Equilibrium signaling of differentiated cells (Drosophila melanogaster)

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1Posterior Signalling CenterProgenitor MaintenanceNiche SignallingGene ExpressionEquilibrium SignallingRpS8Stat92EAdenosinePvrProtein hedgehogNup98-96Inosinebip1Adgf-A


Description

Equilibrium signalling pathway for maintenance of progenitor cells in the lymph gland which is also affected by hedgehog protein niche signaling. Nup98 and Bip1 proteins both necessary for Pvr gene expression. Pvr/STAT92E complex activates Adgf-A to break down adenosine. Break down allows for proper maintenance of progenitor cells in equilibrium signalling. Niche signalling includes the expression of hedgehog by posterior signaling center also promoting progenitor maintenance. This pathway is based on figure 7 from Mondal et al.

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Bibliography

  1. Mondal BC, Shim J, Evans CJ, Banerjee U; ''Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors.''; Elife, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129700view00:52, 22 May 2024EweitzStandardize case
129698view00:50, 22 May 2024EweitzModified title
116408view09:04, 7 May 2021EweitzModified title
90069view19:15, 11 October 2016Khanspersconnected interaction
89223view22:03, 23 August 2016Khansperssimplified
88466view23:04, 9 August 2016AAR&CoOntology Term : 'signaling pathway' added !
88465view23:03, 9 August 2016AAR&CoEdited Interactions
88464view23:01, 9 August 2016AAR&CoFixed Interactions and Labels
87984view13:21, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
85919view18:08, 21 June 2016AAR&CoModified description
85918view18:07, 21 June 2016AAR&CoModified description
85917view18:07, 21 June 2016AAR&CoAdded Citation
85778view19:15, 12 June 2016AAR&CoModified description
85777view19:12, 12 June 2016AAR&CoFixing interactions
85776view19:08, 12 June 2016AAR&CoCorrection of spelling
85775view19:04, 12 June 2016AAR&CoEdit Interaction
85774view18:58, 12 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AdenosineMetaboliteHMDB00050 (HMDB)
Adgf-AGeneProductFBgn0036752 (Ensembl)
InosineMetaboliteHMDB00195 (HMDB)
Nup98-96GeneProductFBgn0039120 (Ensembl)
Protein hedgehogProteinQ02936 (Uniprot-TrEMBL)
PvrGeneProductFBgn0032006 (Ensembl)
RpS8GeneProductFBgn0039713 (Ensembl)
Stat92EGeneProductFBgn0016917 (Ensembl)
bip1GeneProductFBgn0026263 (Ensembl)

Annotated Interactions

No annotated interactions

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