Endochondral ossification (Rattus norvegicus)

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1, 2Removal of extracellular matrixand invasion by bone cellsDyingChondrocyte (pre)hypertrophyBoneChondrocyte proliferationGsintegrinsCartilageCathepsinsand CalpainsBMPsChondrocyte deathWNT signalingcanonical / non-canonicalHypertrophyProliferationVascular invastionOsteoblasticdifferentiationMineralisationRemoval of cartilage matrix?Full differentiationCst10Tgfb2Hdac4Kif3aPlauPtch1Runx2Adamts1Tgfb1Pthr1Bapx1Timp3Fgf2CALM1Fgfr1ScinThyroid hormonePthlhPtch1Cdkn1cCOL10A1VegfaAlplGLI3Chst11AcanRunx2Mmp13Stat1TriiodothyronineSlc38a2Enpp1OxygenGrowth hormoneAkt1Adamts5Stat5bIhhSpp1Igf1rIft88Serpinh1cAMPRunx3Igf1Cab39Runx2LOC312831Thyroid hormoneSox6Ddr2PthAdamts4Mmp9Bmpr1aCtsl1Bmp7Hmgcs1Tgfb1FrzbFgfr3GhrPlatMef2cFGF18PrkacaSox9ThraThraTNAPBmp6MgpCol2a1Igf2


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 88% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  2. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116957view10:08, 16 May 2021EweitzModified title
107233view14:32, 17 September 2019MaintBotChEBI identifier normalization
106961view13:42, 17 September 2019MaintBotHMDB identifier normalization
87975view13:17, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
72214view12:53, 27 October 2013EgonwFixed the ChEBI database name.
72174view22:17, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
69458view19:07, 8 July 2013MaintBotUpdated to 2013 gpml schema
41790view02:43, 2 March 2011MaintBotRemoved redundant pathway information and comments
34154view19:37, 9 December 2009MaintBotAutomatic update of empty xrefs
32311view13:21, 15 August 2009MaintBotFixed text labels
31904view12:48, 14 August 2009MaintBotFixed group labels
31340view20:26, 13 August 2009MaintBotFixed text labels
31006view01:03, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AcanGeneProduct58968 (Entrez Gene)
Adamts1GeneProduct79252 (Entrez Gene)
Adamts4GeneProduct66015 (Entrez Gene)
Adamts5GeneProduct304135 (Entrez Gene)
Akt1GeneProduct24185 (Entrez Gene)
AlplGeneProduct25586 (Entrez Gene)
Bapx1GeneProduct
Bmp6GeneProduct25644 (Entrez Gene)
Bmp7GeneProduct85272 (Entrez Gene)
Bmpr1aGeneProduct81507 (Entrez Gene)
CALM1GeneProduct24242 (Entrez Gene)
COL10A1GeneProduct25681 (Entrez Gene)
Cab39GeneProduct301574 (Entrez Gene)
Cdkn1cGeneProduct246060 (Entrez Gene)
Chst11GeneProduct314694 (Entrez Gene)
Col2a1GeneProduct25412 (Entrez Gene)
Cst10GeneProduct366219 (Entrez Gene)
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
Ctsl1GeneProduct25697 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
Ddr2GeneProduct685781 (Entrez Gene)
Enpp1GeneProduct85496 (Entrez Gene)
FGF18GeneProduct29369 (Entrez Gene)
Fgf2GeneProduct54250 (Entrez Gene)
Fgfr1GeneProduct79114 (Entrez Gene)
Fgfr3GeneProduct84489 (Entrez Gene)
FrzbGeneProduct295691 (Entrez Gene)
GLI3GeneProduct140588 (Entrez Gene)
GhrGeneProduct25235 (Entrez Gene)
Growth hormoneGeneProduct
Hdac4GeneProduct363287 (Entrez Gene)
Hmgcs1GeneProduct29637 (Entrez Gene)
Ift88GeneProduct305918 (Entrez Gene)
Igf1GeneProduct24482 (Entrez Gene)
Igf1rGeneProduct25718 (Entrez Gene)
Igf2GeneProduct24483 (Entrez Gene)
IhhGeneProduct84399 (Entrez Gene)
Kif3aGeneProduct84392 (Entrez Gene)
LOC312831GeneProduct312831 (Entrez Gene)
Mef2cGeneProduct499497 (Entrez Gene)
MgpGeneProduct25333 (Entrez Gene)
Mmp13GeneProduct171052 (Entrez Gene)
Mmp9GeneProduct81687 (Entrez Gene)
OxygenMetaboliteHMDB01377 (HMDB)
PlatGeneProduct25692 (Entrez Gene)
PlauGeneProduct25619 (Entrez Gene)
PrkacaGeneProduct25636 (Entrez Gene)
Ptch1GeneProduct89830 (Entrez Gene)
PthGeneProduct24694 (Entrez Gene)
PthlhGeneProduct24695 (Entrez Gene)
Pthr1GeneProduct56813 (Entrez Gene)
Runx2GeneProduct367218 (Entrez Gene)
Runx3GeneProduct156726 (Entrez Gene)
ScinGeneProduct298975 (Entrez Gene) PMID: 17097081
Serpinh1GeneProduct29345 (Entrez Gene)
Slc38a2GeneProduct29642 (Entrez Gene)
Sox6GeneProduct293165 (Entrez Gene)
Sox9GeneProduct140586 (Entrez Gene)
Spp1GeneProduct25353 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat5bGeneProduct25126 (Entrez Gene)
TNAPGeneProduct
Tgfb1GeneProduct59086 (Entrez Gene)
Tgfb2GeneProduct81809 (Entrez Gene)
ThraGeneProduct81812 (Entrez Gene)
Thyroid hormoneMetabolite60311 (ChEBI)
Thyroid hormoneMetaboliteT4
Timp3GeneProduct25358 (Entrez Gene)
TriiodothyronineMetabolite24864 (ChEBI)
VegfaGeneProduct83785 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions
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