TNF-alpha NF-kB signaling pathway (Canis familiaris)

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Revision as of 11:08, 25 July 2016 by MirellaKalafati (Talk | contribs)
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UbiquitinationGOCY ->NUDesumoylationProteolytic cleavageDPMPalmitoylationNURecruitmentCytoplasmCYMTInhibitionProteins in a complex interactionActivationCY ->NUENLigandControlERReaction through unknown mechanisms/moleculesGolgi apparatusEndosome(Protein-protein interaction)CY ->NUCY ->NUEndoplasmic reticulumMethylationPlasma membraneAutophosphorylationAcetylationEnzyme complexGlycosylationSumoylationMolecular associationDeubiquitinationReceptorPhosphorylationMitochondrionAccession Number: NetPath 9; cellmap:9ECNucleusDeacetylationTranslocationMolecule in the pathwayDemethylationCY ->NUExtracellularDephosphorylationTNFRSF1BTIFATNIP2UBE2IMAP3K3RASAL2FKBP5IQGAP2TNFTRAF2GAB1PSMC2CUL1AKAP8PEG3CYLDUSP11LOC612286DPF2TANKRNF25RIPK3PSMD7KPNA3ZFAND5GeneNALP4SMARCA4SMARCB1DDX3XPSMC3RPL6IKBKETNFRSF8POLR1ACASP8AP2RPL8PKN1TXLNAGSK3BLOC475035RELBRELFLNARELAMAP2K5ALPLPSMB5LOC480907RELAPIAS3MAP3K3SMARCE1CRADDRPL30POLR1DPEBP1FADDUBCH5CUSP2MAP3K7IP3COPS3GeneCASP8IKBKGNFKBIENKIRAS1TNFAIP3UBE2D2BCL3NFKBIAAZI2YWHAQMAP3K8KTN1MAP3K14GLG1NFKB2TRPC4APMAP3K7IP1PSMD12KPNA6NFKB1PFDN2SRCTRAF4EIF4A3PSMD6PMLCASP2GTF2IRELACHUKPSMC1G3BP2AKT1BAG4CASP7CD3EAPHIST3H3POLR2HKPNA2PAPOLASKP1PTK2MARK2CSNK2A1MAP3K7IP2POLR1CGeneKCNQ1DAPTRADDTNFMCM5TNFRSF1ASMARCC1IKBKBFBLPOLR2LNR2C2SUMO1TRAF1IKBKGYWHAEBCL7APSMD13RPS6KA5RIPK2TBK1COMMD1LOC487309TNFRSF1ARPS13BIRC3MCCNFKBIANFKBIBNR2C2PRKCZGeneTRAF2TRAF4RELCHUKBIRC2RPS11TRAF1CDC37ACTL6ATNIP1PPP2CAMTIF2TNFRIPK1HSP90AB1TRAF6TNFRSF1BPDCD2TNFNFKB1RELATRAF5NKIRAS2YWHABUNC5CLLOC486122IKBKAPNFKBIAMAP3K1MCM7BIRC3NFKB1TRAF2CDC34TNFCAPN3LRPPRCCASP3PSMD1CSNK2A2NSMAFCASP10TRADDNFKBIZTBK1AKT2RNF216MAP3K2BIRC2TNFRSF1BTRAF3TNFRSF1APSMD3YWHAZCFLARCAV1RPL4TNFFBXW11PTPN11FAF1TRAIPFANCD2POLR1ECSNK2BBTRCRPS6KB1CREBBPTNFRSF11APOLR1BRIPK1GNB2L1RELBSMARCC2YWHAGGene SymbolSTAT1LOC480438HSPB1PRKACAWDR68YWHAH


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 87% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118009view11:31, 23 May 2021EweitzModified title
108149view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87779view11:09, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87778view11:08, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68568view22:53, 5 July 2013MaintBotUpdated to 2013 gpml schema
40726view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
34005view18:39, 9 December 2009MaintBotAutomatic update of empty xrefs
32256view12:58, 15 August 2009MaintBotFixed text labels
31777view12:10, 14 August 2009MaintBotFixed group labels
31281view20:02, 13 August 2009MaintBotFixed text labels
30732view23:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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AKT1GeneProduct490878 (Entrez Gene)
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AZI2GeneProduct485632 (Entrez Gene)
BAG4GeneProduct607954 (Entrez Gene)
BCL3GeneProduct612349 (Entrez Gene)
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CAPN3GeneProduct487518 (Entrez Gene)
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CD3EAPGeneProduct612284 (Entrez Gene)
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CUL1GeneProduct475512 (Entrez Gene)
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DDX3XGeneProduct480886 (Entrez Gene)
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EIF4A3GeneProduct475922 (Entrez Gene)
FADDGeneProduct
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FLNAGeneProduct481084 (Entrez Gene)
G3BP2GeneProduct478429 (Entrez Gene)
GAB1GeneProduct483808 (Entrez Gene)
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GeneGeneProduct
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IKBKGGeneProduct
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KPNA2GeneProduct
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MAP2K5GeneProduct
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NALP4GeneProduct
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PSMD1GeneProduct
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PTPN11GeneProduct477488 (Entrez Gene)
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RPL4GeneProduct
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RPS6KB1GeneProduct480580 (Entrez Gene)
SKP1GeneProduct474682 (Entrez Gene)
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STAT1GeneProduct488449 (Entrez Gene)
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TIFAGeneProduct487905 (Entrez Gene)
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TNFAIP3GeneProduct484006 (Entrez Gene)
TNFRSF11AGeneProduct483957 (Entrez Gene)
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TNIP1GeneProduct489178 (Entrez Gene)
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TRAF4GeneProduct
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YWHAHGeneProduct
YWHAQGeneProduct607060 (Entrez Gene)
YWHAZGeneProduct475864 (Entrez Gene)
ZFAND5GeneProduct476324 (Entrez Gene)

Annotated Interactions

No annotated interactions
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