"Figure 7. Cu homeostasis in worms is maintained by distinctly localized intestinal CUA-1 isoforms.
(A) Confocal images of transgenic animals [Pvha-6::CUA-1.2::GFP::unc-54 3’UTR] expressing CUA-
1.2::GFP in the intestine in the presence of 50 μM of supplemental Cu or BCS. Scale bar, 10 μm. (B) A
model of Cu homeostasis in C. elegans is shown. Dietary Cu ions are transported from the lumen of the
intestine to the enterocytes by an unidentified Cu importer, and CUC-1 delivers Cu to CUA-1. Under
basal Cu or Cu-deficient conditions, CUA-1.1 isoform localizes to the basolateral membrane and Golgi to
either export Cu ions to peripheral tissues, or to direct Cu into the secretory pathway. CUA-1.2
consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. CUA-1.1 is
redistributed to the gut-granule membranes in response to elevated Cu levels in order to promote Cu
detoxification in C. elegans."
"CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions." Evidence: "Confocal images of transgenic animals [Pvha-6::CUA-1.2::GFP::unc-54 3’UTR] expressing CUA-1.2::GFP in the intestine in the presence of 50 μM of supplemental Cu or BCS."
(A) Confocal images of transgenic animals [Pvha-6::CUA-1.2::GFP::unc-54 3’UTR] expressing CUA-
1.2::GFP in the intestine in the presence of 50 μM of supplemental Cu or BCS. Scale bar, 10 μm. (B) A
model of Cu homeostasis in C. elegans is shown. Dietary Cu ions are transported from the lumen of the
intestine to the enterocytes by an unidentified Cu importer, and CUC-1 delivers Cu to CUA-1. Under
basal Cu or Cu-deficient conditions, CUA-1.1 isoform localizes to the basolateral membrane and Golgi to
either export Cu ions to peripheral tissues, or to direct Cu into the secretory pathway. CUA-1.2
consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. CUA-1.1 is
redistributed to the gut-granule membranes in response to elevated Cu levels in order to promote Cu
detoxification in C. elegans."
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