User:Marvin M2/AOPportal/Mission

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The purpose behind the creation of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the EU-ToxRisk program, in which Open PHACTS Foundation (OPF) is responsible for AOP creation. The subject of the first set of AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.

The proposed list of the first set of AOPs is:

  • Inhibition of β-oxidation leads to liver steatosis
  • HDAC inhibition, folate antagonism, oxidative stress and foetus accumulation lead to teratogenicity
  • Oxidative stress leads to hepatotoxicity
  • Oxidative stress leads to nephrotoxicity
  • Disturbance of the respiratory chain leads to mitotoxicity
  • PPAR activation leads to hepatoxicity
  • OAT overactivation leads to nephrotoxicity
  • PXR activation leads to liver steatosis
  • NAPQI production causes hepatotoxicity
  • MTP impairment leads to hepatotoxicity
  • CYP51 inhibition causes embryotoxicity
  • Epithelial damage leads to popcorn lung

Basic strategies and principles for general AOPs are described in this paper:

Villeneuve et al. (2014). Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. Toxicological Sciences PubMed

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