Hematopoietic stem cell gene regulation by GABP alpha/beta complex (Homo sapiens)

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1LegendHypothetical InteractionsPhysiological AffectsDownregulationGABP Complex AutoregulationKey HSC Transcription FactorsETV6GABPAATMBCL2PTENCREBBPDNMT3BEP300HSC Self RenewalZFXBCL2L1FLT3MCL1GABPBSMAD4DNMT1TERF2Foxo3aHSC SurvivalHSC AgingHSC QuiescenceSMARCA4DNMT3AHSC DifferentiationEpigenetic ModificationsGZMB


Description

GABP alpha/beta complex mediates the maintenance of hematopoietic stem cells (HSCs) through control of proteins necessary for epigenetic modification and transcription regulation. The activation of key transcription factors and proteins required for HSC survival, self renewal, quiescence, differentiation, and aging is controlled by the GABP alpha/beta complex. This complex also down-regulates GZMB, protein important for inhibiting HSC survival. This pathway is based on figure 7 from Yu et al.

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Ontology Terms

 

Bibliography

  1. Yu S, Cui K, Jothi R, Zhao DM, Jing X, Zhao K, Xue HH; ''GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells.''; Blood, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127709view19:58, 24 November 2023EweitzAdd more legend margin
127708view19:55, 24 November 2023EweitzAdd legend margin to prevent overlap outside PathVisio
127707view19:38, 24 November 2023EweitzTailor gene boxes, economize layout
123358view04:46, 18 July 2022EgonwMade five pathways clickable
120797view00:28, 9 January 2022EweitzUse gene symbols, refine graphics and case
117754view12:50, 22 May 2021EweitzModified title
106590view19:32, 10 September 2019KhanspersModified description
105614view04:55, 10 August 2019KhanspersModified description
89276view06:49, 29 August 2016Khansperslayout, added auto-regulatory loop
89067view08:39, 19 August 2016FehrhartFixed unconnected line
88493view22:44, 10 August 2016AAR&CoSpecify description
88491view22:41, 10 August 2016AAR&CoFixed Legend
88490view22:40, 10 August 2016AAR&CoFixed Legend
88486view22:28, 10 August 2016AAR&CoOntology Term : 'DNA modification pathway' added !
88485view22:25, 10 August 2016AAR&CoOntology Term : 'hematopoietic stem cell' added !
88484view22:24, 10 August 2016AAR&CoFixed Labels and interactions
88481view22:16, 10 August 2016AAR&CoPeriodical Save
88479view22:08, 10 August 2016AAR&CoPeriodical save, work in progress
87198view11:46, 19 July 2016EgonwChanged the species to human, as all genes had human IDs.
85925view18:17, 21 June 2016AAR&CoFixed unconnected lines
85924view18:15, 21 June 2016AAR&CoModified description
85802view23:39, 14 June 2016AAR&CoModified description
85797view22:12, 14 June 2016AAR&CoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATMGeneProductENSG00000149311 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
DNMT1GeneProductENSG00000130816 (Ensembl)
DNMT3AGeneProductENSG00000119772 (Ensembl)
DNMT3BGeneProductENSG00000088305 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
ETV6GeneProductENSG00000139083 (Ensembl)
Epigenetic ModificationsPathwayWP3362 (WikiPathways)
FLT3GeneProductENSG00000122025 (Ensembl)
Foxo3aProteinO43524 (Uniprot-TrEMBL)
GABPAGeneProductENSG00000154727 (Ensembl)
GABPBGeneProductENSG00000104064 (Ensembl) GABPB Not Specified
GZMBGeneProductENSG00000100453 (Ensembl)
HSC AgingPathwaymap04213 (KEGG Pathway) Identifier Not Found
HSC DifferentiationPathwayWP2849 (WikiPathways)
HSC QuiescencePathwayIdentifier Not Found
HSC Self RenewalPathwaymap04550 (KEGG Pathway)
HSC SurvivalPathwaymap04210 (KEGG Pathway)
MCL1GeneProductENSG00000143384 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SMARCA4GeneProductENSG00000127616 (Ensembl)
TERF2GeneProductENSG00000132604 (Ensembl)
ZFXGeneProductENSG00000005889 (Ensembl)

Annotated Interactions

No annotated interactions

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