DNA IR-double strand breaks and cellular response via ATM (Homo sapiens)

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40, 59100, 147, 379139, 239, 289, 312, 4206, 63, 157, 307, 310...202, 220, 229, 252102, 151, 206, 380306262, 403181, 234, 3933069365309172234, 30130, 88, 26626330716416535735738, 244414131108, 258, 435282101, 3988125, 3970, 177, 37332384307330, 359, 39778, 386145, 156, 246105, 2158, 62, 91, 95, 22430290, 127, 35311798296277313, 35933121238276, 36416, 175210153, 384375371194, 388292, 37423323333732824244, 366, 38781, 219, 36025316041040, 59225, 365160, 251285, 314201265, 26724172, 370, 417, 437347160, 34429, 165277162, 238, 27821, 13214, 4011322307119421736621083, 115, 144, 166, 184...40010448383ATM-TRAF6-cIAP1moduleDNA DSBsInhibition pathIonizing Radiation (IR)NuA4complex1, 10, 43, 146, 149...137, 186, 243, 298, 327...BAK1LATS1p73DNA-PKKAT5MDM2MDC1DCLRE1CCASP9ApoptosisPARP1RASSF1MRE11ABRCA2BLME2F1CHK2CohesinEXO1UPF1CDK5RAD51SMC3TRIM28RAD17BRCA1RAD52BAXMCPH1M-Phase ProgressionThe intra-S-phasecheckpoint mediatedarrest of cell cycleprogressionNBNHSF1STK3PCNACHK1SMC1ATERF2TRAF6TP53mRNA nonsense-mediateddecay (NMD)NFkB activationOBFC2BRAD50ATMATRACTL6AARF(CDKN2A)MCPH1TP53BP1APAF118, 19, 37, 92, 32616, 71, 17522, 242, 412124, 156, 2466, 103, 2337, 97, 99, 433128, 207, 434111, 142, 153, 231, 285...256, 284, 421, 427214, 297, 362, 399, 428167, 185, 278, 279, 33157, 90, 136, 1984, 56, 176, 255, 33534, 42, 158, 200, 351...133, 237, 286, 367, 381...159, 268, 274, 34940273, 116, 189, 248, 254...35, 135, 272, 30817, 85, 180, 193, 260...159, 268, 282, 4199, 32, 80, 110, 140...20, 218, 416161, 318, 319, 32123, 58, 66, 75, 182...181, 222, 234, 293, 301...27, 64, 69, 261179, 235, 346, 42311, 79, 178, 290, 3225, 54, 188, 216, 315...26, 107, 119, 213, 221...2, 89, 25741, 138, 208, 24752, 339, 41850, 141, 325, 342172, 271, 369101, 303, 42515, 51, 79, 113, 126...50, 212, 238, 269, 294...329, 343, 41336, 61, 78, 3866183, 192, 242, 283, 42968, 74, 332, 39544, 230, 232PATM49, 130, 155, 163, 168...PBID150, 245, 299RAD9A86, 345H2AX12, 76, 87, 170, 226...DNA Repair53, 106, 240, 324, 352PAPAF1CASP9CASP331, 60, 134, 281, 376...RNF8270, 280, 306RIF196, 132, 363Cell CycleCheckpoint Activation55, 118, 174, 195, 259G2/M-Phase Checkpoint120, 122, 311Damage ProcessingDNA Polymerasedelta tetramer123114, 129, 316Member of the groupIntermediate paths not shownPath to processStimulation pathRelation to pathRelation to path(intermediate steps not shown)CDC25C203, 223, 304Translocation pathATMTRAF6Cell Survival190ABL167, 359, 378, 389ACTL6AKAT577250437MDM2ARF(CDKN2A)Cell cycle arrestat G1 & G2ARF-MD2McomplexATF2154, 405, 40922, 242, 41245, 56307400MRE11A400RAD50NBNGammaH2AXMDC1MRNcomplex173YAP130094, 355, 358, 422FANCD2109, 125, 197, 199, 209...46, 60, 82, 112, 205...13, 164, 270, 280, 306FANCD1FANCD1BRCA228, 318, 3211963, 191, 350410


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History

View all...
CompareRevisionActionTimeUserComment
135238view22:34, 8 August 2024EweitzRemove obsolete, incorrect metadata
135237view22:33, 8 August 2024EweitzRefine complex label positions
135236view22:27, 8 August 2024EweitzRefine interaction curves
135235view22:24, 8 August 2024EweitzEconomize layout
135234view22:17, 8 August 2024EweitzRestore complex positions
135233view22:11, 8 August 2024EweitzRefine legend
135232view22:06, 8 August 2024EweitzEconomize layout
135231view22:02, 8 August 2024EweitzEconomize layout
118468view15:12, 27 May 2021Marvin M2removed empty ref
118466view15:10, 27 May 2021Marvin M2corrected author names
116540view12:10, 7 May 2021EweitzModified title
101991view19:16, 22 November 2018EgonwRemove
101834view13:03, 12 November 2018EgonwReplaced an old Uniprot data source with the new one.
95280view18:09, 29 November 2017AmanzoImprovements in conection lines.
95274view17:36, 28 November 2017AmanzoCorrection in line connections.
91367view20:47, 10 February 2017KhanspersModified title
91329view19:06, 31 January 2017Amanzo1 Datanode updated
91328view18:45, 31 January 2017Amanzo2 Datanodes updated
91327view18:13, 31 January 2017Amanzo5 Datanodes updated
91072view18:17, 30 December 2016AmanzoOntology Term : 'disease of cellular proliferation' added !
91071view18:15, 30 December 2016AmanzoOntology Term : 'altered programmed cell death pathway' added !
91070view18:14, 30 December 2016AmanzoOntology Term : 'pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis' added !
91069view18:13, 30 December 2016AmanzoOntology Term : 'altered double-strand DNA repair pathway' added !
91068view18:09, 30 December 2016AmanzoModified description
91065view17:29, 29 December 2016AmanzoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1ProteinP00519 (Uniprot-TrEMBL)
ACTL6AProteinO96019 (Uniprot-TrEMBL)
APAF1ProteinO14727 (Uniprot-TrEMBL)
ARF (CDKN2A)ProteinQ8N726 (Uniprot-TrEMBL)
ATF2GeneProductENSG00000115966 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ATMProteinQ13315 (Uniprot-TrEMBL)
ATRPathwayFrom Pathway: SPIKE 00003
ApoptosisPathwayR-HSA-109581 (Reactome)
BAK1ProteinQ16611 (Uniprot-TrEMBL)
BAXProteinQ07812 (Uniprot-TrEMBL)
BIDProteinP55957 (Uniprot-TrEMBL)
BLMProtein
BRCA1ProteinP38398 (Uniprot-TrEMBL)
BRCA2Protein
CASP3ProteinP42574 (Uniprot-TrEMBL)
CASP9ProteinP55211 (Uniprot-TrEMBL)
CDC25CProteinP30307 (Uniprot-TrEMBL)
CDK5ProteinQ00535 (Uniprot-TrEMBL)
CHK1ProteinO14757 (Uniprot-TrEMBL)
CHK2ProteinO96017 (Uniprot-TrEMBL)
Cell Cycle Checkpoint ActivationPathwayWP1775 (WikiPathways)
Cell SurvivalPathway
Cell cycle arrest at G1 & G2Pathway
CohesinProtein
DCLRE1CProteinQ96SD1 (Uniprot-TrEMBL)
DNA Polymerase delta tetramerProtein
DNA RepairPathwayWP707 (WikiPathways)
DNA-PKProteinP78527 (Uniprot-TrEMBL)
Damage ProcessingPathway
E2F1ProteinQ01094 (Uniprot-TrEMBL)
EXO1ProteinQ9UQ84 (Uniprot-TrEMBL)
FANCD1Protein
FANCD2ProteinQ9BXW9 (Uniprot-TrEMBL)
G2/M-Phase CheckpointPathwayR-HSA-69481 (Reactome)
Gamma H2AXProteinP16104 (Uniprot-TrEMBL)
H2AXProteinP16104 (Uniprot-TrEMBL)
HSF1ProteinQ00613 (Uniprot-TrEMBL)
KAT5ProteinQ92993 (Uniprot-TrEMBL) Q92993 is the catalytic subunit of the NuA4 histone acetyltransferase complex.
LATS1ProteinO95835 (Uniprot-TrEMBL)
M-Phase ProgressionPathwayhsa04110 (KEGG Pathway)
MCPH1ProteinQ8NEM0 (Uniprot-TrEMBL)
MDC1ProteinQ14676 (Uniprot-TrEMBL)
MDM2ProteinQ00987 (Uniprot-TrEMBL)
MRE11AProteinP49959 (Uniprot-TrEMBL)
NBNProteinO60934 (Uniprot-TrEMBL)
NFkB activationPathway
OBFC2BProteinQ9BQ15 (Uniprot-TrEMBL)
PARP1ProteinP09874 (Uniprot-TrEMBL)
PCNAProteinP12004 (Uniprot-TrEMBL)
RAD17ProteinO75943 (Uniprot-TrEMBL)
RAD50ProteinQ92878 (Uniprot-TrEMBL)
RAD51ProteinQ06609 (Uniprot-TrEMBL)
RAD52ProteinP43351 (Uniprot-TrEMBL)
RAD9AGeneProductENSG00000172613 (Ensembl)
RASSF1ProteinQ9NS23 (Uniprot-TrEMBL)
RIF1ProteinQ5UIP0 (Uniprot-TrEMBL)
RNF8Protein
SMC1AProteinQ14683 (Uniprot-TrEMBL)
SMC3ProteinQ9UQE7 (Uniprot-TrEMBL)
STK3ProteinQ13188 (Uniprot-TrEMBL)
TERF2ProteinQ15554 (Uniprot-TrEMBL)
TP53BP1ProteinQ12888 (Uniprot-TrEMBL)
TP53ProteinP04637 (Uniprot-TrEMBL)
TRAF6ProteinQ9Y4K3 (Uniprot-TrEMBL)
TRIM28ProteinQ13263 (Uniprot-TrEMBL)
The intra-S-phase

checkpoint mediated arrest of cell cycle

progression		PathwayR-HSA-5693571 (Reactome)
UPF1ProteinQ92900 (Uniprot-TrEMBL)
YAP1ProteinP46937 (Uniprot-TrEMBL)
mRNA nonsense-mediated decay (NMD)Pathway
p73ProteinO15350 (Uniprot-TrEMBL)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
ATMmim-stimulation00006 (SPIKE)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3959"
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