Insulin signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Glucose TransportCell GrowthDifferentiationRas-MAPK SignalingGRB2SOS1SOS2RAF1GRB10HRASRRADGRB14RAC1RAC2MEK/MAP KinasesMAP2K1MAP2K2MAP2K3MAP2K4MAP2K5MAP2K6MAP3K1MAP3K2MAP3K3MAP3K4MAPK3MAPK4MAPK1MAPK6MAPK13MAPK9MAPK10MAP4K1MAP3K5MAP3K10MAPK8MAPK14MAP3K8MAP3K12MAP4K2MAP3K7MAP3K11MAPK11MAP3K9MAP4K4MAPK7MAP3K13MAP4K3MAP3K6MINK1MAPK12MAP4K5MAP3K14MAP2K7p90 Rsk KinasesRPS6KA2RPS6KA3RPS6KA1RPS6KA5RPS6KA6RPS6KA4Insulin Receptor SubstratesIRS1IRS4GAB1SHC1SHC3IRS2SHC2PI 3-Kinase isoformsPIK3CAPIK3CBPIK3CGPIK3CDPIK3R1PIK3R2PIK3R3PIK3R4PIK3C2APIK3C3PIK3C2GTor SignalingTSC1TSC2PDK/Akt SignalingPDPK1AKT1AKT2GSK3BGSK3ASGKSGK2SGKLTranscriptional Regulators & Immediate Early GenesFOXO1AEGR1FOSJUNFOXO3AELK1SRFVesicular TraffickingPSCD3ARF6ARF1CBLCBLBCBLCRAPGEF1CAP1SORBS1RHOJSNX26RHOQCRKFLOT1FLOT2RAB4ASTXBP4VAMP2SNAP25SNAP23EHD1EHD2MYO1CKIF5BKIF3ATBC1D4STXBP1STXBP2STXBP3STX4AAPSMetabolic RegulationPFKMGYS1PPP1R3ALIPEGYS2GYGPFKLp70 S6 KinasesRPS6KB1RPS6KB2Translation RegulationEIF4EEIF4EBP1Modulators of Insulin ActionPTENPRKCIPRKCZINPP4ATRIB3PTPN11PTPRFPTPN1INPPL1PRKCAPRKCB1PRKCQPRKCHPRKCDENPP1MAPK8SOCS1SOCS3PRKAA1PRKAA2IKBKBXBP1INSRIGF1RSLC2A4FRAP1SLC2A1RHEBPTPPIK3IRS1/2Name: Insulin SignalingOrganism: Homo sapiens


Description

Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

Pathway Ontology : insulin signaling pathway
 

Bibliography

  1. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia
  2. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia
  3. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137476
Approved
view15:04, 2 March 2025EgonwModified description
135171view01:32, 7 August 2024EweitzEconomize layout
135170view01:28, 7 August 2024EweitzIncrease font size
120562view13:03, 16 December 2021EweitzRefine case
116787view09:55, 14 May 2021EweitzModified title
106617view20:44, 12 September 2019KhanspersModified description
105626view05:01, 10 August 2019KhanspersModified description
94171view07:53, 25 August 2017MkutmonReverted to version '21:20, 21 October 2016' by Mkutmon
94128view18:11, 22 August 2017Ycc86829Quick edit to datanode annotation or property
90197view21:20, 21 October 2016Khanspersfixed unconnected
89370view21:48, 9 September 2016AlexanderPicoremoved extra complex groupings and updated cell membrane
82731view00:20, 24 October 2015Andra
82730view00:19, 24 October 2015Andramoved hidden data nodes to make them visible
82729view22:07, 23 October 2015AndraChanged the layout
72080view20:45, 24 October 2013AlexanderPicoremoved IRS3, which does not have a human homolog
71379view18:39, 17 October 2013MaintBotAutomated update of data sources
63219view21:01, 8 May 2013MaintBotUpdating gpml version
59178view18:44, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45380view21:46, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45185view09:32, 7 October 2011Eduatiadded reference
45184view09:28, 7 October 2011Eduatitypo
45183view09:27, 7 October 2011EduatiIndicate complex formation
45179view09:06, 7 October 2011EduatiModified description
44854view09:52, 6 October 2011MartijnVanIerselOntology Term : 'insulin signaling pathway' added !
44853view09:51, 6 October 2011MartijnVanIerselOntology Term : 'PW:0000034' removed !
44835view08:03, 6 October 2011Mkutmonconnected some lines
42706view21:56, 15 April 2011Khanspersminor layout change
41137view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
38887view19:05, 24 September 2010Khanspers
33660view12:22, 2 December 2009AndraSpecify description
33659view12:04, 2 December 2009AndraAdded Geneproduct plus reference
33027view15:23, 5 October 2009AndraSpecify description
33026view15:23, 5 October 2009AndraSpecify description
32444view17:19, 15 August 2009MaintBotFixed text labels
32118view13:51, 14 August 2009MaintBotFixed group labels
28132view19:46, 27 January 2009KhanspersRemoved species code from name
21692view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Insulin Signaling]] moved to [[Pathway:WP481]]: Moved to stable identifier
15807view08:31, 4 June 2008AndraAdd a reference
13887view13:18, 19 May 2008Thomasgrouped datanodes and connected lines
12946view10:43, 17 May 2008MaintBotSticky edges patch by Sjoerd
8212view13:46, 7 January 2008MaintBot[[Pathway:Human:Insulin Signaling]] moved to [[Pathway:Homo sapiens:Insulin Signaling]]: Renaming species
7726view16:13, 18 December 2007MaintBotfixed category names
7265view12:41, 4 November 2007MaintBotAdded categories to GPML
6344view22:18, 22 May 2007M.Pattigpml file for [[Human:Insulin_Signaling]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
APSGeneProduct10603 (Entrez Gene)
ARF1GeneProduct375 (Entrez Gene)
ARF6GeneProduct382 (Entrez Gene)
CAP1GeneProduct10487 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CBLCGeneProduct23624 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
EGR1GeneProduct1958 (Entrez Gene)
EHD1GeneProduct10938 (Entrez Gene)
EHD2GeneProduct30846 (Entrez Gene)
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
ENPP1GeneProduct5167 (Entrez Gene)
FLOT1GeneProduct10211 (Entrez Gene)
FLOT2GeneProduct2319 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
FRAP1GeneProduct2475 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
GRB10GeneProduct2887 (Entrez Gene)
GRB14GeneProduct2888 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
GYGGeneProduct2992 (Entrez Gene)
GYS1GeneProduct2997 (Entrez Gene)
GYS2GeneProduct2998 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
IGF1RGeneProduct3480 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
INPP4AGeneProduct3631 (Entrez Gene)
INPPL1GeneProduct3636 (Entrez Gene)
INSRGeneProduct3643 (Entrez Gene)
IRS1/2GeneProduct3667 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
IRS4GeneProduct8471 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
KIF3AGeneProduct11127 (Entrez Gene)
KIF5BGeneProduct3799 (Entrez Gene)
LIPEGeneProduct3991 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP2K5GeneProduct5607 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K10GeneProduct4294 (Entrez Gene)
MAP3K11GeneProduct4296 (Entrez Gene)
MAP3K12GeneProduct7786 (Entrez Gene)
MAP3K13GeneProduct9175 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene)
MAP3K2GeneProduct10746 (Entrez Gene)
MAP3K3GeneProduct4215 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAP3K6GeneProduct9064 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAP3K8GeneProduct1326 (Entrez Gene)
MAP3K9GeneProduct4293 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAP4K2GeneProduct5871 (Entrez Gene)
MAP4K3GeneProduct8491 (Entrez Gene)
MAP4K4GeneProduct9448 (Entrez Gene)
MAP4K5GeneProduct11183 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MINK1GeneProduct50488 (Entrez Gene)
MYO1CGeneProduct4641 (Entrez Gene)
PDPK1GeneProduct5170 (Entrez Gene)
PFKLGeneProduct5211 (Entrez Gene)
PFKMGeneProduct5213 (Entrez Gene)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3GeneProductENSG00000121879 (Ensembl)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PPP1R3AGeneProduct5506 (Entrez Gene)
PRKAA1GeneProduct5562 (Entrez Gene)
PRKAA2GeneProduct5563 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCHGeneProduct5583 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PSCD3GeneProduct9265 (Entrez Gene)
PTENGeneProduct5728 (Entrez Gene)
PTPGeneProduct5967 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN1GeneProduct5770 (Entrez Gene)
PTPRFGeneProduct5792 (Entrez Gene)
RAB4AGeneProduct5867 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RHEBGeneProduct6009 (Entrez Gene)
RHOJGeneProduct57381 (Entrez Gene)
RHOQGeneProduct23433 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KA2GeneProduct6196 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KA4GeneProduct8986 (Entrez Gene)
RPS6KA5GeneProduct9252 (Entrez Gene)
RPS6KA6GeneProduct27330 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
RPS6KB2GeneProduct6199 (Entrez Gene)
RRADGeneProduct6236 (Entrez Gene)
SGK2GeneProduct10110 (Entrez Gene)
SGKGeneProduct6446 (Entrez Gene)
SGKLGeneProduct23678 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SHC2GeneProduct25759 (Entrez Gene)
SHC3GeneProduct53358 (Entrez Gene)
SLC2A1GeneProduct6513 (Entrez Gene)
SLC2A4GeneProduct6517 (Entrez Gene)
SNAP23GeneProduct8773 (Entrez Gene)
SNAP25GeneProduct6616 (Entrez Gene)
SNX26GeneProduct115703 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SORBS1GeneProduct10580 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SRFGeneProduct6722 (Entrez Gene)
STX4AGeneProduct6810 (Entrez Gene)
STXBP1GeneProduct6812 (Entrez Gene)
STXBP2GeneProduct6813 (Entrez Gene)
STXBP3GeneProduct6814 (Entrez Gene)
STXBP4GeneProduct252983 (Entrez Gene)
TBC1D4GeneProduct9882 (Entrez Gene)
TRIB3GeneProduct57761 (Entrez Gene)
TSC1GeneProduct7248 (Entrez Gene)
TSC2GeneProduct7249 (Entrez Gene)
VAMP2GeneProduct6844 (Entrez Gene)
XBP1GeneProduct7494 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP481"
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