Regulation of apoptosis by parathyroid hormone-related protein (Homo sapiens)

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Integrin A6c-mycBcl-2 FamilyIntegrin B4ApoptosisGSK-3siRNA B4siRNA A6AktPI3-KPTHrPGrowth Factor Receptors


Description

This pathway is based on Figure 8 of "Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling."(See Bibliography). Parathyroid Hormone-related Protein Regulates Cell Survival Pathways via Integrin alpha6beta4-mediated Activation of PI3-K/Akt Signaling Intracrine PTHrP inhibits apoptosis by activating the PI3-K/Akt pathway by increasing levels of integrin A6B4, which signals in harmony with growth factor receptors. The activation of Akt increases the ratio of anti-apoptosis members to pro-apoptosis members in the Bcl-2 Family. The activation of Akt deactivates GSK-3 which leads to higher levels of c-myc, therefore leading to lower levels of apoptosis. Overall, intracrine PTHrP has the effect of increased cell survival on C4-2 cells.

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Bibliography

  1. Bhatia V, Mula RV, Weigel NL, Falzon M; ''Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling.''; Mol Cancer Res, 2009 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128597view01:26, 15 February 2024EweitzModified description
128596view01:22, 15 February 2024EweitzEconomize layout, standardize case
127930view22:43, 17 January 2024Khanspersupdated xrefs
123397view06:25, 23 July 2022EgonwMade a pathway clickable
116648view11:40, 9 May 2021EweitzModified title
106498view21:45, 4 September 2019KhanspersModified description
105802view22:50, 15 August 2019KhanspersModified description
89397view19:40, 10 September 2016AlexanderPicoModified title
89270view23:14, 28 August 2016Khansperstypo
89269view23:13, 28 August 2016Khanspersupdated layout and added BCL2 family
89268view19:13, 27 August 2016Khanspersreplaced label with pathwat node
89267view19:12, 27 August 2016Khanspersunified gene size, updated RNA node color, replaced label with gene
89104view14:28, 22 August 2016EgonwOntology Term : 'regulatory pathway' added !
89065view06:55, 19 August 2016FehrhartModified description
89064view06:53, 19 August 2016Fehrhartfixed greek characters in title
89063view06:50, 19 August 2016FehrhartMinor cosmetic changes
88798view20:40, 14 August 2016AAR&CoModified description
88797view20:39, 14 August 2016AAR&CoModified description
88796view20:38, 14 August 2016AAR&CoModified description
88795view20:36, 14 August 2016AAR&CoModified description
88794view20:32, 14 August 2016AAR&CoOntology Term : 'prostate cancer' added !
88793view20:31, 14 August 2016AAR&CoFix unconnected lines
88792view20:30, 14 August 2016AAR&CoModify Datanode
88789view20:06, 14 August 2016AAR&CoFix excess space
88787view20:03, 14 August 2016AAR&CoModify Datanode
88779view19:54, 14 August 2016AAR&CoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AktGeneProductENSG00000142208 (Ensembl)
Apoptosis PathwayWP254 (WikiPathways)
Bcl-2 Family GeneProductENSG00000002330 (Ensembl) Increases the ratio of anti-apoptosis members to pro-apoptosis members.
GSK-3GeneProductENSG00000082701 (Ensembl)
Growth Factor ReceptorsGeneProduct
Integrin A6 GeneProductENSG00000091409 (Ensembl)
Integrin B4 GeneProductENSG00000132470 (Ensembl)
PI3-KGeneProductENSG00000105851 (Ensembl)
PTHrP GeneProductENSG00000087494 (Ensembl)
c-myc GeneProductENSG00000136997 (Ensembl)
siRNA A6 RnaIdentifier not found
siRNA B4RnaIdentifier not found

Annotated Interactions

No annotated interactions

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