Serotonin and anxiety-related events (Mus musculus)

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23Cell in PreFrontalCortexAnxiety related eventsSerotoninArcSerotonin Receptor Htr2aketanserinSerotonin Receptor Htr2cSerotonin Receptor Htr1a2C-FosPlekPpp3caPrkcb1Plcd4Grin2dNlgn11Crhr13CRF_MOUSE


Description

Stress and anxiety disorders are risk factors for depression and these behaviours are modulated by corticotropin releasing factor (CRFR1) and serotonin (5-HT2R) receptors. (Source: Berg et al "5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms")

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Ontology Terms

 

Bibliography

  1. Benekareddy M, Goodfellow NM, Lambe EK, Vaidya VA; ''Enhanced function of prefrontal serotonin 5-HT(2) receptors in a rat model of psychiatric vulnerability.''; J Neurosci, 2010 PubMed Europe PMC Scholia
  2. Berg KA, Clarke WP, Chen Y, Ebersole BJ, McKay RD, Maayani S; ''5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms.''; Mol Pharmacol, 1994 PubMed Europe PMC Scholia
  3. Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, Drysdale L, Poulter MO, Roth BL, Pin JP, Anisman H, Ferguson SS; ''CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling.''; Nat Neurosci, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
106868view13:34, 17 September 2019MaintBotHMDB identifier normalization
101979view20:05, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
90837view19:18, 14 December 2016KhanspersOntology Term : 'signaling pathway' added !
90830view19:12, 14 December 2016KhanspersOntology Term : 'cerebral cortex neuron' added !
90829view19:11, 14 December 2016KhanspersOntology Term : 'anxiety disorder' added !
90828view19:11, 14 December 2016KhanspersOntology Term : 'neuron' added !
90827view19:09, 14 December 2016KhanspersQuick edit to datanode annotation or property
90826view19:09, 14 December 2016KhanspersQuick edit to datanode annotation or property
90825view19:08, 14 December 2016KhanspersQuick edit to datanode annotation or property
90824view19:06, 14 December 2016KhanspersModified description
89987view19:04, 6 October 2016Mkutmonfixed unconnected lines
87658view08:55, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
78420view10:26, 7 January 2015MaintBotadded missing graphIds
71746view20:19, 17 October 2013MaintBotAutomated update of data sources
71331view17:18, 17 October 2013MaintBotAutomated update of data sources
69158view18:18, 8 July 2013MaintBotUpdated to 2013 gpml schema
59058view20:57, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58159view22:27, 8 February 2013MaintBotModified title
58156view22:23, 8 February 2013MaintBotModified categories
47310view13:59, 15 March 2012Yvesslenteradded crf
47306view13:50, 15 March 2012YvesslenterPeriodical save, work in progress
47301view13:40, 15 March 2012YvesslenterPeriodical save, work in progress
47295view13:29, 15 March 2012YvesslenterPeriodical save, work in progress
47277view12:19, 15 March 2012YvesslenterPeriodical save, work in progress
47275view12:09, 15 March 2012YvesslenterPeriodical save, work in progress
47271view11:58, 15 March 2012YvesslenterPeriodical save, work in progress
47267view11:46, 15 March 2012YvesslenterPeriodical save, work in progress
47257view11:26, 15 March 2012YvesslenterPeriodical save, work in progress
47248view11:16, 15 March 2012YvesslenterPeriodical save, work in progress
47240view11:06, 15 March 2012YvesslenterNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ArcGeneProductENSMUSG00000022602 (Ensembl)
C-FosGeneProductENSMUSG00000021250 (Ensembl)
CRF_MOUSEProteinQ8CIT0 (Uniprot-TrEMBL)
Crhr1GeneProductENSMUSG00000018634 (Ensembl)
Grin2dGeneProductENSMUSG00000002771 (Ensembl)
Nlgn1GeneProductENSMUSG00000063887 (Ensembl)
Plcd4GeneProductENSMUSG00000026173 (Ensembl)
PlekGeneProductENSMUSG00000020120 (Ensembl)
Ppp3caGeneProductMGI:107164 (MGI)
Prkcb1GeneProductENSMUSG00000052889 (Ensembl)
Serotonin Receptor Htr1aGeneProductENSMUSG00000021721 (Ensembl)
Serotonin Receptor Htr2a GeneProductENSMUSG00000034997 (Ensembl)
Serotonin Receptor Htr2cGeneProductENSMUSG00000041380 (Ensembl)
SerotoninMetaboliteHMDB00259 (HMDB)
ketanserinMetaboliteCHEBI:6123 (ChEBI)

Annotated Interactions

No annotated interactions

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