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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none mmu-miR-155-5p Rheb Socs1 Insulin Signaling Eif4e2 Prkx Crkl Bad Acaca Pik3r1 Prkar2a Sos1 Pik3r3 Fasn Exoc7 Mapk3 Flot2 Raf1 Mtor mmu-miR-425-5p mmu-miR-15a-5p PI3K/AKT Signalling Ccnd2 Cdkn1b Bcl2 mmu-miR-503-5p mmu-miR-16-5p Col3a1 Col1a1 Col1a2 Col5a3 Bcl2l11 Col4a2 mmu-miR-29a-3p mmu-miR-29b-3p Name: Dys-regulated miRNA targeting in Liver and Pancreas Organism: Mus musculus
Description
This pathway is modeled after figure 4b from kwon et al. Expression of specific miRNA in Cmah-null mice (mice that develop fasting hyperglycemia, glucose intolerance, and characteristics of type 2 diabetes after being fed a high fat diet) are disregulated, leading to the development of complications. The disregulated miRNA influence the expression of their target genes through interaction with the Insulin signaling and the PI3K/AKT signalling pathways.
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Quality Tags
Open Access This pathway is based on a pathway published in an Open Access journal.
Review changes for Approved Revision 128795 Eric Weitz .
Annotated lists Comment: This pathway depicts miRNA targeting of proteins related to specific pathways.
Annotated lists of gene products are considered useful for analysis and for stimulating future pathway curation.
Ontology Terms
Bibliography
Kwon DN, Chang BS, Kim JH; ''MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling.''; Biomed Res Int, 2014 PubMed Europe PMC Scholia History
External references
DataNodes
Annotated Interactions
No annotated interactions
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