Wnt myofibroblastic activation of hepatic stellate cells (Rattus norvegicus)

From WikiPathways

Revision as of 13:44, 31 July 2016 by AAR&Co (Talk | contribs)
Jump to: navigation, search
1Epigenetic RepressionHSC myofibroblastic activationPpar-yBeta-CateninWnt-3aMeCP2FJ9LeupeptinSer/Cys PeptidasesDPI


Description

This pathway is modeled after figure 5 from Kweon et al. The WNT signaling pathway activates Beta-catenin which inhibits serine and cysteine proteases. This inhibition of these proteins increases MeCP2 stability and induces epigenetic repression of Ppar-y leading to hepatic stellate cell myofibroblastic activation causing liver fibrosis which can lead to liver cirrhosis.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H; ''Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells.''; PLoS One, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129294view17:31, 25 March 2024Khanspersupdated xrefs, updated label
116515view10:51, 7 May 2021EweitzModified title
89262view16:54, 27 August 2016Khanspersupdated xref for beta-catenin
89261view16:50, 27 August 2016KhanspersQuick edit to datanode annotation or property
89219view20:58, 23 August 2016Khansperschanged FJ9 node to metabolite
88841view17:38, 15 August 2016AAR&CoEdited nodes
88840view17:32, 15 August 2016AAR&CoPeriodical save, work in progress
88839view15:40, 15 August 2016AAR&CoPeriodical save, work in progress
88451view15:28, 8 August 2016AAR&CoConnected Lines
88204view13:46, 31 July 2016AAR&CoEdited Data Node
88203view13:44, 31 July 2016AAR&CoAdded Data Node
88202view13:41, 31 July 2016AAR&CoEdited Data Nodes
87862view11:58, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87284view17:09, 20 July 2016AAR&CoModified description
87283view17:01, 20 July 2016AAR&CoOntology Term : 'liver cirrhosis' added !
87282view16:59, 20 July 2016AAR&CoOntology Term : 'hepatic stellate cell' added !
87281view16:54, 20 July 2016AAR&CoAdded metabolites
87280view16:49, 20 July 2016AAR&CoModified description
87278view16:44, 20 July 2016AAR&CoFixed unconnected line and label
86149view19:50, 1 July 2016EgonwReplaced a mim-conversion with Arrow.
85629view15:44, 3 June 2016AAR&CoAdd Literature Citation
85626view15:41, 3 June 2016AAR&CoSpecify description
85625view15:36, 3 June 2016AAR&CoPeriodical save, work in progress
85624view15:23, 3 June 2016AAR&CoPeriodical save, work in progress
85622view13:23, 3 June 2016AAR&CoPeriodical save, work in progress
85621view12:53, 3 June 2016AAR&CoPeriodical save, work in progress
85619view12:43, 3 June 2016AAR&CoPeriodical save, work in progress
85618view12:33, 3 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Beta-CateninProteinENSRNOG00000054172 (Ensembl Rat)
DPIMetabolite3101 (PubChem-compound)
FJ9ProteinSmall molecule inhibitor, see article for more information
LeupeptinMetabolite72429 (PubChem-compound)
MeCP2ProteinENSRNOG00000056659 (Ensembl)
Ppar-yProteinO88275 (Uniprot-TrEMBL)
Ser/Cys PeptidasesProteinNot specified by literature
Wnt-3aProteinF1M077 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3649"
Personal tools