Physico-chemical features and toxicity-associated pathways (Homo sapiens)

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1Ca2+Long-term depressionWnt signaling pathwayOHReactive oxygen speciesScaffoldFocal adhesionCell cycleO2Actin polymerisationNONORegulation of Actin cytoskeletonAdhesion migrationAmyotrophic lateral sclerosis (ALS)Ca2+Receptor ubiquiltylationDNACellular targetsH2ODegradationCell cycleH2O2Pancreatic cancerErbB singaling pathwayONOO-Disturbance of mitochondrial respirationJNKCBLAXIN1PP2AMLCPCAMKSOD1WNT11ActinPLCGTMSB4NEFMFN1NOS1ROCK2GSK3BDVL1STAT5Shc1MLCTGFARafJUNp27FAKARP2SOS1MEKNEFLGPX1ELKErbB-2ARP3NEFHPAKGlutamatePI3KPKB/AKTArginineSrcp21ProfilinJNKKMAPK/ERKGluRFrizzledMYCRHOANCKB-cateninRasErbB-4APCDAAM1ErbB-1GRB2WNT16PAKMLCKNOS1SOD1SOD1


Description

This pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstrate close links between pathways associated with chemical hits and pathways associated with toxicity. The pathways associated with chemical hits (Wnt signaling, long-term depression, and ErbB signaling pathways) and the pathways associated with toxicity (focal adhesion, ALS, and pancreatic Cancer respectively) have been shown to have possible links through shared genes between the two pathways. The mechanisms of action presented by these links were only implied by the toxicity pathways.

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Bibliography

  1. Antczak P, Ortega F, Chipman JK, Falciani F; ''Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome.''; PLoS One, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123395view06:24, 23 July 2022EgonwMade a pathway clickable
117651view11:45, 22 May 2021EweitzModified title
106306view17:45, 20 August 2019KhanspersModified description
106167view12:06, 16 August 2019MaintBotHMDB identifier normalization
105537view06:05, 9 August 2019KhanspersModified description
96435view07:49, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
90113view21:26, 13 October 2016Khanspersoverhaul
90112view20:38, 13 October 2016KhanspersModified title
88751view18:36, 14 August 2016AAR&CoFixed Unonnected Line
88750view18:34, 14 August 2016AAR&CoOntology Term : 'pancreatic cancer' added !
88749view18:33, 14 August 2016AAR&CoOntology Term : 'amyotrophic lateral sclerosis disease pathway' added !
88748view18:32, 14 August 2016AAR&CoModified title
88535view00:46, 11 August 2016AAR&CoOntology Term : 'signaling pathway' added !
88530view00:26, 11 August 2016AAR&CoPeriodical save, work in progress
88528view00:19, 11 August 2016AAR&CoModify Datanode
88526view00:16, 11 August 2016AAR&CoPeriodical save, work in progress
88522view00:06, 11 August 2016AAR&CoPeriodical save, work in progress
88521view23:58, 10 August 2016AAR&CoModify Datanodes
88519view23:56, 10 August 2016AAR&CoPeriodical save, work in progress
88516view23:53, 10 August 2016AAR&CoModify Datanodes
88515view23:51, 10 August 2016AAR&CoModify Datanodes
88513view23:48, 10 August 2016AAR&CoModify Datanode
88511view23:25, 10 August 2016AAR&CoModify Datanoed
88510view23:22, 10 August 2016AAR&CoModify Datanode
88507view23:18, 10 August 2016AAR&CoPeriodical save, work in progress
88504view23:04, 10 August 2016AAR&CoModify Datanode
88500view22:58, 10 August 2016AAR&CoModify Datanode
88495view22:48, 10 August 2016AAR&CoModify Datanode
88494view22:44, 10 August 2016AAR&CoPeriodical save, work in progress
88492view22:43, 10 August 2016AAR&CoModify Datanode
88488view22:32, 10 August 2016AAR&CoModified description
88487view22:28, 10 August 2016AAR&CoModified description
88482view22:22, 10 August 2016AAR&CoModify Datanodes
87131view18:49, 18 July 2016AAR&CoFixed Unconnected Lines
86140view13:23, 1 July 2016AAR&CoModified description
86139view13:23, 1 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APCMetaboliteHMDB60661 (HMDB)
ARP2GeneProductENSG00000138071 (Ensembl)
ARP3GeneProductENSG00000115091 (Ensembl)
AXIN1GeneProductENSG00000103126 (Ensembl)
ActinGeneProductP68133 (Uniprot-TrEMBL)
ArginineMetaboliteHMDB00517 (HMDB)
B-cateninGeneProductENSG00000168036 (Ensembl)
CAMK GeneProductENSG00000134072 (Ensembl)
CBLGeneProductENSG00000110395 (Ensembl)
DAAM1GeneProductENSG00000100592 (Ensembl) assists in formation of Dvl-Rho complex
DVL1GeneProductENSG00000107404 (Ensembl)
ELKGeneProductENSG00000126767 (Ensembl)
ErbB-1GeneProductENSG00000146648 (Ensembl)
ErbB-2GeneProductENSG00000141736 (Ensembl)
ErbB-4GeneProductENSG00000178568 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
  • PRK2
  • Focal adhesion kinase
FN1GeneProductENSG00000115414 (Ensembl)
Frizzled GeneProductENSG00000111432 (Ensembl)
GPX1GeneProductENSG00000233276 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
GluRGeneProductP42261 (Uniprot-TrEMBL) General glutamate receptor
Glutamate MetaboliteHMDB60475 (HMDB)
JNKGeneProductENSG00000107643 (Ensembl)
JNKK GeneProductENSG00000065559 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MAPK/ERKGeneProductENSG00000100030 (Ensembl)
MEKGeneProductENSG00000169032 (Ensembl)
MLCGeneProductENSG00000168530 (Ensembl)
MLCKGeneProductENSG00000065534 (Ensembl) myosin light chain kinase
MLCPGeneProductENSG00000228868 (Ensembl) myosin-light chain phosphatase
MYCGeneProductENSG00000136997 (Ensembl)
NCKGeneProductENSG00000158092 (Ensembl)
NEFHGeneProductENSG00000100285 (Ensembl)
NEFLGeneProductENSG00000277586 (Ensembl)
NEFMGeneProductENSG00000104722 (Ensembl)
NOS1GeneProductENSG00000089250 (Ensembl)
PAKGeneProduct
PAKGeneProductENSG00000149269 (Ensembl)
PI3KGeneProductENSG00000105851 (Ensembl)
PKB/AKTGeneProductENSG00000142208 (Ensembl)
PLCGGeneProductENSG00000124181 (Ensembl)
PP2AGeneProductENSG00000113575 (Ensembl)
ProfilinGeneProductP07737 (Uniprot-TrEMBL)
RHOAGeneProductENSG00000067560 (Ensembl)
ROCK2GeneProductENSG00000134318 (Ensembl)
RafGeneProductENSG00000132155 (Ensembl)
RasGeneProductENSG00000132155 (Ensembl)
SOD1GeneProductENSG00000142168 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
STAT5GeneProductENSG00000126561 (Ensembl)
Shc1 GeneProductENSG00000160691 (Ensembl)
Src GeneProductENSG00000197122 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl)
TMSB4GeneProductP62328 (Uniprot-TrEMBL)
WNT11GeneProductENSG00000085741 (Ensembl)
WNT16GeneProductENSG00000002745 (Ensembl)
p21GeneProductENSG00000124762 (Ensembl)
p27GeneProductENSG00000111276 (Ensembl)

Annotated Interactions

No annotated interactions

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