Wnt signaling in kidney disease (Mus musculus)
From WikiPathways
Description
This pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (See bibliography). The gene product Wnt signals two different paths titled canonical and non-canonical. The non-canonical path is mediated by the membrane bound protein Disheveled (Dvl) which then controls the planar cell Polarity. The canonical path on the other hand is mediated by the cytoplasmic protein Disheveled (Dvl) and then is effected through b-catenin transcription. The complex of NPHP2 and NPHP3 seem to help facilitate the process by controlling the Wnt signaling.
Quality Tags
Ontology Terms
Bibliography
- Stamos JL, Weis WI; ''The β-catenin destruction complex.''; Cold Spring Harb Perspect Biol, 2013 PubMed Europe PMC Scholia
- Bissler JJ, Siroky BJ, Yin H; ''Glomerulocystic kidney disease.''; Pediatr Nephrol, 2010 PubMed Europe PMC Scholia
- Bergmann C, Fliegauf M, Brüchle NO, Frank V, Olbrich H, Kirschner J, Schermer B, Schmedding I, Kispert A, Kränzlin B, Nürnberg G, Becker C, Grimm T, Girschick G, Lynch SA, Kelehan P, Senderek J, Neuhaus TJ, Stallmach T, Zentgraf H, Nürnberg P, Gretz N, Lo C, Lienkamp S, Schäfer T, Walz G, Benzing T, Zerres K, Omran H; ''Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia.''; Am J Hum Genet, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Calcium | Metabolite | HMDB00464 (HMDB) | |
Frizzled | Protein | O70421 (Uniprot-TrEMBL) | |
JNK Kinase | GeneProduct | ENSMUSG00000021936 (Ensembl) | |
LPR | GeneProduct | ENSMUSG00000024778 (Ensembl) | |
NPHP2 | GeneProduct | ENSMUSG00000028344 (Ensembl) | |
Nphp3 | GeneProduct | ENSMUSG00000032558 (Ensembl) | |
Rhoa | GeneProduct | ENSMUSG00000007815 (Ensembl) | |
Wnt | GeneProduct | ENSMUSG00000022997 (Ensembl) | |
beta-catenin | GeneProduct | ENSMUSG00000006932 (Ensembl) | |
cDvl | GeneProduct | ENSMUSG00000029071 (Ensembl) | Cytoplasmic Protein |
mDvl | GeneProduct | ENSMUSG00000029071 (Ensembl) | Membrane Bound Protein |
Annotated Interactions
No annotated interactions