TNF-alpha NF-kB signaling pathway (Canis familiaris)

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Revision as of 11:09, 25 July 2016 by MirellaKalafati (Talk | contribs)
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Proteolytic cleavageERGolgi apparatusSumoylationDephosphorylationReaction through unknown mechanisms/moleculesMTDemethylationActivationTranslocationPalmitoylationGOUbiquitinationLigandDeubiquitinationCY ->NUECReceptorRecruitmentEN(Protein-protein interaction)Endoplasmic reticulumExtracellularMolecular associationCY ->NUCY ->NUEndosomeGlycosylationNucleusDMolecule in the pathwayNUProteins in a complex interactionDeacetylationInhibitionEnzyme complexDesumoylationCY ->NUPMAutophosphorylationPlasma membraneCYMitochondrionAcetylationControlAccession Number: NetPath 9; cellmap:9MethylationCY ->NUCytoplasmPhosphorylationTRADDPSMD13TNIP1WDR68TXLNACHUKCREBBPPMLTNFBIRC2YWHAGFADDNFKBIATNFRSF11APIAS3NFKB1GLG1TRAF6ACTL6ALOC612286IKBKESRCDPF2TRADDKCNQ1HSP90AB1GeneGNB2L1RPL6GSK3BIQGAP2FLNACDC37AZI2RNF216PDCD2TNFRSF8KTN1UNC5CLGTF2IBCL7ALOC487309RPL30PSMC3RELBMAP3K3MAP3K7IP2KPNA3COPS3NFKB1MAP3K7IP3MAP3K8TBK1NALP4PSMD1POLR1BRIPK2STAT1PPP2CANFKBIZKPNA6SMARCE1Gene SymbolCASP10LOC486122POLR1CMTIF2YWHAZHIST3H3PAPOLANFKBIETRAF5YWHAHUBE2IRPL4PTPN11DDX3XPSMD12TRAIPNR2C2PSMD3KPNA2RELGAB1AKT1RELTBK1EIF4A3GeneBCL3CRADDCAV1G3BP2IKBKGFAF1BTRCCHUKTRAF2UBE2D2RELAUBCH5CPOLR1DPKN1PSMC2CUL1BIRC3MAP2K5FBXW11MAP3K7IP1POLR1EGeneLOC475035TNFRIPK1TNFCOMMD1ALPLRELBPOLR2LMAP3K14POLR2HNR2C2MCM7SMARCB1CYLDYWHABUSP11NFKB2MARK2RIPK3IKBKGNFKBIASMARCA4TNFRSF1ARPS11TNFRSF1BLRPPRCCDC34CD3EAPPEBP1TNFGeneTRAF1RPS6KB1RELAAKT2FANCD2RPL8BIRC3SMARCC1AKAP8TNFAIP3PRKACAMCCTNFCSNK2BIKBKAPHSPB1NKIRAS2TNFRSF1ATRAF4PRKCZRPS13NKIRAS1PFDN2SMARCC2IKBKBSUMO1CASP3TANKMCM5BIRC2RNF25NFKBIACAPN3TNFMAP3K2NFKBIBCFLARTIFACSNK2A1USP2RIPK1TRAF2RPS6KA5TRAF1TNIP2TRPC4APCASP7TRAF3TNFRSF1BCASP8TNFRSF1BPSMD7YWHAQPTK2PEG3FBLTNFRSF1ARELALOC480438PSMB5PSMD6DAPRASAL2CSNK2A2SKP1BAG4ZFAND5CASP2POLR1ATRAF2NSMAFTRAF4LOC480907MAP3K3NFKB1PSMC1FKBP5CASP8AP2RELAMAP3K1YWHAE


Description

No description

Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 87% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118009view11:31, 23 May 2021EweitzModified title
108149view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87779view11:09, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87778view11:08, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68568view22:53, 5 July 2013MaintBotUpdated to 2013 gpml schema
40726view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
34005view18:39, 9 December 2009MaintBotAutomatic update of empty xrefs
32256view12:58, 15 August 2009MaintBotFixed text labels
31777view12:10, 14 August 2009MaintBotFixed group labels
31281view20:02, 13 August 2009MaintBotFixed text labels
30732view23:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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CAPN3GeneProduct487518 (Entrez Gene)
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FADDGeneProduct
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GeneGeneProduct
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MAP2K5GeneProduct
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NALP4GeneProduct
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PTPN11GeneProduct477488 (Entrez Gene)
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TIFAGeneProduct487905 (Entrez Gene)
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TNFAIP3GeneProduct484006 (Entrez Gene)
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TNIP1GeneProduct489178 (Entrez Gene)
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TRAF4GeneProduct
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YWHAHGeneProduct
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YWHAZGeneProduct475864 (Entrez Gene)
ZFAND5GeneProduct476324 (Entrez Gene)

Annotated Interactions

No annotated interactions
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