Physiological and pathological hypertrophy of the heart (Bos taurus)

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10, 13, 1566, 93, 124, 75141, 82, 4, 116, 14StressPAKHypertrophic gene expressionGiGqApoptosisGPCR agonistsCytokinesRASPhysioclogical HypertrophyCellular growthContractilityElectrophysiology defectsPathological remodelingContractilityCompensatory hypertrophySurvivalDecompensated heart failure(mechanical, oxidative, metabolic)LabelCalciumMYEF2AGTPRKCEFOSIL6STPPP3CBMAPK11RHOALIFRCTF1NFATC4CAMK2DRAC1MAPK8MAPK1PEEDN1MAPK8JUNMAPK14PRKCBGATA4PPP3CAMAPK14CalmodulinSTAT3MAP2K3


Description

Pathways in physiological and pathological hypertrophy of the heart. Largely based on the article from Wang Y; Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach." Hypertrohpy of the heart can be a physiological compensation for exercise, but it can also be a pathological compensation for hypertension and stress.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1528(78581) with a 96.0% conversion rate.

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Bibliography

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  1. Molkentin JD; ''Calcineurin and beyond: cardiac hypertrophic signaling.''; Circ Res, 2000 PubMed Europe PMC Scholia
  2. Wang Y; ''Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach.''; Curr Opin Pharmacol, 2001 PubMed Europe PMC Scholia
  3. Heineke J, Molkentin JD; ''Regulation of cardiac hypertrophy by intracellular signalling pathways.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  4. Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR; ''Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  5. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR; ''Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  6. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN; ''A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.''; Cell, 1998 PubMed Europe PMC Scholia
  7. Wollert KC, Chien KR; ''Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development.''; J Mol Med, 1997 PubMed Europe PMC Scholia
  8. Lim HW, Molkentin JD; ''Calcineurin and human heart failure.''; Nat Med, 1999 PubMed Europe PMC Scholia
  9. MacLellan WR; ''Advances in the molecular mechanisms of heart failure.''; Curr Opin Cardiol, 2000 PubMed Europe PMC Scholia
  10. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD; ''The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.''; EMBO J, 2000 PubMed Europe PMC Scholia
  11. Hunter JJ, Chien KR; ''Signaling pathways for cardiac hypertrophy and failure.''; N Engl J Med, 1999 PubMed Europe PMC Scholia
  12. Jalili T, Takeishi Y, Walsh RA; ''Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.''; Cardiovasc Res, 1999 PubMed Europe PMC Scholia
  13. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA; ''Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.''; Circ Res, 2000 PubMed Europe PMC Scholia
  14. Clerk A, Sugden PH; ''Small guanine nucleotide-binding proteins and myocardial hypertrophy.''; Circ Res, 2000 PubMed Europe PMC Scholia
  15. Olson EN, Molkentin JD; ''Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?''; Circ Res, 1999 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
116467view10:08, 7 May 2021EweitzModified title
105935view11:46, 16 August 2019MaintBotHMDB identifier normalization
88321view15:40, 1 August 2016FehrhartOntology Term : 'hypertrophic cardiomyopathy pathway' added !
80669view15:21, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AGTGeneProductENSBTAG00000012393 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:183
CAMK2DGeneProductENSBTAG00000014463 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:817
CTF1GeneProductENSBTAG00000017697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1489
CalciumMetaboliteHMDB00464 (HMDB)
CalmodulinProteinHomologyConvert: Multiple homologues found: En:ENSBTAG00000001575;En:ENSBTAG00000025644;
EDN1GeneProductENSBTAG00000008096 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1906
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
GATA4GeneProductENSBTAG00000005425 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2626
IL6STGeneProductENSBTAG00000017745 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3572
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
LIFRGeneProductENSBTAG00000010423 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3977
MAP2K3GeneProductENSBTAG00000010576 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAPK11GeneProductENSBTAG00000030182 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5600
MAPK14GeneProductENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MYEF2GeneProductENSBTAG00000008771 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50804
NFATC4GeneProductENSBTAG00000006366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4776
PEMetaboliteHMDB02182 (HMDB)
PPP3CAGeneProductENSBTAG00000016005 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5530
PPP3CBGeneProductENSBTAG00000019525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5532
PRKCBGeneProductENSBTAG00000020921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
PRKCEGeneProductENSBTAG00000020614 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581
RAC1GeneProductENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RHOAGeneProductENSBTAG00000004279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
STAT3GeneProductENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774

Annotated Interactions

No annotated interactions
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