Regulation of lipid metabolism by PPARalpha (Homo sapiens)

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8, 14, 19, 3922, 31, 4240134, 16745312431, 3231, 34318, 12, 14, 19-21, 27...3, 53124, 33, 416, 31318, 14, 19, 26, 39...2424, 3122, 3131931318, 14, 19, 23, 39...3131242424, 47383125, 35243131362824, 3124, 3124, 3124, 313124mitochondrial outer membranemitochondrial matrixperoxisomal matrixendoplasmic reticulum membranelipid particlecytosolnucleoplasmTBL1XR1 FDFT1SULT2A1NCOA1 GLIPR1PPARA PEX11A genePalm TIAM2MED29 ALAS1ALA CARM1 ESRRAAPOA1(25-266)TNFRSF21 geneCYP4A11 geneNFYB RXRAMED28 HELZ2 SLC27A1WWTR1 MED14 TEAD:YAP1HMGCS1 geneSREBP1A,1C,2:NF-Y:SP1:FDFT1 geneRGL1 geneHMGCS2 geneMED1 GLIPR1 geneGRHL1 geneMED18 MED31 MED12 CTGFCPT1A gene HDAC3 NCOR1 SREBP1A,1C,2:NF-Y:HMGCS1 geneSMARCD3 NRF1 MTF1dimer:12Zn2+:HMGCRgenePPARA:RXRAheterodimerHMGCR-1CDK8 SREBF2(1-484) PPARA:RXRACorepressor complexNPAS2 gene PLIN2 geneNFYC NCOA6 RXRA HMGCS1 gene HDAC3 p-S-NPAS2 NR1D1:heme:Corepressors:NPAS2 geneZn2+ TGS1 YAP1 FABP1:ligands ofPPARAMED11 APOA1 geneNCOR1 Actos NCOA2 FABP1 SMARCD3 MED20 TRIB3NCOA2 NCOA2 CDK19 Palm MED4 NCOA1 HELZ2 MED24 EP300 CHD9 MED15 TEAD4 Coactivators ofPPARalphaSP1 ACOX1 geneCARM1 ABCB4 genePEX11APPARGC1A CPT1A geneMED16 HMGCR gene NFYB SLC27A1 geneCCNC ALAS1gene:NRF1:PPARGC1BTEAD2 G0S2FABP1 geneCTGF geneSIN3A TEAD:WWTR1(TAZ)ME1 geneAGT geneHMGCR geneRXRA NCOA1 p-S-CLOCK APOA2(24-100)PPARA gene SULT2A1 geneTRIB3 geneMED26 ALAS1 gene MED13 NPAS2TEAD3 NFYA NCOA6 TEAD3 SIN3A ACSL1ANKRD1RORA:EP300:CPT1AgeneCREBBP SREBF1-1(1-490) MED21 SREBF1-1(1-490) CREBBP MED6 ALA TEAD2 ABCA1SIN3B-1 NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHACPT1ACD36 geneAPOA2 geneCDCA PPARA geneFADS1CPT2LCHA MED8 MED19 Corepressors ofPPARalphaFHL2ACADM genePeroxisome Proliferator Receptor Element (PPRE) TXNRD1 geneRXRA NPAS2 geneFDFT1 geneTIAM2 geneEPA SIN3B-1 SREBF2(1-484) NPAS2 gene TBL1XR1Peroxisome Proliferator Receptor Element (PPRE) SREBF2(1-484) NCOR2 MED1 UGT1A9CYP1A1MED1 NFYC CPT2RORA:EP300:NPAS2geneNFYA MTF1 FDFT1 gene PPARA:RXRACoactivator complexTXNRD1FADS1 geneNCOA1 PPARGC1B RORA EPA RORA TEAD1 CREBBP SREBF1-3 PeroxisomeProliferatorReceptor Element(PPRE)SREBP1A,2:NF-Y:HMGCRgeneTBL1X CYP4A11PPARA MED23 RXRA PLIN2FABP1ANKRD1 geneAPOA5p-S-ARNTL p-BMAL1:p-CLOCK,NPAS2:PPARA geneAGTNR1H4 NCOA2 ABCB4ferriheme b ANGPTL4PPARG G0S2 geneLINA SREBF1-1(1-490) NCOR1 ACOX1-1ME1CYP1A1 gene9S-HODE AA DCA RGZ NFYC MED22 SREBF1-3 PPARAALAS1 geneMED13L NCOR2 PPARG:FattyAcid:RXRA:Mediator:Coactivator ComplexTBL1XR1 HMGCS1Peroxisome Proliferator Receptor Element (PPRE) TBL1XNCOA3 TEAD1 MED9 4xPalmC-CD36UGT1A9 geneACSL1 geneNFYA APOA5 geneANGPTL geneMED17 HMGCS2CYP7A1 gene13(S')-HODE CYP7A1EP300 HDAC3 HELZ2 TNFRSF21MED10 TGS1 MED27 MED7 RXRA EP300 HMGCR gene AA TEAD4 GRHL1MED25 PPARA CHD9 RGL1ACADMFHL2 geneABCA1 geneNFYB LINA NR1D1 MED30 TBL1X 103018101833, 4115, 4410111812, 2012, 1712, 20103337


Description

Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma lipid levels.
PPAR-alpha is a type II nuclear receptor (its subcellular location does not depend on ligand binding). PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha), another type II nuclear receptor. PPAR-alpha is activated by binding fatty acid ligands, especially polyunsaturated fatty acids having 18-22 carbon groups and 2-6 double bonds.
The PPAR-alpha:RXR-alpha heterodimer binds peroxisome proliferator receptor elements (PPREs) in and around target genes. Binding of fatty acids and synthetic ligands causes a conformational change in PPAR-alpha such that it releases the corepressors and binds coactivators (CBP-SRC-HAT complex, ASC complex, and TRAP-Mediator complex) which initiate transcription of the target genes.
Target genes of PPAR-alpha participate in fatty acid transport, fatty acid oxidation, triglyceride clearance, lipoprotein production, and cholesterol homeostasis. View original pathway at:Reactome.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
115040view16:58, 25 January 2021ReactomeTeamReactome version 75
113484view11:56, 2 November 2020ReactomeTeamReactome version 74
112683view16:07, 9 October 2020ReactomeTeamReactome version 73
109289view21:21, 5 March 2020KhanspersReverted to version '11:47, 1 November 2018' by Khanspers
109272view15:00, 3 March 2020ClorisModified title
101600view11:47, 1 November 2018ReactomeTeamreactome version 66
101136view21:32, 31 October 2018ReactomeTeamreactome version 65
100664view20:05, 31 October 2018ReactomeTeamreactome version 64
100214view16:50, 31 October 2018ReactomeTeamreactome version 63
99765view15:16, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99324view12:47, 31 October 2018ReactomeTeamreactome version 62
93918view13:44, 16 August 2017ReactomeTeamreactome version 61
93495view11:25, 9 August 2017ReactomeTeamreactome version 61
88142view12:57, 26 July 2016RyanmillerOntology Term : 'fatty acid metabolic pathway' added !
88141view12:56, 26 July 2016RyanmillerOntology Term : 'classic metabolic pathway' added !
86591view09:21, 11 July 2016ReactomeTeamreactome version 56
83414view11:10, 18 November 2015ReactomeTeamVersion54
81776view10:35, 26 August 2015ReactomeTeamVersion53
77088view08:38, 17 July 2014ReactomeTeamFixed remaining interactions
76794view12:17, 16 July 2014ReactomeTeamFixed remaining interactions
76117view10:18, 11 June 2014ReactomeTeamRe-fixing comment source
75829view11:39, 10 June 2014ReactomeTeamReactome 48 Update
75190view09:39, 9 May 2014AnweshaFixing comment source for displaying WikiPathways description
74834view10:06, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
13(S')-HODE MetaboliteCHEBI:34154 (ChEBI)
4xPalmC-CD36ProteinP16671 (Uniprot-TrEMBL)
9S-HODE MetaboliteCHEBI:34496 (ChEBI)
AA MetaboliteCHEBI:15843 (ChEBI)
ABCA1 geneGeneProductENSG00000165029 (Ensembl)
ABCA1ProteinO95477 (Uniprot-TrEMBL)
ABCB4 geneGeneProductENSG00000005471 (Ensembl)
ABCB4ProteinP21439 (Uniprot-TrEMBL)
ACADM geneGeneProductENSG00000117054 (Ensembl)
ACADMProteinP11310 (Uniprot-TrEMBL)
ACOX1 geneGeneProductENSG00000161533 (Ensembl)
ACOX1-1ProteinQ15067-1 (Uniprot-TrEMBL)
ACSL1 geneGeneProductENSG00000151726 (Ensembl)
ACSL1ProteinP33121 (Uniprot-TrEMBL)
AGT geneGeneProductENSG00000135744 (Ensembl)
AGTProteinP01019 (Uniprot-TrEMBL)
ALA MetaboliteCHEBI:27432 (ChEBI)
ALAS1 gene:NRF1:PPARGC1BComplexR-HSA-2466384 (Reactome)
ALAS1 gene ProteinENSG00000023330 (Ensembl)
ALAS1 geneGeneProductENSG00000023330 (Ensembl)
ALAS1ProteinP13196 (Uniprot-TrEMBL)
ANGPTL geneGeneProductENSG00000167772 (Ensembl)
ANGPTL4ProteinQ9BY76 (Uniprot-TrEMBL)
ANKRD1 geneGeneProductENSG00000148677 (Ensembl)
ANKRD1ProteinQ15327 (Uniprot-TrEMBL)
APOA1 geneGeneProductENSG00000118137 (Ensembl)
APOA1(25-266)ProteinP02647 (Uniprot-TrEMBL)
APOA2 geneGeneProductENSG00000158874 (Ensembl)
APOA2(24-100)ProteinP02652 (Uniprot-TrEMBL)
APOA5 geneGeneProductENSG00000110243 (Ensembl)
APOA5ProteinQ6Q788 (Uniprot-TrEMBL)
Actos MetaboliteCHEBI:8228 (ChEBI)
CARM1 ProteinQ86X55 (Uniprot-TrEMBL)
CCNC ProteinP24863 (Uniprot-TrEMBL)
CD36 geneGeneProductENSG00000135218 (Ensembl)
CDCA MetaboliteCHEBI:16755 (ChEBI)
CDK19 ProteinQ9BWU1 (Uniprot-TrEMBL)
CDK8 ProteinP49336 (Uniprot-TrEMBL)
CHD9 ProteinQ3L8U1 (Uniprot-TrEMBL)
CPT1A gene ProteinENSG00000110090 (Ensembl)
CPT1A geneGeneProductENSG00000110090 (Ensembl)
CPT1AProteinP50416 (Uniprot-TrEMBL)
CPT2GeneProductENSG00000157184 (Ensembl)
CPT2ProteinP23786 (Uniprot-TrEMBL)
CREBBP ProteinQ92793 (Uniprot-TrEMBL)
CTGF geneGeneProductENSG00000118523 (Ensembl)
CTGFProteinP29279 (Uniprot-TrEMBL)
CYP1A1 geneGeneProductENSG00000140465 (Ensembl)
CYP1A1ProteinP04798 (Uniprot-TrEMBL)
CYP4A11 geneGeneProductENSG00000187048 (Ensembl)
CYP4A11ProteinQ02928 (Uniprot-TrEMBL)
CYP7A1 geneGeneProductENSG00000167910 (Ensembl)
CYP7A1ProteinP22680 (Uniprot-TrEMBL)
Coactivators of PPARalphaComplexR-HSA-400216 (Reactome)
Corepressors of PPARalphaComplexR-HSA-400207 (Reactome)
DCA MetaboliteCHEBI:28834 (ChEBI)
EP300 ProteinQ09472 (Uniprot-TrEMBL)
EPA MetaboliteCHEBI:28364 (ChEBI)
ESRRAProteinP11474 (Uniprot-TrEMBL)
FABP1 ProteinP07148 (Uniprot-TrEMBL) As inferred from mouse, FABP1 localizes to the nucleus where it may deliver lipids to PPARA.
FABP1 geneGeneProductENSG00000163586 (Ensembl)
FABP1:ligands of PPARAComplexR-HSA-2026984 (Reactome)
FABP1ProteinP07148 (Uniprot-TrEMBL) As inferred from mouse, FABP1 localizes to the nucleus where it may deliver lipids to PPARA.
FADS1 geneGeneProductENSG00000149485 (Ensembl)
FADS1ProteinO60427 (Uniprot-TrEMBL)
FDFT1 gene ProteinENSG00000079459 (Ensembl)
FDFT1 geneGeneProductENSG00000079459 (Ensembl)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FHL2 geneGeneProductENSG00000115641 (Ensembl)
FHL2ProteinQ14192 (Uniprot-TrEMBL)
G0S2 geneGeneProductENSG00000123689 (Ensembl)
G0S2ProteinP27469 (Uniprot-TrEMBL)
GLIPR1 geneGeneProductENSG00000139278 (Ensembl)
GLIPR1ProteinP48060 (Uniprot-TrEMBL)
GRHL1 geneGeneProductENSG00000134317 (Ensembl)
GRHL1ProteinQ9NZI5 (Uniprot-TrEMBL)
HDAC3 ProteinO15379 (Uniprot-TrEMBL)
HELZ2 ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene ProteinENSG00000113161 (Ensembl)
HMGCR geneGeneProductENSG00000113161 (Ensembl)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene ProteinENSG00000112972 (Ensembl)
HMGCS1 geneGeneProductENSG00000112972 (Ensembl)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
HMGCS2 geneGeneProductENSG00000134240 (Ensembl)
HMGCS2ProteinP54868 (Uniprot-TrEMBL)
LCHA MetaboliteCHEBI:16325 (ChEBI)
LINA MetaboliteCHEBI:17351 (ChEBI)
ME1 geneGeneProductENSG00000065833 (Ensembl)
ME1ProteinP48163 (Uniprot-TrEMBL)
MED1 ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
MED10 ProteinQ9BTT4 (Uniprot-TrEMBL)
MED11 ProteinQ9P086 (Uniprot-TrEMBL)
MED12 ProteinQ93074 (Uniprot-TrEMBL)
MED13 ProteinQ9UHV7 (Uniprot-TrEMBL)
MED13L ProteinQ71F56 (Uniprot-TrEMBL)
MED14 ProteinO60244 (Uniprot-TrEMBL)
MED15 ProteinQ96RN5 (Uniprot-TrEMBL)
MED16 ProteinQ9Y2X0 (Uniprot-TrEMBL)
MED17 ProteinQ9NVC6 (Uniprot-TrEMBL)
MED18 ProteinQ9BUE0 (Uniprot-TrEMBL)
MED19 ProteinA0JLT2 (Uniprot-TrEMBL)
MED20 ProteinQ9H944 (Uniprot-TrEMBL)
MED21 ProteinQ13503 (Uniprot-TrEMBL)
MED22 ProteinQ15528 (Uniprot-TrEMBL)
MED23 ProteinQ9ULK4 (Uniprot-TrEMBL)
MED24 ProteinO75448 (Uniprot-TrEMBL)
MED25 ProteinQ71SY5 (Uniprot-TrEMBL)
MED26 ProteinO95402 (Uniprot-TrEMBL)
MED27 ProteinQ6P2C8 (Uniprot-TrEMBL)
MED28 ProteinQ9H204 (Uniprot-TrEMBL)
MED29 ProteinQ9NX70 (Uniprot-TrEMBL)
MED30 ProteinQ96HR3 (Uniprot-TrEMBL)
MED31 ProteinQ9Y3C7 (Uniprot-TrEMBL)
MED4 ProteinQ9NPJ6 (Uniprot-TrEMBL)
MED6 ProteinO75586 (Uniprot-TrEMBL)
MED7 ProteinO43513 (Uniprot-TrEMBL)
MED8 ProteinQ96G25 (Uniprot-TrEMBL)
MED9 ProteinQ9NWA0 (Uniprot-TrEMBL)
MTF1

dimer:12Zn2+:HMGCR

gene		ComplexR-HSA-5660440 (Reactome)
MTF1 ProteinQ14872 (Uniprot-TrEMBL)
NCOA1 ProteinQ15788 (Uniprot-TrEMBL)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHAComplexR-HSA-5340274 (Reactome)
NCOA2 ProteinQ15596 (Uniprot-TrEMBL)
NCOA3 ProteinQ9Y6Q9 (Uniprot-TrEMBL)
NCOA6 ProteinQ14686 (Uniprot-TrEMBL)
NCOR1 ProteinO75376 (Uniprot-TrEMBL)
NCOR2 ProteinQ9Y618 (Uniprot-TrEMBL)
NFYA ProteinP23511 (Uniprot-TrEMBL)
NFYB ProteinP25208 (Uniprot-TrEMBL)
NFYC ProteinQ13952 (Uniprot-TrEMBL)
NPAS2 gene ProteinENSG00000170485 (Ensembl)
NPAS2 geneGeneProductENSG00000170485 (Ensembl)
NPAS2ProteinQ99743 (Uniprot-TrEMBL)
NR1D1 ProteinP20393 (Uniprot-TrEMBL)
NR1D1:heme:Corepressors:NPAS2 geneComplexR-HSA-5663274 (Reactome)
NR1H4 ProteinQ96RI1 (Uniprot-TrEMBL)
NRF1 ProteinQ16656 (Uniprot-TrEMBL)
PEX11A geneGeneProductENSG00000166821 (Ensembl)
PEX11AProteinO75192 (Uniprot-TrEMBL)
PLIN2 geneGeneProductENSG00000147872 (Ensembl)
PLIN2ProteinQ99541 (Uniprot-TrEMBL)
PPARA ProteinQ07869 (Uniprot-TrEMBL)
PPARA gene ProteinENSG00000186951 (Ensembl)
PPARA geneGeneProductENSG00000186951 (Ensembl)
PPARA:RXRA Coactivator complexComplexR-HSA-400154 (Reactome)
PPARA:RXRA Corepressor complexComplexR-HSA-400196 (Reactome)
PPARA:RXRA heterodimerComplexR-HSA-400138 (Reactome)
PPARAProteinQ07869 (Uniprot-TrEMBL)
PPARG ProteinP37231 (Uniprot-TrEMBL)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator ComplexComplexR-HSA-381367 (Reactome)
PPARGC1A ProteinQ9UBK2 (Uniprot-TrEMBL)
PPARGC1B ProteinQ86YN6 (Uniprot-TrEMBL)
Palm MetaboliteCHEBI:15756 (ChEBI)
Peroxisome

Proliferator Receptor Element

(PPRE)		R-NUL-422139 (Reactome) Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
Peroxisome Proliferator Receptor Element (PPRE) R-NUL-422139 (Reactome) Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
RGL1 geneGeneProductENSG00000143344 (Ensembl)
RGL1ProteinQ9NZL6 (Uniprot-TrEMBL)
RGZ MetaboliteCHEBI:50122 (ChEBI)
RORA ProteinP35398 (Uniprot-TrEMBL)
RORA:EP300:CPT1A geneComplexR-HSA-5663244 (Reactome)
RORA:EP300:NPAS2 geneComplexR-HSA-5663257 (Reactome)
RXRA ProteinP19793 (Uniprot-TrEMBL)
RXRAProteinP19793 (Uniprot-TrEMBL)
SIN3A ProteinQ96ST3 (Uniprot-TrEMBL)
SIN3B-1 ProteinO75182-1 (Uniprot-TrEMBL)
SLC27A1 geneGeneProductENSG00000130304 (Ensembl)
SLC27A1ProteinQ6PCB7 (Uniprot-TrEMBL)
SMARCD3 ProteinQ6STE5 (Uniprot-TrEMBL)
SP1 ProteinP08047 (Uniprot-TrEMBL)
SREBF1-1(1-490) ProteinP36956-1 (Uniprot-TrEMBL)
SREBF1-3 ProteinP36956-3 (Uniprot-TrEMBL)
SREBF2(1-484) ProteinQ12772 (Uniprot-TrEMBL)
SREBP1A,1C,2:NF-Y:HMGCS1 geneComplexR-HSA-2426129 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneComplexR-HSA-2426135 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneComplexR-HSA-2426128 (Reactome)
SULT2A1 geneGeneProductENSG00000105398 (Ensembl)
SULT2A1ProteinQ06520 (Uniprot-TrEMBL)
TBL1X ProteinO60907 (Uniprot-TrEMBL)
TBL1XProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 ProteinQ9BZK7 (Uniprot-TrEMBL)
TBL1XR1ProteinQ9BZK7 (Uniprot-TrEMBL)
TEAD1 ProteinP28347 (Uniprot-TrEMBL)
TEAD2 ProteinQ15562 (Uniprot-TrEMBL)
TEAD3 ProteinQ99594 (Uniprot-TrEMBL)
TEAD4 ProteinQ15561 (Uniprot-TrEMBL)
TEAD:WWTR1(TAZ)ComplexR-HSA-2032762 (Reactome)
TEAD:YAP1ComplexR-HSA-2032772 (Reactome)
TGS1 ProteinQ96RS0 (Uniprot-TrEMBL)
TIAM2 geneGeneProductENSG00000146426 (Ensembl)
TIAM2ProteinQ8IVF5 (Uniprot-TrEMBL)
TNFRSF21 geneGeneProductENSG00000146072 (Ensembl)
TNFRSF21ProteinO75509 (Uniprot-TrEMBL)
TRIB3 geneGeneProductENSG00000101255 (Ensembl)
TRIB3ProteinQ96RU7 (Uniprot-TrEMBL)
TXNRD1 geneGeneProductENSG00000198431 (Ensembl)
TXNRD1ProteinQ16881 (Uniprot-TrEMBL)
UGT1A9 geneGeneProductENSG00000241119 (Ensembl)
UGT1A9ProteinO60656 (Uniprot-TrEMBL)
WWTR1 ProteinQ9GZV5 (Uniprot-TrEMBL)
YAP1 ProteinP46937 (Uniprot-TrEMBL)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)
ferriheme b MetaboliteCHEBI:36144 (ChEBI)
p-BMAL1:p-CLOCK,NPAS2:PPARA geneComplexR-HSA-5663137 (Reactome)
p-S-ARNTL ProteinO00327 (Uniprot-TrEMBL)
p-S-CLOCK ProteinO15516 (Uniprot-TrEMBL)
p-S-NPAS2 ProteinQ99743 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
4xPalmC-CD36ArrowR-HSA-560517 (Reactome)
ABCA1 geneR-HSA-1989765 (Reactome)
ABCA1ArrowR-HSA-1989765 (Reactome)
ABCB4 geneR-HSA-1989762 (Reactome)
ABCB4ArrowR-HSA-1989762 (Reactome)
ACADM geneR-HSA-1989745 (Reactome)
ACADMArrowR-HSA-1989745 (Reactome)
ACOX1 geneR-HSA-1989749 (Reactome)
ACOX1-1ArrowR-HSA-1989749 (Reactome)
ACSL1 geneR-HSA-1989778 (Reactome)
ACSL1ArrowR-HSA-1989778 (Reactome)
AGT geneR-HSA-1989774 (Reactome)
AGTArrowR-HSA-1989774 (Reactome)
ALAS1 geneR-HSA-1592238 (Reactome)
ALAS1ArrowR-HSA-1592238 (Reactome)
ANGPTL geneR-HSA-560473 (Reactome)
ANGPTL4ArrowR-HSA-560473 (Reactome)
ANKRD1 geneR-HSA-1989779 (Reactome)
ANKRD1ArrowR-HSA-1989779 (Reactome)
APOA1 geneR-HSA-1989754 (Reactome)
APOA1(25-266)ArrowR-HSA-1989754 (Reactome)
APOA2 geneR-HSA-1989776 (Reactome)
APOA2(24-100)ArrowR-HSA-1989776 (Reactome)
APOA5 geneR-HSA-1989761 (Reactome)
APOA5ArrowR-HSA-1989761 (Reactome)
ArrowR-HSA-1368065 (Reactome)
ArrowR-HSA-1592238 (Reactome)
ArrowR-HSA-1801587 (Reactome)
ArrowR-HSA-879724 (Reactome)
CD36 geneR-HSA-560517 (Reactome)
CPT1A geneR-HSA-1801587 (Reactome)
CPT1AArrowR-HSA-1801587 (Reactome)
CPT2ArrowR-HSA-1989773 (Reactome)
CPT2R-HSA-1989773 (Reactome)
CTGF geneR-HSA-1989766 (Reactome)
CTGFArrowR-HSA-1989766 (Reactome)
CYP1A1 geneR-HSA-1989764 (Reactome)
CYP1A1ArrowR-HSA-1989764 (Reactome)
CYP4A11 geneR-HSA-1989755 (Reactome)
CYP4A11ArrowR-HSA-1989755 (Reactome)
CYP7A1 geneR-HSA-1989746 (Reactome)
CYP7A1ArrowR-HSA-1989746 (Reactome)
Coactivators of PPARalphaR-HSA-400143 (Reactome)
Corepressors of PPARalphaArrowR-HSA-400143 (Reactome)
Corepressors of PPARalphaR-HSA-400183 (Reactome)
FABP1 geneR-HSA-1989751 (Reactome)
FABP1:ligands of PPARAR-HSA-400143 (Reactome)
FABP1ArrowR-HSA-1989751 (Reactome)
FABP1ArrowR-HSA-400143 (Reactome)
FADS1 geneR-HSA-1989757 (Reactome)
FADS1ArrowR-HSA-1989757 (Reactome)
FDFT1 geneR-HSA-1655850 (Reactome)
FDFT1ArrowR-HSA-1655850 (Reactome)
FHL2 geneR-HSA-1989747 (Reactome)
FHL2ArrowR-HSA-1989747 (Reactome)
G0S2 geneR-HSA-1989759 (Reactome)
G0S2ArrowR-HSA-1989759 (Reactome)
GLIPR1 geneR-HSA-1989772 (Reactome)
GLIPR1ArrowR-HSA-1989772 (Reactome)
GRHL1 geneR-HSA-1989748 (Reactome)
GRHL1ArrowR-HSA-1989748 (Reactome)
HMGCR geneR-HSA-1655826 (Reactome)
HMGCR-1ArrowR-HSA-1655826 (Reactome)
HMGCS1 geneR-HSA-1655848 (Reactome)
HMGCS1ArrowR-HSA-1655848 (Reactome)
HMGCS2 geneR-HSA-1989760 (Reactome)
HMGCS2ArrowR-HSA-1989760 (Reactome)
ME1 geneR-HSA-1989756 (Reactome)
ME1ArrowR-HSA-1989756 (Reactome)
MTF1

dimer:12Zn2+:HMGCR

gene		TBarR-HSA-1655826 (Reactome)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHATBarR-HSA-1989746 (Reactome)
NPAS2 geneR-HSA-1368065 (Reactome)
NPAS2ArrowR-HSA-1368065 (Reactome)
NR1D1:heme:Corepressors:NPAS2 geneTBarR-HSA-1368065 (Reactome)
PEX11A geneR-HSA-1989753 (Reactome)
PEX11AArrowR-HSA-1989753 (Reactome)
PLIN2 geneR-HSA-1989770 (Reactome)
PLIN2ArrowR-HSA-1989770 (Reactome)
PPARA geneR-HSA-879724 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1368065 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1592238 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655826 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655848 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655850 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1801587 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989745 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989746 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989747 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989748 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989749 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989750 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989751 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989752 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989753 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989754 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989755 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989756 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989757 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989758 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989759 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989760 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989761 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989762 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989764 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989765 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989766 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989767 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989768 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989770 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989771 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989772 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989773 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989774 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989775 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989776 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989777 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989778 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1989779 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-400143 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-560473 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-560517 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-879724 (Reactome)
PPARA:RXRA Corepressor complexArrowR-HSA-400183 (Reactome)
PPARA:RXRA Corepressor complexR-HSA-400143 (Reactome)
PPARA:RXRA heterodimerArrowR-HSA-400204 (Reactome)
PPARA:RXRA heterodimerR-HSA-400183 (Reactome)
PPARAArrowR-HSA-879724 (Reactome)
PPARAR-HSA-400204 (Reactome)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator ComplexArrowR-HSA-560473 (Reactome)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator ComplexArrowR-HSA-560517 (Reactome)
Peroxisome

Proliferator Receptor Element

(PPRE)		R-HSA-400204 (Reactome)
R-HSA-1368065 (Reactome) The NPAS2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of NPAS2 is enhanced by the RORA:Coactivator complex and repressed by the REV-ERBA:Corepressor complex.
R-HSA-1592238 (Reactome) The ALAS1 gene is transcribed to yield mRNA and the mRNA is translated in the cytosol to yield precursor protein. The ALAS1 precursor is imported into the mitochodrial matrix where it catalyzes the synthesis of 5-aminolevulinate from glycine and succinyl-CoA as part of heme biosynthesis.
R-HSA-1655826 (Reactome) The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655848 (Reactome) The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655850 (Reactome) The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1801587 (Reactome) The CPT1A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989745 (Reactome) The ACADM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989746 (Reactome) The CYP7A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989747 (Reactome) The FHL2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989748 (Reactome) The GRHL1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989749 (Reactome) The ACOX1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989750 (Reactome) The FATP1 (SLC27A1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989751 (Reactome) The FABP1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989752 (Reactome) The TXNRD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989753 (Reactome) The PEX11A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989754 (Reactome) The APOA1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989755 (Reactome) The CYP4A11 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989756 (Reactome) The ME1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989757 (Reactome) The FADS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989758 (Reactome) The UGT1A9 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989759 (Reactome) The G0S2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989760 (Reactome) The HMGCS2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989761 (Reactome) The APOA5 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989762 (Reactome) The ABCB4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989764 (Reactome) The CYP1A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989765 (Reactome) The ABCA1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989766 (Reactome) The CTGF gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of the CTGF gene is increased by both YAP1:TEAD and WWTR1(TAZ):TEAD transcriptional coactivator:transcription factor complexes, so that CTFG is one of the many genes whose expression is downregulated by the action of the hippo cascade (Zhang et al. 2009; Zhao et al. 2008).
R-HSA-1989767 (Reactome) The TRIB3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989768 (Reactome) The TIAM2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989770 (Reactome) The Adipophilin (PLIN2) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989771 (Reactome) The TNFRSF21 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989772 (Reactome) The GLIPR1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989773 (Reactome) The CPT2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989774 (Reactome) The AGT gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989775 (Reactome) The SULT2A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989776 (Reactome) The APOA2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989777 (Reactome) The RGL1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989778 (Reactome) The ACSL1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1989779 (Reactome) The ANKRD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-400143 (Reactome) PPAR-alpha is activated by binding polyunsaturated fatty acids especially those having 18-22 carbon groups and 2-6 double bonds. These ligands bind the C-terminal region of PPAR-alpha and include linoleic acid, linolenic acids, arachidonic acid, and eicosapentaenoic acid. The fibrate drugs are also agonists of PPAR-alpha.
Binding of a ligand causes a conformational change in PPAR-alpha so that it recruits coactivators. By analogy with the closely related receptor PPAR-gamma, PPAR-alpha probably binds TBL1 and TBLR1, which are responsible for recruiting the 19S proteasome to degrade corepressors during the exchange of corepressors for coactivators. The coactivators belong to the CBP-SRC-HAT complex (CBP/p300, SRC1, SRC2, SRC3, CARM1, SWI/SNF, BAF60C, PRIC320, and PRIC285), the ASC complex (PRIP/ASC2, PIMT), and the TRAP-DRIP-ARC-MEDIATOR complex (TRAP130, PBP/TRAP220). The coactivators contain LXXLL motifs (Nuclear Receptor Boxes) that interact with the AF-2 region in nuclear receptors such as PPAR-alpha.
R-HSA-400183 (Reactome) In the absence of activating ligands of PPAR-alpha, the PPAR-alpha:RXR-alpha heterodimers recruit corepressors NCoR1, NCoR2(SMRT), and histone deacetylases (HDACs) to genes regulated by PPAR-alpha. The corepressors maintain chromatin at the gene in an inactive conformation and prevent expression of the gene.
R-HSA-400204 (Reactome) Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a type II nuclear receptor (its subcellular location is independent of ligand binding) related to PPAR-beta/delta and PPAR-gamma. PPAR-alpha is expressed highly in the liver where if functions to control lipid metabolism, especially fatty acid oxidation.
PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha). The heterodimers bind peroxisome proliferator receptor elements (PPREs) in and around genes regulated by PPAR-alpha.
R-HSA-560473 (Reactome) The ANGPTL4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-560517 (Reactome) The Platelet glycoprotein IV gene (CD36, PAS IV, GPIV) is transcribed to yield mRNA and the mRNA is translated to yield proteind.
R-HSA-879724 (Reactome) The PPARA gene is transcribed to yield mRNA and the mRNA is translated to yield protein. As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) heterodimers bind the scond intron of the PPARA gene and activate transcription of PPARA.
RGL1 geneR-HSA-1989777 (Reactome)
RGL1ArrowR-HSA-1989777 (Reactome)
RXRAR-HSA-400204 (Reactome)
SLC27A1 geneR-HSA-1989750 (Reactome)
SLC27A1ArrowR-HSA-1989750 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneArrowR-HSA-1655848 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneArrowR-HSA-1655850 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneArrowR-HSA-1655826 (Reactome)
SULT2A1 geneR-HSA-1989775 (Reactome)
SULT2A1ArrowR-HSA-1989775 (Reactome)
TBL1XR-HSA-400183 (Reactome)
TBL1XR1R-HSA-400183 (Reactome)
TEAD:WWTR1(TAZ)ArrowR-HSA-1989766 (Reactome)
TEAD:YAP1ArrowR-HSA-1989766 (Reactome)
TIAM2 geneR-HSA-1989768 (Reactome)
TIAM2ArrowR-HSA-1989768 (Reactome)
TNFRSF21 geneR-HSA-1989771 (Reactome)
TNFRSF21ArrowR-HSA-1989771 (Reactome)
TRIB3 geneR-HSA-1989767 (Reactome)
TRIB3ArrowR-HSA-1989767 (Reactome)
TXNRD1 geneR-HSA-1989752 (Reactome)
TXNRD1ArrowR-HSA-1989752 (Reactome)
UGT1A9 geneR-HSA-1989758 (Reactome)
UGT1A9ArrowR-HSA-1989758 (Reactome)
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