Toll, IMD, JAK/STAT pathways for immune response to pathogens (Drosophila melanogaster)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none FungiYeastK-Type PGNVirusPromote Ubiquitin BindingUpregulation of Immune GenesToll PathwayVirusUnpaired GenePhosphorylationJAK/STAT PathwayDAP-Type PGN VirusIMD PathwayCleavageEffector GenespshnecgrassSPEProtein TollCLIP-SPMyd88Protein TubeProtein pellinoPellePolyubiquitin (Fragment)TRAF2DifDorsalCactusPhosphateSocsPIASPGRP-LEPGRP-LCimdFaddDreddJNKRelishGNBP3GNBP2GNBP1PGRP-SAPGRP-SDsphinx1sphinx2spheroidespiritspzspz2domeJAKSTATdomeJAKSTATPGRP-LBPGRP-SCTak1Tab2IkkyIkkBPolyubiquitin (Fragment)Polyubiquitin (Fragment)PhosphatePhosphatePhosphateSTATSTATSTATSTATPolyubiquitin (Fragment)Polyubiquitin (Fragment)RelishName: Toll, IMD, JAK/STAT Pathways for Immune Response to PathogensOrganism: Drosophila melanogaster


Description

Yeast, fungi, virus, and lysine-type peptidoglycan (k-type PGN) signal proteins persephone (psh) and GRASS in the Toll Pathway. These proteins signal downstream to sphinx1/2, spheroide, and spirit which leads to activation of Spatzle (spz). Spz binds to Toll which activates death domain-containing molecules (MyD88, Tube, Pelle). Pellino ubiquinates Pelle which allows TRAF to activate DIF which activates Dorsal facilitated by the ubiquitination of cactus. Dorsal translocates to nucleus to upregulate immune genes.

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Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:Curated.pngReview changes for Approved
Image:Featured.pngReview changes for Featured
Image:MissingXref.pngAnnotate nodes

Ontology Terms

 

Bibliography

  1. Severo MS, Sakhon OS, Choy A, Stephens KD, Pedra JH; ''The 'ubiquitous' reality of vector immunology.''; Cell Microbiol, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116931
Approved
Featured
view09:46, 16 May 2021EweitzModified title
92694view18:55, 28 June 2017Mkutmonfix invalid xrefs
92693view18:53, 28 June 2017Mkutmonfix invalid xrefs
90119view00:00, 14 October 2016Khanspersupdated states
90116view23:46, 13 October 2016KhanspersQuick edit to datanode annotation or property
90115view23:31, 13 October 2016KhanspersQuick edit to datanode annotation or property
88527view00:17, 11 August 2016AAR&CoFixed Label
88525view00:15, 11 August 2016AAR&CoFixed Data Nodes
88524view00:13, 11 August 2016AAR&CoPeriodical Save
88520view23:58, 10 August 2016AAR&CoAdded New data Nodes
88518view23:55, 10 August 2016AAR&CoAdded New Data Nodes
88517view23:54, 10 August 2016AAR&CoPeriodical save, work in progress
88514view23:51, 10 August 2016AAR&CoAdded New Data Nodes
88512view23:44, 10 August 2016AAR&CoPeriodical save, work in progress
88509view23:21, 10 August 2016AAR&CoPeriodical save, work in progress
88506view23:13, 10 August 2016AAR&CoFixed Labels
88505view23:07, 10 August 2016AAR&CoOntology Term : 'altered transcription pathway' added !
88502view23:00, 10 August 2016AAR&CoPeriodical save, work in progress
88501view22:59, 10 August 2016AAR&CoFixed Interactions
88499view22:58, 10 August 2016AAR&CoPeriodical Save
88497view22:56, 10 August 2016AAR&CoFixed Interactions
87799view11:20, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87313view21:44, 20 July 2016AAR&CoAdded Interaction
87303view20:11, 20 July 2016AAR&CoModified description
87100view17:15, 18 July 2016AAR&CoFixed Unconnected Lines
87071view13:09, 18 July 2016AAR&CoModified description
86813view10:45, 11 July 2016AAR&CoModified description
86812view10:22, 11 July 2016AAR&CoModified description
86811view10:10, 11 July 2016AAR&CoModified description
86705view09:24, 11 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CLIP-SPGeneProduct322812216 (NCBI Protein)
CactusProteinM9PD95 (Uniprot-TrEMBL)
DifGeneProductFBgn0011274 (Ensembl)
DorsalProteinC7LA93 (Uniprot-TrEMBL) Dorsal Not Specified
DreddGeneProductFBgn0020381 (Ensembl)
FaddGeneProductFBgn0038928 (Ensembl)
GNBP1GeneProductFBgn0040323 (Ensembl)
GNBP2GeneProductFBgn0040322 (Ensembl)
GNBP3GeneProductFBgn0040321 (Ensembl)
IkkBGeneProduct386765870 (NCBI Protein)
IkkyGeneProductIdentifier Not Found
JAKGeneProduct24641273 (NCBI Protein)
JNKProteinP92208 (Uniprot-TrEMBL)
Myd88GeneProductFBgn0033402 (Ensembl)
PGRP-LBGeneProductFBgn0037906 (Ensembl)
PGRP-LCGeneProductFBgn0035976 (Ensembl)
PGRP-LEGeneProductFBgn0030695 (Ensembl)
PGRP-SAGeneProductFBgn0030310 (Ensembl)
PGRP-SCGeneProductFBgn0043576 (Ensembl) PGRP-SC Not Specified
PGRP-SDGeneProductFBgn0035806 (Ensembl)
PIASGeneProduct665399736 (NCBI Protein)
PelleProteinQ05652 (Uniprot-TrEMBL)
PhosphateMetaboliteHMDB01429 (HMDB)
Polyubiquitin (Fragment)ProteinH9BVD2 (Uniprot-TrEMBL)
Protein TollProteinP08953 (Uniprot-TrEMBL)
Protein TubeProteinP22812 (Uniprot-TrEMBL)
Protein pellinoProteinO77237 (Uniprot-TrEMBL)
RelishGeneProduct17137094 (NCBI Protein)
SPEGeneProductFBgn0039102 (Ensembl)
STATGeneProduct1145720 (NCBI Protein)
SocsGeneProductFBgn0030869 (Ensembl) Socs Not Specified
TRAF2GeneProduct4959430 (NCBI Protein)
Tab2GeneProductFBgn0086358 (Ensembl)
Tak1GeneProductFBgn0026323 (Ensembl)
domeGeneProductFBgn0043903 (Ensembl)
grassGeneProductFBgn0039494 (Ensembl)
imdGeneProductFBgn0013983 (Ensembl)
necGeneProductFBgn0002930 (Ensembl)
pshGeneProductFBgn0030926 (Ensembl)
spheroideGeneProductFBgn0030774 (Ensembl)
sphinx1GeneProductFBgn0052383 (Ensembl)
sphinx2GeneProductFBgn0052382 (Ensembl)
spiritGeneProductFBgn0030051 (Ensembl)
spz2GeneProduct442630245 (NCBI Protein)
spzGeneProductFBgn0003495 (Ensembl)

Annotated Interactions

No annotated interactions

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