5685606 (Reactome)
KLRC1R-HSA-199062 (Reactome)
KLRD1R-HSA-199062 (Reactome)
KLRF1 dimer:CLEC2B dimerArrowR-HSA-5685608 (Reactome)
KLRF1 dimerR-HSA-5685608 (Reactome)
KLRG1R-HSA-199079 (Reactome)
L-selectin

interacting with

known ligands		ArrowR-HSA-199046 (Reactome)
L-selectin ligandsR-HSA-199046 (Reactome)
LAIR1:Collagen type XVIIArrowR-HSA-5686625 (Reactome)
LAIR1R-HSA-5686625 (Reactome)
LAIR2:Collagen type I,IIIArrowR-HSA-5696357 (Reactome)
LAIR2R-HSA-5696357 (Reactome)
LFA-1:ICAM 1-5ArrowR-HSA-199050 (Reactome)
LILR setR-HSA-199043 (Reactome)
LILR-interacting MHC Class I moleculesR-HSA-199043 (Reactome)
Ligand interacting with NKG2DArrowR-HSA-198983 (Reactome)
Lymphoid-expressed Fc-gamma receptorsR-HSA-199161 (Reactome)
MADCAM1-1R-HSA-199032 (Reactome)
MHC Class I

interacting with

CD160		ArrowR-HSA-199169 (Reactome)
MHC Class I

interacting with

LILRs		ArrowR-HSA-199043 (Reactome)
MHC Class I

molecules interacting with

CD160		R-HSA-199169 (Reactome)
NCR1:FCRG1A:CD3Z dimer:HemagglutininArrowR-HSA-5685600 (Reactome)
NCR1:FCRG1A:CD3Z dimerR-HSA-5685600 (Reactome)
NCR3:FCRG1A:CD3Z dimerR-HSA-5685602 (Reactome)
NCR3:FCRG1A:CD3Z dimerR-HSA-6793275 (Reactome)
NCR3LG1:NCR3:FCRG3A:CD3Z dimerArrowR-HSA-5685602 (Reactome)
NCR3LG1R-HSA-5685602 (Reactome)
NKG2D complexed with DAP10R-HSA-198983 (Reactome)
NKG2D ligandR-HSA-198983 (Reactome)
OSCAR:Collagen I,II,III/SP-DArrowR-HSA-5696356 (Reactome)
OSCARR-HSA-5696356 (Reactome)
PVRL2R-HSA-199112 (Reactome)
PVRL2R-HSA-199144 (Reactome)
PVRR-HSA-199014 (Reactome)
PVRR-HSA-199131 (Reactome)
R-HSA-198941 (Reactome) Integrins play a central role in mediating lymphocyte adhesion to a number of surfaces. Integrin alphaLbeta2 (LFA-1) interacts with Intercellular adhesion molecule (ICAM)1-5, which are typically expressed on other immune system cells. ICAM4 and 5 are known to be expressed on telencepahlic neurons. VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4). To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change. Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion.
R-HSA-198955 (Reactome) T cells distinguish foreign material from self through presentation of fragments of the antigen by the MHC cell surface receptors. Only if an MHC molecule presents an appropriate antigenic peptide will a cellular immune response be triggered. The orchestration of recognition and signaling events, from the initial recognition of antigenic peptides to the lysis of the target cell, is performed in a localized environment on the T cell, called the immunological synapse, and requires the coordinated activities of several T-Cell Receptor (TCR)-associated molecules. This particular reaction depicts the interaction of the TCR with MHC Class I molecules on somatic cell, requiring the support of CD3 and CD8 proteins.
R-HSA-198958 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

R-HSA-198983 (Reactome) NKG2D is an activating immunoreceptor. By engaging NKG2D, HlA Class I-like molecules such as MICA, MICB, ULBP1-4 and RAE-1 provide powerful costimulation for NK cells and T-cells and can determine the magnitude and outcome of certain effector functions. NKG2D ligands are upregulated on the surfaces of cells under conditions of stress, for example infection or tumorigenesis, and therefore act as molecular flags to the immune system that something is wrong.
R-HSA-199014 (Reactome) NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis.

For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions.

Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus.

CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells.

CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets.

R-HSA-199032 (Reactome) Mucosal addressin cell adhesion molecule (MADCAM1) is present in the endothelium of mucosa, and binds alpha-4 beta-7 integrin and L-selectin, regulating both the passage and retention of leukocytes in mucosal tissues. MADCAM1 has been shown to be present as a homodimer.
R-HSA-199043 (Reactome) Leukocyte immunoglobulin (Ig)-like receptors [LILRs, also known as Ig-like transcripts (ILTs)] are a family of inhibitory and stimulatory receptors encoded within the leukocyte receptor complex and are expressed by immune cell types of both myeloid and lymphoid lineage. Several members of the LILR family recognize major histocompatibility complex class I. The immunomodulatory role of LILR receptors indicates that they may exert an influence on signaling pathways of both innate and adaptive immune systems.

Signaling mechanisms are employed that are similar to the ones adopted by the closely related killer cell inhibitory receptors (KIRs). ITIMs recruit inhibitory phosphatases that dephosphorylate ITIM and ITAM domains in order to influence intracellular signaling cascades. In contrast, activating LILRs, which lack any signaling domains of their own, rely on association with an adaptor protein such as FceRI-gamma to transmit their signal through its intracellular ITAMs.

R-HSA-199046 (Reactome) L-selectin plays a major role in leukocyte traffic through lymph node high endothelial venules.

Both MAdCAM and GlyCAM-1 are major L-selectin ligands produced by these venules and mediate leukocyte rolling, particularly in lymphocytes. They are also expressed in mammary tissue and play an important role in the transfer of immune cells into milk secretions.

The adhesive properties of CD34 and its potential role in homing lymphocytes to lymphoid tissues mimics the mechanims leukocytes adopt to travel to inflammatory sites.

R-HSA-199050 (Reactome) Integrins play a central role in mediating lymphocyte adhesion to a number of surfaces. Integrin alphaLbeta2 (LFA-1) interacts with Intercellular adhesion molecule (ICAM)1-5, which are typically expressed on other immune system cells. ICAM4 and 5 are known to be expressed on telencepahlic neurons. VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4). To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change. Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion.
R-HSA-199062 (Reactome) After interaction with its ligand HLA-E, which is expressed on normal cells, the C-type lectin inhibitory receptor CD94/NKG2A suppresses activation signaling processes. CD94/NKG2A receptors continuously recycle from the cell surface through endosomal compartments and back again in a process that requires energy and the cytoskeleton. This steady state process appears to be largely unaffected by exposure to ligand.
R-HSA-199079 (Reactome) The lectin-like NK cell receptor KLRG1 binds to cadherins on epithelial cells and transmits inhibitory signals to the leukocyte.
R-HSA-199093 (Reactome) JAM members, such as JAML, bind coxsackie and adenovirus receptor (CXADR) on epithelial and endothelial cells.
R-HSA-199112 (Reactome) NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis.

For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions.

Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus.

CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells.

CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets.

R-HSA-199131 (Reactome) NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis.

For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions.

Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus.

CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells.

CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets.

R-HSA-199144 (Reactome) NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis.

For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions.

Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus.

CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells.

CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets.

R-HSA-199154 (Reactome) While not ubiquitously distributed, CD200 is expressed on a wide range of cell types including thymocytes, B-cells, activated T-cells, follicular dendritic cells,

endothelium, CNS neurons in the central nervous system, cells in reproductive organs, keratinocytes and renal glomeruli.

CD200R is a myeloid-inhibitory receptor, despite the absence of classical ITIMs in the cytoplasmic portion of the protein.

Interestingly, CD200 is also expressed on neurons within the CNS and would be predicted to modulate activation of microglia through CD200R.
R-HSA-199161 (Reactome) Most cells of the immune system express receptors for the Fc region of IgG. This heterogeneous family of molecules plays a critical role in immunity, by linking the humoral to the cellular responses. NK cells and B cells have been shown to express exclusively Fc-gamma RIIIa and RIIb respectively.
R-HSA-199169 (Reactome) CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic NK cells. MHC class I molecules bind to CD160 receptors on circulating NK lymphocytes and this triggers their cytotoxic activity and cytokine production. NK cells stimulated by IL-15 secrete soluble CD160 protein that binds to MHC-I molecules, resulting in the inhibition of the cytotoxic CD8+ T lymphocyte activity and of the CD160-mediated NK cell cytotoxicity.
R-HSA-199404 (Reactome) CD40 is a member of the Tumour Necrosis Factor receptor family and its ligand CD40L is a type II transmembrane protein of the TNF superfamily. The latter is expressed preferentially on T-cells and platelets. In the immune system, CD40-CD40L interaction affects some key processes such as immune cell activation, differentiation, proliferation, and apoptosis. CD40-CD40L interaction also upregulates costimulatory molecules (ICAM-1, VCAM-1, E-selectin, LFA-3, B7.1, B7.2, class II MHC, and CD40 itself).
R-HSA-199518 (Reactome) CD19 is a lymphocyte cell surface molecule that functions as a general response regulator or rheostat, which defnes signalling thresholds. These responses are infuenced by signals transduced through a CD19-CD21 cell surface receptor complex, where the binding of complement C3d to CD21 links humoral immune responses with the innate immune system. The CD19-CD21 complex is composed of at least four non-covalently associated proteins: CD19, CD21(complement receptor 2),CD81 and CD225.
R-HSA-199558 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

R-HSA-199566 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

R-HSA-199576 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

R-HSA-199579 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

R-HSA-199583 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

R-HSA-199587 (Reactome) A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual).

There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G.

In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1.

R-HSA-5685600 (Reactome) Natural killer (NK) cells express a multitude of activating and inactivating cell surface receptors through which they recognise tumors and infected cells. Among the activating receptors, the family of Ig-like molecules is termed natural cytotoxicity receptors (NCRs). These NCRs include Natural cytotoxicity triggering receptor 1 (NCR1 also referred as NKp46 or LY94), Natural cytotoxicity triggering receptor 2 (NCR2 also referred as NKp44) and Natural cytotoxicity triggering receptor 3 (NCR3 also referred as NKp30 ) (Hecht et al. 2009). All three NCRs are involved in the elimination of both tumor and virus infected cells. NCRs are coupled to different signal transducing adaptor proteins, including CD3zeta, FCER1G, and KARAP/DAP12.
NCR1 (NKp46) is selectively expressed by all resting and activated human NK cells (Sivori et al. 1997). NCRI recognises and targets the direct killing of virus-infected cells. The antiviral activity is initiated by the interaction of NCR1 with hemagglutinin of influenza virus or Sendai virus (Mandelboim et al. 2001). Biochemical analysis revealed that NCR1 molecules are coupled with associated adaptor proteins CD3z and FCERIG that contain immune tyrosine-based activating motifs (ITAM) (Moretta et al. 2001).
R-HSA-5685602 (Reactome) NCR3 (NKp30) is one of the natural cytotoxicity receptors (NCRs) expressed mainly on the surface of the natural killer (NK) cells. NKp30 is a major receptor targeting virus-infected cells, malignantly transformed cells, and immature dendritic cells. NCR3 (NKp30) recognizes tumor antigens B7H6, a member of the B7 family (Kaifu et al. 2011, Brandt et al. 2009). B7H6 is not expressed normally, and is found on tumor cells, and sensitizes targets to NCR3-dependent cytotoxicity by NK cells.
R-HSA-5685603 (Reactome) The cytoplasmic tails of the SLAM-family receptors contain immunoreceptor tyrosine-based switch motifs (ITSMs). These ITSMs act as docking sites for the SH2 domain of SLAM-associated protein (SAP) and the related Ewing's sarcoma-associated transcript (EAT) 2 (Latour & Veillette 2004, Kageyama et al. 2012). Both SAP and EAT2 are expressed in natural killer (NK) cells, and their combined expression is essential for NK cells to kill abnormal hematopoietic cells. SAP mediates this effect by combining SLAM family receptors to the protein kinase FYN and exchange factor VAV, thereby promoting conjugate formation between NK cells and target cells. While EAT2 mediates its effects in NK cells by linking SLAM family receptors to phospholipase C-gamma, calcium fluxes amd ERK kinase (Perez-Quintero et al. 2014).
R-HSA-5685604 (Reactome) Members of the signaling lymphocytic-activation molecule (SLAM) family, are all encoded in the SLAM locus, and are mostly homotypic self-associating receptors expressed by cells of hemopoietic origin (Veillette et al. 2006). SLAMF6 (also called as NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses (Cao et al. 2006).
R-HSA-5685605 (Reactome) Signaling Lymphocyte Activation Molecule family member F7 (SLAMF7 also called as CS1 or CRACC) is a member of the CD2 family. It is expressed on CD8+ cytotoxic T lymphocytes, activated B cells, NK cells and mature dendritic cells (Boles & Mathew 2001, Bouchon et al. 2001). It has been suggested that CS1 has both activating and inhibitory functions in NK cells. It may activate NK mediated cytotoxicity through an ERK-mediated pathway in a SAP-independent manner (Bouchon et al. 2001). Most of the CD2 members interact homophilically and CS1 is shown to be a self-ligand and that homophilic interaction regulate NK cell cytolytic activity (Kumaresan et al. 2002).
R-HSA-5685606 (Reactome) Natural killer cell surface protein P1A (NKRP1A or KLRB1 or CD161) receptor is a lectin like surface molecule expressed as a type II disulphide-linked homodimer on natural killer (NK) cells and subsets of T cells (Lknair et al. 1994, Mesci et al. 2006). Its expression is upregulated on mature NK cells by interleukin-12 (Poggi et al. 2007). It is thought to be involved in the regulation of NK and NKT cell function. Lectin-like transcript-1 molecule (LLT1) (also referred to as CLEC2D) a member of the KLR (killer cell lectin-like receptor) family has been identified as a ligand for the human NKRP1A (Aldemir et al. 2005, Rosen et al. 2005).
R-HSA-5685607 (Reactome) Sialic acid binding immunoglobulins (Ig)-like lectins (SIGLECs) belong to I-type lectin with a selective expression on the haematopoetic cell lineages. These have amazing structural diversity each recognizing differently linked terminal sialic acid on glycoproteins and glycolipids expressed on host cells as well as pathogen (Powell & Varki 1995, Crocker 2002). Fifteen human SIGLECs have been identified so far. Interaction with various sialylated glycoconjugates, SIGLECs undertake various functions such as internalization of sialylated pathogens, attenuation of inflammation, restraining cellular activation, attenuation of damage-associated molecular pattern-mediated in?ammation along with inhibition of NK cell activation (von Gunten & Bochner 2008, Pillai et al. 2012, Matthew et al. 2014). The sialic acid-binding Ig-like lectins CD33 (SIGLEC3), SIGLEC7 and -9 are inhibitory receptors expressed on human NK cells and subsets of peripheral T cells that recognise sialic acid-containing carbohydrates (Hernández-Caselles et al. 2006, Falco et al. 1999).
R-HSA-5685608 (Reactome) Killer cell lectin-like receptor subfamily F member 1 (KLRF1 also referred as NKp80 or CLEC5C) is a homodimeric C-type lectin receptor (CTLR) expressed virtually on all human NK cells, and a minor subsets of effector memory CD8 alpha/beta T cells and gamma/delta T cells (Vitale et al. 2001). NKp80 binds to the genetically linked receptor C-type lectin domain family 2 member B (CLEC2B also referred as AICL) (Welte et al. 2006). CLEC2B is expressed as a myeloid-specific activating receptor that is upregulated by Toll-like receptor stimulation (Hamann et al. 1997). NKp80-CLEC2B interaction triggers NK cell-mediated cytolysis of malignant myeloid cells. Crosslinking of both NKp80 and CLEC2B was shown to promote an activating cross-talk between NK cells and monocytes in the presence of inflammatory cytokines (Welte et al. 2006, Klimosch et al. 2013).
R-HSA-5686625 (Reactome) Leukocyte-associated Ig-like receptor-1 (LAIR1 or CD305) is a member of the Ig superfamily (IgSF), which is expressed on almost all immune cells, mostly on PBMCs and thymocytes (Meyaard et al. 1997). Collagens are functional ligands for LAIR1 and upon their interaction mediate an inhibitory signal to immune cell activation (Lebbink et al. 2006, Meyaard 2008). An interesting implication of the discovery of LAIR1 as an inhibitory collagen receptor is that tumor cells, known to upregulate collagen expression, may use this interaction to downregulate responses directed against the tumor by various effector cells (Meyaard 2010). Upon cross-linking of the receptor with mAbs, LAIR1 gets phosphorylated on the tyrosine residues in the cytoplasmic ITIMs and recruits SHP1 and SHP2 and C-terminal Src Kinase (Csk) (Verbrugge et al. 2006).
R-HSA-5696356 (Reactome) Osteoclast-associated receptor (OSCAR) is specifically expressed by preosteoclasts and it signals through the ITAM-harboring adaptor protein Fc receptor gamma (FCRG) (Merck et al. 2004). Collagen types (Col)I, II, and III have been described as OSCAR ligands, and this interaction induce costimulatory signaling in receptor activator for NF-kB-dependent osteoclastogenesis (Barrow et al. 2011, Schultz et al. 2015).
Surfactant protein D (SP-D) is a member of the collagenous lectins (collectins), which provide a first line of humoral innate immune defense to pathogens at mucosal surfaces. SP-D is mainly produced by alveolar type II epithelial cells, but is also produced outside of the lung, in the gastrointestinal and genital mucosae, salivary glands, prostate, kidney, pancreas, skin, and endothelial cells (Madsen et al. 2000). Polymorphisms in the SP-D-encoding gene SFTPD have been associated with chronic obstructive pulmonary disease and ulcerative colitis. OSCAR binds with SP-D and is localized in an intracellular compartment of alveolar macrophages.This interaction may trigger TNF-alpha productiion by inflammatory monocytes (Barrow et al. 2015).
R-HSA-5696357 (Reactome) Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2 or CD306) a soluble homolog of LAIR1 protein, also has high affinity for various collagen molecules and this can interfere with collagen-dependent platelet aggregation and adhesion. LAIR-2 may function as a natural competitor for LAIR-1, thereby regulating its inhibitory potential (Lebbink et al. 2008, Lenting et al. 2010).
R-HSA-5696358 (Reactome) The CD300 glycoproteins are a family of related leucocyte surface molecules that modulate a broad and diverse array of immune cell processes via their paired activating and inhibitory receptor functions (Clark et al. 2000, 2001, 2009a,b). Human CD300 family include 7 members and they have a single Ig-V like domain. Only CD300a and CD300f have long cytoplasmic tails with ITIMs (immunoreceptor tyrosine-based inhibitory motif), whereas the rest of the members have a short cytoplasmic tail and a short transmembrane residue and associate with adaptor proteins such as DDNAX associated protein (DAP)12, DAP10, and the Fc receptor gamma (FCRG) (Clark et al 2009a, Borrego 2013). CD300 receptors bind to polar lipids including extracellular ceramide, phosphatidylserine, and phosphatidylethanolamine, that are exposed on the outer leaflet of the plasma membrane of dead and activated cells. The CD300 gene complex has been linked to PSOR2, a susceptibility locus for psoriasis (Speckman et al. 2003, Tomfohrde et al. 1994).
R-HSA-6793275 (Reactome) Other potential NCR3 ligands include human cytomegalovirus (HCMV) tegument protein pp65 (CMVPP65). Interaction between NCR3 and pp65 resulted in NK cell inhibition (Arnon et al.2005).
R-HSA-8850326 (Reactome) T lymphocytes have developed the capacity to recognize as antigens a large variety of molecules including peptides, lipids, and vitamin metabolites (Moody DB et al. 2005; Rossjohn J et al. 2015; de Jong A 2015). Specific recognition of lipids by T-cell receptors (TCR) occurs when these molecules form antigenic complexes using functionally nonpolymorphic CD1 molecules (Beckman EM et al. 1994; De Libero G1 & Mori L 2005; Tatituri RV et al. 2013; Van Rhijn I et al. 2015).

Humans express five functional CD1 isotypes (CD1a-e), with CD1e being the only member that does not directly present antigens to T cells (Calabi F et al. 1989; Balk SP et al. 1989; de la Salle H et al. 2005). CD1a, CD1b, CD1c and CD1d are surface expressed proteins that can be found on the plasma membranes of antigen-presenting cells (APC) (Dougan SK et al. 2007). CD1 ectodomains consist of a heavy chain, which folds into three extracellular domains (alpha1, alpha2 and alpha3) noncovalently associated with beta2-microglobulin (B2M) (Moody DB et al. 2005). Antigen-binding grooves nestle between the alpha1 and alpha2 helices and are mostly lined by hydrophobic residues (Zeng Z et al. 1997). This allows the antigenic lipids to be anchored via their hydrophobic chains, so that polar motifs protrude toward the aqueous milieu (Gadola SD et al. 2002; Zajonc DM et al. 2003, 2005; Batuwangala T et al. 2004; Koch M et al. 2005; Zajonc DM et al. 2005; Scharf L et al. 2010; Garcia-Alles LF et al. 2011). Consequently, polar heads establish stimulatory contacts with TCRs, while variation in the number, length and saturation of alkyl chains may contribute to the binding to varying degrees (Borg NA et al. 2007; Garcia-Alles LF et al. 2011; Li Y et al. 2010; Pierce BG et al. 2014). Each of the four CD1 isoforms that directly present antigens to T cells differ in size of the antigen-binding grooves (Zajonc DM et al. 2005; Gadola SD et al. 2002; Zajonc DM et al. 2003, 2005; Batuwangala T et al. 2004; Koch M et al. 2005; Cheng TY et al. 2006; Borg NA et al. 2007; Scharf L et al. 2010; Garcia-Alles LF et al. 2011), intracellular trafficking patterns (Sugita M et al. 1999; Moody DB & Porcelli SA 2003), lipid ligand repertoire (Im JS et al. 2004; Huang S et al. 2011; Ly D & Moody DB 2014), and tissue distribution of expression (Dougan SK et al. 2007). Together with the observation that multiple CD1 isoforms have been maintained throughout mammalian evolution, this argues that each CD1 isoform plays a non-redundant role in the immune system (Dascher CC 2007; de Jong A 2015).

A large spectrum of self- and foreign lipids associates with members of CD1 family (Mattner J et al. 2005; Kinjo Y et al. 2005; Chang DH et al. 2008; Cohen NR et al. 2009; De Libero G et al. 2009; Zajonc DM & Girardi E 2015; Birkinshaw RW et al. 2015; de Jong A 2015). CD1-bound self-derived lipid antigens, including gangliosides, sulfatide, phosphoglycerolipids and sphingomyelin, can stimulate specialized subsets of T cells though the importance of self-lipid interactions with TCRs can vary (Birkinshaw RW et al. 2015; Borg NA et al. 2007; Luoma AM et al. 2013, 2014; Lepore M et al. 2014; Roy S et al. 2016). The ability of of both alphabeta and gammadelta T cells to recognize self lipid loaded CD1 molecules enables these lymphocytes to sense changes in the lipid composition of cells and tissues as a result of infections, inflammation, or malignancies (Brennan PJ et al. 2011; Chang DH et al. 2008; Cohen NR et al. 2009; Luoma et al. 2014; Lepore M et al. 2014; de Jong A 2014, 2015).

The Reactome event shows self lipid-based molecules that have been reported to function as antigens for CD1-restricted T cells (Shamshiev A et al. 2002; Birkinshaw RW et al. 2015; de Jong A 2015).

R-HSA-8850356 (Reactome) The hallmark of T cell activation is the direct binding of T-cell receptor (TCR) to an antigen that is presented by an antigen-presenting molecule. TCRs are able to recognize as antigens a large variety of molecules including peptides, lipids, and vitamin metabolites (Moody DB et al. 2005; Rossjohn J et al. 2015; de Jong A 2015). While TCR responds to peptides when they are presented by classical major histocompatibility complex (MHC)-encoded class I or II molecules, specific recognition of lipids by TCR occurs when lipid-based antigens form antigenic complexes with CD1 antigen-presenting molecules (Garboczi DN et al. 1996; Beckman EM et al. 1994; De Libero G1 & Mori L 2005; Tatituri RV et al. 2013; Van Rhijn I et al. 2015).

Humans express five functional CD1 isotypes (CD1a-e), with CD1e being the only member that does not directly present antigens to T cells (Calabi F et al. 1989; Balk SP et al. 1989; de la Salle H et al. 2005). CD1a, CD1b, CD1c and CD1d are surface expressed proteins that can be found on the plasma membranes of antigen-presenting cells (APC) (Dougan SK et al. 2007). CD1 ectodomains consist of a heavy chain, which folds into three extracellular domains (alpha1, alpha2 and alpha3) noncovalently associated with beta2-microglobulin (B2M) (Moody DB et al. 2005). Antigen-binding grooves nestle between the alpha1 and alpha2 helices and are mostly lined by hydrophobic residues (Zeng Z et al. 1997). This allows the antigenic lipids to be anchored via their hydrophobic chains, so that polar motifs protrude toward the aqueous milieu (Gadola SD et al. 2002; Zajonc DM et al. 2003, 2005; Batuwangala T et al. 2004; Koch M et al. 2005; Zajonc DM et al. 2005; Scharf L et al. 2010; Garcia-Alles LF et al. 2011). Consequently, polar heads establish stimulatory contacts with TCRs, while variation in the number, length and saturation of alkyl chains may contribute to the binding to varying degrees (Borg NA et al. 2007; Garcia-Alles LF et al. 2011; Li Y et al. 2010; Pei B et al 2012; Pierce BG et al. 2014). Each of the four CD1 isoforms that directly present antigens to T cells differ in size of the antigen-binding grooves (Zajonc DM et al. 2005; Gadola SD et al. 2002; Zajonc DM et al. 2003, 2005; Batuwangala T et al. 2004; Koch M et al. 2005; Cheng TY et al. 2006; Borg NA et al. 2007; Scharf L et al. 2010; Garcia-Alles LF et al. 2011), intracellular trafficking patterns (Sugita M et al. 1999; Moody DB & Porcelli SA 2003), lipid ligand repertoire (Im JS et al. 2004; Huang S et al. 2011; Ly D & Moody DB 2014), and tissue distribution of expression (Dougan SK et al. 2007). Together with the observation that multiple CD1 isoforms have been maintained throughout mammalian evolution, this argues that each CD1 isoform plays a non-redundant role in the immune system (Dascher CC 2007; de Jong A 2015).

T cells recognize both endogenous and exogenous (derived from intracellular microbial pathogens) lipid antigens bound to CD1 molecules (Mattner J et al. 2005; Kinjo Y et al. 2005; Chang DH et al. 2008; Cohen NR et al. 2009; De Libero G et al. 2009; Zajonc DM & Girardi E 2015; Birkinshaw RW et al. 2015; de Jong A 2015). Foreign lipid antigens are extremely diverse chemically and include naturally occurring lipopeptide, glycolipids and phospholipid structures that are distinct from mammalian lipids (Moran A 2009). The best studied lipid antigens of microbial origin are glycolipids derived from the cell envelope of Mycobacteria species (De Libero G et al. 2009). They include CD1b-restricted foreign lipid antigens such as lipoarabinomannan (LAM), lipomannan (LM), phosphatidylinositol mannosides (PIM), mycolic acid, glucose monomycolate (GMM), glycerol monomycolate and diacylated sulpholipids (Sieling PA et al. 1995; Moody DB et al. 2000; Layre E et al. 2009; Gilleron M et al. 2004; Kasmar AG et al. 2011). While most mammalian glycolipids have beta-linked carbohydrates attached to the lipid backbone, bacterial glycolipids typically have alpha-linkage. The structural difference in the linkage may contribute to the highly specific interaction of the TCR with the CD1:lipid antigen complex thus dictating the outcome of the immune response (Scott-Browne JP et al. 2007; Zajonc DM et al. 2005, 2007). In addition, lipopeptides, such as didehydroxymycobactin (DDM), an intermediate in the biosynthesis of the mycobacterial iron scavenger mycobactin siderophores, can be recognized by CD1a-restricted T cells (Moody DB et al. 2004; Zajonc DM et al. 2005). Diacylglycerols, such as the alpha-galactosyldiacylglycerol from the spirochete Borrelia burgdorferi or an alpha-linkage glycosphingolipid (alpha-glucuronosylceramide) found in alpha-proteobacteria can be presented by CD1d to stimulate invariant natural killer T (iNKT) cells (Sriram V et al. 2005; Kinjo Y et al. 2006). The ability of T cells to see lipid antigens bound to CD1 proteins enables these lymphocytes to sense changes in the lipid composition of cells and tissues as a result of infections or inflammation (Mattner J et al. 2005; Kinjo Y et al. 2005; Chang DH et al. 2008; Cohen NR et al. 2009; de Jong A 2015).

The Reactome event shows foreign lipid-based molecules that have been reported to function as antigens for CD1-restricted T cells (Batuwangala T et al. 2004; Roy S et al. 2014; Garcia-Alles LF et al. 2011; Wang J et al. 2010; Sieling PA et al. 1995; Guiard J et al. 2009; Kasmar AG et al. 2011).

SAP,EAT2R-HSA-5685603 (Reactome)
SELLR-HSA-199046 (Reactome)
SIGLEC:sialic acidArrowR-HSA-5685607 (Reactome)
SIGLECR-HSA-5685607 (Reactome)
SLAMF6:SLAMF6:SAP,EAT2ArrowR-HSA-5685603 (Reactome)
SLAMF6:SLAMF6ArrowR-HSA-5685604 (Reactome)
SLAMF6:SLAMF6R-HSA-5685603 (Reactome)
SLAMF6R-HSA-5685604 (Reactome)
SLAMF7:SLAMF7ArrowR-HSA-5685605 (Reactome)
SLAMF7R-HSA-5685605 (Reactome)
Sialic acidR-HSA-5685607 (Reactome)
T-cell receptor complex with CD8R-HSA-198955 (Reactome)
T-cell receptor complexR-HSA-8850326 (Reactome)
T-cell receptor complexR-HSA-8850356 (Reactome)
TCR interacting with

antigen-bearing MHC

Class I		ArrowR-HSA-198955 (Reactome)
TREM, CD300R-HSA-5696358 (Reactome)
TRIM, CD300:lipidsArrowR-HSA-5696358 (Reactome)
VCAM1R-HSA-198941 (Reactome)
integrin alpha4beta1:VCAM1ArrowR-HSA-198941 (Reactome)

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