Keap1-Nrf2 (Pan troglodytes)
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Jmelius
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1
T-P
ARE
S-P
T-P
Phase II enzymes
CCAAT/XRE
S-P
Nucleus
Caffeic acid phenethyl ester
EPHB2
6-HITC
MAF
KEAP1
PIK3CA
GCLM
CEBPB
NQO1
HMOX1
MAPK8
AIMP2
NFE2L2
CEBPB
GSTA2
Curcumin
Sulforaphane
PKC
GCLC
NFE2L2
KEAP1
NFE2L2
Description
Based on
Surh, 2003, figure 4
.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP3(r29720)
with a 83% conversion rate.
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.
Quality Tags
Ontology Terms
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Bibliography
Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
106919
view
13:39, 17 September 2019
MaintBot
HMDB identifier normalization
88683
view
15:48, 12 August 2016
Jmelius
Ontology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
88682
view
15:48, 12 August 2016
Jmelius
Ontology Term : 'oxidative stress response pathway' added !
74168
view
09:58, 2 April 2014
Egonw
Updated the PubChem-compound data source.
69297
view
18:41, 8 July 2013
MaintBot
Updated to 2013 gpml schema
41607
view
02:02, 2 March 2011
MaintBot
Removed redundant pathway information and comments
34336
view
22:17, 9 December 2009
MaintBot
Automatic update of empty xrefs
33535
view
09:35, 1 December 2009
MaintBot
Removed group label
30439
view
21:23, 29 July 2009
MaintBot
New pathway
External references
DataNodes
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Name
Type
Database reference
Comment
6-HITC
Metabolite
Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
AIMP2
GeneProduct
741505 (Entrez Gene)
CEBPB
GeneProduct
469969 (Entrez Gene)
Caffeic acid phenethyl ester
Metabolite
Curcumin
Metabolite
HMDB02269 (HMDB)
EPHB2
GeneProduct
456613 (Entrez Gene)
GCLC
GeneProduct
742732 (Entrez Gene)
GCLM
GeneProduct
GSTA2
GeneProduct
462769 (Entrez Gene)
HMOX1
GeneProduct
470195 (Entrez Gene)
KEAP1
GeneProduct
455706 (Entrez Gene)
MAF
GeneProduct
454260 (Entrez Gene)
MAPK8
GeneProduct
450445 (Entrez Gene)
NFE2L2
GeneProduct
742622 (Entrez Gene)
NQO1
GeneProduct
468012 (Entrez Gene)
PIK3CA
GeneProduct
460858 (Entrez Gene)
PKC
GeneProduct
Sulforaphane
Metabolite
5350 (PubChem-compound)
Annotated Interactions
No annotated interactions
Views
Pathway
Discussion
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View approved pathways at the new wikipathways.org.Quality Tags
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Annotated Interactions
No annotated interactions