MicroRNA for targeting cancer growth and vascularization in glioblastoma (Homo sapiens)

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1Notch Intracellular domain- Abnormal angiogenesis- Stem cell maintenance- High levels of Ki67HEY1VEGFAHES1HIF1ANMIR31MIR148AHIF1AHIF1AVEGFBVEGFCHIF1A- More normalized vessels- Reduced stemness- Low levels of Ki67Fast tumor growth and short lifespanSmaller tumor size and lifespan extendedNICD


Description

miR-148a and miR-31 target the factor inhibiting hypoxia (FIH1) to promote downstream HIF1α and Notch signaling

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Ontology Terms

 

Bibliography

  1. Wong HK, Fatimy RE, Onodera C, Wei Z, Yi M, Mohan A, Gowrisankaran S, Karmali P, Marcusson E, Wakimoto H, Stephens R, Uhlmann EJ, Song JS, Tannous B, Krichevsky AM; ''The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma.''; Mol Ther, 2015 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129317view13:54, 26 March 2024MkutmonOntology Term : 'cancer pathway' added !
129316view13:54, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
128547view22:36, 11 February 2024EweitzEconomize layout, standardize case
117786view14:03, 22 May 2021EweitzOntology Term : 'microRNA pathway' added !
117785view14:03, 22 May 2021EweitzOntology Term : 'PW:0000013' removed !
117784view14:03, 22 May 2021EweitzOntology Term : 'PW:0000605' removed !
117783view14:02, 22 May 2021EweitzOntology Term : 'glioblastoma' added !
117782view14:02, 22 May 2021EweitzOntology Term : 'DOID:162' removed !
117781view14:02, 22 May 2021EweitzModified title
108122view10:24, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
97691view01:01, 2 June 2018AlexanderPicoModified title
94282view19:07, 30 August 2017Khanspersupdated for clarity
87762view09:58, 25 July 2016RyanmillerOntology Term : 'glioma pathway' added !
87735view09:42, 25 July 2016RyanmillerOntology Term : 'cancer' added !
87705view09:03, 25 July 2016RyanmillerOntology Term : 'disease pathway' added !
84853view21:49, 28 March 2016Khanspersupdated interactions and refined NICD/HIF1a
84088view05:21, 14 January 2016Khanspersincreased text label size to avoid cutoff text
83871view00:54, 18 December 2015KhanspersModified description
83870view00:54, 18 December 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
HES1GeneProductENSG00000114315 (Ensembl)
HEY1GeneProductENSG00000164683 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HIF1ANGeneProductENSG00000166135 (Ensembl)
MIR148ARnaMI0000253 (miRBase Sequence)
MIR31GeneProductMI0000089 (miRBase Sequence)
VEGFAGeneProductENSG00000112715 (Ensembl)
VEGFBGeneProductENSG00000173511 (Ensembl)
VEGFCGeneProductENSG00000150630 (Ensembl)

Annotated Interactions

No annotated interactions

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