Oxidation by cytochrome P450 (Danio rerio)

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1Cytochrome P450 genesSubstratezgc:153291cyp4CYPCYP2C18CYP4F2dia1LOC570455CYP3A5CYP4F2cyp17a1cyp4v2cyb5bcyp11a1CYP2C9CYP2A13zgc:63920CYP2A7Fe3+CYP3A43O2cyp4CYP4F2cyb5r3zgc:63986CYP4F2CYP2J2NAD+cyp27c1CYP2F1Substratecyp1b1Fe3+cyp26a1LOC793249CYP2S1cyp4Fe2+CYP2B6CYP27A1cyp51zgc:174342O2CYP2G1PCYPNADHCYP2C8cyp51cyp11b2CYPPORA9JRH5_DANREcyb5bcyp24a1lactivated O2cyp1aCYP2E1zgc:112177cyp4cyp26b1cyb5aCYP3A4cyp4CYP2W1CYPSubstratesi:dkey-69h9.1Substrate-OHNADPHCYP46A1cyp1aSubstrateCYP19A1CYP2C19NADP+CYP27B1cyb5aFe2+cyp2u1CYP3A7Fe3+SubstrateFe2+CYPCYP4F2cyp11b2Fe2+CYP2A6CYP2D6cyb5bcyp26c1CYP4F2Fe3+cyb5aH2O


Description

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP43(r29608) with a 56% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Niesink, R.J.M, Vries, de, J., Hollinger, M.A.; ''Toxicology; Principles and Applications''; , 1996
  2. Saad M, Cavanaugh K, Verbueken E, Pype C, Casteleyn C, Van Ginneken C, Van Cruchten S; ''Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1to 3.''; J Toxicol Sci, 2016 PubMed Europe PMC Scholia
  3. Goldstone JV, McArthur AG, Kubota A, Zanette J, Parente T, Jönsson ME, Nelson DR, Stegeman JJ; ''Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish.''; BMC Genomics, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140266view06:08, 9 August 2025EgonwAdded the ISBN of the cited book
140236view08:52, 8 August 2025EgonwMore unicode (iron ions)
140235view07:37, 8 August 2025EgonwTwo recent references (not used yet)
140234view07:30, 8 August 2025EgonwMore unicode
118187view10:51, 25 May 2021EweitzModified title
107100view14:18, 17 September 2019MaintBotChEBI identifier normalization
106084view11:59, 16 August 2019MaintBotHMDB identifier normalization
88275view14:35, 1 August 2016FehrhartOntology Term : 'hepatocyte' added !
88274view14:35, 1 August 2016FehrhartOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
88273view14:35, 1 August 2016FehrhartOntology Term : 'xenobiotics biodegradation pathway' added !
73520view23:32, 29 January 2014KhanspersModified title
71931view20:48, 23 October 2013EgonwFixed the PubChem-compound data source.
68671view05:29, 6 July 2013MaintBotUpdated to 2013 gpml schema
58797view22:46, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
48312view04:37, 18 May 2012KhanspersUpdating PubChem xrefs
46428view20:47, 27 January 2012MaintBotAutomatic update of PubChem xrefs
40844view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
34226view21:36, 9 December 2009MaintBotAutomatic update of empty xrefs
31966view13:06, 14 August 2009MaintBotFixed group labels
31102view01:42, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A9JRH5_DANREGeneProductENSDARG00000056587 (Ensembl)
CYPGeneProduct
CYP19A1GeneProduct
CYP27A1GeneProduct
CYP27B1GeneProductENSDARG00000045015 (Ensembl)
CYP2A13GeneProduct
CYP2A6GeneProduct
CYP2A7GeneProduct
CYP2B6GeneProduct
CYP2C18GeneProduct
CYP2C19GeneProduct
CYP2C8GeneProduct
CYP2C9GeneProduct
CYP2D6GeneProduct
CYP2E1GeneProduct
CYP2F1GeneProduct
CYP2G1PGeneProduct
CYP2J2GeneProduct
CYP2S1GeneProduct
CYP2W1GeneProduct
CYP3A4GeneProduct
CYP3A43GeneProduct
CYP3A5GeneProduct
CYP3A7GeneProduct
CYP46A1GeneProduct553543 (Entrez Gene)
CYP4F2GeneProductENSDARG00000053530 (Ensembl)
Fe2+Metabolite29033 (ChEBI)
Fe3+Metabolite29034 (ChEBI)
H2OMetabolite962 (PubChem-compound)
LOC570455GeneProductENSDARG00000008858 (Ensembl)
LOC793249GeneProductENSDARG00000037550 (Ensembl)
NAD+Metabolite15846 (ChEBI)
NADHMetabolite16908 (ChEBI)
NADP+Metabolite18009 (ChEBI)
NADPHMetabolite16474 (ChEBI)
O2MetaboliteHMDB01377 (HMDB)
PORGeneProduct568202 (Entrez Gene)
SubstrateGeneProduct
Substrate-OHGeneProduct
activated O2Metabolite
cyb5aGeneProductENSDARG00000055643 (Ensembl)
cyb5bGeneProductENSDARG00000053954 (Ensembl)
cyb5r3GeneProductENSDARG00000005891 (Ensembl)
cyp11a1GeneProductENSDARG00000002347 (Ensembl)
cyp11b2GeneProductENSDARG00000042014 (Ensembl)
cyp17a1GeneProductENSDARG00000033566 (Ensembl)
cyp1aGeneProductENSDARG00000026039 (Ensembl)
cyp1b1GeneProductENSDARG00000068934 (Ensembl)
cyp24a1lGeneProductENSDARG00000070420 (Ensembl)
cyp26a1GeneProductENSDARG00000033999 (Ensembl)
cyp26b1GeneProductENSDARG00000077121 (Ensembl)
cyp26c1GeneProductENSDARG00000056029 (Ensembl)
cyp27c1GeneProductENSDARG00000058439 (Ensembl)
cyp2u1GeneProductENSDARG00000026548 (Ensembl)
cyp4GeneProductENSDARG00000004964 (Ensembl)
cyp4v2GeneProductENSDARG00000062132 (Ensembl)
cyp51GeneProductENSDARG00000042641 (Ensembl)
dia1GeneProductENSDARG00000018966 (Ensembl)
si:dkey-69h9.1GeneProductENSDARG00000017982 (Ensembl)
zgc:112177GeneProductENSDARG00000020898 (Ensembl)
zgc:153291GeneProductENSDARG00000051925 (Ensembl)
zgc:174342GeneProductENSDARG00000053068 (Ensembl)
zgc:63920GeneProductENSDARG00000069018 (Ensembl)
zgc:63986GeneProductENSDARG00000006040 (Ensembl)

Annotated Interactions

No annotated interactions
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