Class I MHC mediated antigen processing and presentation (Homo sapiens)

From WikiPathways

Revision as of 19:18, 18 July 2016 by Mkutmon (Talk | contribs)
Jump to: navigation, search
2, 8, 20, 23, 32...53, 8637, 72, 8214, 81, 855, 13, 80, 83, 1021, 7, 66, 7767, 9522, 26, 4429, 47, 9411, 7317, 22, 264, 27, 50, 56, 74...22, 2616, 35, 38, 49, 75...9, 44, 57, 7014, 63, 81, 853, 10, 39, 43, 51...6, 18, 69, 70, 76...4914, 81, 8528, 68, 8646, 1041, 44, 6621, 41, 42, 50, 5655, 106, 11122, 2624, 91, 1051931, 46, 53, 8730, 88, 10922, 26333, 45, 64, 78, 89...52, 62, 71, 9025, 10046, 5555, 11114, 65, 81, 85early endosomeendoplasmic reticulum membraneER to Golgi transport vesiclecytosolendoplasmic reticulum lumenGolgi lumenclathrin-coated endocytic vesiclephagocytic vesiclephagolysosomeHLA class I histocompatibility antigen, A-29 alpha chain class I MHC B81 class I MHC B18 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B8 class I MHC B57 class I MHC B47 L-Lys HLA class I histocompatibility antigen, A-32 alpha chain L-Arg PSMD3 HLA class I histocompatibility antigen, A-2 alpha chain UBC(229-304) L-Arg AMPRNF126 HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B50 HLA class I histocompatibility antigen, A-26 alpha chain HECTD1 B2M(21-119) UNKL class I MHC B41 UBE2V1 class I MHC B81 HLA class I histocompatibility antigen, Cw-15 alpha chain PSMD6 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA-B KLHL9 UBA3 class I MHC B55 class I MHC B38 HLA class I histocompatibility antigen, A-33 alpha chain B2M(21-119) UBC(457-532) SPSB4 SOCS1 PSMA8 HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B78 UBC(1-76) L-Lys UBE2Z PSMA4 PJA2 B2M(21-119) HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain DET1 TRIP12 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor CDC23 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B53 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain RPS27A(1-76) MIB2 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, A-24 alpha chain TAP1 ASB18 HACE1 HLA class I histocompatibility antigen, A-26 alpha chain UBE2J2 HLA class I histocompatibility antigen, A-34 alpha chain MEX3C Exogenous soluble antigen UBE2A class I MHC B73 HLA class I histocompatibility antigen, A-80 alpha chain MEX3C RNF14 RNF6 RNF115 class I MHC B44 UBC(533-608) HLA class I histocompatibility antigen, Cw-8 alpha chain PSME4 HLA-H class I MHC B57 class I MHC B40 UBE2D3 HLA class I histocompatibility antigen, Cw-14 alpha chain SEC23A RNF34 PSME3 HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B15 MRC2 class I MHC B14 HLA class I histocompatibility antigen, A-31 alpha chain CALR L-Ile class I MHC B37 PSMB3 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-14 alpha chain FBXO44 FBXO31 NEDD4 class I MHC B56 ITCH PSMC1 HLA class I histocompatibility antigen, Cw-16 alpha chain FBXW8 HLA class I histocompatibility antigen, A-2 alpha chain PSMD5 HLA class I histocompatibility antigen, A-29 alpha chain SAR1B L-Asp HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor CUL7 LONRF1 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B35 class I MHC B50 UBE2D3 UNKL HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B18 UBE3B L-Thr class I MHC B47 ADPHLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, A-32 alpha chain L-Asn class I MHC B40 MR/other probablereceptorsclass I MHC B73 L-Trp FBXW7 class I MHC B8 E3:Ub:substrateKEAP1 class I MHC B39 class I MHC B49 class I MHC B67 PSME2 Chaperonescalnexin/BiPHLA class I histocompatibility antigen, A-34 alpha chain MGRN1 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA-H RNF123 SH3RF1 ANAPC1 HLA class I histocompatibility antigen, A-30 alpha chain ASB9 class I MHC B38 TRAIP class I MHC B13 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor UBC(229-304) L-Leu KLHL11 HLA class I histocompatibility antigen, A-34 alpha chain PSMD10 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B40 MRC2 PSMD12 HLA class I histocompatibility antigen, A-2 alpha chain DTX3L class I MHC B57 CUL1 PSMB11 class I MHC B55 UBE2S class I MHC B18 SPSB1 ARIH2 HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA class I histocompatibility antigen, A-23 alpha chain L-Val HLA class I histocompatibility antigen, A-68 alpha chain PJA1 class I MHC B40 SEC31A HLA class I histocompatibility antigen, Cw-15 alpha chain SEC24B UBOX5 ANAPC2 HLA class I histocompatibility antigen, A-69 alpha chain L-Gln HLA class I histocompatibility antigen, A-3 alpha chain precursor ITGAV(31-1048) PSMB8 class I MHC B44 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B45 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain L-Amino Acidsclass I MHC B39 STUB1 FBXL8 class I MHC B18 HLA class I histocompatibility antigen, A-11 alpha chain ZBTB16 MRC2 L-Lys PSME1 class I MHC B40 CDC20 class I MHC B49 HUWE1 class I MHC B14 RNF41 ASB10 SPSB1 class I MHC B41 class I MHC B37 UBA7 RBX1 KEAP1 PiL-Met SAR1B TCEB1 UBE2V1 HERC2 HLA class I histocompatibility antigen, A-25 alpha chain (Glc)1 (GlcNAc)2 (Man)9 UBE2O L-Thr class I MHC B53 HLA class I histocompatibility antigen, Cw-14 alpha chain L-Amino AcidsHLA class I histocompatibility antigen, A-26 alpha chain Antigen peptide class I MHC B40 NEDD4L FCGR class I MHC B39 HLA class I histocompatibility antigen, A-69 alpha chain UBC(153-228) TCEB1 ANAPC1 KLHL9 class I MHC B35 class I MHC B52 ASB13 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B15 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B54 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor CTSS-like proteinsL-Tyr CDC23 class I MHC B13 class I MHC B53 HLA class I histocompatibility antigen, A-1 alpha chain precursor L-Met FBXO31 class I MHC B45 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B35 class I MHC B52 class I MHC B46 class I MHC B78 HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B57 L-Amino Acidsclass I MHC B57 ASB11 HLA class I histocompatibility antigen, E alpha chain precursor SH3RF1 class I MHC B82 H2OSEC24A class I MHC B53 H+HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B42 CUL7 class I MHC B7 ASB14 HLA class I histocompatibility antigen, A-25 alpha chain MIB2 class I MHC B15 class I MHC B51 FBXW11 class I MHC B35 CDC16 HLA-B class I MHC B57 L-Cys HLA class I histocompatibility antigen, Cw-16 alpha chain KLHL11 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B15 L-Asp UBC(305-380) TRIM9 class I MHC B67 class I MHC B18 ZNRF1 FBXL8 class I MHC B50 UBR1 class I MHC B67 class I MHC B78 class I MHC B56 UBC(381-456) HLA class I histocompatibility antigen, A-74 alpha chain PSMD10 class I MHC B44 TRIM50 class I MHC B40 FBXL4 class I MHC B59 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain PSMB7 Mg2+class I MHC B38 DET1 HLA class I histocompatibility antigen, A-25 alpha chain FBXO2 FBXW8 class I MHC B59 UBC(77-152) SEC24A Gly class I MHC B37 SIAH1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B73 HLA class I histocompatibility antigen, A-3 alpha chain precursor class I MHC B50 UBC(609-684) RPS27A(1-76) UBE2C SKP1 GDP class I MHC B55 L-Met HLA class I histocompatibility antigen, B-48 alpha chain PSMD11 HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B47 class I MHC B38 class I MHC B15 ERAP2 HERC5 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor K48polyUb-antigenicsubstrateL-Arg UBE2U HLA class I histocompatibility antigen, Cw-18 alpha chain ASB13 Antigen peptideclass I MHC B50 class I MHC B15 NADPHFBXL8 (Glc)1 (GlcNAc)2 (Man)9 HERC3 UBE2Q1 L-Leu class I MHC B8 SEC23A ASB8 UBE2M class I MHC B35 L-Cys ZNRF2 Antigen peptide class I MHC B39 HLA class I histocompatibility antigen, A-3 alpha chain precursor ASB15 KLHL20 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B52 L-Thr class I MHC B40 class I MHC B49 class I MHC B44 class I MHC B27 HLA class I histocompatibility antigen, B-48 alpha chain HLA-H UBB(1-76) IFN gamma stimulatedaminopeptidasesL-Gln TRIM37 HLA class I histocompatibility antigen, Cw-2 alpha chain (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, A-80 alpha chain ASB14 class I MHC B67 class I MHC B54 TRIM41 CDC34 ZNF645 class I MHC B47 UBC(153-228) HECW2 class I MHC B50 PSMB1 HLA class I histocompatibility antigen, Cw-8 alpha chain PSMB1 FBXO17 L-Phe precursor peptidefragment (>16 aa)HECTD2 class I MHC B15 ASB18 CUL3 UBR4 class I MHC B78 HERC5 UBE3D class I MHC B57 L-Ser L-Leu Ag-substrate:E3:E2:UbHLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B7 PSMB10 class I MHC B46 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B41 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B52 PSME2 class I MHC B44 RPS27A(1-76) HLA-B class I MHC B58 CD207 HLA class I histocompatibility antigen, A-43 alpha chain CALR class I MHC B59 HLA class I histocompatibility antigen, A-80 alpha chain RNF138 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor SAR1B:GDPPSMC3 TRIM36 HLA class I histocompatibility antigen, A-80 alpha chain LRR1 HUWE1 PSMB9 HLA class I histocompatibility antigen, A-68 alpha chain UBE2S HLA-B HLA class I histocompatibility antigen, A-1 alpha chain precursor monoglucosylated MHCclass IHC:Calnexin/BiPHLA class I histocompatibility antigen, A-34 alpha chain UBE2Q1 MRC1 ASB5 class I MHC B78 K48polyUb-antigenic substrate HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ExogenousParticulate antigen(Ag)HLA class I histocompatibility antigen, A-11 alpha chain TPP2 L-Pro class I MHC B42 UBB(77-152) SEC23:SEC24class I MHC B44 ADPFBXO17 FBXO6 class I MHC B13 RBBP6 ASB11 RNF123 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B13 NEDD4L TRIM4 PiHLA class I histocompatibility antigen, Cw-6 alpha chain precursor UBE2N UBE2C L-Val class I MHC B42 HLA class I histocompatibility antigen, A-36 alpha chain SAR1B:GTPHLA class I histocompatibility antigen, A-30 alpha chain class I MHC B55 HLA class I histocompatibility antigen, Cw-18 alpha chain L-Ala ASB6 class I MHC B82 GTP UBE2E3 PSMD1 class I MHC B49 HLA class I histocompatibility antigen, A-29 alpha chain UBE2R2 HLA class I histocompatibility antigen, A-2 alpha chain SAR1B HLA class I histocompatibility antigen, alpha chain G precursor FBXW11 class I MHC B39 UBE2R2 UBE4A class I MHC B58 SKP2 RNF220 HLA class I histocompatibility antigen, E alpha chain precursor L-Leu class I MHC B73 HLA class I histocompatibility antigen, A-31 alpha chain L-Gln TRIM21 ASB17 AREL1 class I MHC B57 HLA class I histocompatibility antigen, Cw-1 alpha chain CDC16 HLA class I histocompatibility antigen, A-2 alpha chain MR:soluble antigenL-Gln UBC(533-608) HLA class I histocompatibility antigen, Cw-5 alpha chain precursor RNF25 HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain HLA-B class I MHC B8 HLA class I histocompatibility antigen, Cw-8 alpha chain class I MHC B54 PSMA3 HLA class I histocompatibility antigen, A-31 alpha chain DZIP3 class I MHC B13 HLA-H HLA class I histocompatibility antigen, A-68 alpha chain RNF144B HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor L-Asp SOCS3 HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B58 HERC2 HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain UBE2V2 SPSB1 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B46 HLA class I histocompatibility antigen, A-43 alpha chain Gly UBE2E2 GTP HLA class I histocompatibility antigen, Cw-1 alpha chain class I MHC B15 LRRC41 UBE2F class I MHC B54 HLA class I histocompatibility antigen, A-2 alpha chain SEC31ARNF41 class I MHC B45 L-Asn ASB16 FBXL4 HLA class I histocompatibility antigen, A-32 alpha chain LNX1 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B51 UBA52(1-76) SKP2 FBXO31 CDC20 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B42 SPSB4 UBE2U class I MHC B38 class I MHC B42 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B42 class I MHC B56 TRIM9 ASB9 WWP1 class I MHC B73 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B37 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain SKP2 class I MHC B67 PSMD4 class I MHC B59 UBE2Q2 RNF19A ZNF645 class I MHC B14 HLA class I histocompatibility antigen, A-36 alpha chain PSME4 PSMB6 B2M(21-119) ZNRF1 ANAPC10 PSMD2 HLA class I histocompatibility antigen, A-33 alpha chain UBE3C TAP2 UBE4A MRC1 ASB15 PSMD4 class I MHC B57 L-Ala class I MHC B37 HLA class I histocompatibility antigen, Cw-15 alpha chain Antigen peptide RNF126 GAN class I MHC B73 class I MHC B52 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain SEC24C HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B41 HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B15 class I MHC B42 SIAH1 UBB(77-152) HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain UBE2N FBXW11 PSMD14 class I MHC B14 class I MHC B41 UBE2D3 PSMD12 class I MHC B47 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HERC3 HLA class I histocompatibility antigen, Cw-8 alpha chain RNF114 FBXO6 WSB1 L-Trp Antigen peptidebound class I MHCSEC61B class I MHC B51 HLA class I histocompatibility antigen, A-68 alpha chain ASB8 SEC61G HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B58 HLA class I histocompatibility antigen, A-23 alpha chain BTBD1 class I MHC B46 HLA class I histocompatibility antigen, A-25 alpha chain PSMD9 UBE2K STUB1 class I MHC B14 class I MHC B67 class I MHC B82 HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B7 PSMD5 L-Phe UBA1 UBB(153-228) PSMD7 HLA-B HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B54 (Glc)1 (GlcNAc)2 (Man)9 HLA-H class I MHC B50 class I MHC B14 HACE1 UBE2L6 HLA class I histocompatibility antigen, Cw-12 alpha chain ASB14 HERC4 PSMA4 (Glc)1 (GlcNAc)2 (Man)9 class I MHC B15 L-Pro UBA52(1-76) RNF14 WWP1 class I MHC B73 class I MHC B46 HLA-H RNF126 TRIM9 HLA-B HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor TransloconUBB(1-76) class I MHC B49 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBE2G1 class I MHC B14 RBBP6 HLA class I histocompatibility antigen, A-66 alpha chain PSMA5 class I MHC B59 class I MHC B53 HLA class I histocompatibility antigen, E alpha chain precursor SIAH2 class I MHC B78 HLA class I histocompatibility antigen, A-24 alpha chain RLIM HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B8 PSMB5 HLA class I histocompatibility antigen, A-29 alpha chain PJA1 UBR4 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B46 HLA-H UBC(457-532) Class I MHC peptideloading complexclass I MHC B39 class I MHC B38 class I MHC B40 UBB(153-228) class I MHC B47 RNF6 HERC1 PSMA5 UBE2J2 class I MHC B57 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B35 L-Phe HLA class I histocompatibility antigen, Cw-3 alpha chain precursor RNF182 TRIM32 class I MHC B51 VPRBP class I MHC B81 class I MHC B41 UBE2E2 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B50 class I MHC B54 UFL1 SH3RF1 class I MHC B52 HLA class I histocompatibility antigen, A-69 alpha chain CD36 ASB3 class I MHC B82 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor B2M(21-119) PSMA7 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor CDC26 LRSAM1 CD207 TRIM41 HLA class I histocompatibility antigen, alpha chain F precursor SMURF2 Antigen peptide HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B47 class I MHC B41 UBR2 O2.-HLA class I histocompatibility antigen, E alpha chain precursor SIAH2 class I MHC B14 KLHL13 SEC23A HLA class I histocompatibility antigen, A-2 alpha chain PSMB10 HLA-H HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, A-3 alpha chain precursor CTSS class I MHC B81 UBC(305-380) HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B8 HLA class I histocompatibility antigen, Cw-18 alpha chain HERC4 MIB2 PSMF1 HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B15 class I MHC B18 UBC(77-152) class I MHC B49 TRIM69 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B44 HLA-B CD207 class I MHC B47 class I MHC B27 class I MHC B54 HERC6 RNF130 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, alpha chain G precursor SEC24C class I MHC B27 GAN KLHL21 class I MHC B7 class I MHC B44 class I MHC B82 ANAPC7 L-Arg ITGB5 class I MHC B41 oligopeptidefragment (8-16aa)UBE2O LNPEP HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B35 MR/other probablereceptorsclass I MHC B7 ATPFZR1 class I MHC B51 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain FBXO17 HLA class I histocompatibility antigen, Cw-17 alpha chain MGRN1 ERAP1 class I MHC B78 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B57 class I MHC B44 HLA class I histocompatibility antigen, A-69 alpha chain SOCS1 UBE3A SMURF1 class I MHC B81 RNF130 class I MHC B54 class I MHC B82 WSB1 ZNRF1 PSMB3 class I MHC B51 FBXO6 HLA class I histocompatibility antigen, A-25 alpha chain UBOX5 SMURF1 HLA class I histocompatibility antigen, A-66 alpha chain (Glc)1 (GlcNAc)2 (Man)9 FBXO2 TRAF7 class I MHC B7 PDIA3SAR1B:GTP:SEC23:SEC24L-Asp class I MHC B39 KLHL21 DET1 HLA class I histocompatibility antigen, Cw-17 alpha chain RNF19B HLA class I histocompatibility antigen, Cw-17 alpha chain PJA1 HLA class I histocompatibility antigen, Cw-14 alpha chain LNPEP HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B55 CDC20 UBE2W ASB1 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, A-23 alpha chain MKRN1 SEC24class I MHC B58 LONRF1 ASB17 class I MHC B82 L-Tyr HLA class I histocompatibility antigen, Cw-15 alpha chain TRIM71 UBC(381-456) HLA-B class I MHC B37 PSMA6 class I MHC B27 PARK2 class I MHC B47 class I MHC B51 HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-1 alpha chain precursor ANAPC13 class I MHC B27 SOCS1 HLA class I histocompatibility antigen, Cw-12 alpha chain Mg2+PSMA1 class I MHC B59 PSMD7 class I MHC B18 L-Pro MKRN1 CUL1 DC receptorsrecognizingapoptotic cellsHLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B42 HLA class I histocompatibility antigen, A-24 alpha chain PSMD11 class I MHC B82 FBXO31 HLA class I histocompatibility antigen, Cw-8 alpha chain KLHL9 class I MHC B27 HLA class I histocompatibility antigen, A-2 alpha chain UBE2G2 class I MHC B45 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B39 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B40 Antigen peptidebound class I MHCUBA7 UBE2G1 class I MHC B42 HERC3 HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B73 class I MHC B44 class I MHC B27 class I MHC B58 class I MHC B8 FBXW7 SAR1B CANX HLA class I histocompatibility antigen, A-74 alpha chain SIAH1 FBXW7 PSMB8 HLA class I histocompatibility antigen, Cw-16 alpha chain ASB6 SEC24B RBCK1 HLA class I histocompatibility antigen, A-3 alpha chain precursor VHL HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain UBC(457-532) class I MHC B14 class I MHC B51 ANAPC5 HLA class I histocompatibility antigen, Cw-1 alpha chain L-Lys class I MHC B18 class I MHC B47 PSMD14 class I MHC B78 class I MHC B13 class I MHC B27 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain KLHL21 PSMB9 CTSL1(114-288) TRAIP ITCH RNF115 HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain UBC(533-608) class I MHC B46 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-14 alpha chain FBXO3 UBR2 UBE3C class I MHC B44 class I MHC B59 ANAPC4 TRIM50 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor TRIP12 RNF41 ExogenousParticulate antigen(Ag)TRAF7 CBLB L-Amino AcidsHLA class I histocompatibility antigen, A-66 alpha chain L-Gln TAP2 class I MHC B58 class I MHC B8 HLA class I histocompatibility antigen, A-66 alpha chain UBE2G2 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor ASB13 WSB1 HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B55 class I MHC B41 PPiHLA class I histocompatibility antigen, Cw-16 alpha chain BTRC UBC(77-152) class I MHC B81 HLA-B KLHL11 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B54 HLA class I histocompatibility antigen, A-74 alpha chain HSPA5 ASB4 HLA-H HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B78 ASB11 ARIH2 HLA class I histocompatibility antigen, A-1 alpha chain precursor CDC23 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B38 class I MHC B53 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B53 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B51 class I MHC B50 ASB17 PSMC2 HLA class I histocompatibility antigen, E alpha chain precursor SEC24B PJA2 class I MHC B13 Exogenous solubleantigenSEC24B PSMA4 class I MHC B78 L-Val HLA class I histocompatibility antigen, Cw-16 alpha chain TRIM32 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B18 oligopeptidefragmentSEC61A2 UBE2J1 class I MHC B35 HLA class I histocompatibility antigen, A-11 alpha chain SEC61A1 class I MHC B54 PSMD1 RNF217 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B40 UBE2D2 Class I MHC:B2Mclass I MHC B46 UbUBE4A HLA-H class I MHC B55 class I MHC B81 RNF14 (Glc)1 (GlcNAc)2 (Man)9 TRIM9 HLA class I histocompatibility antigen, Cw-12 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B47 class I MHC B50 class I MHC B57 class I MHC B50 class I MHC B55 HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B15 HLA class I histocompatibility antigen, Cw-18 alpha chain E1 bound ubiquitinmonoglucosylated MHCclass I HCDZIP3 HLA class I histocompatibility antigen, Cw-8 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor ASB3 ASB5 UBE3C SEC24A class I MHC B45 PSME3 Gly class I MHC B55 STUB1 class I MHC B41 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain UBE2Q2 HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-25 alpha chain NEDD4L HLA class I histocompatibility antigen, A-32 alpha chain UBE2D2 class I MHC B41 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ANAPC5 HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B49 HLA-B UBE2F UBC(533-608) HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain RNF34 ASB16 H2OLNX1 SAR1B class I MHC B59 class I MHC B73 GTP HLA class I histocompatibility antigen, A-1 alpha chain precursor UBE2B TRIM32 Gly class I MHC B8 HLA class I histocompatibility antigen, A-2 alpha chain CYBB HLA class I histocompatibility antigen, A-80 alpha chain UBE2B HLA class I histocompatibility antigen, Cw-7 alpha chain precursor CD207 Antigen peptidebound class I MHCZNRF2 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor SMURF2 class I MHC B39 SKP1 class I MHC B53 class I MHC B81 HLA class I histocompatibility antigen, A-25 alpha chain TRIM63 L-Phe MRC1 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B47 HLA class I histocompatibility antigen, Cw-16 alpha chain PSMC6 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain L-Ile UBC(1-76) HLA class I histocompatibility antigen, Cw-5 alpha chain precursor SEC13HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B14 HECTD1 ASB12 HACE1 HECTD1 UBB(77-152) class I MHC B41 UBR4 RNF130 MEX3C FCGR HLA-B HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B54 LRRC41 Antigen UBE2D2 class I MHC B39 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B81 RNF4 HERC4 class I MHC B56 LNX1 class I MHC B14 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain ASB12 HLA class I histocompatibility antigen, A-30 alpha chain L-Thr HLA class I histocompatibility antigen, A-32 alpha chain class I MHC B82 MHC:B2M peptideloading complexHLA class I histocompatibility antigen, Cw-8 alpha chain KLHL20 RNF6 class I MHC B73 ANAPC13 HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B7 ZNRF2 class I MHC B37 partially digestedAgUBE2Z class I MHC B8 HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B50 class I MHC B58 class I MHC B51 class I MHC B39 CTSL2 HLA class I histocompatibility antigen, A-1 alpha chain precursor RNF123 L-Arg class I MHC B8 class I MHC B39 RNF213 class I MHC B40 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B82 ATPHLA class I histocompatibility antigen, Cw-12 alpha chain SAR1B RCHY1 HLA class I histocompatibility antigen, A-69 alpha chain MEX3C class I MHC B35 class I MHC B38 ANAPC10 ASB2 BTRC SEC31A HLA class I histocompatibility antigen, A-25 alpha chain SOCS3 HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor ASB16 class I MHC B44 ANAPC4 NEDD4L class I MHC B78 ASB1 class I MHC B81 class I MHC B15 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B46 L-Arg HLA class I histocompatibility antigen, Cw-17 alpha chain L-Trp L-Ala HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B78 KLHL13 class I MHC B73 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-11 alpha chain L-His HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B8 class I MHC B56 class I MHC B47 class I MHC B78 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B15 class I MHC B82 PSMD10 SEC23ATAP1 class I MHC B52 HLA-B UBC(609-684) class I MHC B50 RNF144B class I MHC B52 class I MHC B67 class I MHC B8 HSPA5 BAP31 oligomerHLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain UBE2J1 class I MHC B52 UBE2K class I MHC B59 FZR1 RPS27A(1-76) CDC27 UBE2L6 PSMC4 class I MHC B37 class I MHC B49 PSMB1 HLA class I histocompatibility antigen, alpha chain G precursor UBC(457-532) RNF182 class I MHC B46 ITGAV(31-1048) (Glc)1 (GlcNAc)2 (Man)9 class I MHC B40 RNF111 TRIM71 TAPBPTRAIP HLA class I histocompatibility antigen, A-11 alpha chain STUB1 class I MHC B39 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, Cw-18 alpha chain RNF182 HLA class I histocompatibility antigen, Cw-18 alpha chain LRR1 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-69 alpha chain CDC20 HLA class I histocompatibility antigen, A-33 alpha chain ANAPC4 HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-34 alpha chain SEC24D PSMA6 LRR1 E3 ligases inproteasomaldegradationPSMD11 HLA class I histocompatibility antigen, Cw-18 alpha chain COPII vesicle withMHC class IHLA class I histocompatibility antigen, A-29 alpha chain L-His class I MHC B58 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B41 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor RNF19A HLA-H class I MHC B54 class I MHC B40 L-Cys HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, Cw-3 alpha chain precursor TCEB2 class I MHC B18 L-Cys CUL3 SOCS3 HLA class I histocompatibility antigen, A-3 alpha chain precursor L-Cys TAPBPASB6 class I MHC B35 RCHY1 UBE2O HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-15 alpha chain UBE3A CALRclass I MHC B67 UBE2L6 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ATG7 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B82 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain UBA52(1-76) HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B39 PSMB6 HLA class I histocompatibility antigen, Cw-14 alpha chain AMPUBA52(1-76) CYBA class I MHC B81 HLA-B GDPWSB1 (Glc)1 (GlcNAc)2 (Man)9 PSMF1 partially digestedAgHLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor VPRBP class I MHC B8 class I MHC B81 HLA class I histocompatibility antigen, Cw-2 alpha chain class I MHC B81 WWP1 MR:soluble antigenHLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-66 alpha chain UBE2E3 KLHL11 HLA class I histocompatibility antigen, alpha chain F precursor BTBD1 HLA class I histocompatibility antigen, A-43 alpha chain PSMC5 FBXW8 HLA class I histocompatibility antigen, A-11 alpha chain 4xPalmC-CD36 class I MHC B8 class I MHC B7 class I MHC B82 class I MHC B56 class I MHC B49 UBC(229-304) SEC23A class I MHC B15 class I MHC B13 SEC24D RNF6 class I MHC B14 UBC(229-304) L-Asn RNF213 HLA class I histocompatibility antigen, Cw-16 alpha chain UBA6 HLA class I histocompatibility antigen, A-69 alpha chain MR:soluble antigenPSME1 class I MHC B13 MKRN1 MGRN1 class I MHC B67 PSMC1 class I MHC B67 L-Glu class I MHC B67 HLA class I histocompatibility antigen, A-69 alpha chain CBLB class I MHC B53 UBE2K CANX MYLIP UBB(153-228) class I MHC B38 CUL2 ANAPC4 class I MHC B51 MHCclassIHC:Calnexin/BiP:Erp57HLA class I histocompatibility antigen, alpha chain G precursor TAPUBR2 UBE2E3 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain PSMB2 oligopeptidefragment (8-16aa)class I MHC B44 class I MHC B27 HECTD3 class I MHC B40 class I MHC B27 Antigen peptidePSMC1 HLA class I histocompatibility antigen, A-24 alpha chain PSMB3 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor LRR1 Ubiquitin:E2conjugating enzymesASB4 class I MHC B46 HLA class I histocompatibility antigen, A-2 alpha chain UBE2F UBE3C class I MHC B14 HLA class I histocompatibility antigen, A-43 alpha chain ASB4 L-Tyr SEC24A class I MHC B50 HLA class I histocompatibility antigen, Cw-15 alpha chain ZNF645 HLA class I histocompatibility antigen, Cw-1 alpha chain FCGR class I MHC B59 class I MHC B47 PJA1 SEC24A PSMC3 class I MHC B49 ASB18 p-T233-NCF2 HLA class I histocompatibility antigen, A-36 alpha chain TRIM50 RNF130 HLA class I histocompatibility antigen, E alpha chain precursor VPRBP HLA class I histocompatibility antigen, Cw-15 alpha chain Antigen peptide TRIM39 HLA class I histocompatibility antigen, A-34 alpha chain ASB17 class I MHC B55 ZBTB16 class I MHC B47 LTN1 FBXO4 class I MHC B58 FBXO44 UBE2B HLA class I histocompatibility antigen, A-31 alpha chain ATPclass I MHC B38 HLA class I histocompatibility antigen, A-31 alpha chain RLIM HLA class I histocompatibility antigen, A-74 alpha chain UBE2N HUWE1 HLA class I histocompatibility antigen, A-30 alpha chain PSMB11 MKRN1 L-His HLA class I histocompatibility antigen, A-36 alpha chain UBE2G2 class I MHC B73 ITGAV(31-1048) HLA class I histocompatibility antigen, A-29 alpha chain UBE3B HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor SEC31A UBE2J1 RNF19A PJA2 HERC6 class I MHC B78 TCEB1 RNF14 RNF19A SEC24B CDC16 L-Met HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B45 class I MHC B37 class I MHC B40 HLA class I histocompatibility antigen, Cw-2 alpha chain ANAPC5 UNKL HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor ANAPC7 class I MHC B49 class I MHC B51 HLA class I histocompatibility antigen, alpha chain G precursor class I MHC B45 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B41 ATPL-Asn ERAP1/2oligopeptide fragment RNF41 L-Ala HLA class I histocompatibility antigen, A-26 alpha chain TRIM39 HLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor UBC(77-152) ASB1 PSMC6 HLA class I histocompatibility antigen, A-34 alpha chain UBC(305-380) UBE2H SEC24B E2Ubiquitin-conjugating enzymeHLA-H Ag peptide boundclass I MHCHLA class I histocompatibility antigen, A-43 alpha chain PSMD9 RBBP6 class I MHC B39 LTN1 PSMF1 class I MHC B58 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B35 RNF144B class I MHC B53 PSMA3 ASB3 class I MHC B73 BAP31 oligomer ITCH BAP31 oligomer UBE3B HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B49 class I MHC B39 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B8 class I MHC B82 HLA class I histocompatibility antigen, Cw-14 alpha chain VHL HLA class I histocompatibility antigen, Cw-2 alpha chain Exogenous soluble antigen class I MHC B42 HLA class I histocompatibility antigen, A-66 alpha chain TRIM11 HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain L-Trp CDC26 HERC1 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain Exogenous solubleantigenclass I MHC B59 PSMA7 class I MHC B58 class I MHC B55 precursor peptidefragment (>16 aa)MRC2 PSMA8 ANAPC11 class I MHC B13 RNF126 UBB(1-76) HLA class I histocompatibility antigen, A-25 alpha chain class I MHC B41 UBC(153-228) HLA class I histocompatibility antigen, A-25 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain HLA-H HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-26 alpha chain MIB2 FBXO2 KLHL13 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B42 CDC27 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B7 class I MHC B45 class I MHC B14 class I MHC B8 UBC(1-76) SIAH2 HLA class I histocompatibility antigen, A-2 alpha chain L-Gln HECTD2 HLA class I histocompatibility antigen, A-32 alpha chain UBC(153-228) RNF114 TCEB2 TRIM21 ZBTB16 HECTD3 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B73 HLA class I histocompatibility antigen, Cw-8 alpha chain UBR1 HLA class I histocompatibility antigen, A-26 alpha chain VHL UBA7 SAR1B class I MHC B44 oligopeptidefragmentANAPC2 LRSAM1 UBE3D SPSB4 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B15 class I MHC B18 ASB4 26S proteasomeRNF138 HLA class I histocompatibility antigen, A-68 alpha chain TRIM63 UBR4 class I MHC B37 CUL1 HERC2 HLA class I histocompatibility antigen, Cw-16 alpha chain Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IUBB(153-228) class I MHC B37 SOCS3 RNF4 TRIM11 p-T154,S315-NCF4 UBE3A UBA6 HECW2 HLA class I histocompatibility antigen, A-11 alpha chain RNF25 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-12 alpha chain PSMA5 HLA class I histocompatibility antigen, Cw-2 alpha chain L-Leu HLA class I histocompatibility antigen, E alpha chain precursor ASB11 UBE2L3 class I MHC B52 UBC(305-380) HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain UBC(229-304) HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B35 HLA class I histocompatibility antigen, A-80 alpha chain class I MHC B18 antigenic substrate HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B45 HLA class I histocompatibility antigen, Cw-1 alpha chain ANAPC11 SH3RF1 class I MHC B35 class I MHC B57 CALRRBCK1 HLA class I histocompatibility antigen, Cw-18 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor RNF4 FBXL4 class I MHC B82 HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B56 HLA class I histocompatibility antigen, A-11 alpha chain class I MHC B13 RPS27A(1-76) HLA class I histocompatibility antigen, Cw-5 alpha chain precursor TRIM36 B2M(21-119) HLA class I histocompatibility antigen, A-23 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor TRIM69 HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, E alpha chain precursor class I MHC B55 TRIM4 HLA class I histocompatibility antigen, Cw-8 alpha chain FBXO3 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor PSMC4 class I MHC B27 class I MHC B40 CUL2 ATPUBC(153-228) HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B18 CDC27 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B13 HLA class I histocompatibility antigen, A-24 alpha chain class I MHC B39 class I MHC B58 class I MHC B45 MRC2 ANAPC2 UBE2Z KEAP1 ExogenousParticulate antigen(Ag)UBC(609-684) HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, alpha chain G precursor L-Ser class I MHC B39 class I MHC B47 B2M(21-119) L-Asp FBXO27 UBA5 class I MHC B35 class I MHC B46 HLA class I histocompatibility antigen, A-66 alpha chain L-Thr UBC(609-684) ANAPC10 PDIA3 PSMD14 ANAPC7 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-16 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain ITCH ASB7 UBC(381-456) FBXO4 class I MHC B53 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, A-43 alpha chain ASB12 class I MHC B54 UBB(1-76) SEC24C PSMD2 HLA class I histocompatibility antigen, A-69 alpha chain HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain SEC24A L-Lys RNF25 CUL7 UBAC1 class I MHC B7 UBE2H HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-34 alpha chain FBXO6 HLA-B HLA class I histocompatibility antigen, A-74 alpha chain LRRC41 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, Cw-2 alpha chain UBC(1-76) HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, Cw-16 alpha chain class I MHC B56 class I MHC B50 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, A-2 alpha chain RBBP6 class I MHC B67 PSMA2 SIAH1 B2M(21-119) TRIM11 HLA class I histocompatibility antigen, Cw-12 alpha chain PSMB2 MYLIP HLA class I histocompatibility antigen, alpha chain G precursor MRC1 PARK2 PSMD6 HERC5 Antigen peptidebound class IMHC:BAP31 oligomerSMURF2 RNF115 class I MHC B53 SEC24D PSMD9 HLA class I histocompatibility antigen, A-25 alpha chain CBLB HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B47 class I MHC B45 PSMB9 ZBTB16 class I MHC B53 TAP2 PSMD3 class I MHC B67 class I MHC B7 HLA class I histocompatibility antigen, A-11 alpha chain UBE2H class I MHC B59 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor RBX1 class I MHC B53 HLA-H HLA class I histocompatibility antigen, A-66 alpha chain TRIM4 class I MHC B81 AMPCOPIIK48polyUb-partiallydigested AgASB10 class I MHC B54 UBC(457-532) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B56 FBXW8 SKP1 class I MHC B49 LTN1 TRIM63 RNF182 HLA class I histocompatibility antigen, A-36 alpha chain UBC(153-228) class I MHC B44 TRIM37 class I MHC B18 class I MHC B13 ZNRF1 HLA class I histocompatibility antigen, A-33 alpha chain MYLIP 4xPalmC-CD36 L-Tyr CUL2 FBXW11 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor PSMB7 class I MHC B35 class I MHC B54 PSMD8 class I MHC B56 HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B58 HLA class I histocompatibility antigen, Cw-15 alpha chain class I MHC B52 TRIM50 HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B41 class I MHC B73 HLA class I histocompatibility antigen, Cw-12 alpha chain RNF19B ASB1 UBB(77-152) class I MHC B59 HLA class I histocompatibility antigen, Cw-14 alpha chain B2M(21-119) ASB12 UBA7 class I MHC B51 ANAPC2 Antigen peptidebound class I MHCclass I MHC B82 PDIA3 PSMB2 HLA class I histocompatibility antigen, A-11 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B40 class I MHC B55 PSMB5 L-His class I MHC B7 ASB15 HERC3 B2M(21-119) HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, alpha chain F precursor PSMC5 SEC24D NOX2 complexUBA5 TRIM21 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B38 PARK2 class I MHC B78 L-Ser HLA class I histocompatibility antigen, A-74 alpha chain FZR1 UBC(457-532) ASB16 L-Amino AcidsB2M(21-119) BTBD1 HECW2 HLA class I histocompatibility antigen, A-23 alpha chain UBE3D HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, Cw-12 alpha chain ANAPC1 class I MHC B13 ASB9 WWP1 26S proteasomeHLA class I histocompatibility antigen, Cw-3 alpha chain precursor NPEPPS UBB(77-152) HLA class I histocompatibility antigen, E alpha chain precursor UBE3D RBCK1 UBE2E1 FBXO4 class I MHC B57 RCHY1 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain TRIM41 HECTD3 TRIM37 ASB2 FBXO3 FBXW7 LRSAM1 class I MHC B57 RNF144B UBE3B UBE2R2 TRAF7 PPiHLA class I histocompatibility antigen, A-26 alpha chain SEC23A HLA class I histocompatibility antigen, alpha chain F precursor Gly BTRC HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain B2M(21-119) class I MHC B56 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B37 HLA class I histocompatibility antigen, A-3 alpha chain precursor BLMH SMURF1 class I MHC B42 UBC(609-684) class I MHC B56 HLA class I histocompatibility antigen, A-74 alpha chain VPRBP HLA class I histocompatibility antigen, A-1 alpha chain precursor TAPBP RNF25 TRIM36 HLA class I histocompatibility antigen, Cw-1 alpha chain CD207 TAP1 FBXO44 CUL7 class I MHC B42 ASB5 HLA class I histocompatibility antigen, A-23 alpha chain L-Val HLA class I histocompatibility antigen, A-31 alpha chain RBX1 UBE2C class I MHC B78 class I MHC B45 HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B18 class I MHC B13 MRC1 class I MHC B13 HLA class I histocompatibility antigen, A-30 alpha chain HLA-H class I MHC B67 HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B81 HLA class I histocompatibility antigen, A-33 alpha chain PSMA1 class I MHC B14 class I MHC B18 UBE2G1 class I MHC B51 class I MHC B15 UBE2M class I MHC B54 HLA class I histocompatibility antigen, alpha chain F precursor CBLB HLA class I histocompatibility antigen, alpha chain G precursor FBXL8 class I MHC B56 HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B56 class I MHC B81 VHL HLA class I histocompatibility antigen, Cw-18 alpha chain class I MHC B82 HUWE1 UBE2J2 HLA class I histocompatibility antigen, A-43 alpha chain PSME2 FCGRA NEDD4 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B55 FBXO27 HLA class I histocompatibility antigen, A-33 alpha chain class I MHC B42 class I MHC B41 HLA class I histocompatibility antigen, A-29 alpha chain L-Glu L-Met HLA class I histocompatibility antigen, A-34 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B81 class I MHC B42 HLA class I histocompatibility antigen, alpha chain G precursor UBC(1-76) RLIM class I MHC B42 HLA class I histocompatibility antigen, A-32 alpha chain SMURF2 B2M(21-119) class I MHC B51 DET1 L-Asp HLA-H HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain B2M(21-119) HLA class I histocompatibility antigen, Cw-4 alpha chain precursor FZR1 UNKL ASB7 HLA class I histocompatibility antigen, E alpha chain precursor HLA class I histocompatibility antigen, alpha chain G precursor HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B59 UBC(609-684) class I MHC B52 UBE2V2 class I MHC B27 TCEB2 UBC(305-380) HLA class I histocompatibility antigen, A-1 alpha chain precursor LONRF1 TRIM39 class I MHC B38 HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain FBXO27 class I MHC B50 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B55 RNF114 UBA3 KLHL21 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B52 CDC26 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor class I MHC B15 HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor UBE4A L-Pro class I MHC B13 class I MHC B57 BTBD1 ASB10 class I MHC B52 DTX3L HECTD2 class I MHC B35 RNF220 IRAP in complex withMHC class IRNF123 HLA class I histocompatibility antigen, A-69 alpha chain Antigen class I MHC B47 RNF138 TRIP12 precursor peptidefragment (>16 aa)PDIA3PSMB6 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor PSMC6 class I MHC B39 UBC(77-152) HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-74 alpha chain PSMB7 UBR2 ASB10 class I MHC B56 class I MHC B50 class I MHC B38 UBE2E1 L-Tyr class I MHC B38 HLA class I histocompatibility antigen, A-69 alpha chain class I MHC B46 HLA class I histocompatibility antigen, A-74 alpha chain L-Pro CUL5 p-6S-NCF1 UBE2D4 class I MHC B38 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor UBA52(1-76) SPSB2 UFL1 HLA class I histocompatibility antigen, A-23 alpha chain class I MHC B73 HLA class I histocompatibility antigen, Cw-7 alpha chain precursor class I MHC B14 class I MHC B7 PDIA3 NEDD4 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor TRIM41 L-Glu class I MHC B37 class I MHC B53 DTX3L RNF213 Antigen peptide class I MHC B78 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-80 alpha chain RNF115 HLA class I histocompatibility antigen, A-25 alpha chain TRAF7 class I MHC B45 UBC(229-304) HLA class I histocompatibility antigen, Cw-17 alpha chain ASB5 CDC26 HLA-B class I MHC B51 class I MHC B55 UBE2D4 class I MHC B38 UBE2U HLA class I histocompatibility antigen, A-29 alpha chain ASB7 L-His SEC24C class I MHC B67 ASB3 HLA class I histocompatibility antigen, Cw-12 alpha chain PARK2 ANAPC13 UBAC1 COPII vesicle withMHC class IHERC1 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor UBC(381-456) DC receptorsrecognizingapoptotic cellsRNF220 UFL1 UBE2L3 class I MHC B54 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain LONRF1 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor RNF217 HLA class I histocompatibility antigen, A-24 alpha chain LRSAM1 class I MHC B13 PSMC3 CUL5 class I MHC B49 HLA class I histocompatibility antigen, A-68 alpha chain class I MHC B42 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA-C RNF217 class I MHC B45 MYLIP TCEB2 class I MHC B27 UBE3A PSMA1 PSMD12 class I MHC B37 SPSB4 class I MHC B49 HLA class I histocompatibility antigen, A-30 alpha chain PSMD7 PSMC2 class I MHC B54 class I MHC B52 CUL2 L-Val class I MHC B49 ANAPC1 HLA class I histocompatibility antigen, Cw-1 alpha chain UBC(381-456) class I MHC B46 CUL3 HLA class I histocompatibility antigen, A-74 alpha chain TRIM36 PSMC4 UBAC1 class I MHC B27 class I MHC B58 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B52 class I MHC B18 class I MHC B42 RNF4 Ubiquitin activatingE1 enzymesHLA class I histocompatibility antigen, A-26 alpha chain TRIM69 HLA class I histocompatibility antigen, A-23 alpha chain SEC24D HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B40 class I MHC B52 PPiASB2 SEC24D HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain class I MHC B44 HSPA5 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor HLA class I histocompatibility antigen, A-32 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor PSMB8 HLA class I histocompatibility antigen, E alpha chain precursor PSMB5 ANAPC11 PJA2 HLA class I histocompatibility antigen, A-69 alpha chain PSMD4 RNF19B UBA1 class I MHC B14 HLA class I histocompatibility antigen, A-32 alpha chain PSMB10 UBC(77-152) class I MHC B44 class I MHC B56 class I MHC B53 class I MHC B46 ITGB5 class I MHC B38 L-Ile class I MHC B8 HLA class I histocompatibility antigen, A-29 alpha chain L-Glu class I MHC B59 UFL1 UBA7 HLA class I histocompatibility antigen, A-74 alpha chain class I MHC B18 SEC13 PSMD2 HLA class I histocompatibility antigen, A-23 alpha chain L-Thr class I MHC B82 L-His class I MHC B58 HLA-H GTP UBE2S class I MHC B54 AREL1 (Glc)1 (GlcNAc)2 (Man)9 SEC13 Antigen peptidebound class I MHCARIH2 class I MHC B67 PSMD5 UBE2V2 PSMD8 TRAIP HLA class I histocompatibility antigen, Cw-12 alpha chain Gly PSMB11 HECW2 HLA class I histocompatibility antigen, A-68 alpha chain UBOX5 HLA class I histocompatibility antigen, A-25 alpha chain TRIM37 HLA class I histocompatibility antigen, Cw-2 alpha chain HERC5 class I MHC B18 ANAPC11 class I MHC B46 HERC2 L-Cys HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-32 alpha chain PSMA3 class I MHC B46 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain HLA class I histocompatibility antigen, A-31 alpha chain PSMB4 HLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, Cw-8 alpha chain antigenic substrateclass I MHC B67 AREL1 CDC23 FBXO3 class I MHC B56 class I MHC B67 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor UBAC1 class I MHC B27 HLA class I histocompatibility antigen, A-43 alpha chain HLA class I histocompatibility antigen, Cw-14 alpha chain UBB(153-228) UBC(381-456) HLA class I histocompatibility antigen, Cw-6 alpha chain precursor antigenic substrate RBX1 SPSB2 L-Ser class I MHC B27 UBE2W UBE2E1 class I MHC B35 PSMD13 ANAPC10 HLA class I histocompatibility antigen, alpha chain F precursor HLA class I histocompatibility antigen, Cw-8 alpha chain TRIM11 PSMD13 HERC1 TRIM39 class I MHC B27 RLIM HLA class I histocompatibility antigen, A-11 alpha chain TRIM4 L-Ser class I MHC B55 L-Leu HLA-C class I MHC B78 class I MHC B53 MGRN1 HLA class I histocompatibility antigen, A-36 alpha chain SEC24C ITGB5 GTP class I MHC B81 ASB2 HLA class I histocompatibility antigen, Cw-2 alpha chain SEC13 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-3 alpha chain precursor DZIP3 class I MHC B27 UBE2E2 RNF138 HLA class I histocompatibility antigen, A-32 alpha chain UbHLA class I histocompatibility antigen, A-80 alpha chain CUL1 class I MHC B49 UBB(153-228) HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B45 L-Asn PSMB4 HLA class I histocompatibility antigen, A-26 alpha chain UBE2A HLA class I histocompatibility antigen, A-69 alpha chain HERC6 HLA class I histocompatibility antigen, alpha chain F precursor class I MHC B7 UBE2V1 UBE2L3 HLA class I histocompatibility antigen, A-31 alpha chain TRIM71 PSMA7 L-Trp HLA class I histocompatibility antigen, Cw-17 alpha chain O2TRIM69 class I MHC B8 class I MHC B82 L-Pro HLA class I histocompatibility antigen, Cw-17 alpha chain CDC34 SEC24A class I MHC B14 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor class I MHC B53 DTX3L HLA class I histocompatibility antigen, A-34 alpha chain UBC(533-608) HLA class I histocompatibility antigen, A-2 alpha chain HLA class I histocompatibility antigen, Cw-1 alpha chain PSMD13 class I MHC B45 class I MHC B57 HLA class I histocompatibility antigen, A-80 alpha chain KLHL13 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor L-Asn class I MHC B7 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, Cw-7 alpha chain precursor CANX UBE2D1 class I MHC B41 HLA class I histocompatibility antigen, A-80 alpha chain TRIM32 class I MHC B59 class I MHC B47 L-Glu UBE2D1 (Glc)1 (GlcNAc)2 (Man)9 HLA class I histocompatibility antigen, Cw-5 alpha chain precursor RNF19B L-Tyr UBE2Q2 GAN TRIM63 HLA class I histocompatibility antigen, A-23 alpha chain L-Trp UBR1 RBCK1 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor HLA class I histocompatibility antigen, A-29 alpha chain UBE2D1 PSMC2 HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, A-3 alpha chain precursor PSMB4 ARIH2 RNF111 CUL3 CDC16 GTPHLA class I histocompatibility antigen, A-66 alpha chain HLA class I histocompatibility antigen, Cw-17 alpha chain class I MHC B78 ANAPC7 ASB9 UBB(1-76) BTRC HLA class I histocompatibility antigen, A-43 alpha chain class I MHC B52 HACE1 HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-68 alpha chain FBXO27 LNX1 class I MHC B45 FBXO4 class I MHC B7 HLA class I histocompatibility antigen, E alpha chain precursor Antigen peptide HLA class I histocompatibility antigen, A-11 alpha chain SEC24C 26S proteasomePSMA2 Exogenous soluble antigen class I MHC B50 HLA class I histocompatibility antigen, A-11 alpha chain HECTD1 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain PSMA2 ANAPC5 HLA class I histocompatibility antigen, A-66 alpha chain class I MHC B45 HLA class I histocompatibility antigen, A-30 alpha chain ASB8 RPS27A(1-76) SOCS1 RNF213 HLA class I histocompatibility antigen, A-2 alpha chain SPSB1 B2M(21-119)HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-2 alpha chain HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, Cw-18 alpha chain RNF114 PSMA6 UBOX5 class I MHC B53 class I MHC B13 PSMD8 HLA class I histocompatibility antigen, A-29 alpha chain class I MHC B51 SPSB2 class I MHC B56 Particulate Ag:DCreceptorsclass I MHC B42 HLA class I histocompatibility antigen, alpha chain F precursor FBXO2 (Glc)1 (GlcNAc)2 (Man)9 TCEB1 class I MHC B46 class I MHC B59 MHC HC:B2M:Erp57GAN class I MHC B58 HLA class I histocompatibility antigen, A-68 alpha chain HLA-B UBE2W HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, A-33 alpha chain L-Amino AcidsHLA class I histocompatibility antigen, Cw-16 alpha chain SIAH2 RNF34 class I MHC B37 Exogenous solubleantigenHLA class I histocompatibility antigen, A-33 alpha chain HLA class I histocompatibility antigen, Cw-16 alpha chain UBE2Q1 HLA class I histocompatibility antigen, A-29 alpha chain HLA class I histocompatibility antigen, Cw-2 alpha chain Antigen peptidebound class I MHCclass I MHC B14 SPSB2 CDC27 TRIM21 HLA class I histocompatibility antigen, A-80 alpha chain HLA class I histocompatibility antigen, E alpha chain precursor L-Phe HLA class I histocompatibility antigen, Cw-18 alpha chain HLA-H HLA class I histocompatibility antigen, Cw-5 alpha chain precursor HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B7 class I MHC B81 PSMD6 HLA class I histocompatibility antigen, A-31 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor L-Glu RNF34 HLA class I histocompatibility antigen, A-31 alpha chain class I MHC B52 HECTD2 class I MHC B27 HLA class I histocompatibility antigen, A-30 alpha chain HLA class I histocompatibility antigen, alpha chain G precursor NADP+class I MHC B50 PSME3 class I MHC B7 HLA class I histocompatibility antigen, Cw-8 alpha chain RNF217 SEC23A KLHL20 PSMD3 ASB6 UBA52(1-76) FBXL4 HLA class I histocompatibility antigen, A-66 alpha chain FCGRA HLA class I histocompatibility antigen, A-36 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor class I MHC B58 class I MHC B15 class I MHC B37 class I MHC B44 HLA class I histocompatibility antigen, E alpha chain precursor UBE2D4 HLA class I histocompatibility antigen, A-34 alpha chain LTN1 HLA class I histocompatibility antigen, Cw-12 alpha chain class I MHC B51 class I MHC B38 class I MHC B57 UBB(77-152) HLA class I histocompatibility antigen, A-34 alpha chain class I MHC B45 TAPBP Exogenous Particulate antigen (Ag) HLA class I histocompatibility antigen, A-68 alpha chain HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA-H class I MHC B38 CUL5 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor H2OHLA class I histocompatibility antigen, A-32 alpha chain CDC34 ASB8 RCHY1 L-Ile TRIM71 HLA class I histocompatibility antigen, A-24 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain B2M(21-119) HLA class I histocompatibility antigen, A-43 alpha chain ASB13 ZNRF2 ATG7 ASB15 SEC24C HLA class I histocompatibility antigen, A-30 alpha chain class I MHC B37 class I MHC B44 HLA class I histocompatibility antigen, Cw-4 alpha chain precursor HLA class I histocompatibility antigen, Cw-15 alpha chain HLA class I histocompatibility antigen, A-23 alpha chain UBC(533-608) HLA class I histocompatibility antigen, A-66 alpha chain ZNF645 HLA class I histocompatibility antigen, A-68 alpha chain KLHL9 RNF220 class I MHC B57 ASB7 HLA class I histocompatibility antigen, Cw-12 alpha chain PSMA8 Antigen peptide class I MHC B46 ASB14 class I MHC B73 class I MHC B58 SEC24B class I MHC B35 RNF111 class I MHC B7 SKP2 HLA class I histocompatibility antigen, A-80 alpha chain PSMC5 B2M(21-119) FBXO17 class I MHC B59 PSME1 SKP1 PDIA3 HERC4 KEAP1 L-Ile class I MHC B59 L-Ala L-Ile UBE2M HLA class I histocompatibility antigen, A-36 alpha chain L-Ala class I MHC B67 UBB(1-76) HLA class I histocompatibility antigen, A-3 alpha chain precursor L-Met class I MHC B41 HLA class I histocompatibility antigen, Cw-1 alpha chain ANAPC13 RNF111 HLA class I histocompatibility antigen, A-26 alpha chain HLA class I histocompatibility antigen, A-24 alpha chain HECTD3 HLA class I histocompatibility antigen, Cw-6 alpha chain precursor class I MHC B49 NEDD4 HLA class I histocompatibility antigen, A-33 alpha chain HERC6 FBXO44 class I MHC B51 UBR1 SEC24D L-Ser PSMD1 SMURF1 DZIP3 ASB18 L-Val E3:K48-polyubiquitinated substrateclass I MHC B49 UBC(305-380) HLA class I histocompatibility antigen, A-26 alpha chain class I MHC B73 class I MHC B37 AREL1 L-Lys class I MHC B37 HLA class I histocompatibility antigen, Cw-8 alpha chain L-Phe class I MHC B55 CUL5 HLA class I histocompatibility antigen, Cw-3 alpha chain precursor class I MHC B35 UBC(1-76) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor HLA class I histocompatibility antigen, Cw-14 alpha chain class I MHC B56 HLA class I histocompatibility antigen, A-34 alpha chain TAPHLA class I histocompatibility antigen, A-32 alpha chain KLHL20 class I MHC B55 UBE2A PSME4 class I MHC B73 TRIP12 LRRC41 9716969798409612, 34, 36, 54, 58...38106, 1081515961596


Description

Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface. View original pathway at:Reactome.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Rodriguez A, Regnault A, Kleijmeer M, Ricciardi-Castagnoli P, Amigorena S.; ''Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells.''; PubMed Europe PMC Scholia
  2. York IA, Rock KL.; ''Antigen processing and presentation by the class I major histocompatibility complex.''; PubMed Europe PMC Scholia
  3. Howarth M, Williams A, Tolstrup AB, Elliott T.; ''Tapasin enhances MHC class I peptide presentation according to peptide half-life.''; PubMed Europe PMC Scholia
  4. Stephens DJ, Lin-Marq N, Pagano A, Pepperkok R, Paccaud JP.; ''COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites.''; PubMed Europe PMC Scholia
  5. Glick BS, Nakano A.; ''Membrane traffic within the Golgi apparatus.''; PubMed Europe PMC Scholia
  6. Lee I, Schindelin H.; ''Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.''; PubMed Europe PMC Scholia
  7. da Silva Correia J, Ulevitch RJ.; ''MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor.''; PubMed Europe PMC Scholia
  8. Ohmura-Hoshino M, Goto E, Matsuki Y, Aoki M, Mito M, Uematsu M, Hotta H, Ishido S.; ''A novel family of membrane-bound E3 ubiquitin ligases.''; PubMed Europe PMC Scholia
  9. Zhao X, Xu B, Bhattacharjee A, Oldfield CM, Wientjes FB, Feldman GM, Cathcart MK.; ''Protein kinase Cdelta regulates p67phox phosphorylation in human monocytes.''; PubMed Europe PMC Scholia
  10. Ye Y, Rape M.; ''Building ubiquitin chains: E2 enzymes at work.''; PubMed Europe PMC Scholia
  11. Tao N, Wagner SJ, Lublin DM.; ''CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.''; PubMed Europe PMC Scholia
  12. Plafker SM, Plafker KS, Weissman AM, Macara IG.; ''Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import.''; PubMed Europe PMC Scholia
  13. Rock KL, Farfán-Arribas DJ, Shen L.; ''Proteases in MHC class I presentation and cross-presentation.''; PubMed Europe PMC Scholia
  14. Purcell AW, Elliott T.; ''Molecular machinations of the MHC-I peptide loading complex.''; PubMed Europe PMC Scholia
  15. Pfeifer JD, Wick MJ, Roberts RL, Findlay K, Normark SJ, Harding CV.; ''Phagocytic processing of bacterial antigens for class I MHC presentation to T cells.''; PubMed Europe PMC Scholia
  16. Matsuzawa K, Izawa S, Ohkura T, Ohkura H, Ishiguro K, Yoshida A, Takiyama Y, Haneda M, Shigemasa C, Yamamoto K, Taniguchi S.; ''Implication of intracellular localization of transcriptional repressor PLZF in thyroid neoplasms.''; PubMed Europe PMC Scholia
  17. Karim ZA, Zhang J, Banerjee M, Chicka MC, Al Hawas R, Hamilton TR, Roche PA, Whiteheart SW.; ''IκB kinase phosphorylation of SNAP-23 controls platelet secretion.''; PubMed Europe PMC Scholia
  18. Albert ML, Pearce SF, Francisco LM, Sauter B, Roy P, Silverstein RL, Bhardwaj N.; ''Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes.''; PubMed Europe PMC Scholia
  19. Lakadamyali M, Rust MJ, Zhuang X.; ''Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes.''; PubMed Europe PMC Scholia
  20. Garstka M, Borchert B, Al-Balushi M, Praveen PV, Kühl N, Majoul I, Duden R, Springer S.; ''Peptide-receptive major histocompatibility complex class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild-type lymphocytes.''; PubMed Europe PMC Scholia
  21. Tector M, Salter RD.; ''Calnexin influences folding of human class I histocompatibility proteins but not their assembly with beta 2-microglobulin.''; PubMed Europe PMC Scholia
  22. Mitaksov V, Fremont DH.; ''Structural definition of the H-2Kd peptide-binding motif.''; PubMed Europe PMC Scholia
  23. Stoltze L, Schirle M, Schwarz G, Schröter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H.; ''Two new proteases in the MHC class I processing pathway.''; PubMed Europe PMC Scholia
  24. Putilina T, Jaworski C, Gentleman S, McDonald B, Kadiri M, Wong P.; ''Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain.''; PubMed Europe PMC Scholia
  25. Kleijmeer MJ, Escola JM, UytdeHaag FG, Jakobson E, Griffith JM, Osterhaus AD, Stoorvogel W, Melief CJ, Rabouille C, Geuze HJ.; ''Antigen loading of MHC class I molecules in the endocytic tract.''; PubMed Europe PMC Scholia
  26. Cebrian I, Visentin G, Blanchard N, Jouve M, Bobard A, Moita C, Enninga J, Moita LF, Amigorena S, Savina A.; ''Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.''; PubMed Europe PMC Scholia
  27. Kuang Z, Lewis RS, Curtis JM, Zhan Y, Saunders BM, Babon JJ, Kolesnik TB, Low A, Masters SL, Willson TA, Kedzierski L, Yao S, Handman E, Norton RS, Nicholson SE.; ''The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation.''; PubMed Europe PMC Scholia
  28. Wearsch PA, Cresswell P.; ''The quality control of MHC class I peptide loading.''; PubMed Europe PMC Scholia
  29. Kawai T, Akira S.; ''TLR signaling.''; PubMed Europe PMC Scholia
  30. Lee PC, Sowa ME, Gygi SP, Harper JW.; ''Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.''; PubMed Europe PMC Scholia
  31. Simone LC, Wang X, Solheim JC.; ''A transmembrane tail: interaction of tapasin with TAP and the MHC class I molecule.''; PubMed Europe PMC Scholia
  32. Koch J, Tampé R.; ''The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation.''; PubMed Europe PMC Scholia
  33. Spiliotis ET, Manley H, Osorio M, Zúñiga MC, Edidin M.; ''Selective export of MHC class I molecules from the ER after their dissociation from TAP.''; PubMed Europe PMC Scholia
  34. Schulman BA, Harper JW.; ''Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.''; PubMed Europe PMC Scholia
  35. Schölz C, Tampé R.; ''The peptide-loading complex--antigen translocation and MHC class I loading.''; PubMed Europe PMC Scholia
  36. Krappmann D, Hatada EN, Tegethoff S, Li J, Klippel A, Giese K, Baeuerle PA, Scheidereit C.; ''The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.''; PubMed Europe PMC Scholia
  37. Jackson CL.; ''Mechanisms of transport through the Golgi complex.''; PubMed Europe PMC Scholia
  38. Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, Goldberg AL.; ''An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.''; PubMed Europe PMC Scholia
  39. Rock KL, York IA, Goldberg AL.; ''Post-proteasomal antigen processing for major histocompatibility complex class I presentation.''; PubMed Europe PMC Scholia
  40. Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM.; ''TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation.''; PubMed Europe PMC Scholia
  41. Suzuki K, Verma IM.; ''Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation.''; PubMed Europe PMC Scholia
  42. Dong G, Wearsch PA, Peaper DR, Cresswell P, Reinisch KM.; ''Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.''; PubMed Europe PMC Scholia
  43. Watanabe K, Yumimoto K, Nakayama KI.; ''FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1.''; PubMed Europe PMC Scholia
  44. Kim DT, Mitchell DJ, Brockstedt DG, Fong L, Nolan GP, Fathman CG, Engleman EG, Rothbard JB.; ''Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide.''; PubMed Europe PMC Scholia
  45. Vyas JM, Van der Veen AG, Ploegh HL.; ''The known unknowns of antigen processing and presentation.''; PubMed Europe PMC Scholia
  46. Costoya JA, Hobbs RM, Pandolfi PP.; ''Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation.''; PubMed Europe PMC Scholia
  47. Motshwene PG, Moncrieffe MC, Grossmann JG, Kao C, Ayaluru M, Sandercock AM, Robinson CV, Latz E, Gay NJ.; ''An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.''; PubMed Europe PMC Scholia
  48. York IA, Bhutani N, Zendzian S, Goldberg AL, Rock KL.; ''Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.''; PubMed Europe PMC Scholia
  49. Kovacsovics-Bankowski M, Rock KL.; ''A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules.''; PubMed Europe PMC Scholia
  50. Segura E, Albiston AL, Wicks IP, Chai SY, Villadangos JA.; ''Different cross-presentation pathways in steady-state and inflammatory dendritic cells.''; PubMed Europe PMC Scholia
  51. Park Y, Yoon SK, Yoon JB.; ''TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.''; PubMed Europe PMC Scholia
  52. Rodriguez-Boulan E, Müsch A.; ''Protein sorting in the Golgi complex: shifting paradigms.''; PubMed Europe PMC Scholia
  53. Tan MK, Lim HJ, Bennett EJ, Shi Y, Harper JW.; ''Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.''; PubMed Europe PMC Scholia
  54. Hewitt EW, Lehner PJ.; ''The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP.''; PubMed Europe PMC Scholia
  55. Kanaseki T, Blanchard N, Hammer GE, Gonzalez F, Shastri N.; ''ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  56. el Benna J, Faust LP, Babior BM.; ''The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.''; PubMed Europe PMC Scholia
  57. Starostina NG, Simpliciano JM, McGuirk MA, Kipreos ET.; ''CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.''; PubMed Europe PMC Scholia
  58. Saveanu L, Carroll O, Weimershaus M, Guermonprez P, Firat E, Lindo V, Greer F, Davoust J, Kratzer R, Keller SR, Niedermann G, van Endert P.; ''IRAP identifies an endosomal compartment required for MHC class I cross-presentation.''; PubMed Europe PMC Scholia
  59. Amigorena S, Savina A.; ''Intracellular mechanisms of antigen cross presentation in dendritic cells.''; PubMed Europe PMC Scholia
  60. Mantegazza AR, Savina A, Vermeulen M, Pérez L, Geffner J, Hermine O, Rosenzweig SD, Faure F, Amigorena S.; ''NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells.''; PubMed Europe PMC Scholia
  61. Nillegoda NB, Theodoraki MA, Mandal AK, Mayo KJ, Ren HY, Sultana R, Wu K, Johnson J, Cyr DM, Caplan AJ.; ''Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.''; PubMed Europe PMC Scholia
  62. Hammond AT, Glick BS.; ''Dynamics of transitional endoplasmic reticulum sites in vertebrate cells.''; PubMed Europe PMC Scholia
  63. Ding W, Li C, Hu T, Graves-Deal R, Fotia AB, Weissman AM, Coffey RJ.; ''EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.''; PubMed Europe PMC Scholia
  64. Winchester JF, Salsberg JA, Levin NW.; ''Beta-2 microglobulin in ESRD: an in-depth review.''; PubMed Europe PMC Scholia
  65. Basha G, Lizée G, Reinicke AT, Seipp RP, Omilusik KD, Jefferies WA.; ''MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells.''; PubMed Europe PMC Scholia
  66. Voges D, Zwickl P, Baumeister W.; ''The 26S proteasome: a molecular machine designed for controlled proteolysis.''; PubMed Europe PMC Scholia
  67. Rogers LD, Foster LJ.; ''Contributions of proteomics to understanding phagosome maturation.''; PubMed Europe PMC Scholia
  68. Grenfell SJ, Trausch-Azar JS, Handley-Gearhart PM, Ciechanover A, Schwartz AL.; ''Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent.''; PubMed Europe PMC Scholia
  69. Neumann L, Tampé R.; ''Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate binding.''; PubMed Europe PMC Scholia
  70. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
  71. Houde M, Bertholet S, Gagnon E, Brunet S, Goyette G, Laplante A, Princiotta MF, Thibault P, Sacks D, Desjardins M.; ''Phagosomes are competent organelles for antigen cross-presentation.''; PubMed Europe PMC Scholia
  72. Cui J, Zhu L, Xia X, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ, Wang RF.; ''NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.''; PubMed Europe PMC Scholia
  73. Hu Q, Guo C, Li Y, Aronow BJ, Zhang J.; ''LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.''; PubMed Europe PMC Scholia
  74. Huang AY, Bruce AT, Pardoll DM, Levitsky HI.; ''In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter.''; PubMed Europe PMC Scholia
  75. Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C.; ''CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.''; PubMed Europe PMC Scholia
  76. Ladasky JJ, Boyle S, Seth M, Li H, Pentcheva T, Abe F, Steinberg SJ, Edidin M.; ''Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules.''; PubMed Europe PMC Scholia
  77. Ohnishi T, Muroi M, Tanamoto K.; ''N-linked glycosylations at Asn(26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide.''; PubMed Europe PMC Scholia
  78. Kloetzel PM, Ossendorp F.; ''Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.''; PubMed Europe PMC Scholia
  79. Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL.; ''Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.''; PubMed Europe PMC Scholia
  80. Franz J, Jerome J, Lear T, Gong Q, Weathington NM.; ''The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.''; PubMed Europe PMC Scholia
  81. Burgdorf S, Kurts C.; ''Endocytosis mechanisms and the cell biology of antigen presentation.''; PubMed Europe PMC Scholia
  82. Craiu A, Akopian T, Goldberg A, Rock KL.; ''Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide.''; PubMed Europe PMC Scholia
  83. Beninga J, Rock KL, Goldberg AL.; ''Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase.''; PubMed Europe PMC Scholia
  84. Mulherkar SA, Sharma J, Jana NR.; ''The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein.''; PubMed Europe PMC Scholia
  85. Aderem A, Underhill DM.; ''Mechanisms of phagocytosis in macrophages.''; PubMed Europe PMC Scholia
  86. Loureiro J, Ploegh HL.; ''Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.''; PubMed Europe PMC Scholia
  87. Vendeville A, Rayne F, Bonhoure A, Bettache N, Montcourrier P, Beaumelle B.; ''HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses.''; PubMed Europe PMC Scholia
  88. Elliott T, Neefjes J.; ''The complex route to MHC class I-peptide complexes.''; PubMed Europe PMC Scholia
  89. Palmowski MJ, Gileadi U, Salio M, Gallimore A, Millrain M, James E, Addey C, Scott D, Dyson J, Simpson E, Cerundolo V.; ''Role of immunoproteasomes in cross-presentation.''; PubMed Europe PMC Scholia
  90. Neefjes JJ, Momburg F, Hämmerling GJ.; ''Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter.''; PubMed Europe PMC Scholia
  91. Michelle C, Vourc'h P, Mignon L, Andres CR.; ''What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor?''; PubMed Europe PMC Scholia
  92. Fortier JM, Kornbluth J.; ''NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase.''; PubMed Europe PMC Scholia
  93. Hatakeyama S, Nakayama KI.; ''U-box proteins as a new family of ubiquitin ligases.''; PubMed Europe PMC Scholia
  94. Nakano A, Luini A.; ''Passage through the Golgi.''; PubMed Europe PMC Scholia
  95. Ulbrecht M, Couturier A, Martinozzi S, Pla M, Srivastava R, Peterson PA, Weiss EH.; ''Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences.''; PubMed Europe PMC Scholia
  96. van Wijk SJ, Timmers HT.; ''The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins.''; PubMed Europe PMC Scholia
  97. Van Hateren A, James E, Bailey A, Phillips A, Dalchau N, Elliott T.; ''The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding.''; PubMed Europe PMC Scholia
  98. Saper MA, Bjorkman PJ, Wiley DC.; ''Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution.''; PubMed Europe PMC Scholia
  99. Hochman JH, Shimizu Y, DeMars R, Edidin M.; ''Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulin.''; PubMed Europe PMC Scholia
  100. Procko E, Gaudet R.; ''Antigen processing and presentation: TAPping into ABC transporters.''; PubMed Europe PMC Scholia
  101. Ackerman AL, Kyritsis C, Tampé R, Cresswell P.; ''Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells.''; PubMed Europe PMC Scholia
  102. Diedrich G, Bangia N, Pan M, Cresswell P.; ''A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  103. Harris MR, Yu YY, Kindle CS, Hansen TH, Solheim JC.; ''Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I.''; PubMed Europe PMC Scholia
  104. Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J.; ''G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.''; PubMed Europe PMC Scholia
  105. Lührig S, Kolb S, Mellies N, Nolte J.; ''The novel BTB-kelch protein, KBTBD8, is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis.''; PubMed Europe PMC Scholia
  106. Stronge VS, Saito Y, Ihara Y, Williams DB.; ''Relationship between calnexin and BiP in suppressing aggregation and promoting refolding of protein and glycoprotein substrates.''; PubMed Europe PMC Scholia
  107. Bouin AP, Grandvaux N, Vignais PV, Fuchs A.; ''p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process.''; PubMed Europe PMC Scholia
  108. Howe C, Garstka M, Al-Balushi M, Ghanem E, Antoniou AN, Fritzsche S, Jankevicius G, Kontouli N, Schneeweiss C, Williams A, Elliott T, Springer S.; ''Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules.''; PubMed Europe PMC Scholia
  109. Lange S, Perera S, Teh P, Chen J.; ''Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover.''; PubMed Europe PMC Scholia
  110. Lin ML, Zhan Y, Villadangos JA, Lew AM.; ''The cell biology of cross-presentation and the role of dendritic cell subsets.''; PubMed Europe PMC Scholia
  111. Vieira OV, Botelho RJ, Grinstein S.; ''Phagosome maturation: aging gracefully.''; PubMed Europe PMC Scholia
  112. Paulsson KM, Wang P.; ''Quality control of MHC class I maturation.''; PubMed Europe PMC Scholia
  113. Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES.; ''Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate.''; PubMed Europe PMC Scholia
  114. Katayama K, Noguchi K, Sugimoto Y.; ''FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells.''; PubMed Europe PMC Scholia
  115. Kloetzel PM.; ''Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.''; PubMed Europe PMC Scholia
  116. Matyskiela ME, Rodrigo-Brenni MC, Morgan DO.; ''Mechanisms of ubiquitin transfer by the anaphase-promoting complex.''; PubMed Europe PMC Scholia
  117. Grommé M, Uytdehaag FG, Janssen H, Calafat J, van Binnendijk RS, Kenter MJ, Tulp A, Verwoerd D, Neefjes J.; ''Recycling MHC class I molecules and endosomal peptide loading.''; PubMed Europe PMC Scholia
  118. Ramachandra L, Simmons D, Harding CV.; ''MHC molecules and microbial antigen processing in phagosomes.''; PubMed Europe PMC Scholia
  119. Hotton SK, Callis J.; ''Regulation of cullin RING ligases.''; PubMed Europe PMC Scholia
  120. Rothwarf DM, Zandi E, Natoli G, Karin M.; ''IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.''; PubMed Europe PMC Scholia
  121. Kong Q, Zeng W, Wu J, Hu W, Li C, Mao B.; ''RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination.''; PubMed Europe PMC Scholia
  122. Cascio P, Hilton C, Kisselev AF, Rock KL, Goldberg AL.; ''26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.''; PubMed Europe PMC Scholia
  123. Abe F, Van Prooyen N, Ladasky JJ, Edidin M.; ''Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  124. Deshaies RJ, Joazeiro CA.; ''RING domain E3 ubiquitin ligases.''; PubMed Europe PMC Scholia
  125. Kloetzel PM.; ''The proteasome and MHC class I antigen processing.''; PubMed Europe PMC Scholia
  126. Doherty GJ, McMahon HT.; ''Mechanisms of endocytosis.''; PubMed Europe PMC Scholia
  127. York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL, Rock KL.; ''The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.''; PubMed Europe PMC Scholia
  128. Burgdorf S, Lukacs-Kornek V, Kurts C.; ''The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.''; PubMed Europe PMC Scholia
  129. Crotzer VL, Blum JS.; ''Autophagy and its role in MHC-mediated antigen presentation.''; PubMed Europe PMC Scholia
  130. Li ZH, Zhang XH, Li GY.; ''[Study on the fusion expression of FBXO30: a novel member of F-box protein family].''; PubMed Europe PMC Scholia
  131. Antoniou AN, Powis SJ, Elliott T.; ''Assembly and export of MHC class I peptide ligands.''; PubMed Europe PMC Scholia
  132. Jancic C, Savina A, Wasmeier C, Tolmachova T, El-Benna J, Dang PM, Pascolo S, Gougerot-Pocidalo MA, Raposo G, Seabra MC, Amigorena S.; ''Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes.''; PubMed Europe PMC Scholia
  133. Danilczyk UG, Cohen-Doyle MF, Williams DB.; ''Functional relationship between calreticulin, calnexin, and the endoplasmic reticulum luminal domain of calnexin.''; PubMed Europe PMC Scholia
  134. Norbury CC, Chambers BJ, Prescott AR, Ljunggren HG, Watts C.; ''Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells.''; PubMed Europe PMC Scholia
  135. Meroni G, Diez-Roux G.; ''TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases.''; PubMed Europe PMC Scholia
  136. Ware FE, Vassilakos A, Peterson PA, Jackson MR, Lehrman MA, Williams DB.; ''The molecular chaperone calnexin binds Glc1Man9GlcNAc2 oligosaccharide as an initial step in recognizing unfolded glycoproteins.''; PubMed Europe PMC Scholia
  137. D'Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn MP, Dynlacht B, Pagano M.; ''SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.''; PubMed Europe PMC Scholia
  138. Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang YH, Muller S, Scheffner M, Haupt S, Haupt Y.; ''E6AP promotes the degradation of the PML tumor suppressor.''; PubMed Europe PMC Scholia
  139. Tokgöz Z, Bohnsack RN, Haas AL.; ''Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme.''; PubMed Europe PMC Scholia
  140. Ebstein F, Lange N, Urban S, Seifert U, Krüger E, Kloetzel PM.; ''Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.''; PubMed Europe PMC Scholia
  141. Sato K, Nakano A.; ''Mechanisms of COPII vesicle formation and protein sorting.''; PubMed Europe PMC Scholia
  142. Kallijärvi J, Lahtinen U, Hämäläinen R, Lipsanen-Nyman M, Palvimo JJ, Lehesjoki AE.; ''TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117684view12:08, 22 May 2021EweitzModified title
114758view16:24, 25 January 2021ReactomeTeamReactome version 75
113202view11:26, 2 November 2020ReactomeTeamReactome version 74
112427view15:37, 9 October 2020ReactomeTeamReactome version 73
101331view11:21, 1 November 2018ReactomeTeamreactome version 66
100869view20:55, 31 October 2018ReactomeTeamreactome version 65
100410view19:28, 31 October 2018ReactomeTeamreactome version 64
99959view16:13, 31 October 2018ReactomeTeamreactome version 63
99514view14:45, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99156view12:41, 31 October 2018ReactomeTeamreactome version 62
94507view09:31, 14 September 2017Mkutmonreactome version 61
87162view19:18, 18 July 2016MkutmonOntology Term : 'adaptive immune response pathway' added !
87068view11:35, 18 July 2016ReactomeTeamReactome version 56
83467view12:31, 18 November 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(Glc)1 (GlcNAc)2 (Man)9 MetaboliteCHEBI:59080 (ChEBI)
26S proteasomeComplexR-HSA-68819 (Reactome)
4xPalmC-CD36 ProteinP16671 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ANAPC1 ProteinQ9H1A4 (Uniprot-TrEMBL)
ANAPC10 ProteinQ9UM13 (Uniprot-TrEMBL)
ANAPC11 ProteinQ9NYG5 (Uniprot-TrEMBL)
ANAPC13 ProteinQ9BS18 (Uniprot-TrEMBL)
ANAPC2 ProteinQ9UJX6 (Uniprot-TrEMBL)
ANAPC4 ProteinQ9UJX5 (Uniprot-TrEMBL)
ANAPC5 ProteinQ9UJX4 (Uniprot-TrEMBL)
ANAPC7 ProteinQ9UJX3 (Uniprot-TrEMBL)
AREL1 ProteinO15033 (Uniprot-TrEMBL)
ARIH2 ProteinO95376 (Uniprot-TrEMBL)
ASB1 ProteinQ9Y576 (Uniprot-TrEMBL)
ASB10 ProteinQ8WXI3 (Uniprot-TrEMBL)
ASB11 ProteinQ8WXH4 (Uniprot-TrEMBL)
ASB12 ProteinQ8WXK4 (Uniprot-TrEMBL)
ASB13 ProteinQ8WXK3 (Uniprot-TrEMBL)
ASB14 ProteinA6NK59 (Uniprot-TrEMBL)
ASB15 ProteinQ8WXK1 (Uniprot-TrEMBL)
ASB16 ProteinQ96NS5 (Uniprot-TrEMBL)
ASB17 ProteinQ8WXJ9 (Uniprot-TrEMBL)
ASB18 ProteinQ6ZVZ8 (Uniprot-TrEMBL)
ASB2 ProteinQ96Q27 (Uniprot-TrEMBL)
ASB3 ProteinQ9Y575 (Uniprot-TrEMBL)
ASB4 ProteinQ9Y574 (Uniprot-TrEMBL)
ASB5 ProteinQ8WWX0 (Uniprot-TrEMBL)
ASB6 ProteinQ9NWX5 (Uniprot-TrEMBL)
ASB7 ProteinQ9H672 (Uniprot-TrEMBL)
ASB8 ProteinQ9H765 (Uniprot-TrEMBL)
ASB9 ProteinQ96DX5 (Uniprot-TrEMBL)
ATG7 ProteinO95352 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
Ag peptide bound class I MHCComplexR-HSA-1236931 (Reactome)
Ag-substrate:E3:E2:UbComplexR-HSA-983126 (Reactome)
Antigen R-NUL-173548 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		ComplexR-HSA-983132 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-1236934 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-198904 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983114 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983412 (Reactome)
Antigen peptide bound class I MHCComplexR-HSA-983416 (Reactome)
Antigen peptide R-NUL-1236727 (Reactome)
Antigen peptide R-NUL-983033 (Reactome)
Antigen peptide R-NUL-983324 (Reactome)
Antigen peptide R-NUL-983326 (Reactome)
Antigen peptideR-NUL-1236727 (Reactome)
Antigen peptideR-NUL-983033 (Reactome)
B2M(21-119) ProteinP61769 (Uniprot-TrEMBL)
B2M(21-119)ProteinP61769 (Uniprot-TrEMBL)
BAP31 oligomer R-HSA-983323 (Reactome)
BAP31 oligomerR-HSA-983323 (Reactome)
BLMH ProteinQ13867 (Uniprot-TrEMBL)
BTBD1 ProteinQ9H0C5 (Uniprot-TrEMBL)
BTRC ProteinQ9Y297 (Uniprot-TrEMBL)
CALR ProteinP27797 (Uniprot-TrEMBL)
CALRProteinP27797 (Uniprot-TrEMBL)
CANX ProteinP27824 (Uniprot-TrEMBL)
CBLB ProteinQ13191 (Uniprot-TrEMBL)
CD207 ProteinQ9UJ71 (Uniprot-TrEMBL)
CD36 ProteinP16671 (Uniprot-TrEMBL)
CDC16 ProteinQ13042 (Uniprot-TrEMBL)
CDC20 ProteinQ12834 (Uniprot-TrEMBL)
CDC23 ProteinQ9UJX2 (Uniprot-TrEMBL)
CDC26 ProteinQ8NHZ8 (Uniprot-TrEMBL)
CDC27 ProteinP30260 (Uniprot-TrEMBL)
CDC34 ProteinP49427 (Uniprot-TrEMBL)
COPII vesicle with MHC class IComplexR-HSA-983414 (Reactome)
COPII vesicle with MHC class IComplexR-HSA-983418 (Reactome)
COPIIComplexR-HSA-204019 (Reactome)
CTSL1(114-288) ProteinP07711 (Uniprot-TrEMBL)
CTSL2 ProteinO60911 (Uniprot-TrEMBL)
CTSS ProteinP25774 (Uniprot-TrEMBL)
CTSS-like proteinsComplexR-HSA-4127472 (Reactome) This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.
CUL1 ProteinQ13616 (Uniprot-TrEMBL)
CUL2 ProteinQ13617 (Uniprot-TrEMBL)
CUL3 ProteinQ13618 (Uniprot-TrEMBL)
CUL5 ProteinQ93034 (Uniprot-TrEMBL)
CUL7 ProteinQ14999 (Uniprot-TrEMBL)
CYBA ProteinP13498 (Uniprot-TrEMBL)
CYBB ProteinP04839 (Uniprot-TrEMBL)
Chaperones calnexin/BiPComplexR-HSA-983129 (Reactome)
Class I MHC peptide loading complexComplexR-HSA-1236932 (Reactome)
Class I MHC:B2MComplexR-HSA-1236930 (Reactome)
DC receptors

recognizing

apoptotic cells		ComplexR-HSA-1236899 (Reactome)
DC receptors

recognizing

apoptotic cells		ComplexR-HSA-1236904 (Reactome)
DET1 ProteinQ7L5Y6 (Uniprot-TrEMBL)
DTX3L ProteinQ8TDB6 (Uniprot-TrEMBL)
DZIP3 ProteinQ86Y13 (Uniprot-TrEMBL)
E1 bound ubiquitinComplexR-HSA-976164 (Reactome)
E2 Ubiquitin-conjugating enzymeComplexR-HSA-947628 (Reactome)
E3 ligases in

proteasomal

degradation		ComplexR-HSA-976075 (Reactome)
E3:K48-polyubiquitinated substrateComplexR-HSA-983134 (Reactome)
E3:Ub:substrateComplexR-HSA-983131 (Reactome)
ERAP1 ProteinQ9NZ08 (Uniprot-TrEMBL)
ERAP1/2ComplexR-HSA-983125 (Reactome)
ERAP2 ProteinQ6P179 (Uniprot-TrEMBL)
Exogenous

Particulate antigen

(Ag)		R-NUL-1236714 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-NUL-1236716 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-NUL-1236726 (Reactome)
Exogenous Particulate antigen (Ag) R-NUL-1236726 (Reactome)
Exogenous soluble antigenR-NUL-1236715 (Reactome)
Exogenous soluble antigenR-NUL-1236719 (Reactome)
Exogenous soluble antigenR-NUL-1236720 (Reactome)
Exogenous soluble antigen R-NUL-1236720 (Reactome)
Exogenous soluble antigen R-NUL-1236723 (Reactome)
Exogenous soluble antigen R-NUL-1236724 (Reactome)
FBXL4 ProteinQ9UKA2 (Uniprot-TrEMBL)
FBXL8 ProteinQ96CD0 (Uniprot-TrEMBL)
FBXO17 ProteinQ96EF6 (Uniprot-TrEMBL)
FBXO2 ProteinQ9UK22 (Uniprot-TrEMBL)
FBXO27 ProteinQ8NI29 (Uniprot-TrEMBL)
FBXO3 ProteinQ9UK99 (Uniprot-TrEMBL)
FBXO31 ProteinQ5XUX0 (Uniprot-TrEMBL)
FBXO4 ProteinQ9UKT5 (Uniprot-TrEMBL)
FBXO44 ProteinQ9H4M3 (Uniprot-TrEMBL)
FBXO6 ProteinQ9NRD1 (Uniprot-TrEMBL)
FBXW11 ProteinQ9UKB1 (Uniprot-TrEMBL)
FBXW7 ProteinQ969H0 (Uniprot-TrEMBL)
FBXW8 ProteinQ8N3Y1 (Uniprot-TrEMBL)
FCGR R-HSA-1236898 (Reactome)
FCGR R-HSA-1236905 (Reactome)
FCGRA R-HSA-1031694 (Reactome)
FZR1 ProteinQ9UM11 (Uniprot-TrEMBL)
GAN ProteinQ9H2C0 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
Gly MetaboliteCHEBI:15428 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HACE1 ProteinQ8IYU2 (Uniprot-TrEMBL)
HECTD1 ProteinQ9ULT8 (Uniprot-TrEMBL)
HECTD2 ProteinQ5U5R9 (Uniprot-TrEMBL)
HECTD3 ProteinQ5T447 (Uniprot-TrEMBL)
HECW2 ProteinQ9P2P5 (Uniprot-TrEMBL)
HERC1 ProteinQ15751 (Uniprot-TrEMBL)
HERC2 ProteinO95714 (Uniprot-TrEMBL)
HERC3 ProteinQ15034 (Uniprot-TrEMBL)
HERC4 ProteinQ5GLZ8 (Uniprot-TrEMBL)
HERC5 ProteinQ9UII4 (Uniprot-TrEMBL)
HERC6 ProteinQ8IVU3 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-1 alpha chain precursor ProteinP30443 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-11 alpha chain ProteinP13746 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-2 alpha chain ProteinP01892 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-23 alpha chain ProteinP30447 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-24 alpha chain ProteinP05534 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-25 alpha chain ProteinP18462 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-26 alpha chain ProteinP30450 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-29 alpha chain ProteinP30512 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-3 alpha chain precursor ProteinP04439 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-30 alpha chain ProteinP16188 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-31 alpha chain ProteinP16189 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-32 alpha chain ProteinP10314 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-33 alpha chain ProteinP16190 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-34 alpha chain ProteinP30453 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-36 alpha chain ProteinP30455 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-43 alpha chain ProteinP30456 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-66 alpha chain ProteinP30457 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-68 alpha chain ProteinP01891 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-69 alpha chain ProteinP10316 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-74 alpha chain ProteinP30459 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, A-80 alpha chain ProteinQ09160 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, B-48 alpha chain ProteinP30486 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-1 alpha chain ProteinP30499 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-12 alpha chain ProteinP30508 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-14 alpha chain ProteinP30510 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-15 alpha chain ProteinQ07000 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-16 alpha chain ProteinQ29960 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-17 alpha chain ProteinQ95604 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-18 alpha chain ProteinQ29865 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-2 alpha chain ProteinP30501 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-3 alpha chain precursor ProteinP04222 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-4 alpha chain precursor ProteinP30504 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-5 alpha chain precursor ProteinQ9TNN7 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-6 alpha chain precursor ProteinQ29963 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor ProteinP10321 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, Cw-8 alpha chain ProteinP30505 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, E alpha chain precursor ProteinP13747 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain F precursor ProteinP30511 (Uniprot-TrEMBL)
HLA class I histocompatibility antigen, alpha chain G precursor ProteinP17693 (Uniprot-TrEMBL)
HLA-B ProteinP30486 (Uniprot-TrEMBL)
HLA-C ProteinP10321 (Uniprot-TrEMBL)
HLA-H ProteinP01893 (Uniprot-TrEMBL)
HSPA5 ProteinP11021 (Uniprot-TrEMBL)
HUWE1 ProteinQ7Z6Z7 (Uniprot-TrEMBL)
IFN gamma stimulated aminopeptidasesComplexR-HSA-983128 (Reactome)
IRAP in complex with MHC class IComplexR-HSA-1236916 (Reactome)
ITCH ProteinQ96J02 (Uniprot-TrEMBL)
ITGAV(31-1048) ProteinP06756 (Uniprot-TrEMBL)
ITGB5 ProteinP18084 (Uniprot-TrEMBL)
K48polyUb-antigenic substrateR-NUL-983123 (Reactome)
K48polyUb-antigenic substrate R-NUL-983123 (Reactome)
K48polyUb-partially digested AgR-NUL-1236918 (Reactome)
KEAP1 ProteinQ14145 (Uniprot-TrEMBL)
KLHL11 ProteinQ9NVR0 (Uniprot-TrEMBL)
KLHL13 ProteinQ9P2N7 (Uniprot-TrEMBL)
KLHL20 ProteinQ9Y2M5 (Uniprot-TrEMBL)
KLHL21 ProteinQ9UJP4 (Uniprot-TrEMBL)
KLHL9 ProteinQ9P2J3 (Uniprot-TrEMBL)
L-Ala MetaboliteCHEBI:16977 (ChEBI)
L-Amino AcidsComplexR-ALL-1225821 (Reactome)
L-Amino AcidsComplexR-ALL-400144 (Reactome)
L-Amino AcidsComplexR-ALL-983135 (Reactome)
L-Arg MetaboliteCHEBI:16467 (ChEBI)
L-Asn MetaboliteCHEBI:17196 (ChEBI)
L-Asp MetaboliteCHEBI:17053 (ChEBI)
L-Cys MetaboliteCHEBI:17561 (ChEBI)
L-Gln MetaboliteCHEBI:18050 (ChEBI)
L-Glu MetaboliteCHEBI:16015 (ChEBI)
L-His MetaboliteCHEBI:15971 (ChEBI)
L-Ile MetaboliteCHEBI:17191 (ChEBI)
L-Leu MetaboliteCHEBI:15603 (ChEBI)
L-Lys MetaboliteCHEBI:18019 (ChEBI)
L-Met MetaboliteCHEBI:16643 (ChEBI)
L-Phe MetaboliteCHEBI:17295 (ChEBI)
L-Pro MetaboliteCHEBI:17203 (ChEBI)
L-Ser MetaboliteCHEBI:17115 (ChEBI)
L-Thr MetaboliteCHEBI:16857 (ChEBI)
L-Trp MetaboliteCHEBI:16828 (ChEBI)
L-Tyr MetaboliteCHEBI:17895 (ChEBI)
L-Val MetaboliteCHEBI:16414 (ChEBI)
LNPEP ProteinQ9UIQ6 (Uniprot-TrEMBL)
LNX1 ProteinQ8TBB1 (Uniprot-TrEMBL)
LONRF1 ProteinQ17RB8 (Uniprot-TrEMBL)
LRR1 ProteinQ96L50 (Uniprot-TrEMBL)
LRRC41 ProteinQ15345 (Uniprot-TrEMBL)
LRSAM1 ProteinQ6UWE0 (Uniprot-TrEMBL)
LTN1 ProteinO94822 (Uniprot-TrEMBL)
MEX3C ProteinQ5U5Q3 (Uniprot-TrEMBL)
MGRN1 ProteinO60291 (Uniprot-TrEMBL)
MHC

class I

HC:Calnexin/BiP:Erp57		ComplexR-HSA-983119 (Reactome)
MHC HC:B2M:Erp57ComplexR-HSA-983136 (Reactome)
MHC:B2M peptide loading complexComplexR-HSA-983121 (Reactome)
MIB2 ProteinQ96AX9 (Uniprot-TrEMBL)
MKRN1 ProteinQ9UHC7 (Uniprot-TrEMBL)
MR/other probable receptorsComplexR-HSA-1236909 (Reactome)
MR/other probable receptorsComplexR-HSA-1236911 (Reactome)
MR:soluble antigenComplexR-HSA-1236923 (Reactome)
MR:soluble antigenComplexR-HSA-1236926 (Reactome)
MR:soluble antigenComplexR-HSA-1236929 (Reactome)
MRC1 ProteinP22897 (Uniprot-TrEMBL)
MRC2 ProteinQ9UBG0 (Uniprot-TrEMBL)
MYLIP ProteinQ8WY64 (Uniprot-TrEMBL)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NEDD4 ProteinP46934 (Uniprot-TrEMBL)
NEDD4L ProteinQ96PU5 (Uniprot-TrEMBL)
NOX2 complexComplexR-HSA-1996217 (Reactome)
NPEPPS ProteinP55786 (Uniprot-TrEMBL)
O2.-MetaboliteCHEBI:18421 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
PARK2 ProteinO60260 (Uniprot-TrEMBL)
PDIA3 ProteinP30101 (Uniprot-TrEMBL)
PDIA3ProteinP30101 (Uniprot-TrEMBL)
PJA1 ProteinQ8NG27 (Uniprot-TrEMBL)
PJA2 ProteinO43164 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7 ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1 ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6 ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4 ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6 ProteinQ15008 (Uniprot-TrEMBL)
PSMD7 ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1 ProteinQ92530 (Uniprot-TrEMBL)
Particulate Ag:DC receptorsComplexR-HSA-1236920 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RBBP6 ProteinQ7Z6E9 (Uniprot-TrEMBL)
RBCK1 ProteinQ9BYM8 (Uniprot-TrEMBL)
RBX1 ProteinP62877 (Uniprot-TrEMBL)
RCHY1 ProteinQ96PM5 (Uniprot-TrEMBL)
RLIM ProteinQ9NVW2 (Uniprot-TrEMBL)
RNF111 ProteinQ6ZNA4 (Uniprot-TrEMBL)
RNF114 ProteinQ9Y508 (Uniprot-TrEMBL)
RNF115 ProteinQ9Y4L5 (Uniprot-TrEMBL)
RNF123 ProteinQ5XPI4 (Uniprot-TrEMBL)
RNF126 ProteinQ9BV68 (Uniprot-TrEMBL)
RNF130 ProteinQ86XS8 (Uniprot-TrEMBL)
RNF138 ProteinQ8WVD3 (Uniprot-TrEMBL)
RNF14 ProteinQ9UBS8 (Uniprot-TrEMBL)
RNF144B ProteinQ7Z419 (Uniprot-TrEMBL)
RNF182 ProteinQ8N6D2 (Uniprot-TrEMBL)
RNF19A ProteinQ9NV58 (Uniprot-TrEMBL)
RNF19B ProteinQ6ZMZ0 (Uniprot-TrEMBL)
RNF213 ProteinQ63HN8 (Uniprot-TrEMBL)
RNF217 ProteinQ8TC41 (Uniprot-TrEMBL)
RNF220 ProteinQ5VTB9 (Uniprot-TrEMBL)
RNF25 ProteinQ96BH1 (Uniprot-TrEMBL)
RNF34 ProteinQ969K3 (Uniprot-TrEMBL)
RNF4 ProteinP78317 (Uniprot-TrEMBL)
RNF41 ProteinQ9H4P4 (Uniprot-TrEMBL)
RNF6 ProteinQ9Y252 (Uniprot-TrEMBL)
RPS27A(1-76) ProteinP62979 (Uniprot-TrEMBL)
SAR1B ProteinQ9Y6B6 (Uniprot-TrEMBL)
SAR1B:GDPComplexR-HSA-203989 (Reactome)
SAR1B:GTP:SEC23:SEC24ComplexR-HSA-203997 (Reactome)
SAR1B:GTPComplexR-HSA-204003 (Reactome)
SEC13 ProteinP55735 (Uniprot-TrEMBL)
SEC13ProteinP55735 (Uniprot-TrEMBL)
SEC23:SEC24ComplexR-HSA-203975 (Reactome)
SEC23A ProteinQ15436 (Uniprot-TrEMBL)
SEC23AProteinQ15436 (Uniprot-TrEMBL)
SEC24A ProteinO95486 (Uniprot-TrEMBL)
SEC24B ProteinO95487 (Uniprot-TrEMBL)
SEC24C ProteinP53992 (Uniprot-TrEMBL)
SEC24D ProteinO94855 (Uniprot-TrEMBL)
SEC24ComplexR-HSA-203991 (Reactome)
SEC31A ProteinO94979 (Uniprot-TrEMBL)
SEC31AProteinO94979 (Uniprot-TrEMBL)
SEC61A1 ProteinP61619 (Uniprot-TrEMBL)
SEC61A2 ProteinQ9H9S3 (Uniprot-TrEMBL)
SEC61B ProteinP60468 (Uniprot-TrEMBL)
SEC61G ProteinP60059 (Uniprot-TrEMBL)
SH3RF1 ProteinQ7Z6J0 (Uniprot-TrEMBL)
SIAH1 ProteinQ8IUQ4 (Uniprot-TrEMBL)
SIAH2 ProteinO43255 (Uniprot-TrEMBL)
SKP1 ProteinP63208 (Uniprot-TrEMBL)
SKP2 ProteinQ13309 (Uniprot-TrEMBL)
SMURF1 ProteinQ9HCE7 (Uniprot-TrEMBL)
SMURF2 ProteinQ9HAU4 (Uniprot-TrEMBL)
SOCS1 ProteinO15524 (Uniprot-TrEMBL)
SOCS3 ProteinO14543 (Uniprot-TrEMBL)
SPSB1 ProteinQ96BD6 (Uniprot-TrEMBL)
SPSB2 ProteinQ99619 (Uniprot-TrEMBL)
SPSB4 ProteinQ96A44 (Uniprot-TrEMBL)
STUB1 ProteinQ9UNE7 (Uniprot-TrEMBL)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IComplexR-HSA-983413 (Reactome)
TAP1 ProteinQ03518 (Uniprot-TrEMBL)
TAP2 ProteinQ03519 (Uniprot-TrEMBL)
TAPBP ProteinO15533 (Uniprot-TrEMBL)
TAPBPProteinO15533 (Uniprot-TrEMBL)
TAPComplexR-HSA-1236915 (Reactome)
TAPComplexR-HSA-983113 (Reactome)
TCEB1 ProteinQ15369 (Uniprot-TrEMBL)
TCEB2 ProteinQ15370 (Uniprot-TrEMBL)
TPP2 ProteinP29144 (Uniprot-TrEMBL)
TRAF7 ProteinQ6Q0C0 (Uniprot-TrEMBL)
TRAIP ProteinQ9BWF2 (Uniprot-TrEMBL)
TRIM11 ProteinQ96F44 (Uniprot-TrEMBL)
TRIM21 ProteinP19474 (Uniprot-TrEMBL)
TRIM32 ProteinQ13049 (Uniprot-TrEMBL)
TRIM36 ProteinQ9NQ86 (Uniprot-TrEMBL)
TRIM37 ProteinO94972 (Uniprot-TrEMBL)
TRIM39 ProteinQ9HCM9 (Uniprot-TrEMBL)
TRIM4 ProteinQ9C037 (Uniprot-TrEMBL)
TRIM41 ProteinQ8WV44 (Uniprot-TrEMBL)
TRIM50 ProteinQ86XT4 (Uniprot-TrEMBL)
TRIM63 ProteinQ969Q1 (Uniprot-TrEMBL)
TRIM69 ProteinQ86WT6 (Uniprot-TrEMBL)
TRIM71 ProteinQ2Q1W2 (Uniprot-TrEMBL)
TRIM9 ProteinQ9C026 (Uniprot-TrEMBL)
TRIP12 ProteinQ14669 (Uniprot-TrEMBL)
TransloconComplexR-HSA-1236927 (Reactome)
UBA1 ProteinP22314 (Uniprot-TrEMBL)
UBA3 ProteinQ8TBC4 (Uniprot-TrEMBL)
UBA5 ProteinQ9GZZ9 (Uniprot-TrEMBL)
UBA52(1-76) ProteinP62987 (Uniprot-TrEMBL)
UBA6 ProteinA0AVT1 (Uniprot-TrEMBL)
UBA7 ProteinP41226 (Uniprot-TrEMBL)
UBAC1 ProteinQ9BSL1 (Uniprot-TrEMBL)
UBB(1-76) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(153-228) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(77-152) ProteinP0CG47 (Uniprot-TrEMBL)
UBC(1-76) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(153-228) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(229-304) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(305-380) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(381-456) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(457-532) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(533-608) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(609-684) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(77-152) ProteinP0CG48 (Uniprot-TrEMBL)
UBE2A ProteinP49459 (Uniprot-TrEMBL)
UBE2B ProteinP63146 (Uniprot-TrEMBL)
UBE2C ProteinO00762 (Uniprot-TrEMBL)
UBE2D1 ProteinP51668 (Uniprot-TrEMBL)
UBE2D2 ProteinP62837 (Uniprot-TrEMBL)
UBE2D3 ProteinP61077 (Uniprot-TrEMBL)
UBE2D4 ProteinQ9Y2X8 (Uniprot-TrEMBL)
UBE2E1 ProteinP51965 (Uniprot-TrEMBL)
UBE2E2 ProteinQ96LR5 (Uniprot-TrEMBL)
UBE2E3 ProteinQ969T4 (Uniprot-TrEMBL)
UBE2F ProteinQ969M7 (Uniprot-TrEMBL)
UBE2G1 ProteinP62253 (Uniprot-TrEMBL)
UBE2G2 ProteinP60604 (Uniprot-TrEMBL)
UBE2H ProteinP62256 (Uniprot-TrEMBL)
UBE2J1 ProteinQ9Y385 (Uniprot-TrEMBL)
UBE2J2 ProteinQ8N2K1 (Uniprot-TrEMBL)
UBE2K ProteinP61086 (Uniprot-TrEMBL)
UBE2L3 ProteinP68036 (Uniprot-TrEMBL)
UBE2L6 ProteinO14933 (Uniprot-TrEMBL)
UBE2M ProteinP61081 (Uniprot-TrEMBL)
UBE2N ProteinP61088 (Uniprot-TrEMBL)
UBE2O ProteinQ9C0C9 (Uniprot-TrEMBL)
UBE2Q1 ProteinQ7Z7E8 (Uniprot-TrEMBL)
UBE2Q2 ProteinQ8WVN8 (Uniprot-TrEMBL)
UBE2R2 ProteinQ712K3 (Uniprot-TrEMBL)
UBE2S ProteinQ16763 (Uniprot-TrEMBL)
UBE2U ProteinQ5VVX9 (Uniprot-TrEMBL)
UBE2V1 ProteinQ13404 (Uniprot-TrEMBL)
UBE2V2 ProteinQ15819 (Uniprot-TrEMBL)
UBE2W ProteinQ96B02 (Uniprot-TrEMBL)
UBE2Z ProteinQ9H832 (Uniprot-TrEMBL)
UBE3A ProteinQ05086 (Uniprot-TrEMBL)
UBE3B ProteinQ7Z3V4 (Uniprot-TrEMBL)
UBE3C ProteinQ15386 (Uniprot-TrEMBL)
UBE3D ProteinQ7Z6J8 (Uniprot-TrEMBL)
UBE4A ProteinQ14139 (Uniprot-TrEMBL)
UBOX5 ProteinO94941 (Uniprot-TrEMBL)
UBR1 ProteinQ8IWV7 (Uniprot-TrEMBL)
UBR2 ProteinQ8IWV8 (Uniprot-TrEMBL)
UBR4 ProteinQ5T4S7 (Uniprot-TrEMBL)
UFL1 ProteinO94874 (Uniprot-TrEMBL)
UNKL ProteinQ9H9P5 (Uniprot-TrEMBL)
UbComplexR-HSA-113595 (Reactome)
Ubiquitin activating E1 enzymesComplexR-HSA-947695 (Reactome)
Ubiquitin:E2 conjugating enzymesComplexR-HSA-976165 (Reactome)
VHL ProteinP40337 (Uniprot-TrEMBL)
VPRBP ProteinQ9Y4B6 (Uniprot-TrEMBL)
WSB1 ProteinQ9Y6I7 (Uniprot-TrEMBL)
WWP1 ProteinQ9H0M0 (Uniprot-TrEMBL)
ZBTB16 ProteinQ05516 (Uniprot-TrEMBL)
ZNF645 ProteinQ8N7E2 (Uniprot-TrEMBL)
ZNRF1 ProteinQ8ND25 (Uniprot-TrEMBL)
ZNRF2 ProteinQ8NHG8 (Uniprot-TrEMBL)
antigenic substrate R-NUL-983035 (Reactome)
antigenic substrateR-NUL-983035 (Reactome)
class I MHC B13 ProteinP30461 (Uniprot-TrEMBL)
class I MHC B14 ProteinP30462 (Uniprot-TrEMBL)
class I MHC B15 ProteinP30464 (Uniprot-TrEMBL)
class I MHC B18 ProteinP30466 (Uniprot-TrEMBL)
class I MHC B27 ProteinP03989 (Uniprot-TrEMBL)
class I MHC B35 ProteinP30685 (Uniprot-TrEMBL)
class I MHC B37 ProteinP18463 (Uniprot-TrEMBL)
class I MHC B38 ProteinQ95365 (Uniprot-TrEMBL)
class I MHC B39 ProteinP30475 (Uniprot-TrEMBL)
class I MHC B40 ProteinQ04826 (Uniprot-TrEMBL)
class I MHC B41 ProteinP30479 (Uniprot-TrEMBL)
class I MHC B42 ProteinP30480 (Uniprot-TrEMBL)
class I MHC B44 ProteinP30481 (Uniprot-TrEMBL)
class I MHC B45 ProteinP30483 (Uniprot-TrEMBL)
class I MHC B46 ProteinP30484 (Uniprot-TrEMBL)
class I MHC B47 ProteinP30485 (Uniprot-TrEMBL)
class I MHC B49 ProteinP30487 (Uniprot-TrEMBL)
class I MHC B50 ProteinP30488 (Uniprot-TrEMBL)
class I MHC B51 ProteinP18464 (Uniprot-TrEMBL)
class I MHC B52 ProteinP30490 (Uniprot-TrEMBL)
class I MHC B53 ProteinP30491 (Uniprot-TrEMBL)
class I MHC B54 ProteinP30492 (Uniprot-TrEMBL)
class I MHC B55 ProteinP30493 (Uniprot-TrEMBL)
class I MHC B56 ProteinP30495 (Uniprot-TrEMBL)
class I MHC B57 ProteinP18465 (Uniprot-TrEMBL)
class I MHC B58 ProteinP10319 (Uniprot-TrEMBL)
class I MHC B59 ProteinQ29940 (Uniprot-TrEMBL)
class I MHC B67 ProteinQ29836 (Uniprot-TrEMBL)
class I MHC B7 ProteinP01889 (Uniprot-TrEMBL)
class I MHC B73 ProteinQ31612 (Uniprot-TrEMBL)
class I MHC B78 ProteinP30498 (Uniprot-TrEMBL)
class I MHC B8 ProteinP30460 (Uniprot-TrEMBL)
class I MHC B81 ProteinQ31610 (Uniprot-TrEMBL)
class I MHC B82 ProteinQ29718 (Uniprot-TrEMBL)
monoglucosylated MHC

class I

HC:Calnexin/BiP		ComplexR-HSA-983116 (Reactome)
monoglucosylated MHC class I HCComplexR-HSA-983120 (Reactome)
oligopeptide fragment (8-16aa)R-NUL-983032 (Reactome)
oligopeptide fragmentR-NUL-1236721 (Reactome)
oligopeptide fragmentR-NUL-983034 (Reactome)
oligopeptide fragment R-NUL-1236721 (Reactome)
p-6S-NCF1 ProteinP14598 (Uniprot-TrEMBL)
p-T154,S315-NCF4 ProteinQ15080 (Uniprot-TrEMBL)
p-T233-NCF2 ProteinP19878 (Uniprot-TrEMBL)
partially digested AgR-NUL-1236713 (Reactome)
partially digested AgR-NUL-1236718 (Reactome)
precursor peptide fragment (>16 aa)R-NUL-1236722 (Reactome)
precursor peptide fragment (>16 aa)R-NUL-983036 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisR-HSA-1236935 (Reactome)
26S proteasomemim-catalysisR-HSA-1236970 (Reactome)
26S proteasomemim-catalysisR-HSA-983150 (Reactome)
ADPArrowR-HSA-1236949 (Reactome)
ADPArrowR-HSA-983144 (Reactome)
AMPArrowR-HSA-983140 (Reactome)
AMPArrowR-HSA-983153 (Reactome)
AMPArrowR-HSA-983156 (Reactome)
ATPR-HSA-1236949 (Reactome)
ATPR-HSA-983140 (Reactome)
ATPR-HSA-983144 (Reactome)
ATPR-HSA-983153 (Reactome)
ATPR-HSA-983156 (Reactome)
Ag peptide bound class I MHCArrowR-HSA-1236971 (Reactome)
Ag peptide bound class I MHCR-HSA-1236965 (Reactome)
Ag-substrate:E3:E2:UbArrowR-HSA-983157 (Reactome)
Ag-substrate:E3:E2:UbR-HSA-983140 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		ArrowR-HSA-983161 (Reactome)
Antigen peptide

bound class I

MHC:BAP31 oligomer		R-HSA-983138 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236943 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236964 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-1236965 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983138 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983421 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983422 (Reactome)
Antigen peptide bound class I MHCArrowR-HSA-983427 (Reactome)
Antigen peptide bound class I MHCR-HSA-1236964 (Reactome)
Antigen peptide bound class I MHCR-HSA-983421 (Reactome)
Antigen peptide bound class I MHCR-HSA-983426 (Reactome)
Antigen peptide bound class I MHCR-HSA-983427 (Reactome)
Antigen peptideArrowR-HSA-1236954 (Reactome)
Antigen peptideArrowR-HSA-983158 (Reactome)
Antigen peptideR-HSA-1236943 (Reactome)
Antigen peptideR-HSA-983161 (Reactome)
B2M(21-119)R-HSA-983146 (Reactome)
BAP31 oligomerArrowR-HSA-983138 (Reactome)
BAP31 oligomerR-HSA-983142 (Reactome)
CALRArrowR-HSA-1236971 (Reactome)
CALRArrowR-HSA-983161 (Reactome)
CALRR-HSA-983142 (Reactome)
COPII vesicle with MHC class IArrowR-HSA-983424 (Reactome)
COPII vesicle with MHC class IArrowR-HSA-983425 (Reactome)
COPII vesicle with MHC class IR-HSA-983422 (Reactome)
COPII vesicle with MHC class IR-HSA-983424 (Reactome)
COPIImim-catalysisR-HSA-983422 (Reactome)
CTSS-like proteinsmim-catalysisR-HSA-1236948 (Reactome)
Chaperones calnexin/BiPArrowR-HSA-983146 (Reactome)
Chaperones calnexin/BiPR-HSA-983145 (Reactome)
Class I MHC peptide loading complexR-HSA-1236971 (Reactome)
Class I MHC:B2MR-HSA-1236943 (Reactome)
DC receptors

recognizing

apoptotic cells		ArrowR-HSA-1236956 (Reactome)
DC receptors

recognizing

apoptotic cells		R-HSA-1236958 (Reactome)
E1 bound ubiquitinArrowR-HSA-983153 (Reactome)
E1 bound ubiquitinR-HSA-983152 (Reactome)
E2 Ubiquitin-conjugating enzymeArrowR-HSA-983140 (Reactome)
E2 Ubiquitin-conjugating enzymeArrowR-HSA-983156 (Reactome)
E2 Ubiquitin-conjugating enzymeR-HSA-983152 (Reactome)
E2 Ubiquitin-conjugating enzymemim-catalysisR-HSA-983152 (Reactome)
E3 ligases in

proteasomal

degradation		ArrowR-HSA-983147 (Reactome)
E3 ligases in

proteasomal

degradation		R-HSA-983157 (Reactome)
E3 ligases in

proteasomal

degradation		mim-catalysisR-HSA-983140 (Reactome)
E3:K48-polyubiquitinated substrateArrowR-HSA-983156 (Reactome)
E3:K48-polyubiquitinated substrateR-HSA-983147 (Reactome)
E3:Ub:substrateArrowR-HSA-983140 (Reactome)
E3:Ub:substrateR-HSA-983156 (Reactome)
E3:Ub:substratemim-catalysisR-HSA-983156 (Reactome)
ERAP1/2mim-catalysisR-HSA-983158 (Reactome)
Exogenous

Particulate antigen

(Ag)		ArrowR-HSA-1236956 (Reactome)
Exogenous

Particulate antigen

(Ag)		ArrowR-HSA-1236963 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236938 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236958 (Reactome)
Exogenous

Particulate antigen

(Ag)		R-HSA-1236963 (Reactome)
Exogenous soluble antigenArrowR-HSA-1236940 (Reactome)
Exogenous soluble antigenArrowR-HSA-1236968 (Reactome)
Exogenous soluble antigenR-HSA-1236939 (Reactome)
Exogenous soluble antigenR-HSA-1236948 (Reactome)
Exogenous soluble antigenR-HSA-1236968 (Reactome)
Exogenous soluble antigenR-HSA-1236970 (Reactome)
GDPR-HSA-983422 (Reactome)
GTPArrowR-HSA-983422 (Reactome)
H+ArrowR-HSA-1236967 (Reactome)
H2OR-HSA-1236949 (Reactome)
H2OR-HSA-983144 (Reactome)
H2OR-HSA-983422 (Reactome)
IFN gamma stimulated aminopeptidasesmim-catalysisR-HSA-983162 (Reactome)
IRAP in complex with MHC class Imim-catalysisR-HSA-1236954 (Reactome)
K48polyUb-antigenic substrateArrowR-HSA-983147 (Reactome)
K48polyUb-antigenic substrateR-HSA-983150 (Reactome)
K48polyUb-partially digested AgR-HSA-1236935 (Reactome)
L-Amino AcidsArrowR-HSA-1236935 (Reactome)
L-Amino AcidsArrowR-HSA-1236948 (Reactome)
L-Amino AcidsArrowR-HSA-1236954 (Reactome)
L-Amino AcidsArrowR-HSA-1236970 (Reactome)
L-Amino AcidsArrowR-HSA-983150 (Reactome)
L-Amino AcidsArrowR-HSA-983158 (Reactome)
L-Amino AcidsArrowR-HSA-983162 (Reactome)
MHC

class I

HC:Calnexin/BiP:Erp57		ArrowR-HSA-983148 (Reactome)
MHC

class I

HC:Calnexin/BiP:Erp57		R-HSA-983146 (Reactome)
MHC HC:B2M:Erp57ArrowR-HSA-983146 (Reactome)
MHC HC:B2M:Erp57R-HSA-983142 (Reactome)
MHC:B2M peptide loading complexArrowR-HSA-983142 (Reactome)
MHC:B2M peptide loading complexR-HSA-983161 (Reactome)
MR/other probable receptorsArrowR-HSA-1236940 (Reactome)
MR/other probable receptorsR-HSA-1236939 (Reactome)
MR:soluble antigenArrowR-HSA-1236939 (Reactome)
MR:soluble antigenArrowR-HSA-1236941 (Reactome)
MR:soluble antigenArrowR-HSA-1236955 (Reactome)
MR:soluble antigenR-HSA-1236940 (Reactome)
MR:soluble antigenR-HSA-1236941 (Reactome)
MR:soluble antigenR-HSA-1236955 (Reactome)
Mg2+ArrowR-HSA-983153 (Reactome)
Mg2+R-HSA-983153 (Reactome)
NADP+ArrowR-HSA-1236967 (Reactome)
NADPHR-HSA-1236967 (Reactome)
NOX2 complexmim-catalysisR-HSA-1236967 (Reactome)
O2.-ArrowR-HSA-1236967 (Reactome)
O2R-HSA-1236967 (Reactome)
PDIA3ArrowR-HSA-1236971 (Reactome)
PDIA3ArrowR-HSA-983161 (Reactome)
PDIA3R-HSA-983148 (Reactome)
PPiArrowR-HSA-983140 (Reactome)
PPiArrowR-HSA-983153 (Reactome)
PPiArrowR-HSA-983156 (Reactome)
Particulate Ag:DC receptorsArrowR-HSA-1236958 (Reactome)
Particulate Ag:DC receptorsR-HSA-1236956 (Reactome)
PiArrowR-HSA-1236949 (Reactome)
PiArrowR-HSA-983144 (Reactome)
R-HSA-1236935 (Reactome) Proteasomes are usually localized to the cytoplasm but are also present in the nucleus and ER. Houde et al. (2003) investigated the distribution of proteasomes in J774 macrophages and observed them on phagosomes. The proteasomes present on phagosomes may not come directly from ER, but instead assemble on phagosomes to play a function at a precise point during phagolysosomal biogenesis. Houde et al. also observed polyubiquitinated proteins on the cytoplasmic side of phagosomes and highlighted the link between the ubiquitination process and proteasomal degradation; translocated peptides are ubiquitinated and processed by the proteasome complex assembled on the cytoplasmic side of phagosomes, leading to the generation of MHC class I binding peptides.
R-HSA-1236938 (Reactome) Phagocytosed particulate antigens are partially digested in the lumen of phagolysosomes by various lysosomal hydrolases.
R-HSA-1236939 (Reactome) Soluble antigens are presented to dendritic cells (DCs) in some cases by receptor mediated endocytosis or fluid-phase endocytosis. Burgdorf et al. (2008) suggest that there are two different endocytic compartments for antigen processing: one dedicated to MHC class I (early endosomes) and the other one for MHC class II presentation (lysosomes). Sorting of cargo into these different compartments occurs at the plasma membrane and is likely to depend on the type of endocytic receptor the cargo is interacting with (Burgdorf et al. 2008, Zhuang et al. 2006). The mannose receptor (MR) is the best studied receptor that targets soluble antigens to early endosomes but not to lysosomes (Burgdorf et al. 2006). Antigens taken up by the MR are targeted towards a mildly acidic stable early endosomal compartment for exclusive presentation on MHC I molecules (Burgdorf et al. 2008).
R-HSA-1236940 (Reactome) Within the endosome the receptor and cargo separate and the receptor recycles back to the cell surface. Soluble antigens are targeted into the stable early endosome lumen for efficient cross presentation. Early endosomes are mildly acidic and relatively poor in proteases.
R-HSA-1236941 (Reactome) Receptor-bound exogenous antigens in coated pits on the cell surface are internalized into clathrin-coated vesicles.
R-HSA-1236943 (Reactome) Peptides generated by Cathepsin S or IRAP-mediated proteolysis in the endosomes are loaded onto MHC class I molecules, which are internalized and transported to early and late endosomal compartments where antigenic peptides can be loaded. A fraction of the internalized cell surface class I molecules enter MHC class II compartments (MIICs) within endocytic vesicles (Gromme et al. 1999, Kleijmeer et al. 2001). Microscopic analysis has revealed that surface MHC-I molecules are internalized and transported to early and late endosomal compartments (Basha et al. 2008, Lizee et al. 2003). A tyrosine-based endocytic trafficking motif (YXXA) is required for the constitutive internalization of MHC-I molecules from the cell surface into early/late endosomes for peptide loading (Basha et al. 2008, Lizee et al. 2003). Upon entry in to these endosomal compartments the MHC class I complexes exchange their pre-bound peptides with exogenously derived antigenic peptides.
R-HSA-1236947 (Reactome) Fusion of the maturing phagosome with the ER mediates the exchange of materials resulting in the formation of a hybrid ER-phagosome compartment (Gagnon et al. 2002, Guermonprez et al. 2003, Houde et al. 2003, Ackerman et al. 2003, Blanchard et al. 2010). This hybrid contains the retrotranslocon factor Sec61 that mediates the access of proteasomes on the cytosolic surface of the phagosome. Using fluorescence imaging, Houde et al. (2003) provided evidence for the role of Sec61 in the retrotranslocation of internalized exogenous proteins from phagosomes to the cytoplasmic face of J774 macrophages. Sec61 factor is a heterotrimeric complex composed of alpha, beta and gamma subunits forming the core of the mammalian ER translocon (Greenfield et al. 1999). Oligomers of the Sec61 complex form a transmembrane channel involved in the retrotranslocation of misfolded proteins from ER to the cytosol for degradation, and thus it has been proposed that Sec61 might be involved in the translocation of proteins in phagosomes to the cytosol (Kasturi et al. 2008).
R-HSA-1236948 (Reactome) Endocytic compartments contain many cysteine proteases such as cathepsin S that can generate cross-presented peptides. Cathepsins may participate in the generation of MHC class II-presentated peptides (Villadangos et al. 1999). Shen et al. (2004) demonstrated that cathepsin S contributes to TAP-independent cross-presentation in vivo, showing that ovalbumin was cross-presented by denritic cells (DCs) through both TAP-dependent and TAP-independent pathways. The TAP-independent pathway was sensitive to the cystine protease inhibitor leupeptin, but not to proteasome inhibitors. Further experiments with knockout mice showed that cathepsin S contributed to cross-presentation. DCs lacking cathepsin S lack the TAP-independent pathway (Khor et al. 2008, Shen et al. 2004).
R-HSA-1236949 (Reactome) After processing by the proteasome, some of the oligopeptides could be reinternalized to the phagosome lumen of the same phagosome through the TAP complex probably acquired during ER-phagosome fusion. Guermonprez et al. (2003) tested this model and observed abundant TAP complex in early phagosomes and its reduction over time. Electron microscopy analysis of purified phagosomes also showed the insertion of TAP2 into the phagosomal membrane.
R-HSA-1236954 (Reactome) While it is established that cathepsin S is involved in antigen processing in endocytotic vesicles, it is less certain whether other proteases present in endocytic vesicles are also involved in generating the peptide fragments. Insulin regulated aminopeptidase (IRAP) is an epitope-trimming zinc-dependent aminopeptidase closely related to ERAP1 and ERAP2. IRAP may be involved in vacuolar processing of the peptide fragments within endosomes (Saveanu et al. 2009, Segura et al. 2009). IRAP is detected predominantly in the early and recycling endosome fractions. Saveanu et al. (2009) observed the physical association of IRAP with internalized class I MHC molecules and suggested that this may favour a direct linkage between peptide trimming and MHC class I loading. They also showed that IRAP-dependent processing of antigens requires active proteasome but not lysosomal proteases, which suggests that this pathway utilizes cytosolic degradation followed by peptide transport into IRAP-containing endosomes.
R-HSA-1236955 (Reactome) The antigen:receptor complex moves from clathrin-coated vesicles to the early endosome membrane.
R-HSA-1236956 (Reactome) After internalization, F-actin is depolymerized from the phagosome, and the newly denuded vacuole membrane becomes accessible to early endosomes (Aderem & Underhill. 1999).
R-HSA-1236958 (Reactome) Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle.
R-HSA-1236963 (Reactome) Following fission of the phagosome vesicle from the plasma membrane, the phagosome undergoes maturation by a series of fusion and fission events, fusing with late endosomes and ultimately lysosomes, to form a phagolysosome.

fuses sequentially with sorting/early endosomes, late endosomes and finally lysosomes to acquire degradative capabilities. This process is referred to as phagosome maturation.
R-HSA-1236964 (Reactome) Peptide-loaded MHC class I complexes are transported by an undefined mechanism back to the cell surface for cross-presentation to T cells.
R-HSA-1236965 (Reactome) Exogenous antigen loaded class I MHC molecules in phagosomes may be delivered to the surface by membrane recycling machinery.
R-HSA-1236967 (Reactome) After the fusion of phagosome and lysosome lumen acidity rises and the activity of lysosomal proteases increases, conferring proteolytic ability. However antigens must be spared from complete proteolytic destruction. Dendritic cells (DCs) achieve this by regulating the level of proteolysis and phagosomal acidification. DCs recruit the NADPH oxidase NOX2 to the phagosome and mediate sustained production of low levels of reactive oxygen species (ROS), causing active alkalization of the phagosomal lumen (Savina et al. 2006, Ramachandra et al. 2009). NOX2 consumes oxygen and protons (pumped by V-ATPase or other H+ voltage-gated channels) to produce ROS and this lowers phagosome acidity. This apparently reduces antigen proteolysis to a level that allows processing but does not fully destroy the antigenic peptides, favouring increased MHC-I cross presentation (Ramachandra et al. 2009). Rab27a controls the recruitment of NOX2 to DC phagosomes (Savina et al. 2007).
R-HSA-1236968 (Reactome) Endocytosed antigens must leave the endocytic structure to enter into the MHC I pathway before exhaustive degradation within lysosomes. The canonical pathway is the transporter associated with antigen processing (TAP)-dependent cytosolic pathway, which involves the translocation of endocytosed antigens into the cytosol where they are degraded into antigenic peptides by the proteasome and transported to ER through TAP. This hypothesis comes from indirect evidences showing that proteasome inhibitors block cross presentation of certain antigens (Amigorena et al. 2010, Burgdorf et al. 2008) . According to this model antigens are translocated into the cytosol by an undefined mechanism.
There are less well-characterized mechanisms for the delivery of exogenous antigens into the cytosol. Certain peptides with highly positively charged sequences derived from HIV tat protein or the Antennapedia homeodomain (AntHD) protein seem to penetrate into the cytosol directly across the plasma membrane (Monu et al. 2007, Vendeville et al. 2004). It is also proposed that some exogenous antigens can be exchanged between neighboring cells through gap junctions, leading to cross presentation by the recipient cell (Monu et al. 2007, Neijssen et al. 2005).
Once internalized antigens are routed into the cytosol, they follow the conventional pathway of proteasome digestion and TAP mediated transport of peptides into the ER lumen.
R-HSA-1236970 (Reactome) Exogenous antigens are thought to be processed for cross-presentation in much the same manner as endogenous proteins once they enter the cytosolic pathway (Rock et al. 2010). Immunoproteasome components are the major proteases involved in generating the antigenic fragments. The precurssor peptides are further trimmed by cytosolic aminopeptidases and shuttled to ER through TAP for MHC class I loading.
R-HSA-1236971 (Reactome) Peptides translocated back into the phagosomal lumen are loaded onto MHC class I molecules. Guermonprez et al. (2003) detected the components of the peptide loading complex (TAP, tapasin, calreticulin and ERp57) together with MHC class I in purified early phagosomes. They observed peptide loading in the presence of ATP in purified phagosomes expressing HLA-A2, incubated with iodinated S-9-L peptide. From these experiments they concluded that TAP-imported peptides can be loaded on MHC class I molecules in the lumen of phagosomes. Houde et al. (2003) also observed OVA peptide SIINFEKL:MHC-I complex in the phagosome lumen.
R-HSA-1236972 (Reactome) Upon phagolysosomal proteolysis the phagocytosed proteins still need to gain access to the cytosol for proteasomal access, transport into the ER and loading onto MHC class I. The mechanism for this escape of phagocytosed antigens remain unknown.
R-HSA-203979 (Reactome) Sar1p-GTP recruits the cytoplasmic Sec23p-Sec24p complex. (Though not represented in the subsequent steps, Sec23p-Sec24p would bind to members of the p24 protein family of possible cargo receptors, and together with Sar1p bind the appropiate v-SNARE, and Rab-GTP.)



R-HSA-983138 (Reactome) When the loaded peptide is of a sufficiently high-affinity the trimeric complex is transported to a special ER exit site by a putative cargo receptor, B cell receptor-associated protein (BAP31), where it translocates to the cell surface, possibly by transport in COPII-coated vesicles.
R-HSA-983140 (Reactome) Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).
R-HSA-983142 (Reactome) Upon interaction of Beta-2-microglobin (B2M) with MHC class I Heavy Chain (HC), calnexin is fully replaced by its soluble ortholog calreticulin (CRT) and this complex is incorporated into the peptide loading complex (PLC). PLC is a multiprotein complex that includes CRT, ERp57 and the additional components tapasin, transporter associated with antigen processing (TAP) and Bap31. The stoichometry of components in PLC remains unclear. The PLC loads antigenic peptides onto MHC class I molecules; components of the PLC cooperate to stabilize the MHC class I complex and optimally load peptides. Tapasin is a type I transmembrane protein that interacts directly with TAP and tethers the MHC complex to it. TAP facilitates the transport of peptides from the cytosol to the ER lumen. B cell receptor–associated protein (Bap31), a putative cargo receptor, associates with HC and acts as a retrograde transporter, carrying peptide-loaded class I MHC molecules.
R-HSA-983144 (Reactome) Ttransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome.
R-HSA-983145 (Reactome) The newly synthesized MHC class I heavy chain (HC) translocates into the endoplasmic reticulum (ER) and binds rapidly to calnexin (CNX), a transmembrane calcium-dependent lectin with chaperone activity. CNX recognizes and binds to an N-linked monoglycosylated Glc1Man9GlcNAc2 carbohydrate group found attached to the conserved Asn-86 in the HC. Interaction of HC with CNX promotes the formation of intrachain disulfide bonds. Another candidate ER chaperon protein is immunoglobulin binding protein (BiP), found to associate with HC in the absence of CNX. These chaperones can cooperate in protein folding and prevention of aggregation.
R-HSA-983146 (Reactome) Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.
R-HSA-983147 (Reactome) K48 polyubiquitinated substrate dissociates from E3 to become a substrate for a multicatalytic complex called the 26S proteasome.
R-HSA-983148 (Reactome) Endoplasmic reticulum resident protein 57 (ERp57), is a member of the protein disulphide isomerase (PDI) family of thiol oxidoreducatases. It associates with Calnexin (CNX), and its soluble homolog calreticulin (CRT) and is recruited to MHC Class I Heavy Chain (HC). ERp57 is involved in the formation of HC disulphide bonds.
R-HSA-983150 (Reactome) The 26S proteasome complex consists of the 20S catalytic core particle which harbours the proteolytically active sites and the regulatory 19S particle which is responsible for substrate interaction. This process generates a vast number (perhaps hundreds) of different peptides, depending on the length and sequence of the substrate protein. Only a small fraction of these peptides (nearly 10%) form the exact length to be presented by class I MHC; most (approximately 70%) are too short to bind. The remaining proteasome products (10-20%) are N-terminally extended precursors that require additional cleavage by cytosolic aminopeptidases for presentation by MHC class I molecules.
R-HSA-983152 (Reactome) Activated ubiquitin is transferred from E1 to the active site cystine of ubiquitin conjugating enzymes (E2s) via a trans-esterification reaction. E2s catalyze covalent attachment of ubiquitin to target proteins. They all share an active-site ubiquitin-binding cysteine residue and are distinguished by the presence of a ubiquitin-conjugating catalytic (UBC) fold required for binding of distinct ubiquitin ligases or E3s. Once conjugated to ubiquitin, the E2 molecule binds one of several E3s (Glickman et al. 2002).
R-HSA-983153 (Reactome) Ubiquitin is activated in an ATP-dependent manner, catalyzed by E1 ubiquitin-activating enzymes. In the first step of ubiquitin activation, the E1 enzyme binds ATP, Mg+2 and ubiquitin, and catalyses ubiquitin C-terminal acyl-adenylation (Ubiquitin-AMP). In the second step, the catalytic cystine in the E1 attacks the ubiquitin-adenylate (Ub-AMP) to form the activated ubiquitin-E1 thioester-bonded complex and an AMP leaving group. The intermediate reaction involving the formation of the ubiquitin-AMP complex is not represented here.
R-HSA-983156 (Reactome) Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).
R-HSA-983157 (Reactome) Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).
R-HSA-983158 (Reactome) Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.
R-HSA-983161 (Reactome) MHC class I heterodimers are only stable in peptide bound form and only as a trimer (with bound peptide) present on the cell surface. Class I MHC molecules prefer nonapeptides, and less frequently use octa- or deca-peptides. The peptide binding groove in MHC class I molecules is formed by the intimate association of the alpha1 and alpha2 domains of the heavy chain. Structural studies have revealed that the alpha1:alpha2 domains form a single peptide binding groove consisting of 2 parallel helices on a floor of 8 beta-strands. Hydrogen bonding networks are established in the binding groove with the antigenic peptide main chain and terminal atoms that enable largely sequence independent ligation. Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.
MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al, 2009; Garstka et al, 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al, 2009).
R-HSA-983162 (Reactome) Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).
R-HSA-983421 (Reactome) Cargo must pass through the various compartments of the Golgi complex to reach the plasma membrane. This may occur through either of the two well known models, cisternal maturation or vesicular transport (Refer to review articles Glick et al. 2009, Jackson 2009, Nakano et al. 2010).
R-HSA-983422 (Reactome) Before the cargo vesicle can fuse with target membrane, the COPII protein coat must be disassembled and its components released into cytosol. This uncoating is triggered by hydrolysis of the bound GTP to produce Sar1p-GDP, which has decreased affinity for the vesicle membrane. Disassociation of Sar1p-GDP from the membrane is followed by the release of the other COPII subunits.
R-HSA-983424 (Reactome) Once the entire COPII coat has been assembled, the bud is separated from the ER membrane in the form of a COPII coated vesicle.
R-HSA-983425 (Reactome) Sec13-Sec31 binds the prebudding complex and this Sec13-Sec31 heterotetramer forms the outer structural scaffold of the coat. Sec13-Sec31 is likely to crosslink the prebudding complexes generating COPII-coated vesicles.
R-HSA-983426 (Reactome) The cytoplasmic tails of MHC class I molecules do not possess any of the known ER export sequences. BAP31 acts as a cargo receptor by exporting peptide-loaded class I MHC molecules to the ER exit sites or ER/Golgi intermediate compartment. Sec24 of the Sec23-Sec24/Sar1-GTP complex catches cargo by direct contact, forming the prebudding complex. Sar1/Sec23-Sec24 can bring about curvature of the membrane in the formation of vesicle. The cargo (antigen-bound MHC) accumulates within the COPII vesicle by binding to the Sec24 polypeptide of the COPII coat.
R-HSA-983427 (Reactome) After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane.
SAR1B:GDPArrowR-HSA-983422 (Reactome)
SAR1B:GTP:SEC23:SEC24ArrowR-HSA-203979 (Reactome)
SAR1B:GTP:SEC23:SEC24R-HSA-983426 (Reactome)
SAR1B:GTPR-HSA-203979 (Reactome)
SEC13ArrowR-HSA-983422 (Reactome)
SEC13R-HSA-983425 (Reactome)
SEC23:SEC24R-HSA-203979 (Reactome)
SEC23AArrowR-HSA-983422 (Reactome)
SEC24ArrowR-HSA-983422 (Reactome)
SEC31AArrowR-HSA-983422 (Reactome)
SEC31AR-HSA-983425 (Reactome)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IArrowR-HSA-983426 (Reactome)
Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class IR-HSA-983425 (Reactome)
TAPArrowR-HSA-983161 (Reactome)
TAPBPArrowR-HSA-1236971 (Reactome)
TAPBPArrowR-HSA-983161 (Reactome)
TAPBPR-HSA-983142 (Reactome)
TAPR-HSA-983142 (Reactome)
TAPmim-catalysisR-HSA-1236949 (Reactome)
TAPmim-catalysisR-HSA-983144 (Reactome)
Transloconmim-catalysisR-HSA-1236947 (Reactome)
UbArrowR-HSA-1236935 (Reactome)
UbArrowR-HSA-983150 (Reactome)
UbR-HSA-983153 (Reactome)
Ubiquitin activating E1 enzymesArrowR-HSA-983152 (Reactome)
Ubiquitin activating E1 enzymesR-HSA-983153 (Reactome)
Ubiquitin activating E1 enzymesmim-catalysisR-HSA-983153 (Reactome)
Ubiquitin:E2 conjugating enzymesArrowR-HSA-983152 (Reactome)
Ubiquitin:E2 conjugating enzymesR-HSA-983156 (Reactome)
Ubiquitin:E2 conjugating enzymesR-HSA-983157 (Reactome)
antigenic substrateR-HSA-983157 (Reactome)
monoglucosylated MHC

class I

HC:Calnexin/BiP		ArrowR-HSA-983145 (Reactome)
monoglucosylated MHC

class I

HC:Calnexin/BiP		R-HSA-983148 (Reactome)
monoglucosylated MHC class I HCR-HSA-983145 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-1236935 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-983150 (Reactome)
oligopeptide fragment (8-16aa)ArrowR-HSA-983162 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-1236949 (Reactome)
oligopeptide fragment (8-16aa)R-HSA-983144 (Reactome)
oligopeptide fragmentArrowR-HSA-1236949 (Reactome)
oligopeptide fragmentArrowR-HSA-983144 (Reactome)
oligopeptide fragmentR-HSA-1236971 (Reactome)
oligopeptide fragmentR-HSA-983158 (Reactome)
partially digested AgArrowR-HSA-1236938 (Reactome)
partially digested AgArrowR-HSA-1236947 (Reactome)
partially digested AgArrowR-HSA-1236972 (Reactome)
partially digested AgR-HSA-1236947 (Reactome)
partially digested AgR-HSA-1236972 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-1236948 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-1236970 (Reactome)
precursor peptide fragment (>16 aa)ArrowR-HSA-983150 (Reactome)
precursor peptide fragment (>16 aa)R-HSA-1236954 (Reactome)
precursor peptide fragment (>16 aa)R-HSA-983162 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3577"
Personal tools