p53 signal pathway (Rattus norvegicus)

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132232DNADNA-damageG2 arrestCell cycle arrestG1 arrestGenesROSApoptosisCyclin B3Ei24BaxPhenobarbitalCytochrome C1Casp9Mdm2NoxaScotinDexamethazoneCyclin ESiahTp53Igfbp3Casp3Igf1Gtse1Zmat3FasCdk4Parp1Perpp21PumaCdc2BidSfnCdk2Apaf 1Gadd45Casp8ReprimoTp53Cyclin D


Description

We've used the following pathway as a reference: http://www.genome.jp/dbget-bin/show_pathway?rno04115+58918

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Quality Tags

Ontology Terms

 

Bibliography

  1. Nelson DM, Bhaskaran V, Foster WR, Lehman-McKeeman LD; ''p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.''; Toxicol Sci, 2006 PubMed Europe PMC Scholia
  2. Simbulan-Rosenthal CM, Rosenthal DS, Ding R, Bhatia K, Smulson ME; ''Prolongation of the p53 response to DNA strand breaks in cells depleted of PARP by antisense RNA expression.''; Biochem Biophys Res Commun, 1998 PubMed Europe PMC Scholia
  3. Malanga M, Pleschke JM, Kleczkowska HE, Althaus FR; ''Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions.''; J Biol Chem, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
107003view13:46, 17 September 2019MaintBotHMDB identifier normalization
87405view11:05, 22 July 2016MaintBotadded missing graphids
83038view03:46, 18 November 2015Mkutmonadded ref to WP apoptosis pathway
83037view03:44, 18 November 2015Mkutmonremove test comment
83036view03:44, 18 November 2015Mkutmonfix outdated identifiers, connected interactions and improved layout
71284view04:57, 17 October 2013MaintBotUpdated Uniprot-TrEMBL datasources
69340view18:51, 8 July 2013MaintBotUpdated to 2013 gpml schema
67574view11:28, 26 June 2013DdiglesOntology Term : 'p53-dependent G1/S DNA damage checkpoint pathway' added !
58920view05:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48274view23:22, 17 May 2012KhanspersUpdating PubChem xrefs
48263view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41652view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
33398view14:46, 30 November 2009MaintBotRemoved group label
32821view15:27, 9 September 2009JinggaoSpecify description
32820view15:20, 9 September 2009Jinggaotest
29867view15:16, 8 June 2009Thomasremoved whitespace from some ensembl ids
29752view23:06, 1 June 2009KhanspersModified categories
28536view14:38, 11 February 2009EmmaververModified description
28535view14:37, 11 February 2009EmmaververSpecify description
28531view14:32, 11 February 2009EmmaververSpecify description
28529view14:30, 11 February 2009EmmaververPeriodical save, work in progress
28527view14:27, 11 February 2009EmmaververSpecify description
28523view14:19, 11 February 2009EmmaververPeriodical save, work in progress
28517view14:09, 11 February 2009EmmaververPeriodical save, work in progress
28509view13:59, 11 February 2009EmmaververPeriodical save, work in progress
28498view13:49, 11 February 2009EmmaververPeriodical save, work in progress
28489view13:39, 11 February 2009EmmaververPeriodical save, work in progress
28473view13:18, 11 February 2009EmmaververPeriodical save, work in progress
28463view13:07, 11 February 2009EmmaververPeriodical save, work in progress
28455view12:57, 11 February 2009EmmaververPeriodical save, work in progress
28446view12:48, 11 February 2009EmmaververSpecify description
28444view12:47, 11 February 2009EmmaververPeriodical save, work in progress
28434view12:37, 11 February 2009EmmaververPeriodical save, work in progress
28425view12:27, 11 February 2009EmmaververPeriodical save, work in progress
28411view12:07, 11 February 2009EmmaververNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apaf 1GeneProductENSRNOG00000008022 (Ensembl)
ApoptosisPathwayWP1290 (WikiPathways)
BaxGeneProductENSRNOG00000020876 (Ensembl)
BidGeneProductENSRNOG00000012439 (Ensembl)
Casp3GeneProductENSRNOG00000010475 (Ensembl)
Casp8GeneProductENSRNOG00000012331 (Ensembl)
Casp9GeneProductENSRNOG00000012944 (Ensembl)
Cdc2GeneProductENSRNOG00000000632 (Ensembl)
Cdk2GeneProductENSRNOG00000006469 (Ensembl)
Cdk4GeneProductENSRNOG00000025602 (Ensembl)
Cell cycle arrestPathway
Cyclin B3GeneProductENSRNOG00000002951 (Ensembl)
Cyclin DGeneProductP48961 (Uniprot-TrEMBL)
Cyclin EGeneProductENSRNOG00000014786 (Ensembl)
Cytochrome C1MetaboliteCHEBI:4067 (ChEBI)
DexamethazoneMetaboliteHMDB15364 (HMDB)
Ei24GeneProductENSRNOG00000030391 (Ensembl)
FasGeneProductENSRNOG00000019142 (Ensembl)
Gadd45GeneProductENSRNOG00000013090 (Ensembl)
Gtse1GeneProductENSRNOG00000016148 (Ensembl)
Igf1GeneProductENSRNOG00000004517 (Ensembl)
Igfbp3GeneProductENSRNOG00000061910 (Ensembl)
Mdm2GeneProductENSRNOG00000006304 (Ensembl)
NoxaGeneProductENSRNOG00000018770 (Ensembl)
Parp1GeneProductENSRNOG00000003084 (Ensembl)
PerpGeneProductENSRNOG00000011994 (Ensembl)
PhenobarbitalMetaboliteHMDB15305 (HMDB)
PumaGeneProductQ80ZG6 (Uniprot-TrEMBL)
ReprimoGeneProductENSRNOG00000005109 (Ensembl)
ScotinGeneProductENSRNOG00000020667 (Ensembl)
SfnGeneProductENSRNOG00000033153 (Ensembl)
SiahGeneProductENSRNOG00000015143 (Ensembl)
Tp53GeneProductENSRNOG00000010756 (Ensembl)
Zmat3GeneProductENSRNOG00000010119 (Ensembl)
p21GeneProduct24525 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP656"
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