MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens)

From WikiPathways

Revision as of 11:46, 25 July 2016 by Elisa (Talk | contribs)
Jump to: navigation, search
1Calcium selective/non-selectivecation channelCofactorTroponin C mRNAActivated JUN forms transcription complex with cofactorTNNC1 geneCAF-derived MFAP5Extracellular calcium sourceIncrease cell motilityTroponin C interacts with F-actinOvarian Cancer CellIncrease traction forceTranscription of Troponin CMFAP5FAKJUNCa2+Troponin CIP3ITGB3DAGCREB5PRKCQITGAVERKITPR3PIP2PLCG1RYR3PCancer-associated stromal fibroblasts(CAFs)PCa2+Ca2+Ca2+Ca2+Ca2+ERIncreased cytoplasmicCa2+ concentrationFAKPPRKCQPPLCG1PTroponin CJUN geneCofactorCREB5PTranscription of JunCREB5ERKPCa2+Ca2+Troponin C mRNA


Description

A graphical summary of the molecular signalling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC; ''Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.''; Nat Commun, 2014 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127230view20:08, 25 August 2023Khanspersadded lit ref and updated description
127188view22:11, 9 August 2023Khanspersupdated phosphosites
126996view19:27, 14 July 2023Khanspersclarify interactions, updated labels, some reactions
120029view23:19, 15 October 2021Khanspersupdated phosphosites
108104view10:16, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106638view21:02, 12 September 2019KhanspersModified description
106199view12:09, 16 August 2019MaintBotHMDB identifier normalization
105459view05:09, 8 August 2019KhanspersModified description
103743view20:48, 2 April 2019KhanspersModified description
103742view20:47, 2 April 2019KhanspersModified description
97674view11:23, 1 June 2018AMTanOntology Term : 'ovarian cancer' added !
94277view18:09, 30 August 2017Khanspersphosphorylations, updated for clarity
87836view11:46, 25 July 2016ElisaOntology Term : 'disease of cellular proliferation' added !
87835view11:46, 25 July 2016ElisaOntology Term : 'disease pathway' added !
81279view04:54, 14 August 2015KhanspersModified description
81278view04:52, 14 August 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CREB5GeneProductENSG00000146592 (Ensembl)
Ca2+MetaboliteHMDB00464 (HMDB)
DAGMetaboliteHMDB07098 (HMDB)
ERKGeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
IP3Metabolite85166-31-0 (CAS)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MFAP5GeneProductENSG00000197614 (Ensembl)
PIP2Metabolite245126-95-8 (CAS)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
RYR3GeneProductENSG00000198838 (Ensembl)
Troponin CGeneProductENSG00000114854 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3301"
Personal tools