Canonical and non-canonical Notch signaling (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Tao J, Chen S, Lee B; ''Alteration of Notch signaling in skeletal development and disease.''; Ann N Y Acad Sci, 2010 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	127900 Approved	view	23:15, 10 January 2024	Khanspers	updated representation of Notch intracellular domain and Notch xrefs
	123396	view	06:25, 23 July 2022	Egonw	Made a pathway clickable
	116460	view	10:05, 7 May 2021	Eweitz	Modified title
	110756	view	15:31, 2 June 2020	Egonw	Added missing @Type annotation
	110724	view	14:37, 29 May 2020	Evelo	Fixed unknonw datanodes, we should still look at the fact that NICD is actually a subpeptide
	90027	view	19:36, 8 October 2016	AlexanderPico	Modified description
	89632	view	22:58, 21 September 2016	Khanspers	updating PMID for ref
	89631	view	22:46, 21 September 2016	Khanspers	added label for nucleus and adjusted interactions
	88837	view	14:59, 15 August 2016	AAR&Co	Edited Aesthetics and Added Label
	88378	view	00:44, 2 August 2016	AAR&Co	Ontology Term : 'Notch signaling pathway' added !
	88377	view	00:44, 2 August 2016	AAR&Co	Ontology Term : 'signaling pathway' added !
	88376	view	00:40, 2 August 2016	AAR&Co	Fixed Labels
	88375	view	00:36, 2 August 2016	AAR&Co	Edited Labels
	88372	view	21:34, 1 August 2016	AAR&Co	Modify Datanode
	88371	view	21:33, 1 August 2016	AAR&Co	Periodical save, work in progress
	88370	view	21:25, 1 August 2016	AAR&Co	Modify Datanode
	88368	view	21:14, 1 August 2016	AAR&Co	Modify Datanode
	88215	view	17:59, 31 July 2016	AAR&Co	Modify Datanode
	88214	view	17:53, 31 July 2016	AAR&Co	Modify Datanode
	87102	view	17:20, 18 July 2016	AAR&Co	Fixed Unconnected Lines
	86823	view	23:26, 11 July 2016	AAR&Co	Modified description
	86822	view	23:25, 11 July 2016	AAR&Co	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ADAM10	GeneProduct	ENSG00000137845 (Ensembl)
DLK1	GeneProduct	ENSG00000185559 (Ensembl)
DLK2	GeneProduct	ENSG00000171462 (Ensembl)
DLL1	GeneProduct	ENSG00000198719 (Ensembl)
DLL3	GeneProduct	ENSG00000090932 (Ensembl)
DLL4	GeneProduct	ENSG00000128917 (Ensembl)
DNER	GeneProduct	ENSG00000187957 (Ensembl)
HES1	GeneProduct	ENSG00000114315 (Ensembl)
HEY1	GeneProduct	ENSG00000164683 (Ensembl)
IKKa	GeneProduct	ENSG00000213341 (Ensembl)
JAG1	GeneProduct	ENSG00000101384 (Ensembl)
JAG2	GeneProduct	ENSG00000184916 (Ensembl)
LEF1	GeneProduct	ENSG00000138795 (Ensembl)
MAGP1	GeneProduct	ENSG00000140259 (Ensembl)
MAGP2	GeneProduct	ENSG00000117122 (Ensembl)
MAML1	GeneProduct	ENSG00000161021 (Ensembl)
MAML2	GeneProduct	ENSG00000184384 (Ensembl)
MAML3	GeneProduct	ENSG00000196782 (Ensembl)
NB3	GeneProduct	ENSG00000134115 (Ensembl)
NECD	Protein	IPR000800 (InterPro)
NF-kB pathway	Pathway	hsa04064 (KEGG Pathway)
NICD		IPR000800 (InterPro)
NOTCH1	GeneProduct	ENSG00000148400 (Ensembl)
NOTCH2	GeneProduct	ENSG00000134250 (Ensembl)
NOTCH3	GeneProduct	ENSG00000074181 (Ensembl)
NOTCH4	GeneProduct	ENSG00000204301 (Ensembl)
PSEN1	GeneProduct	ENSG00000080815 (Ensembl)
PSEN2	GeneProduct	ENSG00000143801 (Ensembl)
RBPJ	GeneProduct	ENSG00000168214 (Ensembl)
RRAS	GeneProduct	ENSG00000126458 (Ensembl)

Annotated Interactions

No annotated interactions