Interactions between LOXL4 and oxidative stress pathway (Homo sapiens)

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1LegendOS pathwayRTK/MAPK PathwayOxidativeStressesTGFB PathwayTGFB1ECSITSUV39H1LOXL4NQO1NRF1SIRT1EXOC6CDC37COL2A1BMP2NFE2L2PKD1FN1ANXA5FGF7DDR1IGFBP7Direct physical interactionTranscriptional activation by OS pathwayImpact by OS pathway via phosphorylation, activity or nuclear-cytoplasmic distribution of Nrf1/2 proteinsDirect interaction, with repression


Description

This pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAPK and TGFB pathways. These pathways along with oxidative stress promotes NRF1/2 activation of theoxidative stress pathway. This pathway promotes the transcription of NQO1, ECSIT, EXOC6, and SIRT1. SIRT1 then activates SUV39H1. LOXL2 also activates some of these proteins downstream in the pathway (SUV39H1, EXOC6, ECSIT). This pathway has been modeled after figure 7 in Deng et al.

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Bibliography

  1. Deng H, Lv L, Li Y, Zhang C, Meng F, Pu Y, Xiao J, Qian L, Zhao W, Liu Q, Zhang D, Wang Y, Zhang H, He Y, Zhu J; ''miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the oxidative stress pathway.''; Mol Cancer, 2014 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117829view15:09, 22 May 2021EweitzModified title
108164view10:46, 29 November 2019FehrhartOntology Term : 'urinary bladder cancer' added !
105818view23:01, 15 August 2019KhanspersModified description
90107view18:28, 13 October 2016KhanspersModified title
90106view18:27, 13 October 2016Khanspersadded legend
90105view18:22, 13 October 2016Khansperscleanup and xrefs
88614view01:16, 12 August 2016AAR&CoEdited Data Node
88613view01:15, 12 August 2016AAR&CoEdited Pathways
87046view22:47, 17 July 2016AlexanderPicoModified description
87045view22:46, 17 July 2016AlexanderPicoOntology Term : 'disease pathway' added !
87044view22:45, 17 July 2016AlexanderPicoOntology Term : 'regulatory pathway' added !
87043view22:45, 17 July 2016AlexanderPicoOntology Term : 'oxidative stress response pathway' added !
87042view22:44, 17 July 2016AlexanderPicoOntology Term : 'bladder cancer pathway' added !
87041view22:41, 17 July 2016AlexanderPicoReduced white space
87040view22:39, 17 July 2016AlexanderPicoFixed interactions and updated OS
87039view22:32, 17 July 2016AlexanderPicoAdded pathway identifiers
86014view11:10, 25 June 2016AAR&CoModified description
86013view10:56, 25 June 2016AAR&CoAdd Citation
86012view10:54, 25 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ANXA5GeneProductENSG00000164111 (Ensembl)
BMP2GeneProductENSG00000125845 (Ensembl)
CDC37GeneProductENSG00000105401 (Ensembl)
COL2A1GeneProductENSG00000139219 (Ensembl)
DDR1GeneProductENSG00000204580 (Ensembl)
ECSITGeneProductENSG00000130159 (Ensembl)
EXOC6GeneProductENSG00000138190 (Ensembl)
FGF7GeneProductENSG00000140285 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
IGFBP7GeneProductENSG00000163453 (Ensembl)
LOXL4GeneProductENSG00000138131 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NQO1GeneProductENSG00000181019 (Ensembl)
NRF1GeneProductENSG00000106459 (Ensembl)
PKD1GeneProductENSG00000008710 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SUV39H1GeneProductENSG00000101945 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)

Annotated Interactions

No annotated interactions

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