This pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway WP2011(75253) with a 100.0% conversion rate.
Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT; ''Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.''; J Biol Chem, 2010 PubMedEurope PMCScholia
Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM; ''Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.''; Genes Dev, 2010 PubMedEurope PMCScholia
Joseph T Rodgers, Pere Puigserver; ''Receptor feasts on sugar and cholesterol.''; Nature Medicine, 2007 DOIScholia
Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P; ''mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.''; Nature, 2007 PubMedEurope PMCScholia
Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T; ''MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo.''; Proc Natl Acad Sci U S A, 2010 PubMedEurope PMCScholia
Rodgers JT, Puigserver P; ''Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.''; Proc Natl Acad Sci U S A, 2007 PubMedEurope PMCScholia
Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH; ''SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.''; EMBO J, 2007 PubMedEurope PMCScholia
Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P; ''Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.''; EMBO J, 2007 PubMedEurope PMCScholia
Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM; ''An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.''; Nature, 2006 PubMedEurope PMCScholia
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