Cytokines and inflammatory response (Bos taurus)

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1Plasma CellTcEosTcMacrophageHypothalamus(fever)B CellT-helperClonal expansion of T cellsantibodiesFibroblastsThT-helperHematopoiesisB CellB CellNK cellTCRLymphocyte ActivatedKiller Cells (LAK)MHC IIB CellEndothelial CellsNeutrophilThEos Hematopoietic Stem CellThMast CellTcEosantigenIL4TGFB1CSF1IL5CSF3IL5IL15IL1BIL1AIL6IL1BIL2IL6IL12BTNFIFNGIL12BIL11IL2CSF2CD4TNFPDGFAIL12BIL1AIL4IL10IL3IL1AIL10TNFIL15IFN1@IL3IL6IL10IFN1@GRO1TNFIL15TGFB1IL1BTRBGRO1IL4IL4IL1BIL2IL1BIL13IL2TNFIL6IL1AIL3IL2IL6IL2IFNGIL13IL7TGFB1IL4IL2TRA Inflammatory ResponseTNFIL1AIL10CSF2IL3TNFBOLA-DRAIFNGIL6HLA-DRB1


Description

Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an important part of the immune response, but chronic inappropriate inflammation can lead to destruction of tissues in autoimmune disorders and perhaps neurodegenerative or cardiovascular disease. Secreted cytokine proteins provide signals between immune cells to coordinate the inflammatory response. Sources: BioCarta.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP530(79331) with a 89.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kataoka T; ''Chemical biology of inflammatory cytokine signaling.''; J Antibiot (Tokyo), 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117494view11:03, 21 May 2021EweitzModified title
111165view09:28, 21 July 2020EgonwMade another pathway clickable
86911view08:03, 14 July 2016MkutmonOntology Term : 'inflammatory response pathway' added !
86910view08:03, 14 July 2016MkutmonOntology Term : 'PW:0000029' removed !
80658view15:21, 30 June 2015Mkutmonhomology conversion
70163view00:27, 13 July 2013AlexanderPicoModified title
67132view10:10, 26 June 2013Christine ChichesterOntology Term : 'inflammatory response pathway' added !
63344view22:21, 9 May 2013MaintBotUpdated to 2013 gpml schema
40518view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
38656view12:56, 23 September 2010FerryJagersfixed database @ linked pathway
38649view12:37, 23 September 2010FerryJagersLinked pathway
38648view12:34, 23 September 2010FerryJagersLinked Inflammatory Response Pathway
35251view19:57, 11 February 2010Thomasadded literature
33761view00:03, 9 December 2009MaintBotAutomatic update of empty xrefs
33638view10:06, 1 December 2009MaintBotRemoved group label
31643view22:27, 13 August 2009MaintBotFixed text labels
30566view22:04, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Inflammatory ResponsePathwayWP453 (WikiPathways)
BOLA-DRAGeneProductENSBTAG00000010645 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3122
CD4GeneProductENSBTAG00000003255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:920
CSF1GeneProductENSBTAG00000000283 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1435
CSF2GeneProductENSBTAG00000001570 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1437
CSF3GeneProductENSBTAG00000021462 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1440
GRO1GeneProductENSBTAG00000037558 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2919
HLA-DRB1GeneProductENSBTAG00000038397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3123
IFN1@GeneProduct
IFNGGeneProductENSBTAG00000012529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
IL10GeneProductENSBTAG00000006685 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3586
IL11GeneProductENSBTAG00000047400 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3589
IL12BGeneProductENSBTAG00000004741 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3593
IL13GeneProductENSBTAG00000015953 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3596
IL15GeneProductENSBTAG00000018200 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3600
IL1AGeneProductENSBTAG00000010349 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552
IL1BGeneProductENSBTAG00000001321 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL2GeneProductENSBTAG00000020883 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3558
IL3GeneProduct
IL4GeneProductENSBTAG00000015957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3565
IL5GeneProductENSBTAG00000031235 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3567
IL6GeneProductENSBTAG00000014921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3569
IL6GeneProductENSBTAG00000046456 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3456
IL7GeneProductENSBTAG00000016284 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3574
PDGFAGeneProductENSBTAG00000014541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5154
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
TNFGeneProductENSBTAG00000025471 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
TRAGeneProduct
TRBGeneProduct

Annotated Interactions

No annotated interactions
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