BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation (Homo sapiens)

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FOXO1 Targets such as SST, DCN, LEFTY2, BCL2L11cAMPBMP2SMAD5B-CateninFOXO1SFRPsDKKsSMAD8Differentiation of Human Endometrial Stromal CellsWNT4SMAD1


Description

This pathway is based on figure 6 from Li et al. BMP2 is activated by cAMP which promotes WNT4 expression in Human Primary Endometrial Stromal Cells (HPESCs) through SMAD1/5/8. WNT4 then induces FOXO1 function through B-Catenin which indirectly stimulates HPESC differentiation. DKKs and SFRPs are activated by BMP2 inhibit WNT4 and stop downstream signaling.

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Ontology Terms

 

Bibliography

  1. Li Q, Kannan A, Das A, Demayo FJ, Hornsby PJ, Young SL, Taylor RN, Bagchi MK, Bagchi IC; ''WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal celldifferentiation.''; Endocrinology, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123398view06:26, 23 July 2022EgonwMade a pathway clickable
116398view00:00, 7 May 2021EweitzModified title
106755view13:23, 17 September 2019MaintBotHMDB identifier normalization
106308view17:46, 20 August 2019KhanspersModified description
105539view06:06, 9 August 2019KhanspersModified description
94744view15:12, 5 October 2017Mkutmonfix unconnected line
90122view04:37, 14 October 2016Khanspersfixed unconnected
89273view05:11, 29 August 2016Khanspersupdated layout, added nodes
89060view06:40, 19 August 2016Fehrhartconnected line
88814view22:41, 14 August 2016AAR&CoOntology Term : 'Wnt signaling pathway' added !
88813view22:41, 14 August 2016AAR&CoOntology Term : 'stromal cell' added !
88812view22:39, 14 August 2016AAR&CoModified description
88811view22:31, 14 August 2016AAR&CoModified title
88810view22:31, 14 August 2016AAR&CoModified description
88809view22:30, 14 August 2016AAR&CoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
B-CateninProteinB4DGU4 (Uniprot-TrEMBL)
BMP2GeneProductENSG00000125845 (Ensembl)
DKKsGeneProductO94907 (Uniprot-TrEMBL) Protein Family
Differentiation of Human Endometrial Stromal CellsPathwayWP2848 (WikiPathways)
FOXO1GeneProductENSG00000150907 (Ensembl)
SFRPsGeneProductENSG00000104332 (Ensembl) Protein Family
SMAD1GeneProductENSG00000170365 (Ensembl)
SMAD5GeneProductENSG00000113658 (Ensembl)
SMAD8GeneProductENSG00000120693 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions

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